Danio rerio

0 known processes

map4k5

mitogen-activated protein kinase kinase kinase kinase 5

(Aliases: zgc:55719,zgc:55985,fl74c10,wu:fl74c10,MGC55719)

map4k5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.367
blood vessel development GO:0001568 246 0.178
meiotic nuclear division GO:0007126 4 0.164
negative regulation of protein kinase activity GO:0006469 4 0.126
chordate embryonic development GO:0043009 271 0.124
negative regulation of protein phosphorylation GO:0001933 4 0.109
phagocytosis GO:0006909 3 0.079
cellular nitrogen compound metabolic process GO:0034641 290 0.079
cellular component movement GO:0006928 335 0.078
cellular macromolecule metabolic process GO:0044260 391 0.077
Human Fly
single organism metabolic process GO:0044710 217 0.076
Fly
regulation of multicellular organism growth GO:0040014 4 0.071
embryo development ending in birth or egg hatching GO:0009792 271 0.070
negative regulation of kinase activity GO:0033673 4 0.069
blood vessel morphogenesis GO:0048514 216 0.067
vasculature development GO:0001944 278 0.066
establishment of localization GO:0051234 244 0.064
positive regulation of transport GO:0051050 2 0.063
regulation of reproductive process GO:2000241 4 0.055
regulation of cellular component organization GO:0051128 86 0.054
heart development GO:0007507 313 0.054
locomotion GO:0040011 313 0.053
positive regulation of biological process GO:0048518 253 0.053
Fly
organelle fusion GO:0048284 3 0.052
regulation of developmental process GO:0050793 247 0.051
regulation of oocyte development GO:0060281 3 0.050
cellular response to external stimulus GO:0071496 2 0.049
establishment of protein localization to organelle GO:0072594 4 0.049
regulation of primary metabolic process GO:0080090 311 0.049
localization of cell GO:0051674 244 0.049
nitrogen compound metabolic process GO:0006807 319 0.049
positive regulation of protein complex assembly GO:0031334 2 0.049
cellular response to extracellular stimulus GO:0031668 2 0.048
cell morphogenesis GO:0000902 289 0.048
rna metabolic process GO:0016070 219 0.047
regulation of protein complex assembly GO:0043254 3 0.047
nucleobase containing compound metabolic process GO:0006139 274 0.047
cell cycle GO:0007049 93 0.046
embryonic organ development GO:0048568 381 0.045
regulation of cell development GO:0060284 100 0.045
organelle organization GO:0006996 227 0.045
Fly
regulation of cellular metabolic process GO:0031323 320 0.044
Fly
cell motility GO:0048870 244 0.044
cell cycle process GO:0022402 53 0.043
cortical actin cytoskeleton organization GO:0030866 1 0.043
regulation of nitrogen compound metabolic process GO:0051171 251 0.043
aging GO:0007568 2 0.043
cellular biosynthetic process GO:0044249 286 0.041
transcription dna templated GO:0006351 181 0.040
nucleocytoplasmic transport GO:0006913 4 0.040
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.040
cellular response to starvation GO:0009267 1 0.040
regulation of macromolecule metabolic process GO:0060255 317 0.040
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.039
cell migration GO:0016477 237 0.039
negative regulation of cellular process GO:0048523 283 0.039
Fly
negative regulation of biological process GO:0048519 304 0.039
Fly
negative regulation of synapse assembly GO:0051964 2 0.039
endocytosis GO:0006897 16 0.038
cellular response to nutrient levels GO:0031669 2 0.038
biosynthetic process GO:0009058 294 0.038
transport GO:0006810 220 0.037
tube morphogenesis GO:0035239 349 0.037
heterocycle metabolic process GO:0046483 290 0.037
lamellipodium assembly GO:0030032 1 0.037
cortical cytoskeleton organization GO:0030865 1 0.036
positive regulation of cellular component biogenesis GO:0044089 3 0.036
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.035
regulation of cellular biosynthetic process GO:0031326 245 0.035
generation of neurons GO:0048699 385 0.035
single organism organelle organization GO:1902589 199 0.035
