Danio rerio

0 known processes

ethe1

ethylmalonic encephalopathy 1

(Aliases: zgc:85680,MGC85680)

ethe1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.070
aging GO:0007568 2 0.059
positive regulation of transport GO:0051050 2 0.038
maintenance of location GO:0051235 4 0.038
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.037
modification dependent protein catabolic process GO:0019941 3 0.036
cellular protein catabolic process GO:0044257 4 0.036
establishment of protein localization to organelle GO:0072594 4 0.035
nitrogen compound metabolic process GO:0006807 319 0.034
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.033
multicellular organism growth GO:0035264 4 0.032
proteasomal protein catabolic process GO:0010498 2 0.032
amine metabolic process GO:0009308 2 0.031
protein localization to nucleus GO:0034504 3 0.031
ubiquitin dependent protein catabolic process GO:0006511 3 0.030
guanosine containing compound catabolic process GO:1901069 2 0.030
protein localization to plasma membrane GO:0072659 1 0.030
regulation of protein complex assembly GO:0043254 3 0.029
cellular amine metabolic process GO:0044106 2 0.029
mitochondrion organization GO:0007005 4 0.029
modification dependent macromolecule catabolic process GO:0043632 3 0.028
cytokinesis GO:0000910 3 0.028
regulation of multicellular organism growth GO:0040014 4 0.027
guanosine containing compound metabolic process GO:1901068 4 0.027
positive regulation of cell cycle GO:0045787 3 0.027
phagocytosis GO:0006909 3 0.027
cellular response to external stimulus GO:0071496 2 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
meiotic nuclear division GO:0007126 4 0.026
cellular nitrogen compound metabolic process GO:0034641 290 0.026
gtp catabolic process GO:0006184 2 0.026
xenobiotic metabolic process GO:0006805 4 0.026
organelle fusion GO:0048284 3 0.025
cognition GO:0050890 1 0.025
endosomal transport GO:0016197 2 0.025
exocytosis GO:0006887 1 0.025
autophagy GO:0006914 4 0.025
immune system process GO:0002376 241 0.025
ribonucleoside monophosphate catabolic process GO:0009158 4 0.025
cellular response to extracellular stimulus GO:0031668 2 0.024
cellular response to nutrient levels GO:0031669 2 0.024
gene expression GO:0010467 252 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
organic cyclic compound metabolic process GO:1901360 301 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
regulation of cytokine production GO:0001817 3 0.023
regulation of protein transport GO:0051223 3 0.023
response to drug GO:0042493 3 0.022
regulation of metabolic process GO:0019222 359 0.022
nucleocytoplasmic transport GO:0006913 4 0.022
single organism membrane fusion GO:0044801 2 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
positive regulation of catabolic process GO:0009896 4 0.022
small molecule metabolic process GO:0044281 77 0.022
atp catabolic process GO:0006200 4 0.022
protein import into nucleus GO:0006606 3 0.022
membrane fusion GO:0061025 2 0.022
regulation of binding GO:0051098 3 0.022
response to chemical GO:0042221 320 0.022
single organism metabolic process GO:0044710 217 0.022
positive regulation of cellular component biogenesis GO:0044089 3 0.022
regulation of meiotic cell cycle GO:0051445 1 0.022
organic acid catabolic process GO:0016054 3 0.022
signal transduction GO:0007165 455 0.022
lipid storage GO:0019915 1 0.022
regulation of synapse assembly GO:0051963 3 0.022
neurotransmitter secretion GO:0007269 2 0.021
organelle organization GO:0006996 227 0.021
single organism nuclear import GO:1902593 3 0.021
cellular macromolecule metabolic process GO:0044260 391 0.021
protein import GO:0017038 3 0.021
single organism transport GO:0044765 206 0.021
sensory organ development GO:0007423 393 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.021
secondary metabolic process GO:0019748 3 0.021
extrinsic apoptotic signaling pathway GO:0097191 3 0.021
cellular ketone metabolic process GO:0042180 11 0.021
stem cell maintenance GO:0019827 4 0.021
gtp metabolic process GO:0046039 4 0.021
negative regulation of biological process GO:0048519 304 0.021
nucleic acid metabolic process GO:0090304 244 0.021
biosynthetic process GO:0009058 294 0.021
organic acid metabolic process GO:0006082 31 0.021
cellular aromatic compound metabolic process GO:0006725 295 0.020
organic substance biosynthetic process GO:1901576 289 0.020
carboxylic acid catabolic process GO:0046395 3 0.020
cell morphogenesis GO:0000902 289 0.020
organic cyclic compound biosynthetic process GO:1901362 223 0.020
regulation of synapse organization GO:0050807 3 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
single organism localization GO:1902578 225 0.020
establishment of localization GO:0051234 244 0.020
nuclear import GO:0051170 3 0.019
