Danio rerio

0 known processes

ak4

adenylate kinase 4

(Aliases: zgc:85790,ak3l1,wu:fc37g02)

ak4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular nitrogen compound metabolic process GO:0034641 290 0.141
Human
organic cyclic compound metabolic process GO:1901360 301 0.130
Human
regulation of biological quality GO:0065008 263 0.099
biosynthetic process GO:0009058 294 0.093
Human
aging GO:0007568 2 0.083
maintenance of location GO:0051235 4 0.080
single organism metabolic process GO:0044710 217 0.079
Human
head development GO:0060322 303 0.065
cellular macromolecule metabolic process GO:0044260 391 0.053
locomotion GO:0040011 313 0.053
growth GO:0040007 174 0.053
phagocytosis GO:0006909 3 0.050
brain development GO:0007420 293 0.048
heterocycle metabolic process GO:0046483 290 0.048
Human
regulation of multicellular organism growth GO:0040014 4 0.047
aromatic compound biosynthetic process GO:0019438 217 0.047
Human
neuron differentiation GO:0030182 353 0.047
organonitrogen compound metabolic process GO:1901564 74 0.047
Human
single organism biosynthetic process GO:0044711 71 0.046
Human
central nervous system development GO:0007417 387 0.046
regulation of developmental process GO:0050793 247 0.045
negative regulation of biological process GO:0048519 304 0.044
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.044
neuron projection development GO:0031175 180 0.044
amine metabolic process GO:0009308 2 0.043
response to external stimulus GO:0009605 264 0.042
mononuclear cell proliferation GO:0032943 1 0.041
protein targeting to membrane GO:0006612 1 0.041
lipid storage GO:0019915 1 0.040
multicellular organism growth GO:0035264 4 0.040
nucleobase containing compound metabolic process GO:0006139 274 0.039
Human
cell surface receptor signaling pathway GO:0007166 325 0.039
nitrogen compound metabolic process GO:0006807 319 0.039
Human
organonitrogen compound biosynthetic process GO:1901566 47 0.037
regulation of cell differentiation GO:0045595 142 0.035
regulation of cellular metabolic process GO:0031323 320 0.035
astrocyte differentiation GO:0048708 1 0.034
lateral inhibition GO:0046331 1 0.034
positive regulation of biological process GO:0048518 253 0.034
oxoacid metabolic process GO:0043436 31 0.032
cellular biosynthetic process GO:0044249 286 0.032
Human
organic substance biosynthetic process GO:1901576 289 0.032
Human
alpha amino acid metabolic process GO:1901605 3 0.032
somatic muscle development GO:0007525 4 0.032
response to chemical GO:0042221 320 0.032
cellular aromatic compound metabolic process GO:0006725 295 0.032
Human
developmental growth GO:0048589 166 0.031
generation of neurons GO:0048699 385 0.031
neuron development GO:0048666 262 0.031
organic acid metabolic process GO:0006082 31 0.030
transport GO:0006810 220 0.030
heart development GO:0007507 313 0.030
regulation of multicellular organismal process GO:0051239 277 0.030
phosphorus metabolic process GO:0006793 109 0.030
Human
leukocyte proliferation GO:0070661 1 0.030
transmission of nerve impulse GO:0019226 19 0.030
alcohol biosynthetic process GO:0046165 2 0.029
positive regulation of cell cycle GO:0045787 3 0.029
glycerophospholipid biosynthetic process GO:0046474 1 0.029
negative regulation of cellular process GO:0048523 283 0.028
lymphocyte proliferation GO:0046651 1 0.028
neuron neuron synaptic transmission GO:0007270 1 0.028
adult behavior GO:0030534 2 0.027
positive regulation of cellular component biogenesis GO:0044089 3 0.026
cation transmembrane transport GO:0098655 65 0.025
single organism transport GO:0044765 206 0.025
regulation of meiotic cell cycle GO:0051445 1 0.025
organophosphate biosynthetic process GO:0090407 23 0.025
Human
response to stress GO:0006950 263 0.025
cellular response to external stimulus GO:0071496 2 0.024
cellular component morphogenesis GO:0032989 336 0.024
cellular amine metabolic process GO:0044106 2 0.024
regulation of protein transport GO:0051223 3 0.024
convergent extension GO:0060026 118 0.024
system process GO:0003008 185 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.024
immune system process GO:0002376 241 0.023
regulation of metabolic process GO:0019222 359 0.023
positive regulation of catabolic process GO:0009896 4 0.023
negative regulation of secretion GO:0051048 2 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.023
cell morphogenesis GO:0000902 289 0.022
signal transduction GO:0007165 455 0.022
tube morphogenesis GO:0035239 349 0.022
regulation of metal ion transport GO:0010959 4 0.022
cellular transition metal ion homeostasis GO:0046916 3 0.022
cellular component movement GO:0006928 335 0.021
single organism organelle organization GO:1902589 199 0.021
inorganic ion transmembrane transport GO:0098660 57 0.021
regulation of establishment of protein localization GO:0070201 4 0.021
regulation of reproductive process GO:2000241 4 0.020
regulation of autophagy GO:0010506 3 0.020
negative regulation of macromolecule metabolic process GO:0010605 76 0.020