phosphate containing compound metabolic process GO:0006796 108 0.034
Human Fly
multicellular organism growth GO:0035264 4 0.034
somitogenesis GO:0001756 87 0.034
regionalization GO:0003002 274 0.034
cell morphogenesis involved in differentiation GO:0000904 195 0.034
single organism nuclear import GO:1902593 3 0.034
nuclear transport GO:0051169 4 0.034
positive regulation of protein polymerization GO:0032273 2 0.034
response to drug GO:0042493 3 0.033
embryonic organ morphogenesis GO:0048562 274 0.033
positive regulation of map kinase activity GO:0043406 3 0.033
protein targeting to nucleus GO:0044744 3 0.032
negative regulation of mapk cascade GO:0043409 4 0.032
mitotic cell cycle GO:0000278 64 0.032
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.032
protein import GO:0017038 3 0.031
single organism transport GO:0044765 206 0.031
gene expression GO:0010467 252 0.031
lamellipodium organization GO:0097581 1 0.030
regulation of cell shape GO:0008360 1 0.030
positive regulation of cytoskeleton organization GO:0051495 3 0.029
regulation of multicellular organismal development GO:2000026 223 0.029
activation of mapk activity GO:0000187 3 0.028
death GO:0016265 121 0.028
Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.028
liver development GO:0001889 96 0.028
actin filament based movement GO:0030048 1 0.028
embryonic skeletal system development GO:0048706 97 0.028
nuclear import GO:0051170 3 0.028
programmed cell death GO:0012501 119 0.028
Fly
positive regulation of catabolic process GO:0009896 4 0.028
nucleic acid templated transcription GO:0097659 181 0.027
negative regulation of map kinase activity GO:0043407 2 0.027
protein metabolic process GO:0019538 183 0.027
Human Fly
macroautophagy GO:0016236 1 0.027
regulation of cellular amine metabolic process GO:0033238 0 0.027
oxoacid metabolic process GO:0043436 31 0.027
membrane invagination GO:0010324 1 0.027
regulation of synapse organization GO:0050807 3 0.027
response to chemical GO:0042221 320 0.027
Fly
gtp catabolic process GO:0006184 2 0.027
protein localization to nucleus GO:0034504 3 0.026
stem cell division GO:0017145 1 0.026
neuron differentiation GO:0030182 353 0.026
protein polymerization GO:0051258 4 0.026
stem cell proliferation GO:0072089 4 0.026
growth GO:0040007 174 0.026
Fly
protein import into nucleus GO:0006606 3 0.025
regulation of multicellular organismal process GO:0051239 277 0.025
positive regulation of stress activated mapk cascade GO:0032874 3 0.025
Fly
positive regulation of cellular catabolic process GO:0031331 3 0.025
guanosine containing compound catabolic process GO:1901069 2 0.025
regulation of meiotic cell cycle GO:0051445 1 0.025
guanosine containing compound metabolic process GO:1901068 4 0.024
response to external stimulus GO:0009605 264 0.024
regulation of cell communication GO:0010646 232 0.024
Fly
cell death GO:0008219 121 0.024
Fly
rna biosynthetic process GO:0032774 181 0.024
meiotic cell cycle process GO:1903046 3 0.024
small molecule metabolic process GO:0044281 77 0.024
establishment of synaptic vesicle localization GO:0097480 1 0.024
regulation of protein catabolic process GO:0042176 1 0.024
regulation of cell differentiation GO:0045595 142 0.024
membrane fusion GO:0061025 2 0.024
regulation of establishment of protein localization GO:0070201 4 0.023
cellular protein catabolic process GO:0044257 4 0.023
regulation of metabolic process GO:0019222 359 0.023
Fly
cell aging GO:0007569 2 0.023
response to stress GO:0006950 263 0.023
Fly
developmental growth GO:0048589 166 0.023
nucleic acid metabolic process GO:0090304 244 0.023
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.022
ubiquitin dependent protein catabolic process GO:0006511 3 0.022
cellular protein modification process GO:0006464 100 0.022
Human Fly
negative regulation of response to stimulus GO:0048585 104 0.022
Fly
apoptotic process GO:0006915 116 0.022
Fly
carboxylic acid metabolic process GO:0019752 22 0.022