aromatic compound biosynthetic process GO:0019438 217 0.019
regulation of reproductive process GO:2000241 4 0.019
cell projection organization GO:0030030 284 0.019
nucleobase containing compound metabolic process GO:0006139 274 0.019
protein targeting to nucleus GO:0044744 3 0.019
regulation of nitrogen compound metabolic process GO:0051171 251 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
rna localization GO:0006403 4 0.019
cellular response to starvation GO:0009267 1 0.019
system process GO:0003008 185 0.019
nucleoside monophosphate catabolic process GO:0009125 4 0.018
lipid catabolic process GO:0016042 4 0.018
carboxylic acid metabolic process GO:0019752 22 0.018
regulation of nucleotide catabolic process GO:0030811 2 0.018
negative regulation of sequestering of calcium ion GO:0051283 4 0.018
nuclear transport GO:0051169 4 0.018
regulation of cellular biosynthetic process GO:0031326 245 0.018
purine nucleoside monophosphate catabolic process GO:0009128 4 0.018
adult behavior GO:0030534 2 0.018
spermatid differentiation GO:0048515 2 0.018
oxoacid metabolic process GO:0043436 31 0.018
regulation of nucleoside metabolic process GO:0009118 2 0.018
synaptic vesicle localization GO:0097479 1 0.018
neurotransmitter transport GO:0006836 2 0.018
heterocycle metabolic process GO:0046483 290 0.018
small molecule catabolic process GO:0044282 3 0.018
transcription dna templated GO:0006351 181 0.018
immune system development GO:0002520 191 0.018
cellular biosynthetic process GO:0044249 286 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.017
golgi vesicle transport GO:0048193 3 0.017
compound eye development GO:0048749 2 0.017
regulation of metal ion transport GO:0010959 4 0.017
protein metabolic process GO:0019538 183 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
positive regulation of secretion GO:0051047 1 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
transport GO:0006810 220 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
macromolecule biosynthetic process GO:0009059 227 0.017
cellular nitrogen compound biosynthetic process GO:0044271 218 0.017
cellular amide metabolic process GO:0043603 4 0.017
regulation of protein targeting GO:1903533 2 0.016
regulation of erk1 and erk2 cascade GO:0070372 4 0.016
cell projection morphogenesis GO:0048858 244 0.016
regulation of synaptic plasticity GO:0048167 1 0.016
cellular component disassembly GO:0022411 1 0.016
rna metabolic process GO:0016070 219 0.016
response to nutrient GO:0007584 3 0.016
response to external stimulus GO:0009605 264 0.016
establishment of protein localization to plasma membrane GO:0090002 1 0.016
fertilization GO:0009566 3 0.016
meiotic cell cycle process GO:1903046 3 0.016
positive regulation of nucleotide catabolic process GO:0030813 1 0.016
cellular component morphogenesis GO:0032989 336 0.016
rna biosynthetic process GO:0032774 181 0.016
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.016
regulation of biosynthetic process GO:0009889 250 0.016
cell surface receptor signaling pathway GO:0007166 325 0.016
generation of neurons GO:0048699 385 0.016
synaptic vesicle transport GO:0048489 1 0.016
protein polyubiquitination GO:0000209 4 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
embryonic organ development GO:0048568 381 0.016
response to topologically incorrect protein GO:0035966 2 0.016
positive regulation of nucleoside metabolic process GO:0045979 1 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
cell substrate adhesion GO:0031589 4 0.016
membrane invagination GO:0010324 1 0.016
stem cell proliferation GO:0072089 4 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.016
regulation of gtp catabolic process GO:0033124 2 0.015
positive regulation of protein complex assembly GO:0031334 2 0.015
germ line stem cell maintenance GO:0030718 2 0.015
negative regulation of kinase activity GO:0033673 4 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.015
peptide metabolic process GO:0006518 1 0.015
regulation of signaling GO:0023051 235 0.015
regulation of gene expression GO:0010468 265 0.015
regulation of transporter activity GO:0032409 2 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
single organism organelle organization GO:1902589 199 0.015
response to uv GO:0009411 3 0.015
eye development GO:0001654 277 0.015
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
protein acetylation GO:0006473 2 0.015
vasculature development GO:0001944 278 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
spermatid development GO:0007286 2 0.015
neuroblast proliferation GO:0007405 2 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
lateral inhibition GO:0046331 1 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
sequestering of metal ion GO:0051238 3 0.015
negative regulation of cellular process GO:0048523 283 0.015
