Danio rerio

0 known processes

asah1a

N-acylsphingosine amidohydrolase (acid ceramidase) 1a

(Aliases: zgc:101637,asah1,MGC173782)

asah1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
single organism metabolic process GO:0044710 217 0.104
larval development GO:0002164 2 0.090
nitrogen compound metabolic process GO:0006807 319 0.065
cellular nitrogen compound metabolic process GO:0034641 290 0.063
aging GO:0007568 2 0.060
small molecule metabolic process GO:0044281 77 0.056
organonitrogen compound metabolic process GO:1901564 74 0.055
positive regulation of cell cycle GO:0045787 3 0.054
organic cyclic compound metabolic process GO:1901360 301 0.053
cellular amine metabolic process GO:0044106 2 0.050
extrinsic apoptotic signaling pathway GO:0097191 3 0.046
cellular ketone metabolic process GO:0042180 11 0.046
phosphorus metabolic process GO:0006793 109 0.044
amine metabolic process GO:0009308 2 0.042
signal transduction GO:0007165 455 0.042
biosynthetic process GO:0009058 294 0.042
maintenance of location GO:0051235 4 0.041
positive regulation of transport GO:0051050 2 0.040
regulation of response to stimulus GO:0048583 269 0.040
cellular aromatic compound metabolic process GO:0006725 295 0.040
regulation of primary metabolic process GO:0080090 311 0.039
positive regulation of protein complex assembly GO:0031334 2 0.038
regulation of cellular amine metabolic process GO:0033238 0 0.038
establishment of localization GO:0051234 244 0.038
response to stress GO:0006950 263 0.038
gtp catabolic process GO:0006184 2 0.038
stem cell proliferation GO:0072089 4 0.037
regulation of metabolic process GO:0019222 359 0.037
heterocycle metabolic process GO:0046483 290 0.037
cellular protein catabolic process GO:0044257 4 0.037
regulation of cell differentiation GO:0045595 142 0.036
regulation of cell communication GO:0010646 232 0.036
negative regulation of protein phosphorylation GO:0001933 4 0.036
positive regulation of catabolic process GO:0009896 4 0.035
organic substance biosynthetic process GO:1901576 289 0.035
multicellular organism growth GO:0035264 4 0.034
regulation of signaling GO:0023051 235 0.034
gtp metabolic process GO:0046039 4 0.034
regulation of establishment of protein localization GO:0070201 4 0.034
guanosine containing compound metabolic process GO:1901068 4 0.034
regulation of developmental process GO:0050793 247 0.033
positive regulation of cellular component biogenesis GO:0044089 3 0.033
regulation of protein complex assembly GO:0043254 3 0.033
establishment of protein localization to organelle GO:0072594 4 0.033
centrosome cycle GO:0007098 1 0.032
negative regulation of kinase activity GO:0033673 4 0.031
protein acylation GO:0043543 3 0.031
positive regulation of cellular process GO:0048522 201 0.031
lipid catabolic process GO:0016042 4 0.031
phosphate containing compound metabolic process GO:0006796 108 0.030
regulation of cell activation GO:0050865 1 0.029
positive regulation of cytokine production GO:0001819 2 0.029
lipid storage GO:0019915 1 0.029
single organism localization GO:1902578 225 0.029
guanosine containing compound catabolic process GO:1901069 2 0.028
transport GO:0006810 220 0.028
microtubule organizing center organization GO:0031023 1 0.028
spindle assembly GO:0051225 2 0.028
protein metabolic process GO:0019538 183 0.027
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.027
regulation of binding GO:0051098 3 0.027
cytoskeleton dependent cytokinesis GO:0061640 3 0.027
positive regulation of biological process GO:0048518 253 0.027
negative regulation of protein kinase activity GO:0006469 4 0.026
b cell activation GO:0042113 2 0.026
regulation of nitrogen compound metabolic process GO:0051171 251 0.026
negative regulation of biological process GO:0048519 304 0.026
organelle fusion GO:0048284 3 0.026
regulation of stem cell differentiation GO:2000736 4 0.025
response to chemical GO:0042221 320 0.025
positive regulation of cell activation GO:0050867 1 0.025
immune system development GO:0002520 191 0.025