production of molecular mediator of immune response GO:0002440 2 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
vacuolar transport GO:0007034 2 0.021
morphogenesis of an epithelium GO:0002009 333 0.021
regulation of neurogenesis GO:0050767 87 0.021
embryonic skeletal system morphogenesis GO:0048704 93 0.021
erk1 and erk2 cascade GO:0070371 4 0.021
organic cyclic compound biosynthetic process GO:1901362 223 0.021
regulation of nervous system development GO:0051960 90 0.020
regulation of programmed cell death GO:0043067 101 0.020
Fly
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.020
Fly
neuroblast proliferation GO:0007405 2 0.020
cell part morphogenesis GO:0032990 246 0.020
proteasomal protein catabolic process GO:0010498 2 0.020
positive regulation of jnk cascade GO:0046330 3 0.020
Fly
lipid storage GO:0019915 1 0.020
phosphorylation GO:0016310 69 0.020
Human Fly
somite development GO:0061053 96 0.020
gtp metabolic process GO:0046039 4 0.020
regulation of organelle organization GO:0033043 29 0.020
regulation of catalytic activity GO:0050790 55 0.020
hepaticobiliary system development GO:0061008 98 0.019
regulation of erk1 and erk2 cascade GO:0070372 4 0.019
adult behavior GO:0030534 2 0.019
Fly
single organism localization GO:1902578 225 0.019
cellular amine metabolic process GO:0044106 2 0.019
regulation of biosynthetic process GO:0009889 250 0.019
regulation of stem cell proliferation GO:0072091 2 0.019
cytokinesis GO:0000910 3 0.019
epithelial tube morphogenesis GO:0060562 148 0.019
endosomal transport GO:0016197 2 0.019
spindle assembly GO:0051225 2 0.018
regulation of rna metabolic process GO:0051252 224 0.018
actin filament polymerization GO:0030041 2 0.018
regulation of gene expression GO:0010468 265 0.018
regulation of protein targeting GO:1903533 2 0.018
negative regulation of developmental process GO:0051093 65 0.018
digestive tract development GO:0048565 265 0.018
centrosome organization GO:0051297 1 0.018
angiogenesis GO:0001525 158 0.018
organic acid metabolic process GO:0006082 31 0.018
regulation of gtp catabolic process GO:0033124 2 0.018
mechanosensory behavior GO:0007638 2 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
organic substance biosynthetic process GO:1901576 289 0.018
neuron projection development GO:0031175 180 0.018
modification dependent macromolecule catabolic process GO:0043632 3 0.018
cellular ketone metabolic process GO:0042180 11 0.018
primary neural tube formation GO:0014020 1 0.018
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
somatic stem cell maintenance GO:0035019 1 0.017
regulation of gtpase activity GO:0043087 2 0.017
positive regulation of dna metabolic process GO:0051054 1 0.017
positive regulation of cell cycle GO:0045787 3 0.017
digestive system development GO:0055123 289 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
single organism membrane fusion GO:0044801 2 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
negative regulation of multicellular organismal process GO:0051241 69 0.017
sensory organ development GO:0007423 393 0.017
amine metabolic process GO:0009308 2 0.017
regulation of protein transport GO:0051223 3 0.017
reactive nitrogen species metabolic process GO:2001057 0 0.017
female sex differentiation GO:0046660 4 0.017
transcription from rna polymerase ii promoter GO:0006366 80 0.017
positive regulation of cell adhesion GO:0045785 1 0.017
regulation of response to cytokine stimulus GO:0060759 3 0.016
response to carbohydrate GO:0009743 3 0.016
segmentation GO:0035282 97 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
positive regulation of gtpase activity GO:0043547 1 0.016
cellular response to chemical stimulus GO:0070887 157 0.016
Fly
skeletal system development GO:0001501 181 0.016
axon development GO:0061564 166 0.016
negative regulation of cell communication GO:0010648 96 0.016
Fly
regulation of protein binding GO:0043393 3 0.016
negative regulation of innate immune response GO:0045824 2 0.016
