Danio rerio

0 known processes

ctsc

cathepsin C

(Aliases: ik:tdsubc_1h2,wu:fb34g12,cb912,wu:fj58d01,sb:cb146)

ctsc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular protein catabolic process GO:0044257 4 0.637
Rat
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.626
Rat
larval development GO:0002164 2 0.350
establishment of localization GO:0051234 244 0.282
response to organic substance GO:0010033 153 0.175
Rat
multicellular organismal macromolecule metabolic process GO:0044259 2 0.169
collagen metabolic process GO:0032963 2 0.168
response to external stimulus GO:0009605 264 0.161
positive regulation of cellular extravasation GO:0002693 1 0.158
lipid storage GO:0019915 1 0.123
muscle structure development GO:0061061 196 0.122
organic substance catabolic process GO:1901575 28 0.107
Rat
lymph vessel morphogenesis GO:0036303 25 0.105
autophagy GO:0006914 4 0.104
response to abiotic stimulus GO:0009628 122 0.100
regulation of blood vessel size GO:0050880 2 0.096
response to nutrient GO:0007584 3 0.095
tissue regeneration GO:0042246 74 0.094
organonitrogen compound metabolic process GO:1901564 74 0.087
regulation of cell communication GO:0010646 232 0.083
Mouse
taxis GO:0042330 109 0.082
positive regulation of catabolic process GO:0009896 4 0.082
Rat
response to carbohydrate GO:0009743 3 0.080
gtp metabolic process GO:0046039 4 0.077
guanosine containing compound metabolic process GO:1901068 4 0.075
small molecule metabolic process GO:0044281 77 0.074
tube morphogenesis GO:0035239 349 0.073
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.071
response to hexose GO:0009746 3 0.069
regulation of primary metabolic process GO:0080090 311 0.068
Mouse Rat
regulation of nitrogen compound metabolic process GO:0051171 251 0.067
regulation of metabolic process GO:0019222 359 0.066
Mouse Rat
guanosine containing compound catabolic process GO:1901069 2 0.065
multicellular organismal metabolic process GO:0044236 2 0.063
signal transduction GO:0007165 455 0.061
Mouse
cell morphogenesis GO:0000902 289 0.060
developmental growth GO:0048589 166 0.058
positive regulation of transport GO:0051050 2 0.056
nucleobase containing compound metabolic process GO:0006139 274 0.056
regulation of neutrophil migration GO:1902622 6 0.056
cell surface receptor signaling pathway GO:0007166 325 0.056
immune system process GO:0002376 241 0.055
Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.053
establishment or maintenance of cell polarity GO:0007163 29 0.052
camera type eye development GO:0043010 222 0.052
glycosyl compound metabolic process GO:1901657 11 0.051
cellular protein metabolic process GO:0044267 129 0.051
Mouse Rat
nucleobase containing small molecule metabolic process GO:0055086 32 0.050
immune response GO:0006955 28 0.050
Mouse
transport GO:0006810 220 0.050
multicellular organism growth GO:0035264 4 0.050
neuron differentiation GO:0030182 353 0.049
cellular catabolic process GO:0044248 27 0.049
Rat
tissue remodeling GO:0048771 4 0.049
oxidoreduction coenzyme metabolic process GO:0006733 1 0.047
blood vessel morphogenesis GO:0048514 216 0.047
Zebrafish
regulation of signaling GO:0023051 235 0.045
Mouse
purine nucleotide metabolic process GO:0006163 27 0.044
response to monosaccharide GO:0034284 3 0.044
negative regulation of biological process GO:0048519 304 0.044
blood vessel development GO:0001568 246 0.044
Zebrafish
fin regeneration GO:0031101 51 0.043
multi organism process GO:0051704 134 0.043
programmed cell death GO:0012501 119 0.043
Mouse
regulation of multicellular organismal process GO:0051239 277 0.042
muscle organ development GO:0007517 101 0.042
cellular aldehyde metabolic process GO:0006081 4 0.042
nucleoside phosphate metabolic process GO:0006753 28 0.042
gtp catabolic process GO:0006184 2 0.041
response to ph GO:0009268 2 0.041
gene expression GO:0010467 252 0.041
system process GO:0003008 185 0.040
regeneration GO:0031099 91 0.040
amine metabolic process GO:0009308 2 0.040
epithelial cell differentiation GO:0030855 116 0.040
angiogenesis GO:0001525 158 0.040
Zebrafish
smooth muscle contraction GO:0006939 2 0.039
aging GO:0007568 2 0.039
Rat
response to stress GO:0006950 263 0.039
cellular aromatic compound metabolic process GO:0006725 295 0.039
morphogenesis of an epithelium GO:0002009 333 0.039
modification dependent protein catabolic process GO:0019941 3 0.038
generation of neurons GO:0048699 385 0.038
branching morphogenesis of an epithelial tube GO:0048754 15 0.038