regulation of filopodium assembly GO:0051489 2 0.020
rna metabolic process GO:0016070 219 0.020
small molecule metabolic process GO:0044281 77 0.020
Human
establishment of protein localization to plasma membrane GO:0090002 1 0.020
dna templated transcription initiation GO:0006352 1 0.019
cellular component assembly GO:0022607 170 0.019
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.019
negative regulation of response to stimulus GO:0048585 104 0.019
synaptic growth at neuromuscular junction GO:0051124 2 0.019
golgi vesicle transport GO:0048193 3 0.019
intracellular signal transduction GO:0035556 85 0.019
cellular component biogenesis GO:0044085 178 0.019
development of primary female sexual characteristics GO:0046545 4 0.019
autophagy GO:0006914 4 0.019
regulation of nitrogen compound metabolic process GO:0051171 251 0.019
regulation of binding GO:0051098 3 0.018
response to hexose GO:0009746 3 0.018
protein metabolic process GO:0019538 183 0.018
cellular biogenic amine metabolic process GO:0006576 2 0.018
regulation of cell projection assembly GO:0060491 4 0.018
cellular ketone metabolic process GO:0042180 11 0.018
female sex differentiation GO:0046660 4 0.018
dendrite guidance GO:0070983 0 0.018
vasculature development GO:0001944 278 0.018
negative regulation of multicellular organismal process GO:0051241 69 0.018
negative regulation of protein phosphorylation GO:0001933 4 0.018
meiotic nuclear division GO:0007126 4 0.018
cellular carbohydrate metabolic process GO:0044262 4 0.018
single organism nuclear import GO:1902593 3 0.018
regulation of cytoplasmic transport GO:1903649 4 0.017
lipid metabolic process GO:0006629 52 0.017
organic cyclic compound biosynthetic process GO:1901362 223 0.017
Human
regulation of muscle contraction GO:0006937 3 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
regulation of rna metabolic process GO:0051252 224 0.017
circulatory system process GO:0003013 87 0.017
positive regulation of cytoskeleton organization GO:0051495 3 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
Human
regulation of nucleoside metabolic process GO:0009118 2 0.017
cellular response to chemical stimulus GO:0070887 157 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
negative regulation of chemotaxis GO:0050922 4 0.017
cell part morphogenesis GO:0032990 246 0.016
response to biotic stimulus GO:0009607 97 0.016
secondary metabolic process GO:0019748 3 0.016
regulation of primary metabolic process GO:0080090 311 0.016
regulation of cell communication GO:0010646 232 0.016
cellular response to nutrient levels GO:0031669 2 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
regulation of cell shape GO:0008360 1 0.016
regulation of smoothened signaling pathway GO:0008589 18 0.016
ion transmembrane transport GO:0034220 91 0.016
cellular response to organic substance GO:0071310 105 0.016
cellular nitrogen compound biosynthetic process GO:0044271 218 0.016
Human
single organism localization GO:1902578 225 0.015
heterocycle biosynthetic process GO:0018130 215 0.015
Human
regulation of synapse assembly GO:0051963 3 0.015
cell cycle arrest GO:0007050 1 0.015
calcium mediated signaling GO:0019722 2 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
regulation of dendrite development GO:0050773 3 0.015
negative regulation of signaling GO:0023057 96 0.015
enzyme linked receptor protein signaling pathway GO:0007167 106 0.015
organophosphate metabolic process GO:0019637 37 0.015
Human
regulation of response to stimulus GO:0048583 269 0.015
negative regulation of metabolic process GO:0009892 86 0.015
cellular response to extracellular stimulus GO:0031668 2 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
neurological system process GO:0050877 62 0.014
g1 s transition of mitotic cell cycle GO:0000082 1 0.014
regulation of biosynthetic process GO:0009889 250 0.014
centrosome organization GO:0051297 1 0.014
gastrulation GO:0007369 208 0.014
extrinsic apoptotic signaling pathway GO:0097191 3 0.014
blood circulation GO:0008015 87 0.014
erk1 and erk2 cascade GO:0070371 4 0.014
inositol lipid mediated signaling GO:0048017 2 0.014
mucopolysaccharide metabolic process GO:1903510 2 0.014
regulation of cell activation GO:0050865 1 0.014
tissue remodeling GO:0048771 4 0.014
response to external biotic stimulus GO:0043207 97 0.014
small gtpase mediated signal transduction GO:0007264 8 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
regulation of blood pressure GO:0008217 1 0.014
protein acylation GO:0043543 3 0.014
rna biosynthetic process GO:0032774 181 0.014
internal peptidyl lysine acetylation GO:0018393 2 0.014
regulation of signaling GO:0023051 235 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
regulation of nervous system development GO:0051960 90 0.013
establishment of localization GO:0051234 244 0.013
purine nucleotide metabolic process GO:0006163 27 0.013
Human
branched chain amino acid metabolic process GO:0009081 1 0.013