regulation of nucleoside metabolic process GO:0009118 2 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
phagocytosis GO:0006909 3 0.025
response to uv GO:0009411 3 0.024
single organism transport GO:0044765 206 0.024
cellular macromolecule metabolic process GO:0044260 391 0.024
cytokinesis GO:0000910 3 0.024
single organism organelle organization GO:1902589 199 0.024
regulation of multicellular organismal process GO:0051239 277 0.024
centrosome organization GO:0051297 1 0.024
leukocyte proliferation GO:0070661 1 0.024
regulation of cellular metabolic process GO:0031323 320 0.023
regulation of protein catabolic process GO:0042176 1 0.023
internal protein amino acid acetylation GO:0006475 2 0.023
regulation of signal transduction GO:0009966 225 0.023
immune system process GO:0002376 241 0.023
response to carbohydrate GO:0009743 3 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
intracellular signal transduction GO:0035556 85 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
system process GO:0003008 185 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.022
nuclear import GO:0051170 3 0.022
cell cycle g1 s phase transition GO:0044843 1 0.022
hematopoietic or lymphoid organ development GO:0048534 191 0.022
peptidyl lysine acetylation GO:0018394 2 0.022
cellular response to radiation GO:0071478 4 0.022
response to abiotic stimulus GO:0009628 122 0.022
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.022
nucleobase containing compound metabolic process GO:0006139 274 0.022
protein acetylation GO:0006473 2 0.022
response to amino acid GO:0043200 2 0.021
regulation of cytokine production GO:0001817 3 0.021
proteasomal protein catabolic process GO:0010498 2 0.021
synaptic vesicle localization GO:0097479 1 0.021
organelle organization GO:0006996 227 0.021
response to organic substance GO:0010033 153 0.021
protein localization to nucleus GO:0034504 3 0.021
g1 s transition of mitotic cell cycle GO:0000082 1 0.021
positive regulation of nucleoside metabolic process GO:0045979 1 0.021
protein homooligomerization GO:0051260 3 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
tissue remodeling GO:0048771 4 0.020
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.020
oxoacid metabolic process GO:0043436 31 0.020
negative regulation of cellular process GO:0048523 283 0.020
b cell differentiation GO:0030183 1 0.020
negative regulation of mapk cascade GO:0043409 4 0.020
internal peptidyl lysine acetylation GO:0018393 2 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
er nucleus signaling pathway GO:0006984 2 0.020
synaptic vesicle transport GO:0048489 1 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
dorsal ventral pattern formation GO:0009953 125 0.020
mononuclear cell proliferation GO:0032943 1 0.019
nuclear transport GO:0051169 4 0.019
exocytosis GO:0006887 1 0.019
regulation of gtpase activity GO:0043087 2 0.019
hemopoiesis GO:0030097 183 0.019
positive regulation of map kinase activity GO:0043406 3 0.019
regulation of multicellular organism growth GO:0040014 4 0.019
homeostatic process GO:0042592 142 0.019
regulation of purine nucleotide catabolic process GO:0033121 2 0.019
cellular biosynthetic process GO:0044249 286 0.019
mitochondrion organization GO:0007005 4 0.019
regionalization GO:0003002 274 0.019
cellular component assembly GO:0022607 170 0.019
endoplasmic reticulum unfolded protein response GO:0030968 2 0.019
response to topologically incorrect protein GO:0035966 2 0.019
protein import GO:0017038 3 0.018
hormone secretion GO:0046879 2 0.018
response to hexose GO:0009746 3 0.018
stem cell maintenance GO:0019827 4 0.018
meiotic nuclear division GO:0007126 4 0.018
peptide transport GO:0015833 1 0.018
single organism membrane fusion GO:0044801 2 0.018
regulation of biological quality GO:0065008 263 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
modification dependent macromolecule catabolic process GO:0043632 3 0.018
single organism nuclear import GO:1902593 3 0.018