positive regulation of cgmp biosynthetic process GO:0030828 6 0.038
nitrogen compound metabolic process GO:0006807 319 0.037
cellular macromolecule catabolic process GO:0044265 12 0.037
Rat
neuron projection development GO:0031175 180 0.037
establishment of protein localization to organelle GO:0072594 4 0.037
regulation of dendrite development GO:0050773 3 0.037
positive regulation of gtp catabolic process GO:0033126 1 0.037
response to glucose GO:0009749 3 0.036
regulation of biological quality GO:0065008 263 0.036
blood circulation GO:0008015 87 0.035
circulatory system process GO:0003013 87 0.035
regulation of tube size GO:0035150 2 0.035
regulation of synapse assembly GO:0051963 3 0.035
regulation of response to stimulus GO:0048583 269 0.035
Mouse
organic cyclic compound metabolic process GO:1901360 301 0.034
ribonucleotide metabolic process GO:0009259 27 0.034
peptide metabolic process GO:0006518 1 0.033
maintenance of location GO:0051235 4 0.033
cellular nitrogen compound metabolic process GO:0034641 290 0.033
regulation of cell shape GO:0008360 1 0.032
cellular component disassembly GO:0022411 1 0.032
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.032
cellular component morphogenesis GO:0032989 336 0.032
cell motility GO:0048870 244 0.031
oxalate transport GO:0019532 1 0.031
response to chemical GO:0042221 320 0.030
Rat
developmental cell growth GO:0048588 52 0.030
hematopoietic stem cell migration GO:0035701 4 0.029
regulation of blood pressure GO:0008217 1 0.029
sulfate transmembrane transport GO:1902358 2 0.029
interspecies interaction between organisms GO:0044419 4 0.029
single organism metabolic process GO:0044710 217 0.028
proteolysis GO:0006508 38 0.028
Human Mouse Rat
regulation of cell activation GO:0050865 1 0.028
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.028
cellular amino acid metabolic process GO:0006520 7 0.028
positive regulation of nucleoside metabolic process GO:0045979 1 0.028
axonogenesis GO:0007409 152 0.027
response to bacterium GO:0009617 58 0.027
negative regulation of protein kinase activity GO:0006469 4 0.027
nucleic acid transport GO:0050657 2 0.027
response to wounding GO:0009611 116 0.027
protein import into nucleus GO:0006606 3 0.027
regulation of leukocyte migration GO:0002685 8 0.026
homeostasis of number of cells within a tissue GO:0048873 4 0.026
nuclear transport GO:0051169 4 0.026
purine containing compound metabolic process GO:0072521 29 0.026
regulation of signal transduction GO:0009966 225 0.026
Mouse
sequestering of calcium ion GO:0051208 3 0.026
protein targeting to nucleus GO:0044744 3 0.026
epithelial tube morphogenesis GO:0060562 148 0.026
single organism membrane organization GO:0044802 20 0.026
cellular amide metabolic process GO:0043603 4 0.026
cell projection morphogenesis GO:0048858 244 0.025
cell projection organization GO:0030030 284 0.025
heterocycle metabolic process GO:0046483 290 0.025
regulation of anatomical structure morphogenesis GO:0022603 130 0.025
response to amine GO:0014075 1 0.024
retina development in camera type eye GO:0060041 146 0.024
response to corticosteroid GO:0031960 1 0.024
axon development GO:0061564 166 0.024
protein metabolic process GO:0019538 183 0.024
Human Mouse Rat
regulation of gtpase activity GO:0043087 2 0.024
defense response to bacterium GO:0042742 22 0.024
neuron development GO:0048666 262 0.024
catabolic process GO:0009056 32 0.024
Rat
central nervous system development GO:0007417 387 0.023
regulation of nucleotide catabolic process GO:0030811 2 0.023
striated muscle tissue development GO:0014706 110 0.023
stem cell proliferation GO:0072089 4 0.023
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.023
positive regulation of nucleotide catabolic process GO:0030813 1 0.023
modification dependent macromolecule catabolic process GO:0043632 3 0.023
cellular component assembly GO:0022607 170 0.022
regulation of multicellular organism growth GO:0040014 4 0.022
wound healing GO:0042060 90 0.022
negative regulation of rna splicing GO:0033119 1 0.022
g protein coupled receptor signaling pathway GO:0007186 74 0.022
ubiquitin dependent protein catabolic process GO:0006511 3 0.022
ribose phosphate metabolic process GO:0019693 27 0.022
organic acid metabolic process GO:0006082 31 0.022
cell part morphogenesis GO:0032990 246 0.022
negative regulation of cellular metabolic process GO:0031324 77 0.021
negative regulation of epithelial cell proliferation GO:0050680 1 0.021
superoxide metabolic process GO:0006801 2 0.021