rna localization GO:0006403 4 0.016
tube closure GO:0060606 1 0.016
cellular component biogenesis GO:0044085 178 0.016
microtubule organizing center organization GO:0031023 1 0.016
response to monosaccharide GO:0034284 3 0.016
cellular response to biotic stimulus GO:0071216 3 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
protein heterooligomerization GO:0051291 1 0.015
macromolecule modification GO:0043412 111 0.015
Human Fly
reproductive process GO:0022414 40 0.015
organic cyclic compound metabolic process GO:1901360 301 0.015
epithelial cell morphogenesis GO:0003382 2 0.015
stem cell maintenance GO:0019827 4 0.015
phosphorus metabolic process GO:0006793 109 0.015
Human Fly
regulation of synapse assembly GO:0051963 3 0.015
positive regulation of apoptotic signaling pathway GO:2001235 1 0.015
regulation of localization GO:0032879 104 0.015
homeostatic process GO:0042592 142 0.015
Fly
positive regulation of jun kinase activity GO:0043507 2 0.015
regulation of signal transduction GO:0009966 225 0.015
Fly
regulation of biological quality GO:0065008 263 0.015
Fly
mitochondrion organization GO:0007005 4 0.015
regulation of phosphate metabolic process GO:0019220 43 0.015
Fly
response to hexose GO:0009746 3 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
cellular component morphogenesis GO:0032989 336 0.015
cell substrate adhesion GO:0031589 4 0.015
multi organism process GO:0051704 134 0.015
cell surface receptor signaling pathway GO:0007166 325 0.015
Fly
response to corticosteroid GO:0031960 1 0.015
anterior posterior pattern specification GO:0009952 152 0.015
cell adhesion mediated by integrin GO:0033627 1 0.014
negative regulation of cellular metabolic process GO:0031324 77 0.014
immune system process GO:0002376 241 0.014
regulation of response to stress GO:0080134 36 0.014
Fly
autophagy GO:0006914 4 0.014
regulation of molecular function GO:0065009 70 0.014
cell projection organization GO:0030030 284 0.014
extrinsic apoptotic signaling pathway GO:0097191 3 0.014
regulation of mitochondrion organization GO:0010821 1 0.014
axonogenesis GO:0007409 152 0.014
protein dephosphorylation GO:0006470 3 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
actin mediated cell contraction GO:0070252 1 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
synaptic target recognition GO:0008039 1 0.014
regulation of jun kinase activity GO:0043506 3 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
cellular response to stress GO:0033554 62 0.013
Fly
organonitrogen compound metabolic process GO:1901564 74 0.013
heart morphogenesis GO:0003007 156 0.013
cell death in response to oxidative stress GO:0036473 2 0.013
organelle fission GO:0048285 23 0.013
regulation of cell activation GO:0050865 1 0.013
neuron development GO:0048666 262 0.013
regulation of cell death GO:0010941 103 0.013
Fly
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.013
cognition GO:0050890 1 0.013
mitotic nuclear division GO:0007067 18 0.013
cellular aromatic compound metabolic process GO:0006725 295 0.013
regulation of phosphorus metabolic process GO:0051174 43 0.013
Fly
female meiotic division GO:0007143 2 0.013
regulation of filopodium assembly GO:0051489 2 0.013
intracellular signal transduction GO:0035556 85 0.013
Human Fly
golgi vesicle transport GO:0048193 3 0.013
mitochondrial transport GO:0006839 2 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
regulation of response to biotic stimulus GO:0002831 2 0.013
central nervous system development GO:0007417 387 0.013
synaptic vesicle transport GO:0048489 1 0.013
aromatic compound biosynthetic process GO:0019438 217 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
germ cell development GO:0007281 22 0.012
macromolecular complex subunit organization GO:0043933 74 0.012
meiotic chromosome segregation GO:0045132 3 0.012
mitotic cytokinesis GO:0000281 3 0.012
cellular localization GO:0051641 97 0.012
establishment of apical basal cell polarity GO:0035089 2 0.012