vacuolar transport GO:0007034 2 0.015
establishment of synaptic vesicle localization GO:0097480 1 0.014
regulation of gtpase activity GO:0043087 2 0.014
nucleic acid templated transcription GO:0097659 181 0.014
fatty acid catabolic process GO:0009062 1 0.014
single fertilization GO:0007338 3 0.014
regulation of cell communication GO:0010646 232 0.014
interspecies interaction between organisms GO:0044419 4 0.014
sequestering of calcium ion GO:0051208 3 0.014
response to carbohydrate GO:0009743 3 0.014
central nervous system development GO:0007417 387 0.014
regulation of cell activation GO:0050865 1 0.014
cellular response to xenobiotic stimulus GO:0071466 35 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
internal protein amino acid acetylation GO:0006475 2 0.014
peptidyl serine phosphorylation GO:0018105 1 0.014
alcohol biosynthetic process GO:0046165 2 0.014
sleep GO:0030431 1 0.014
cellular component movement GO:0006928 335 0.014
regulation of dendrite development GO:0050773 3 0.014
cellular response to organic substance GO:0071310 105 0.014
negative regulation of catabolic process GO:0009895 3 0.014
pigmentation GO:0043473 85 0.014
regulation of cellular metabolic process GO:0031323 320 0.014
positive regulation of biological process GO:0048518 253 0.014
macromolecular complex disassembly GO:0032984 1 0.014
intracellular mrna localization GO:0008298 1 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
organelle assembly GO:0070925 110 0.014
cell part morphogenesis GO:0032990 246 0.014
chemosensory behavior GO:0007635 1 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
cytoplasm organization GO:0007028 4 0.014
regulation of protein catabolic process GO:0042176 1 0.014
heterocycle biosynthetic process GO:0018130 215 0.014
cellular lipid catabolic process GO:0044242 3 0.013
regulation of macromolecule metabolic process GO:0060255 317 0.013
neuron differentiation GO:0030182 353 0.013
regulation of response to extracellular stimulus GO:0032104 1 0.013
viral process GO:0016032 1 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
response to organic substance GO:0010033 153 0.013
cell migration GO:0016477 237 0.013
macroautophagy GO:0016236 1 0.013
protein complex disassembly GO:0043241 1 0.013
multi organism cellular process GO:0044764 2 0.013
antimicrobial humoral response GO:0019730 2 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.013
meiotic chromosome segregation GO:0045132 3 0.013
response to stress GO:0006950 263 0.013
leukocyte proliferation GO:0070661 1 0.013
cellular response to radiation GO:0071478 4 0.013
regulation of signal transduction GO:0009966 225 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.013
positive regulation of immune effector process GO:0002699 3 0.013
mitotic dna integrity checkpoint GO:0044774 4 0.013
negative regulation of mapk cascade GO:0043409 4 0.013
protein homooligomerization GO:0051260 3 0.013
protein acylation GO:0043543 3 0.013
regulation of sequestering of calcium ion GO:0051282 4 0.013
regulation of autophagy GO:0010506 3 0.013
mitochondrial transport GO:0006839 2 0.013
positive regulation of gtpase activity GO:0043547 1 0.013
regulation of response to stimulus GO:0048583 269 0.013
regulation of primary metabolic process GO:0080090 311 0.013
regulation of neurotransmitter transport GO:0051588 1 0.013
response to glucose GO:0009749 3 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
response to hexose GO:0009746 3 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
skeletal system development GO:0001501 181 0.012
cilium organization GO:0044782 71 0.012
cytoskeleton dependent cytokinesis GO:0061640 3 0.012
cellular response to oxygen levels GO:0071453 1 0.012
cellular response to topologically incorrect protein GO:0035967 2 0.012
developmental programmed cell death GO:0010623 4 0.012
regulation of rna metabolic process GO:0051252 224 0.012
cytokinetic process GO:0032506 2 0.012
peptidyl serine modification GO:0018209 2 0.012
monocarboxylic acid catabolic process GO:0072329 3 0.012
rna 3 end processing GO:0031123 2 0.012
positive regulation of cytokine production GO:0001819 2 0.012
cellular component biogenesis GO:0044085 178 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.012
estrogen metabolic process GO:0008210 2 0.012
morphogenesis of an epithelium GO:0002009 333 0.012
response to xenobiotic stimulus GO:0009410 45 0.012
oocyte anterior posterior axis specification GO:0007314 4 0.012
camera type eye development GO:0043010 222 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
cortical cytoskeleton organization GO:0030865 1 0.012
positive regulation of cell activation GO:0050867 1 0.012
adherens junction organization GO:0034332 4 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
