Danio rerio

0 known processes

zgc:92712

zgc:92712

zgc:92712 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
maintenance of location GO:0051235 4 0.081
cellular macromolecule metabolic process GO:0044260 391 0.078
cellular nitrogen compound metabolic process GO:0034641 290 0.071
macromolecule biosynthetic process GO:0009059 227 0.069
regulation of metal ion transport GO:0010959 4 0.069
cell projection organization GO:0030030 284 0.068
aging GO:0007568 2 0.065
larval development GO:0002164 2 0.065
organic cyclic compound metabolic process GO:1901360 301 0.064
neuron differentiation GO:0030182 353 0.062
regulation of biological quality GO:0065008 263 0.061
cellular biosynthetic process GO:0044249 286 0.058
organic substance biosynthetic process GO:1901576 289 0.058
generation of neurons GO:0048699 385 0.054
nucleic acid metabolic process GO:0090304 244 0.054
nucleic acid templated transcription GO:0097659 181 0.054
organic cyclic compound biosynthetic process GO:1901362 223 0.053
nitrogen compound metabolic process GO:0006807 319 0.052
eye development GO:0001654 277 0.052
adult behavior GO:0030534 2 0.052
cellular component morphogenesis GO:0032989 336 0.049
cellular component movement GO:0006928 335 0.049
negative regulation of biological process GO:0048519 304 0.048
Mouse
response to chemical GO:0042221 320 0.048
gene expression GO:0010467 252 0.047
transcription dna templated GO:0006351 181 0.047
sensory organ development GO:0007423 393 0.044
determination of bilateral symmetry GO:0009855 204 0.043
heterocycle biosynthetic process GO:0018130 215 0.043
aromatic compound biosynthetic process GO:0019438 217 0.043
guanosine containing compound catabolic process GO:1901069 2 0.043
biosynthetic process GO:0009058 294 0.042
regulation of nitrogen compound metabolic process GO:0051171 251 0.042
cognition GO:0050890 1 0.041
cellular aromatic compound metabolic process GO:0006725 295 0.041
rna metabolic process GO:0016070 219 0.041
system process GO:0003008 185 0.041
autophagy GO:0006914 4 0.040
regulation of cellular biosynthetic process GO:0031326 245 0.040
cellular nitrogen compound biosynthetic process GO:0044271 218 0.040
lipid storage GO:0019915 1 0.040
locomotion GO:0040011 313 0.039
cell morphogenesis GO:0000902 289 0.039
multicellular organism growth GO:0035264 4 0.039
nucleobase containing compound metabolic process GO:0006139 274 0.038
regulation of macromolecule metabolic process GO:0060255 317 0.038
regulation of metabolic process GO:0019222 359 0.038
embryonic organ development GO:0048568 381 0.038
heterocycle metabolic process GO:0046483 290 0.038
regulation of protein complex assembly GO:0043254 3 0.037
response to external stimulus GO:0009605 264 0.037
positive regulation of transport GO:0051050 2 0.036
guanosine containing compound metabolic process GO:1901068 4 0.036
gtp catabolic process GO:0006184 2 0.036
cellular macromolecule biosynthetic process GO:0034645 224 0.035
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.035
single organism localization GO:1902578 225 0.034
regulation of biosynthetic process GO:0009889 250 0.034
nucleobase containing compound biosynthetic process GO:0034654 205 0.033
regulation of multicellular organism growth GO:0040014 4 0.033
stem cell proliferation GO:0072089 4 0.033
camera type eye development GO:0043010 222 0.033
chordate embryonic development GO:0043009 271 0.032
signal transduction GO:0007165 455 0.032
Mouse
sensory organ morphogenesis GO:0090596 200 0.032
embryo development ending in birth or egg hatching GO:0009792 271 0.032
response to organic substance GO:0010033 153 0.032
regulation of cellular metabolic process GO:0031323 320 0.032
regulation of gene expression GO:0010468 265 0.032
regulation of tube size GO:0035150 2 0.031
positive regulation of catabolic process GO:0009896 4 0.031
cellular component disassembly GO:0022411 1 0.031
regulation of nucleic acid templated transcription GO:1903506 213 0.031
positive regulation of biological process GO:0048518 253 0.031
fertilization GO:0009566 3 0.031
regulation of rna biosynthetic process GO:2001141 213 0.031
neuron development GO:0048666 262 0.030
digestive system development GO:0055123 289 0.029
digestive tract development GO:0048565 265 0.029
cell surface receptor signaling pathway GO:0007166 325 0.029
Mouse
cilium assembly GO:0042384 58 0.029
protein localization to nucleus GO:0034504 3 0.029