convergent extension GO:0060026 118 0.012
regulation of protein polymerization GO:0032271 2 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
g2 dna damage checkpoint GO:0031572 3 0.012
regulation of binding GO:0051098 3 0.012
regulation of cell projection assembly GO:0060491 4 0.012
cell projection morphogenesis GO:0048858 244 0.012
nitric oxide biosynthetic process GO:0006809 2 0.012
establishment of protein localization to vacuole GO:0072666 1 0.012
adherens junction organization GO:0034332 4 0.012
neural tube patterning GO:0021532 33 0.012
mitotic cell cycle process GO:1903047 48 0.011
cellular component disassembly GO:0022411 1 0.011
positive regulation of camp metabolic process GO:0030816 2 0.011
neurotransmitter transport GO:0006836 2 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
negative regulation of response to cytokine stimulus GO:0060761 2 0.011
cytoskeleton organization GO:0007010 96 0.011
signal transduction GO:0007165 455 0.011
Human Fly
centrosome cycle GO:0007098 1 0.011
determination of bilateral symmetry GO:0009855 204 0.011
glycerolipid biosynthetic process GO:0045017 1 0.011
spermatid development GO:0007286 2 0.011
negative regulation of defense response GO:0031348 2 0.011
multi organism reproductive process GO:0044703 36 0.011
cell matrix adhesion GO:0007160 4 0.011
locomotory behavior GO:0007626 34 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
gland development GO:0048732 143 0.011
digestive tract morphogenesis GO:0048546 231 0.011
cartilage development GO:0051216 96 0.011
positive regulation of cell communication GO:0010647 56 0.011
Fly
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
regulation of neuron differentiation GO:0045664 56 0.011
gastrulation GO:0007369 208 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
response to nicotine GO:0035094 2 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
Fly
regulation of mrna processing GO:0050684 3 0.011
regulation of cellular component movement GO:0051270 55 0.011
positive regulation of cellular process GO:0048522 201 0.011
Fly
regulation of locomotion GO:0040012 55 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
response to nutrient GO:0007584 3 0.011
response to glucose GO:0009749 3 0.011
muscle cell migration GO:0014812 4 0.011
nucleobase containing compound transport GO:0015931 2 0.011
sensory organ morphogenesis GO:0090596 200 0.011
response to wounding GO:0009611 116 0.011
skeletal system morphogenesis GO:0048705 102 0.011
regulation of bone mineralization GO:0030500 2 0.011
peptidyl serine modification GO:0018209 2 0.011
negative regulation of signaling GO:0023057 96 0.010
Fly
oogenesis GO:0048477 14 0.010
dna templated transcription elongation GO:0006354 3 0.010
heterocycle biosynthetic process GO:0018130 215 0.010
synaptic vesicle endocytosis GO:0048488 1 0.010
embryonic heart tube morphogenesis GO:0003143 108 0.010
regulation of protein localization to nucleus GO:1900180 2 0.010
regulation of macromolecule biosynthetic process GO:0010556 225 0.010
negative regulation of protein transport GO:0051224 3 0.010
regulation of inflammatory response GO:0050727 2 0.010
response to hormone GO:0009725 48 0.010
Fly
axon regeneration GO:0031103 14 0.010
cellular response to oxygen levels GO:0071453 1 0.010
negative chemotaxis GO:0050919 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
wnt signaling pathway GO:0016055 80 0.010
b cell activation GO:0042113 2 0.010
protein localization to vacuole GO:0072665 1 0.010
sexual reproduction GO:0019953 36 0.010

map4k5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.030
nervous system disease DOID:863 0 0.019
myopathy DOID:423 0 0.019
muscular disease DOID:0080000 0 0.019
musculoskeletal system disease DOID:17 0 0.019
muscle tissue disease DOID:66 0 0.019
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
disease of metabolism DOID:0014667 0 0.013
immune system disease DOID:2914 0 0.011