Danio rerio

0 known processes

sqstm1

sequestosome 1

(Aliases: sb:cb621,zgc:85784)

sqstm1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.239
regulation of cytokine production GO:0001817 3 0.221
regulation of metabolic process GO:0019222 359 0.218
biosynthetic process GO:0009058 294 0.210
regulation of macromolecule metabolic process GO:0060255 317 0.199
cellular macromolecule metabolic process GO:0044260 391 0.197
signal transduction GO:0007165 455 0.190
negative regulation of cellular process GO:0048523 283 0.171
immune system development GO:0002520 191 0.167
response to stress GO:0006950 263 0.147
positive regulation of cellular process GO:0048522 201 0.143
multi organism process GO:0051704 134 0.128
leukocyte mediated cytotoxicity GO:0001909 1 0.124
regulation of cell communication GO:0010646 232 0.121
positive regulation of biological process GO:0048518 253 0.119
nitrogen compound metabolic process GO:0006807 319 0.113
generation of neurons GO:0048699 385 0.113
organic cyclic compound biosynthetic process GO:1901362 223 0.110
organic substance biosynthetic process GO:1901576 289 0.106
hemopoiesis GO:0030097 183 0.102
hematopoietic or lymphoid organ development GO:0048534 191 0.102
cell killing GO:0001906 2 0.095
regulation of response to stimulus GO:0048583 269 0.093
protein localization to nucleus GO:0034504 3 0.090
response to organic substance GO:0010033 153 0.084
locomotion GO:0040011 313 0.083
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.080
establishment of protein localization to organelle GO:0072594 4 0.079
developmental growth GO:0048589 166 0.074
regulation of gene expression GO:0010468 265 0.073
transcription dna templated GO:0006351 181 0.070
cellular nitrogen compound biosynthetic process GO:0044271 218 0.069
cellular protein metabolic process GO:0044267 129 0.069
protein targeting to nucleus GO:0044744 3 0.068
maintenance of location GO:0051235 4 0.067
regulation of cellular metabolic process GO:0031323 320 0.067
regulation of signal transduction GO:0009966 225 0.066
response to external stimulus GO:0009605 264 0.065
regulation of response to oxidative stress GO:1902882 2 0.063
heterocycle metabolic process GO:0046483 290 0.063
growth GO:0040007 174 0.062
response to other organism GO:0051707 97 0.062
extrinsic apoptotic signaling pathway GO:0097191 3 0.061
aromatic compound biosynthetic process GO:0019438 217 0.061
regulation of nitrogen compound metabolic process GO:0051171 251 0.061
autophagy GO:0006914 4 0.061
positive regulation of cell killing GO:0031343 2 0.061
neuron projection development GO:0031175 180 0.061
transport GO:0006810 220 0.060
immune system process GO:0002376 241 0.060
i kappab kinase nf kappab signaling GO:0007249 4 0.060
response to chemical GO:0042221 320 0.059
regulation of signaling GO:0023051 235 0.058
negative regulation of macromolecule metabolic process GO:0010605 76 0.057
neuron differentiation GO:0030182 353 0.056
response to inorganic substance GO:0010035 38 0.056
response to bacterium GO:0009617 58 0.056
neuron development GO:0048666 262 0.056
positive regulation of transport GO:0051050 2 0.054
apoptotic process GO:0006915 116 0.053
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.052
regulation of primary metabolic process GO:0080090 311 0.052
single organism nuclear import GO:1902593 3 0.051
multicellular organism growth GO:0035264 4 0.051
myeloid cell homeostasis GO:0002262 56 0.050
regulation of multicellular organism growth GO:0040014 4 0.050
single organism membrane fusion GO:0044801 2 0.050
membrane fusion GO:0061025 2 0.049
response to alkaloid GO:0043279 2 0.049
nucleic acid templated transcription GO:0097659 181 0.049
regulation of developmental process GO:0050793 247 0.049
death GO:0016265 121 0.048
regulation of multicellular organismal process GO:0051239 277 0.048
positive regulation of macromolecule metabolic process GO:0010604 93 0.047
regulation of cell death GO:0010941 103 0.047
cellular biosynthetic process GO:0044249 286 0.046
positive regulation of myeloid cell differentiation GO:0045639 2 0.044
phagocytosis GO:0006909 3 0.044
positive regulation of secretion by cell GO:1903532 1 0.042
positive regulation of exocytosis GO:0045921 1 0.042
homeostatic process GO:0042592 142 0.042
macromolecule biosynthetic process GO:0009059 227 0.040