cell part morphogenesis GO:0032990 246 0.029
rna biosynthetic process GO:0032774 181 0.029
regulation of transcription dna templated GO:0006355 213 0.028
cell projection morphogenesis GO:0048858 244 0.028
establishment of localization GO:0051234 244 0.028
central nervous system development GO:0007417 387 0.028
single organism organelle organization GO:1902589 199 0.027
regulation of developmental process GO:0050793 247 0.027
specification of symmetry GO:0009799 204 0.027
determination of left right symmetry GO:0007368 179 0.027
actin polymerization or depolymerization GO:0008154 2 0.027
regulation of cell projection assembly GO:0060491 4 0.027
single organism metabolic process GO:0044710 217 0.026
cellular component assembly GO:0022607 170 0.026
organelle assembly GO:0070925 110 0.026
regulation of gtp catabolic process GO:0033124 2 0.026
embryonic organ morphogenesis GO:0048562 274 0.026
cell motility GO:0048870 244 0.026
regulation of intracellular protein transport GO:0033157 3 0.026
regulation of macromolecule biosynthetic process GO:0010556 225 0.026
positive regulation of cellular component biogenesis GO:0044089 3 0.026
vasculature development GO:0001944 278 0.025
regulation of cell communication GO:0010646 232 0.025
Mouse
developmental growth GO:0048589 166 0.025
inorganic ion transmembrane transport GO:0098660 57 0.025
meiotic nuclear division GO:0007126 4 0.025
regulation of reproductive process GO:2000241 4 0.025
growth GO:0040007 174 0.025
retina development in camera type eye GO:0060041 146 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.025
protein complex disassembly GO:0043241 1 0.025
regulation of stem cell differentiation GO:2000736 4 0.025
regulation of multicellular organismal development GO:2000026 223 0.025
response to monosaccharide GO:0034284 3 0.025
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.024
cilium organization GO:0044782 71 0.024
amine metabolic process GO:0009308 2 0.024
regulation of meiotic cell cycle GO:0051445 1 0.024
phagocytosis GO:0006909 3 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.024
cellular response to external stimulus GO:0071496 2 0.024
regulation of primary metabolic process GO:0080090 311 0.024
regulation of calcium ion transport GO:0051924 2 0.023
negative regulation of metabolic process GO:0009892 86 0.023
regulation of establishment of protein localization GO:0070201 4 0.023
homeostatic process GO:0042592 142 0.023
stem cell division GO:0017145 1 0.023
regulation of protein transport GO:0051223 3 0.023
heart development GO:0007507 313 0.023
small molecule metabolic process GO:0044281 77 0.023
regulation of protein polymerization GO:0032271 2 0.023
gtp metabolic process GO:0046039 4 0.023
organic acid metabolic process GO:0006082 31 0.023
organelle organization GO:0006996 227 0.023
regulation of blood vessel size GO:0050880 2 0.023
regulation of nucleotide catabolic process GO:0030811 2 0.023
tube morphogenesis GO:0035239 349 0.022
nuclear migration GO:0007097 3 0.022
cellular lipid catabolic process GO:0044242 3 0.022
cell projection assembly GO:0030031 64 0.022
transport GO:0006810 220 0.022
cellular response to chemical stimulus GO:0070887 157 0.022
cellular response to organic substance GO:0071310 105 0.022
cellular amine metabolic process GO:0044106 2 0.022
golgi vesicle transport GO:0048193 3 0.022
regulation of multicellular organismal process GO:0051239 277 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
regulation of dendrite development GO:0050773 3 0.022
cell migration GO:0016477 237 0.022
cellular response to nutrient levels GO:0031669 2 0.022
negative regulation of cellular process GO:0048523 283 0.021
Mouse
cellular component assembly involved in morphogenesis GO:0010927 107 0.021
ear development GO:0043583 127 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.021
metal ion transport GO:0030001 58 0.021
response to drug GO:0042493 3 0.021
cell morphogenesis involved in differentiation GO:0000904 195 0.021
localization of cell GO:0051674 244 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.021
ion transport GO:0006811 114 0.021
regulation of transmembrane transporter activity GO:0022898 2 0.021
response to carbohydrate GO:0009743 3 0.021
muscle structure development GO:0061061 196 0.021
regulation of purine nucleotide catabolic process GO:0033121 2 0.021
neuron projection development GO:0031175 180 0.020