regulation of cellular component organization GO:0051128 86 0.021
cellular biosynthetic process GO:0044249 286 0.021
locomotion GO:0040011 313 0.021
neutrophil mediated immunity GO:0002446 1 0.021
regulation of ph GO:0006885 3 0.021
lytic vacuole organization GO:0080171 1 0.021
positive regulation of exocytosis GO:0045921 1 0.020
glucose homeostasis GO:0042593 1 0.020
skeletal muscle organ development GO:0060538 78 0.020
syncytium formation GO:0006949 12 0.020
cellular component movement GO:0006928 335 0.020
regulation of purine nucleotide catabolic process GO:0033121 2 0.020
positive regulation of gtpase activity GO:0043547 1 0.020
regulation of chemotaxis GO:0050920 18 0.020
nucleoside triphosphate metabolic process GO:0009141 9 0.020
cellular macromolecule metabolic process GO:0044260 391 0.019
Mouse Rat
positive regulation of secretion by cell GO:1903532 1 0.019
purine ribonucleotide metabolic process GO:0009150 27 0.019
single organism catabolic process GO:0044712 13 0.019
biological adhesion GO:0022610 40 0.019
regulation of cell motility GO:2000145 46 0.019
nucleotide metabolic process GO:0009117 28 0.019
brain development GO:0007420 293 0.019
bone remodeling GO:0046849 2 0.019
negative regulation of mrna processing GO:0050686 1 0.019
positive regulation of cellular catabolic process GO:0031331 3 0.019
Rat
sexual reproduction GO:0019953 36 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
ameboidal type cell migration GO:0001667 143 0.018
cellular response to extracellular stimulus GO:0031668 2 0.018
intracellular signal transduction GO:0035556 85 0.018
regulation of metal ion transport GO:0010959 4 0.018
response to nicotine GO:0035094 2 0.018
muscle tissue development GO:0060537 110 0.018
metal ion homeostasis GO:0055065 26 0.018
meiotic cell cycle process GO:1903046 3 0.017
response to vitamin GO:0033273 3 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.017
regulation of synapse organization GO:0050807 3 0.017
regulation of establishment of planar polarity GO:0090175 4 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
response to external biotic stimulus GO:0043207 97 0.017
morphogenesis of a branching epithelium GO:0061138 16 0.017
multicellular organismal response to stress GO:0033555 2 0.017
phagosome maturation GO:0090382 1 0.017
regulation of gtp catabolic process GO:0033124 2 0.017
synaptic transmission cholinergic GO:0007271 4 0.017
small gtpase mediated signal transduction GO:0007264 8 0.016
regulation of muscle contraction GO:0006937 3 0.016
response to glucocorticoid GO:0051384 1 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
transmission of nerve impulse GO:0019226 19 0.016
cellular response to external stimulus GO:0071496 2 0.016
negative regulation of muscle contraction GO:0045932 1 0.016
signal transduction in absence of ligand GO:0038034 1 0.016
somatic stem cell maintenance GO:0035019 1 0.016
fatty acid transport GO:0015908 1 0.016
multicellular organismal reproductive process GO:0048609 35 0.015
release of sequestered calcium ion into cytosol GO:0051209 3 0.015
retina morphogenesis in camera type eye GO:0060042 79 0.015
embryonic viscerocranium morphogenesis GO:0048703 52 0.015
embryonic skeletal system development GO:0048706 97 0.015
regulation of synaptic plasticity GO:0048167 1 0.015
regulation of localization GO:0032879 104 0.015
regulation of response to extracellular stimulus GO:0032104 1 0.015
calcium ion homeostasis GO:0055074 19 0.015
organic substance transport GO:0071702 58 0.015
chemotaxis GO:0006935 104 0.015
endosome to lysosome transport GO:0008333 1 0.015
macromolecule biosynthetic process GO:0009059 227 0.014
protein targeting to membrane GO:0006612 1 0.014
oxoacid metabolic process GO:0043436 31 0.014
regulation of cytoplasmic transport GO:1903649 4 0.014
negative regulation of kinase activity GO:0033673 4 0.014
retinal metabolic process GO:0042574 3 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
negative regulation of protein phosphorylation GO:0001933 4 0.014
neurotransmitter secretion GO:0007269 2 0.014
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.014
nucleoside metabolic process GO:0009116 11 0.014
ph reduction GO:0045851 1 0.014
macroautophagy GO:0016236 1 0.014
regulation of immune system process GO:0002682 34 0.014
establishment of protein localization to plasma membrane GO:0090002 1 0.013
positive regulation of response to external stimulus GO:0032103 9 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.013
extracellular matrix organization GO:0030198 27 0.013