protein polymerization GO:0051258 4 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
neuronal action potential GO:0019228 18 0.013
striated muscle tissue development GO:0014706 110 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
homeostatic process GO:0042592 142 0.013
protein import GO:0017038 3 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
positive regulation of transport GO:0051050 2 0.013
germ line stem cell maintenance GO:0030718 2 0.013
protein localization to nucleus GO:0034504 3 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
cell morphogenesis involved in differentiation GO:0000904 195 0.013
response to monosaccharide GO:0034284 3 0.012
stem cell proliferation GO:0072089 4 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
multicellular organismal signaling GO:0035637 22 0.012
response to alkaloid GO:0043279 2 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
Human
regulation of cytokine production GO:0001817 3 0.012
regulation of hormone secretion GO:0046883 2 0.012
urogenital system development GO:0001655 97 0.012
positive regulation of cellular process GO:0048522 201 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
nuclear transport GO:0051169 4 0.012
glycerolipid biosynthetic process GO:0045017 1 0.012
peptidyl lysine acetylation GO:0018394 2 0.012
negative regulation of cytokine production GO:0001818 1 0.012
lytic vacuole organization GO:0080171 1 0.012
regulation of biomineral tissue development GO:0070167 2 0.012
protein acetylation GO:0006473 2 0.012
chordate embryonic development GO:0043009 271 0.012
axonogenesis GO:0007409 152 0.012
negative regulation of developmental process GO:0051093 65 0.012
negative chemotaxis GO:0050919 1 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
meiotic chromosome segregation GO:0045132 3 0.012
macromolecular complex subunit organization GO:0043933 74 0.012
negative regulation of blood circulation GO:1903523 2 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
negative regulation of secretion by cell GO:1903531 2 0.012
cellular localization GO:0051641 97 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
peptidyl serine phosphorylation GO:0018105 1 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
activation of mapk activity GO:0000187 3 0.012
response to glucose GO:0009749 3 0.012
regulation of gtpase activity GO:0043087 2 0.011
pyruvate metabolic process GO:0006090 1 0.011
cell cycle process GO:0022402 53 0.011
pyrimidine containing compound metabolic process GO:0072527 3 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
hemopoiesis GO:0030097 183 0.011
macromolecule modification GO:0043412 111 0.011
energy reserve metabolic process GO:0006112 2 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
photoreceptor cell fate commitment GO:0046552 1 0.011
protein import into nucleus GO:0006606 3 0.011
regulation of response to nutrient levels GO:0032107 1 0.011
cell projection morphogenesis GO:0048858 244 0.011
inorganic cation transmembrane transport GO:0098662 50 0.011
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.011
carboxylic acid catabolic process GO:0046395 3 0.011
response to abiotic stimulus GO:0009628 122 0.011
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
cellular amino acid biosynthetic process GO:0008652 2 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
nucleic acid templated transcription GO:0097659 181 0.011
hormone transport GO:0009914 2 0.011
connective tissue development GO:0061448 99 0.011
regulation of protein catabolic process GO:0042176 1 0.011
nucleobase containing small molecule metabolic process GO:0055086 32 0.011
Human
cell substrate adherens junction assembly GO:0007045 1 0.011
kidney development GO:0001822 92 0.011
leukocyte mediated cytotoxicity GO:0001909 1 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
specification of symmetry GO:0009799 204 0.011
protein dephosphorylation GO:0006470 3 0.010
carbohydrate homeostasis GO:0033500 1 0.010
regulation of transporter activity GO:0032409 2 0.010
behavior GO:0007610 74 0.010
cell projection organization GO:0030030 284 0.010
guanosine containing compound metabolic process GO:1901068 4 0.010
Human
regulation of cellular biosynthetic process GO:0031326 245 0.010
gene expression GO:0010467 252 0.010
nephron tubule morphogenesis GO:0072078 1 0.010
nucleocytoplasmic transport GO:0006913 4 0.010
establishment of protein localization to organelle GO:0072594 4 0.010
localization of cell GO:0051674 244 0.010
regulation of synapse organization GO:0050807 3 0.010
medulla oblongata development GO:0021550 4 0.010
cell substrate adhesion GO:0031589 4 0.010
cartilage development GO:0051216 96 0.010
regulation of circadian rhythm GO:0042752 4 0.010

ak4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.020
inherited metabolic disorder DOID:655 0 0.020
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015
neuromuscular disease DOID:440 0 0.011
charcot marie tooth disease DOID:10595 0 0.011
neuropathy DOID:870 0 0.011