regulation of biosynthetic process GO:0009889 250 0.040
cellular response to chemical stimulus GO:0070887 157 0.039
homeostasis of number of cells GO:0048872 62 0.039
protein metabolic process GO:0019538 183 0.038
central nervous system development GO:0007417 387 0.038
regulation of biological quality GO:0065008 263 0.038
lipid storage GO:0019915 1 0.038
response to biotic stimulus GO:0009607 97 0.038
endosome to lysosome transport GO:0008333 1 0.037
nucleocytoplasmic transport GO:0006913 4 0.037
cell death GO:0008219 121 0.037
organic cyclic compound metabolic process GO:1901360 301 0.037
nucleobase containing compound biosynthetic process GO:0034654 205 0.037
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.036
response to glucocorticoid GO:0051384 1 0.036
cellular nitrogen compound metabolic process GO:0034641 290 0.036
cellular response to lipopolysaccharide GO:0071222 3 0.036
nuclear transport GO:0051169 4 0.035
cell surface receptor signaling pathway GO:0007166 325 0.035
tissue remodeling GO:0048771 4 0.035
cell projection morphogenesis GO:0048858 244 0.035
regulation of cell killing GO:0031341 2 0.034
response to external biotic stimulus GO:0043207 97 0.034
positive regulation of immune effector process GO:0002699 3 0.033
cellular amide metabolic process GO:0043603 4 0.033
cell motility GO:0048870 244 0.033
cellular response to external stimulus GO:0071496 2 0.032
positive regulation of metabolic process GO:0009893 108 0.032
negative regulation of biological process GO:0048519 304 0.032
nuclear import GO:0051170 3 0.032
regulation of rna metabolic process GO:0051252 224 0.032
negative regulation of cellular biosynthetic process GO:0031327 55 0.032
neuron projection morphogenesis GO:0048812 161 0.032
response to corticosteroid GO:0031960 1 0.031
regulation of cellular biosynthetic process GO:0031326 245 0.031
regulation of nucleic acid templated transcription GO:1903506 213 0.031
regulation of cellular response to oxidative stress GO:1900407 2 0.030
cellular response to extracellular stimulus GO:0031668 2 0.030
protein import into nucleus GO:0006606 3 0.030
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.030
hydrogen peroxide metabolic process GO:0042743 2 0.030
positive regulation of signal transduction GO:0009967 56 0.029
nucleic acid metabolic process GO:0090304 244 0.029
cellular response to molecule of bacterial origin GO:0071219 3 0.029
response to abiotic stimulus GO:0009628 122 0.029
cellular amino acid metabolic process GO:0006520 7 0.029
regulation of intracellular signal transduction GO:1902531 57 0.029
cellular macromolecule biosynthetic process GO:0034645 224 0.028
rna biosynthetic process GO:0032774 181 0.028
single organism metabolic process GO:0044710 217 0.028
peptide metabolic process GO:0006518 1 0.028
heterocycle biosynthetic process GO:0018130 215 0.028
mitochondrion organization GO:0007005 4 0.027
positive regulation of response to stimulus GO:0048584 80 0.027
membrane invagination GO:0010324 1 0.027
axon development GO:0061564 166 0.027
negative regulation of cellular metabolic process GO:0031324 77 0.027
response to radiation GO:0009314 51 0.027
phosphate containing compound metabolic process GO:0006796 108 0.027
tissue homeostasis GO:0001894 25 0.027
response to metal ion GO:0010038 34 0.026
natural killer cell mediated immunity GO:0002228 1 0.026
positive regulation of signaling GO:0023056 56 0.026
cellular protein catabolic process GO:0044257 4 0.026
multi organism cellular process GO:0044764 2 0.026
regulation of transcription dna templated GO:0006355 213 0.026
interspecies interaction between organisms GO:0044419 4 0.026
anterior posterior pattern specification GO:0009952 152 0.025
regeneration GO:0031099 91 0.025
regulation of tube size GO:0035150 2 0.025
apoptotic signaling pathway GO:0097190 23 0.025
regulation of response to stress GO:0080134 36 0.024
leukocyte mediated immunity GO:0002443 6 0.024
intracellular signal transduction GO:0035556 85 0.024
macromolecule modification GO:0043412 111 0.024
signal transduction in absence of ligand GO:0038034 1 0.024
regulation of rna biosynthetic process GO:2001141 213 0.024
cellular aromatic compound metabolic process GO:0006725 295 0.023
epithelial cell differentiation GO:0030855 116 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