positive regulation of apoptotic signaling pathway GO:2001235 1 0.018
hormone transport GO:0009914 2 0.017
regulation of hormone secretion GO:0046883 2 0.017
response to glucose GO:0009749 3 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.017
heart development GO:0007507 313 0.017
response to nutrient GO:0007584 3 0.017
regulation of nucleotide catabolic process GO:0030811 2 0.017
cellular component morphogenesis GO:0032989 336 0.017
cortical cytoskeleton organization GO:0030865 1 0.017
positive regulation of leukocyte differentiation GO:1902107 1 0.017
positive regulation of gtpase activity GO:0043547 1 0.017
positive regulation of cytoskeleton organization GO:0051495 3 0.017
response to drug GO:0042493 3 0.017
negative regulation of map kinase activity GO:0043407 2 0.017
positive regulation of gtp catabolic process GO:0033126 1 0.017
positive regulation of immune effector process GO:0002699 3 0.017
cellular protein metabolic process GO:0044267 129 0.017
signal transduction in absence of ligand GO:0038034 1 0.017
regulation of protein transport GO:0051223 3 0.017
gland development GO:0048732 143 0.017
er to golgi vesicle mediated transport GO:0006888 1 0.016
entrainment of circadian clock GO:0009649 2 0.016
nucleic acid metabolic process GO:0090304 244 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.016
positive regulation of secretion GO:0051047 1 0.016
regulation of programmed cell death GO:0043067 101 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
response to monosaccharide GO:0034284 3 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
specification of symmetry GO:0009799 204 0.016
cellular response to topologically incorrect protein GO:0035967 2 0.016
membrane fusion GO:0061025 2 0.015
regulation of gtp catabolic process GO:0033124 2 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
autophagy GO:0006914 4 0.015
regulation of dendrite morphogenesis GO:0048814 3 0.015
regulation of ph GO:0006885 3 0.015
regulation of inflammatory response GO:0050727 2 0.015
spermatid development GO:0007286 2 0.015
macromolecular complex subunit organization GO:0043933 74 0.015
regulation of jak stat cascade GO:0046425 3 0.015
meiotic cell cycle process GO:1903046 3 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
cellular response to external stimulus GO:0071496 2 0.015
protein targeting to nucleus GO:0044744 3 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
regulation of protein targeting GO:1903533 2 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
heterocycle biosynthetic process GO:0018130 215 0.015
organic acid metabolic process GO:0006082 31 0.015
neuroblast proliferation GO:0007405 2 0.015
protein polymerization GO:0051258 4 0.015
regulation of multicellular organismal development GO:2000026 223 0.015
cell cycle GO:0007049 93 0.015
liver development GO:0001889 96 0.015
regulation of reactive oxygen species metabolic process GO:2000377 2 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
cell killing GO:0001906 2 0.015
synaptic growth at neuromuscular junction GO:0051124 2 0.015
regulation of dendrite development GO:0050773 3 0.015
peptidyl serine phosphorylation GO:0018105 1 0.015
rna metabolic process GO:0016070 219 0.015
establishment of synaptic vesicle localization GO:0097480 1 0.015
positive regulation of nucleotide catabolic process GO:0030813 1 0.015
cell morphogenesis GO:0000902 289 0.015
death GO:0016265 121 0.015
regulation of cell death GO:0010941 103 0.014
phosphorylation GO:0016310 69 0.014
positive regulation of response to stimulus GO:0048584 80 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.014
digestive system development GO:0055123 289 0.014
regulation of protein import into nucleus GO:0042306 2 0.014
determination of bilateral symmetry GO:0009855 204 0.014
purine nucleoside monophosphate catabolic process GO:0009128 4 0.014
sensory organ development GO:0007423 393 0.014
protein localization to plasma membrane GO:0072659 1 0.014
macromolecule modification GO:0043412 111 0.014