glucose homeostasis GO:0042593 1 0.020
single fertilization GO:0007338 3 0.020
nuclear transport GO:0051169 4 0.020
response to hexose GO:0009746 3 0.020
regulation of signaling GO:0023051 235 0.020
Mouse
cellular component biogenesis GO:0044085 178 0.020
response to alkaloid GO:0043279 2 0.020
cellular ketone metabolic process GO:0042180 11 0.020
cilium morphogenesis GO:0060271 85 0.020
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.020
positive regulation of cell cycle GO:0045787 3 0.020
fatty acid transport GO:0015908 1 0.020
response to nutrient GO:0007584 3 0.020
regulation of rna metabolic process GO:0051252 224 0.019
transmembrane transport GO:0055085 120 0.019
macromolecule modification GO:0043412 111 0.019
neuron neuron synaptic transmission GO:0007270 1 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
peptidyl lysine acetylation GO:0018394 2 0.019
neuroblast proliferation GO:0007405 2 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
carboxylic acid catabolic process GO:0046395 3 0.019
protein metabolic process GO:0019538 183 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
regulation of nucleoside metabolic process GO:0009118 2 0.019
modification dependent macromolecule catabolic process GO:0043632 3 0.019
membrane invagination GO:0010324 1 0.019
ion transmembrane transport GO:0034220 91 0.018
regulation of synapse organization GO:0050807 3 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
neurotransmitter transport GO:0006836 2 0.018
gastrulation GO:0007369 208 0.018
regulation of neurotransmitter transport GO:0051588 1 0.018
cellular protein metabolic process GO:0044267 129 0.018
positive regulation of cellular process GO:0048522 201 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
response to lipid GO:0033993 60 0.018
response to glucose GO:0009749 3 0.018
regulation of gtpase activity GO:0043087 2 0.018
neuron projection morphogenesis GO:0048812 161 0.018
single organism nuclear import GO:1902593 3 0.018
inorganic cation transmembrane transport GO:0098662 50 0.018
response to stress GO:0006950 263 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
regulation of fatty acid metabolic process GO:0019217 1 0.017
ameboidal type cell migration GO:0001667 143 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
regulation of cytoplasmic transport GO:1903649 4 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.017
regulation of transporter activity GO:0032409 2 0.017
regulation of protein localization to nucleus GO:1900180 2 0.017
rna localization GO:0006403 4 0.017
cellular carbohydrate metabolic process GO:0044262 4 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
immune system process GO:0002376 241 0.017
cell death GO:0008219 121 0.017
Mouse
sequestering of metal ion GO:0051238 3 0.017
actin filament polymerization GO:0030041 2 0.017
protein targeting to nucleus GO:0044744 3 0.017
nuclear import GO:0051170 3 0.017
single organism transport GO:0044765 206 0.016
oxoacid metabolic process GO:0043436 31 0.016
morphogenesis of an epithelium GO:0002009 333 0.016
activation of mapk activity GO:0000187 3 0.016
post golgi vesicle mediated transport GO:0006892 1 0.016
regulation of circadian rhythm GO:0042752 4 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
phagocytosis engulfment GO:0006911 1 0.016
membrane fusion GO:0061025 2 0.016
regulation of inflammatory response GO:0050727 2 0.016
negative regulation of gene expression GO:0010629 65 0.016
regulation of response to stimulus GO:0048583 269 0.016
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
response to food GO:0032094 1 0.016
protein acylation GO:0043543 3 0.016
regulation of neurogenesis GO:0050767 87 0.016
small molecule catabolic process GO:0044282 3 0.016
protein acetylation GO:0006473 2 0.016
exocytosis GO:0006887 1 0.016
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
estrogen metabolic process GO:0008210 2 0.016
transcription from rna polymerase ii promoter GO:0006366 80 0.016
peptide transport GO:0015833 1 0.016
protein import GO:0017038 3 0.015
regulation of signal transduction GO:0009966 225 0.015
Mouse
positive regulation of reproductive process GO:2000243 2 0.015
mononuclear cell proliferation GO:0032943 1 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
stem cell maintenance GO:0019827 4 0.015
single organism biosynthetic process GO:0044711 71 0.015
cation transport GO:0006812 81 0.015