transcription from rna polymerase iii promoter GO:0006383 1 0.023
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.023
regulation of dna templated transcription in response to stress GO:0043620 0 0.022
enzyme linked receptor protein signaling pathway GO:0007167 106 0.022
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.022
response to drug GO:0042493 3 0.022
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.022
multicellular organismal macromolecule metabolic process GO:0044259 2 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.022
cellular response to biotic stimulus GO:0071216 3 0.022
membrane organization GO:0061024 21 0.021
myeloid cell differentiation GO:0030099 86 0.021
negative regulation of cytokine production GO:0001818 1 0.021
protein import GO:0017038 3 0.021
macrophage chemotaxis GO:0048246 3 0.021
organic acid metabolic process GO:0006082 31 0.020
organelle fusion GO:0048284 3 0.020
single organism organelle organization GO:1902589 199 0.020
regulation of neurogenesis GO:0050767 87 0.020
larval development GO:0002164 2 0.020
regulation of reactive oxygen species metabolic process GO:2000377 2 0.020
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.020
blood vessel morphogenesis GO:0048514 216 0.019
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.019
gene expression GO:0010467 252 0.019
anatomical structure homeostasis GO:0060249 36 0.019
regionalization GO:0003002 274 0.019
cellular response to organic substance GO:0071310 105 0.019
response to transition metal nanoparticle GO:1990267 28 0.019
positive regulation of cellular metabolic process GO:0031325 94 0.019
myotube differentiation GO:0014902 45 0.018
single organism membrane organization GO:0044802 20 0.018
organelle organization GO:0006996 227 0.018
oxoacid metabolic process GO:0043436 31 0.018
single organism cellular localization GO:1902580 46 0.018
regulation of oxidative stress induced cell death GO:1903201 2 0.018
cellular modified amino acid metabolic process GO:0006575 3 0.018
regulation of glial cell differentiation GO:0045685 4 0.017
regulation of cytokine biosynthetic process GO:0042035 1 0.017
negative regulation of metabolic process GO:0009892 86 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.017
production of molecular mediator of immune response GO:0002440 2 0.017
nucleobase containing compound metabolic process GO:0006139 274 0.017
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
cellular response to starvation GO:0009267 1 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.017
vacuolar transport GO:0007034 2 0.017
embryonic organ development GO:0048568 381 0.016
response to ketone GO:1901654 1 0.016
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.016
camera type eye development GO:0043010 222 0.016
b cell activation GO:0042113 2 0.016
positive regulation of jnk cascade GO:0046330 3 0.016
superoxide metabolic process GO:0006801 2 0.016
cellular response to stress GO:0033554 62 0.016
protein complex localization GO:0031503 1 0.016
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.015
cellular protein modification process GO:0006464 100 0.015
establishment of localization GO:0051234 244 0.015
protein modification process GO:0036211 100 0.015
positive regulation of secretion GO:0051047 1 0.015
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.015
establishment of localization in cell GO:0051649 77 0.015
erythrocyte differentiation GO:0030218 54 0.015
lytic vacuole organization GO:0080171 1 0.015
gland development GO:0048732 143 0.015
regulation of protein metabolic process GO:0051246 56 0.015
smooth muscle tissue development GO:0048745 1 0.015
peripheral nervous system neuron differentiation GO:0048934 28 0.015
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.015
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.015
brain development GO:0007420 293 0.015
multicellular organismal homeostasis GO:0048871 29 0.015
germ cell development GO:0007281 22 0.014
response to oxygen levels GO:0070482 25 0.014
regulation of blood pressure GO:0008217 1 0.014
cellular amine metabolic process GO:0044106 2 0.014
response to organic cyclic compound GO:0014070 51 0.014
regulation of establishment of protein localization GO:0070201 4 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
cell proliferation GO:0008283 80 0.014