lipid metabolic process GO:0006629 52 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
fertilization GO:0009566 3 0.014
neuron differentiation GO:0030182 353 0.014
golgi vesicle transport GO:0048193 3 0.014
protein complex assembly GO:0006461 30 0.014
secondary metabolic process GO:0019748 3 0.014
response to endogenous stimulus GO:0009719 83 0.014
mitochondrial transport GO:0006839 2 0.014
germ line stem cell maintenance GO:0030718 2 0.014
protein import into nucleus GO:0006606 3 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
mitotic cytokinesis GO:0000281 3 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
regulation of production of molecular mediator of immune response GO:0002700 1 0.013
regulation of cell shape GO:0008360 1 0.013
regulation of rna biosynthetic process GO:2001141 213 0.013
regulation of cellular protein metabolic process GO:0032268 52 0.013
locomotion GO:0040011 313 0.013
recombinational repair GO:0000725 1 0.013
cellular protein modification process GO:0006464 100 0.013
negative regulation of metabolic process GO:0009892 86 0.013
centrosome duplication GO:0051298 1 0.013
endosome organization GO:0007032 2 0.013
lymphocyte proliferation GO:0046651 1 0.013
regulation of synapse organization GO:0050807 3 0.013
rna localization GO:0006403 4 0.013
cellular component disassembly GO:0022411 1 0.013
protein dephosphorylation GO:0006470 3 0.013
spermatid differentiation GO:0048515 2 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.013
programmed cell death GO:0012501 119 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
macromolecular complex assembly GO:0065003 35 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
gene expression GO:0010467 252 0.013
positive regulation of multi organism process GO:0043902 3 0.013
cellular response to unfolded protein GO:0034620 2 0.013
response to glucocorticoid GO:0051384 1 0.013
neuron development GO:0048666 262 0.013
regulation of blood vessel size GO:0050880 2 0.013
response to corticosteroid GO:0031960 1 0.013
cellular lipid catabolic process GO:0044242 3 0.013
camera type eye development GO:0043010 222 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
glucose homeostasis GO:0042593 1 0.013
urogenital system development GO:0001655 97 0.013
response to external stimulus GO:0009605 264 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
regulation of localization GO:0032879 104 0.012
protein modification process GO:0036211 100 0.012
regulation of gene expression GO:0010468 265 0.012
glycerolipid biosynthetic process GO:0045017 1 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
response to unfolded protein GO:0006986 2 0.012
regulation of microtubule cytoskeleton organization GO:0070507 3 0.012
determination of left right symmetry GO:0007368 179 0.012
cellular localization GO:0051641 97 0.012
endosomal transport GO:0016197 2 0.012
positive regulation of lipid metabolic process GO:0045834 1 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
type b pancreatic cell development GO:0003323 4 0.012
aromatic compound biosynthetic process GO:0019438 217 0.012
antimicrobial humoral response GO:0019730 2 0.012
hormone biosynthetic process GO:0042446 3 0.012
cellular response to stress GO:0033554 62 0.012
cell cycle arrest GO:0007050 1 0.012
chordate embryonic development GO:0043009 271 0.012
cellular component movement GO:0006928 335 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
response to other organism GO:0051707 97 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
regulation of circadian rhythm GO:0042752 4 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
interaction with host GO:0051701 4 0.012
development of primary female sexual characteristics GO:0046545 4 0.012
transmembrane transport GO:0055085 120 0.012
regulation of meiotic cell cycle GO:0051445 1 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
mitotic dna damage checkpoint GO:0044773 4 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.012