cytokinesis GO:0000910 3 0.015
neurological system process GO:0050877 62 0.015
internal protein amino acid acetylation GO:0006475 2 0.015
axon development GO:0061564 166 0.015
regulation of hormone secretion GO:0046883 2 0.015
transmission of nerve impulse GO:0019226 19 0.015
digestive tract morphogenesis GO:0048546 231 0.015
protein polymerization GO:0051258 4 0.015
cellular response to starvation GO:0009267 1 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.015
positive regulation of map kinase activity GO:0043406 3 0.015
skeletal system development GO:0001501 181 0.015
multicellular organismal response to stress GO:0033555 2 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
cation transmembrane transport GO:0098655 65 0.015
negative regulation of secretion GO:0051048 2 0.015
cellular localization GO:0051641 97 0.015
positive regulation of secretion by cell GO:1903532 1 0.014
regulation of neurotransmitter secretion GO:0046928 1 0.014
protein localization to plasma membrane GO:0072659 1 0.014
endothelial cell fate commitment GO:0060839 3 0.014
cytoskeleton organization GO:0007010 96 0.014
lipid catabolic process GO:0016042 4 0.014
protein secretion GO:0009306 1 0.014
regulation of synapse assembly GO:0051963 3 0.014
negative regulation of cellular metabolic process GO:0031324 77 0.014
angiogenesis GO:0001525 158 0.014
negative regulation of protein localization to nucleus GO:1900181 2 0.014
negative regulation of biosynthetic process GO:0009890 55 0.014
regulation of dendrite morphogenesis GO:0048814 3 0.014
regulation of filopodium assembly GO:0051489 2 0.014
sensory perception of chemical stimulus GO:0007606 3 0.014
calcium mediated signaling GO:0019722 2 0.014
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
protein modification process GO:0036211 100 0.014
macromolecular complex disassembly GO:0032984 1 0.014
positive regulation of secretion GO:0051047 1 0.014
regulation of autophagy GO:0010506 3 0.014
multicellular organismal signaling GO:0035637 22 0.014
positive regulation of protein complex assembly GO:0031334 2 0.014
response to endogenous stimulus GO:0009719 83 0.014
camera type eye morphogenesis GO:0048593 108 0.014
actin filament based process GO:0030029 64 0.014
regulation of cytokine production GO:0001817 3 0.014
determination of heart left right asymmetry GO:0061371 117 0.013
leukocyte proliferation GO:0070661 1 0.013
response to corticosteroid GO:0031960 1 0.013
striated muscle tissue development GO:0014706 110 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
response to glucocorticoid GO:0051384 1 0.013
hindbrain development GO:0030902 91 0.013
positive regulation of transcription dna templated GO:0045893 57 0.013
blood vessel development GO:0001568 246 0.013
negative regulation of intracellular protein transport GO:0090317 3 0.013
circulatory system process GO:0003013 87 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
regulation of cell shape GO:0008360 1 0.013
retina morphogenesis in camera type eye GO:0060042 79 0.013
positive regulation of gtpase activity GO:0043547 1 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
positive regulation of metabolic process GO:0009893 108 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
cellular protein catabolic process GO:0044257 4 0.013
response to ketone GO:1901654 1 0.013
organic acid catabolic process GO:0016054 3 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
regulation of sequestering of calcium ion GO:0051282 4 0.013
intracellular signal transduction GO:0035556 85 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
lymphocyte proliferation GO:0046651 1 0.012
carbohydrate homeostasis GO:0033500 1 0.012
eye morphogenesis GO:0048592 144 0.012
epithelial tube morphogenesis GO:0060562 148 0.012
regulation of localization GO:0032879 104 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
blood vessel morphogenesis GO:0048514 216 0.012
g protein coupled receptor signaling pathway GO:0007186 74 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
muscle cell development GO:0055001 115 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
response to oxygen containing compound GO:1901700 55 0.012
regulation of dna replication GO:0006275 3 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
negative regulation of defense response GO:0031348 2 0.012
response to abiotic stimulus GO:0009628 122 0.012