regulation of blood vessel size GO:0050880 2 0.014
cellular ketone metabolic process GO:0042180 11 0.014
tissue regeneration GO:0042246 74 0.014
b cell differentiation GO:0030183 1 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
phagocytosis engulfment GO:0006911 1 0.014
protein localization GO:0008104 40 0.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
embryonic skeletal system morphogenesis GO:0048704 93 0.014
tube morphogenesis GO:0035239 349 0.013
myeloid leukocyte migration GO:0097529 12 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
response to lipid GO:0033993 60 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
regulation of response to nutrient levels GO:0032107 1 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.013
regulation of localization GO:0032879 104 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
immune response GO:0006955 28 0.013
negative regulation of signaling GO:0023057 96 0.013
leukocyte differentiation GO:0002521 25 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
negative regulation of response to cytokine stimulus GO:0060761 2 0.013
smooth muscle contraction GO:0006939 2 0.012
response to xenobiotic stimulus GO:0009410 45 0.012
positive regulation of cell communication GO:0010647 56 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
regulation of oligodendrocyte differentiation GO:0048713 1 0.012
regulation of programmed cell death GO:0043067 101 0.012
lymphocyte differentiation GO:0030098 9 0.012
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.012
peptide transport GO:0015833 1 0.012
cell activation GO:0001775 16 0.012
regulation of cytokine mediated signaling pathway GO:0001959 3 0.012
regulation of autophagy GO:0010506 3 0.012
cellular response to reactive oxygen species GO:0034614 2 0.012
endosomal transport GO:0016197 2 0.012
immune effector process GO:0002252 23 0.012
muscle structure development GO:0061061 196 0.012
notch signaling pathway GO:0007219 35 0.012
exocytosis GO:0006887 1 0.012
interaction with host GO:0051701 4 0.012
regulation of binding GO:0051098 3 0.012
toxin metabolic process GO:0009404 1 0.012
reactive oxygen species metabolic process GO:0072593 6 0.012
negative regulation of intracellular protein transport GO:0090317 3 0.012
respiratory system development GO:0060541 5 0.011
regulation of apoptotic process GO:0042981 98 0.011
regulation of locomotion GO:0040012 55 0.011
bone remodeling GO:0046849 2 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
viral process GO:0016032 1 0.011
regulation of nervous system development GO:0051960 90 0.011
response to hydrogen peroxide GO:0042542 3 0.011
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.011
localization of cell GO:0051674 244 0.011
response to nicotine GO:0035094 2 0.011
eye development GO:0001654 277 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
leukocyte proliferation GO:0070661 1 0.011
homeostasis of number of cells within a tissue GO:0048873 4 0.011
negative regulation of apoptotic process GO:0043066 55 0.011
negative regulation of multi organism process GO:0043901 3 0.011
erythrocyte homeostasis GO:0034101 55 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.011
system process GO:0003008 185 0.011
cognition GO:0050890 1 0.011
response to molecule of bacterial origin GO:0002237 14 0.010
response to hexose GO:0009746 3 0.010
neuron projection guidance GO:0097485 86 0.010
single organism intracellular transport GO:1902582 25 0.010
regulation of response to cytokine stimulus GO:0060759 3 0.010
leukocyte migration GO:0050900 15 0.010
positive regulation of cytokine production GO:0001819 2 0.010
retina development in camera type eye GO:0060041 146 0.010
cellular component movement GO:0006928 335 0.010
negative regulation of innate immune response GO:0045824 2 0.010
sensory organ development GO:0007423 393 0.010
response to light stimulus GO:0009416 46 0.010
behavior GO:0007610 74 0.010

sqstm1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.167
nervous system disease DOID:863 0 0.062
immune system disease DOID:2914 0 0.022
neuromuscular disease DOID:440 0 0.022
charcot marie tooth disease DOID:10595 0 0.022
neuropathy DOID:870 0 0.022
cardiovascular system disease DOID:1287 0 0.021
disease of metabolism DOID:0014667 0 0.020
disease of cellular proliferation DOID:14566 0 0.012