protein secretion GO:0009306 1 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
regulation of glucose transport GO:0010827 1 0.012
regulation of growth rate GO:0040009 1 0.012
multi organism process GO:0051704 134 0.012
embryonic organ development GO:0048568 381 0.011
microtubule based process GO:0007017 60 0.011
regulation of biosynthetic process GO:0009889 250 0.011
regulation of tube size GO:0035150 2 0.011
translational initiation GO:0006413 3 0.011
protein complex disassembly GO:0043241 1 0.011
response to wounding GO:0009611 116 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
peptidyl serine modification GO:0018209 2 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
regulation of cell projection assembly GO:0060491 4 0.011
organelle assembly GO:0070925 110 0.011
somatic muscle development GO:0007525 4 0.011
spindle assembly involved in mitosis GO:0090307 1 0.011
establishment of localization in cell GO:0051649 77 0.011
positive regulation of reproductive process GO:2000243 2 0.011
cellular response to light stimulus GO:0071482 4 0.011
regulation of blood pressure GO:0008217 1 0.011
actin filament polymerization GO:0030041 2 0.011
positive regulation of muscle organ development GO:0048636 1 0.011
adult behavior GO:0030534 2 0.011
calcium ion import GO:0070509 4 0.011
positive regulation of cell killing GO:0031343 2 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
kidney development GO:0001822 92 0.011
negative regulation of nuclear division GO:0051784 3 0.011
locomotor rhythm GO:0045475 3 0.011
neurotransmitter transport GO:0006836 2 0.011
atp catabolic process GO:0006200 4 0.011
regulation of macromolecule biosynthetic process GO:0010556 225 0.011
regulation of synapse assembly GO:0051963 3 0.011
response to external biotic stimulus GO:0043207 97 0.011
cilium morphogenesis GO:0060271 85 0.011
carbohydrate homeostasis GO:0033500 1 0.011
toxin metabolic process GO:0009404 1 0.011
single fertilization GO:0007338 3 0.011
digestive tract development GO:0048565 265 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
cellular transition metal ion homeostasis GO:0046916 3 0.011
regulation of reproductive process GO:2000241 4 0.011
female sex differentiation GO:0046660 4 0.010
negative regulation of cellular metabolic process GO:0031324 77 0.010
regulation of phosphorus metabolic process GO:0051174 43 0.010
regulation of protein depolymerization GO:1901879 1 0.010
embryonic limb morphogenesis GO:0030326 2 0.010
regulation of carbohydrate metabolic process GO:0006109 4 0.010
response to biotic stimulus GO:0009607 97 0.010
regulation of receptor activity GO:0010469 2 0.010
regulation of protein complex disassembly GO:0043244 1 0.010
protein complex subunit organization GO:0071822 46 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
ion transmembrane transport GO:0034220 91 0.010
membrane invagination GO:0010324 1 0.010
neurotransmitter secretion GO:0007269 2 0.010
cell migration GO:0016477 237 0.010
regulation of mrna processing GO:0050684 3 0.010
macromolecular complex disassembly GO:0032984 1 0.010
activation of mapk activity GO:0000187 3 0.010
cell motility GO:0048870 244 0.010
female meiotic division GO:0007143 2 0.010
hepaticobiliary system development GO:0061008 98 0.010
somatic stem cell maintenance GO:0035019 1 0.010
regulation of dna replication GO:0006275 3 0.010
synaptic vesicle endocytosis GO:0048488 1 0.010
macromolecule biosynthetic process GO:0009059 227 0.010
regulation of protein binding GO:0043393 3 0.010
regulation of cellular component organization GO:0051128 86 0.010
ribonucleoside monophosphate catabolic process GO:0009158 4 0.010

asah1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
disease of metabolism DOID:0014667 0 0.015
Human
nervous system disease DOID:863 0 0.013
disease of cellular proliferation DOID:14566 0 0.012
cancer DOID:162 0 0.011
inherited metabolic disorder DOID:655 0 0.011
Human
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010
eye disease DOID:5614 0 0.010
organ system cancer DOID:0050686 0 0.010