positive regulation of dna metabolic process GO:0051054 1 0.012
post embryonic organ development GO:0048569 4 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
chordate embryonic development GO:0043009 271 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
locomotion GO:0040011 313 0.012
production of molecular mediator of immune response GO:0002440 2 0.012
tissue remodeling GO:0048771 4 0.012
neuron neuron synaptic transmission GO:0007270 1 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
cellular protein metabolic process GO:0044267 129 0.012
heart development GO:0007507 313 0.012
negative regulation of nuclear division GO:0051784 3 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
negative regulation of intracellular protein transport GO:0090317 3 0.011
regulation of mrna processing GO:0050684 3 0.011
regulation of response to biotic stimulus GO:0002831 2 0.011
protein secretion GO:0009306 1 0.011
death GO:0016265 121 0.011
negative regulation of stem cell differentiation GO:2000737 2 0.011
regulation of transcription dna templated GO:0006355 213 0.011
response to alkaloid GO:0043279 2 0.011
regulation of jak stat cascade GO:0046425 3 0.011
lipid oxidation GO:0034440 1 0.011
regulation of calcium ion transport GO:0051924 2 0.011
blood vessel development GO:0001568 246 0.011
skeletal system morphogenesis GO:0048705 102 0.011
regulation of receptor mediated endocytosis GO:0048259 4 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
regulation of cell shape GO:0008360 1 0.011
locomotor rhythm GO:0045475 3 0.011
pole plasm assembly GO:0007315 4 0.011
negative regulation of ras protein signal transduction GO:0046580 1 0.011
protein stabilization GO:0050821 2 0.011
digestive system development GO:0055123 289 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
retina development in camera type eye GO:0060041 146 0.011
peptide transport GO:0015833 1 0.011
brain development GO:0007420 293 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
regulation of neuronal synaptic plasticity GO:0048168 1 0.011
neuron projection development GO:0031175 180 0.011
digestive tract development GO:0048565 265 0.011
neuron development GO:0048666 262 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
protein polymerization GO:0051258 4 0.011
stem cell division GO:0017145 1 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
negative regulation of cytokine production GO:0001818 1 0.011
negative regulation of reproductive process GO:2000242 3 0.011
hemopoiesis GO:0030097 183 0.011
axon development GO:0061564 166 0.011
b cell activation GO:0042113 2 0.011
female meiotic division GO:0007143 2 0.011
cilium assembly GO:0042384 58 0.011
digestive tract morphogenesis GO:0048546 231 0.011
cellular component assembly GO:0022607 170 0.011
primary neural tube formation GO:0014020 1 0.011
regulation of inflammatory response GO:0050727 2 0.011
tube morphogenesis GO:0035239 349 0.011
organism emergence from protective structure GO:0071684 4 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
negative regulation of multi organism process GO:0043901 3 0.010
response to monosaccharide GO:0034284 3 0.010
positive regulation of chromosome organization GO:2001252 1 0.010
signal transduction in absence of ligand GO:0038034 1 0.010
cellular response to lipopolysaccharide GO:0071222 3 0.010
response to external biotic stimulus GO:0043207 97 0.010
regulation of macromolecule biosynthetic process GO:0010556 225 0.010
apoptotic process involved in development GO:1902742 2 0.010
cellular localization GO:0051641 97 0.010
cellular response to light stimulus GO:0071482 4 0.010
multi organism process GO:0051704 134 0.010
phosphatidylinositol mediated signaling GO:0048015 2 0.010
head development GO:0060322 303 0.010
negative regulation of protein transport GO:0051224 3 0.010
cellular response to hypoxia GO:0071456 1 0.010
regulation of ion transmembrane transporter activity GO:0032412 2 0.010
localization of cell GO:0051674 244 0.010
somatic muscle development GO:0007525 4 0.010
regulation of nucleic acid templated transcription GO:1903506 213 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010
phototransduction GO:0007602 2 0.010
regulation of biological quality GO:0065008 263 0.010
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.010
growth GO:0040007 174 0.010
lymphocyte proliferation GO:0046651 1 0.010
muscle structure development GO:0061061 196 0.010
cell matrix adhesion GO:0007160 4 0.010

ethe1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.042
nervous system disease DOID:863 0 0.021
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
disease of metabolism DOID:0014667 0 0.017
inherited metabolic disorder DOID:655 0 0.014
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.012
immune system disease DOID:2914 0 0.012