cell growth GO:0016049 57 0.013
regulation of gene expression GO:0010468 265 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
cell migration GO:0016477 237 0.013
establishment of blood brain barrier GO:0060856 2 0.013
ion transport GO:0006811 114 0.013
ion homeostasis GO:0050801 41 0.013
negative regulation of synapse assembly GO:0051964 2 0.013
carbohydrate derivative metabolic process GO:1901135 61 0.013
response to endogenous stimulus GO:0009719 83 0.013
heart rudiment formation GO:0003315 5 0.013
synaptic growth at neuromuscular junction GO:0051124 2 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
growth GO:0040007 174 0.013
medulla oblongata development GO:0021550 4 0.013
phosphorus metabolic process GO:0006793 109 0.013
single organism transport GO:0044765 206 0.013
cognition GO:0050890 1 0.013
positive regulation of myeloid cell differentiation GO:0045639 2 0.013
atp catabolic process GO:0006200 4 0.012
establishment of rna localization GO:0051236 3 0.012
regulation of cell differentiation GO:0045595 142 0.012
cation transport GO:0006812 81 0.012
chemical homeostasis GO:0048878 49 0.012
cellular hormone metabolic process GO:0034754 19 0.012
macromolecule localization GO:0033036 54 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
neutrophil extravasation GO:0072672 1 0.012
transcription dna templated GO:0006351 181 0.012
innate immune response GO:0045087 13 0.012
beta amyloid metabolic process GO:0050435 1 0.012
response to biotic stimulus GO:0009607 97 0.012
cellular component biogenesis GO:0044085 178 0.012
response to alkaloid GO:0043279 2 0.012
neutrophil migration GO:1990266 10 0.012
dorsal ventral pattern formation GO:0009953 125 0.012
mitochondrion organization GO:0007005 4 0.012
positive regulation of inflammatory response GO:0050729 1 0.012
defense response to gram positive bacterium GO:0050830 6 0.012
vasculature development GO:0001944 278 0.011
Zebrafish
negative regulation of signaling GO:0023057 96 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
endosomal transport GO:0016197 2 0.011
somatic muscle development GO:0007525 4 0.011
amino acid transport GO:0006865 2 0.011
regulation of bone remodeling GO:0046850 2 0.011
embryonic heart tube development GO:0035050 133 0.011
nucleobase containing compound transport GO:0015931 2 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
rna transport GO:0050658 2 0.011
localization of cell GO:0051674 244 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
positive regulation of cell activation GO:0050867 1 0.011
negative regulation of chromatin modification GO:1903309 1 0.011
neurotransmitter transport GO:0006836 2 0.011
intracellular transport GO:0046907 32 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
Rat
defense response to gram negative bacterium GO:0050829 8 0.011
protein localization to membrane GO:0072657 9 0.011
cellular response to starvation GO:0009267 1 0.011
regulation of oxidative stress induced cell death GO:1903201 2 0.011
muscle cell differentiation GO:0042692 139 0.011
cellular response to nutrient levels GO:0031669 2 0.011
melanosome organization GO:0032438 4 0.011
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
organelle assembly GO:0070925 110 0.011
organophosphate metabolic process GO:0019637 37 0.011
negative regulation of cellular process GO:0048523 283 0.011
regulation of protein localization to plasma membrane GO:1903076 1 0.011
purine ribonucleoside metabolic process GO:0046128 10 0.010
regulation of cellular biosynthetic process GO:0031326 245 0.010
positive regulation of secretion GO:0051047 1 0.010
protein localization to nucleus GO:0034504 3 0.010
myeloid leukocyte migration GO:0097529 12 0.010
protein acylation GO:0043543 3 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 9 0.010
terpenoid metabolic process GO:0006721 15 0.010

ctsc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.342
lysosomal storage disease DOID:3211 0 0.342
inherited metabolic disorder DOID:655 0 0.342
disease of anatomical entity DOID:7 0 0.124
Human
immune system disease DOID:2914 0 0.024
nervous system disease DOID:863 0 0.023
primary immunodeficiency disease DOID:612 0 0.023
lipid storage disease DOID:9455 0 0.021
central nervous system disease DOID:331 0 0.016
brain disease DOID:936 0 0.016
dementia DOID:1307 0 0.014
alzheimer s disease DOID:10652 0 0.014
disease of mental health DOID:150 0 0.014
tauopathy DOID:680 0 0.014
neurodegenerative disease DOID:1289 0 0.014
cognitive disorder DOID:1561 0 0.014