ear morphogenesis GO:0042471 64 0.012
apoptotic process GO:0006915 116 0.012
Mouse
regulation of cellular component organization GO:0051128 86 0.012
inositol lipid mediated signaling GO:0048017 2 0.012
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.012
phosphatidylinositol mediated signaling GO:0048015 2 0.012
protein import into nucleus GO:0006606 3 0.012
positive regulation of multi organism process GO:0043902 3 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
embryonic skeletal system development GO:0048706 97 0.012
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
organelle fusion GO:0048284 3 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
compound eye development GO:0048749 2 0.012
blood circulation GO:0008015 87 0.012
epithelial cell differentiation GO:0030855 116 0.012
regulation of cell differentiation GO:0045595 142 0.012
regulation of response to extracellular stimulus GO:0032104 1 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
negative regulation of cellular catabolic process GO:0031330 3 0.011
regulation of axonogenesis GO:0050770 32 0.011
cell substrate adhesion GO:0031589 4 0.011
negative regulation of cytoplasmic transport GO:1903650 2 0.011
phosphorus metabolic process GO:0006793 109 0.011
axonogenesis GO:0007409 152 0.011
response to vitamin GO:0033273 3 0.011
regulation of protein targeting GO:1903533 2 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
spermatid differentiation GO:0048515 2 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
cellular protein modification process GO:0006464 100 0.011
response to organic cyclic compound GO:0014070 51 0.011
regulation of cell development GO:0060284 100 0.011
regulation of cell activation GO:0050865 1 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
oxidation reduction process GO:0055114 41 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
inner ear development GO:0048839 126 0.011
positive regulation of blood circulation GO:1903524 2 0.011
long chain fatty acid transport GO:0015909 1 0.011
sequestering of calcium ion GO:0051208 3 0.011
hormone biosynthetic process GO:0042446 3 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
positive regulation of cell division GO:0051781 2 0.011
adherens junction organization GO:0034332 4 0.011
response to amine GO:0014075 1 0.011
fatty acid oxidation GO:0019395 1 0.011
single organism membrane fusion GO:0044801 2 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
embryonic heart tube development GO:0035050 133 0.011
cellular response to hormone stimulus GO:0032870 39 0.011
embryonic heart tube morphogenesis GO:0003143 108 0.011
chemosensory behavior GO:0007635 1 0.011
neuronal action potential GO:0019228 18 0.011
axon ensheathment in central nervous system GO:0032291 2 0.011
protein stabilization GO:0050821 2 0.011
smooth muscle contraction GO:0006939 2 0.010
regulation of binding GO:0051098 3 0.010
positive regulation of synapse assembly GO:0051965 1 0.010
endosomal transport GO:0016197 2 0.010
central nervous system neuron differentiation GO:0021953 74 0.010
neurotransmitter secretion GO:0007269 2 0.010
establishment of synaptic vesicle localization GO:0097480 1 0.010
regulation of synaptic plasticity GO:0048167 1 0.010
heart looping GO:0001947 94 0.010
inner ear morphogenesis GO:0042472 63 0.010
striated muscle cell differentiation GO:0051146 129 0.010
superoxide metabolic process GO:0006801 2 0.010
germ line stem cell maintenance GO:0030718 2 0.010
striated muscle cell development GO:0055002 108 0.010
cellular response to endogenous stimulus GO:0071495 68 0.010
positive regulation of gtp catabolic process GO:0033126 1 0.010
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
meiotic cell cycle process GO:1903046 3 0.010
maternal determination of anterior posterior axis embryo GO:0008358 4 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010
embryonic skeletal system morphogenesis GO:0048704 93 0.010
regulation of neuron differentiation GO:0045664 56 0.010
negative regulation of protein transport GO:0051224 3 0.010
negative regulation of kinase activity GO:0033673 4 0.010
cell growth GO:0016049 57 0.010

zgc:92712 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
nervous system disease DOID:863 0 0.020
sensory system disease DOID:0050155 0 0.016
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011
musculoskeletal system disease DOID:17 0 0.010