Danio rerio

17 known processes

ctsz

cathepsin Z

(Aliases: zgc:103420,wu:fj81f10)

ctsz biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular protein catabolic process GO:0044257 4 0.526
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.359
aging GO:0007568 2 0.232
larval development GO:0002164 2 0.179
Worm
response to chemical GO:0042221 320 0.178
regulation of multicellular organismal process GO:0051239 277 0.177
regulation of multicellular organism growth GO:0040014 4 0.170
multicellular organism growth GO:0035264 4 0.134
collagen metabolic process GO:0032963 2 0.124
response to nicotine GO:0035094 2 0.118
organelle fusion GO:0048284 3 0.118
positive regulation of cellular catabolic process GO:0031331 3 0.112
response to alkaloid GO:0043279 2 0.106
leukocyte mediated cytotoxicity GO:0001909 1 0.098
regulation of tube size GO:0035150 2 0.098
blood vessel morphogenesis GO:0048514 216 0.095
programmed cell death GO:0012501 119 0.092
response to external stimulus GO:0009605 264 0.084
regulation of protein catabolic process GO:0042176 1 0.083
hydrogen peroxide metabolic process GO:0042743 2 0.081
positive regulation of transport GO:0051050 2 0.080
immune system development GO:0002520 191 0.079
positive regulation of catabolic process GO:0009896 4 0.074
regulation of cell death GO:0010941 103 0.074
establishment of localization GO:0051234 244 0.073
multicellular organismal metabolic process GO:0044236 2 0.073
proteolysis GO:0006508 38 0.072
multicellular organismal macromolecule metabolic process GO:0044259 2 0.072
response to organic substance GO:0010033 153 0.070
cell death GO:0008219 121 0.069
regulation of response to stimulus GO:0048583 269 0.069
signal transduction GO:0007165 455 0.068
monovalent inorganic cation homeostasis GO:0055067 9 0.068
single organism membrane fusion GO:0044801 2 0.067
response to amine GO:0014075 1 0.066
lipid storage GO:0019915 1 0.063
developmental growth GO:0048589 166 0.062
death GO:0016265 121 0.062
vasculature development GO:0001944 278 0.061
cell surface receptor signaling pathway GO:0007166 325 0.061
regulation of nucleotide catabolic process GO:0030811 2 0.060
positive regulation of biological process GO:0048518 253 0.058
regulation of metal ion transport GO:0010959 4 0.058
negative regulation of multicellular organismal process GO:0051241 69 0.057
cell killing GO:0001906 2 0.057
negative regulation of cellular process GO:0048523 283 0.056
phagolysosome assembly GO:0001845 1 0.056
negative regulation of biological process GO:0048519 304 0.055
endosomal transport GO:0016197 2 0.055
regulation of signaling GO:0023051 235 0.055
cellular protein metabolic process GO:0044267 129 0.054
xenobiotic metabolic process GO:0006805 4 0.053
immune system process GO:0002376 241 0.051
blood vessel development GO:0001568 246 0.050
lytic vacuole organization GO:0080171 1 0.050
single organism transport GO:0044765 206 0.049
phagosome maturation GO:0090382 1 0.049
intracellular transport GO:0046907 32 0.049
generation of neurons GO:0048699 385 0.048
lipid catabolic process GO:0016042 4 0.048
ion transport GO:0006811 114 0.047
membrane fusion GO:0061025 2 0.046
maintenance of location GO:0051235 4 0.046
regulation of apoptotic process GO:0042981 98 0.046
regulation of blood vessel size GO:0050880 2 0.045
single organism metabolic process GO:0044710 217 0.045
response to acidic ph GO:0010447 2 0.044
vacuolar transport GO:0007034 2 0.042
single organism localization GO:1902578 225 0.042
superoxide metabolic process GO:0006801 2 0.041
macromolecule catabolic process GO:0009057 15 0.041
angiogenesis GO:0001525 158 0.041
regulation of blood pressure GO:0008217 1 0.041
transport GO:0006810 220 0.039
regulation of cell communication GO:0010646 232 0.038
membrane lipid biosynthetic process GO:0046467 2 0.038
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.038
organic substance catabolic process GO:1901575 28 0.038
cellular component biogenesis GO:0044085 178 0.038
vacuole organization GO:0007033 9 0.038
apoptotic process GO:0006915 116 0.037
protein metabolic process GO:0019538 183 0.037
neuron differentiation GO:0030182 353 0.036
neuron projection development GO:0031175 180 0.036
response to nutrient GO:0007584 3 0.036
intramembranous ossification GO:0001957 3 0.035
regulation of programmed cell death GO:0043067 101 0.035
regulation of intracellular ph GO:0051453 1 0.035
establishment of synaptic vesicle localization GO:0097480 1 0.034
signal transduction in absence of ligand GO:0038034 1 0.034
positive regulation of apoptotic signaling pathway GO:2001235 1 0.034
synaptic vesicle endocytosis GO:0048488 1 0.032
cellular response to chemical stimulus GO:0070887 157 0.032
glucose homeostasis GO:0042593 1 0.032
cellular response to lipopolysaccharide GO:0071222 3 0.032
extrinsic apoptotic signaling pathway GO:0097191 3 0.031
organonitrogen compound metabolic process GO:1901564 74 0.031
sphingolipid biosynthetic process GO:0030148 2 0.031
protein import into nucleus GO:0006606 3 0.031
response to endogenous stimulus GO:0009719 83 0.030
cellular response to biotic stimulus GO:0071216 3 0.030
embryo development ending in birth or egg hatching GO:0009792 271 0.030
Worm
regulation of biological quality GO:0065008 263 0.030
regulation of cell activation GO:0050865 1 0.029
membrane organization GO:0061024 21 0.028
multi organism process GO:0051704 134 0.028
smooth muscle contraction GO:0006939 2 0.028
amine metabolic process GO:0009308 2 0.028
response to monosaccharide GO:0034284 3 0.028
guanosine containing compound metabolic process GO:1901068 4 0.028
nuclear transport GO:0051169 4 0.028
protein catabolic process GO:0030163 7 0.028
cell morphogenesis GO:0000902 289 0.027
regulation of growth GO:0040008 42 0.027
response to alcohol GO:0097305 14 0.027
cell motility GO:0048870 244 0.027
regulation of nucleocytoplasmic transport GO:0046822 2 0.027
ph reduction GO:0045851 1 0.027
regulation of inflammatory response GO:0050727 2 0.027
cell projection organization GO:0030030 284 0.027
cellular component assembly GO:0022607 170 0.027
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.027
response to biotic stimulus GO:0009607 97 0.026
regulation of cytoplasmic transport GO:1903649 4 0.026
autophagy GO:0006914 4 0.026
response to drug GO:0042493 3 0.026
nitrogen compound metabolic process GO:0006807 319 0.026
oxidoreduction coenzyme metabolic process GO:0006733 1 0.025
axon development GO:0061564 166 0.025
response to wounding GO:0009611 116 0.025
regulation of response to oxidative stress GO:1902882 2 0.025
regulation of cellular ph GO:0030641 1 0.025
regulation of ph GO:0006885 3 0.024
organic acid metabolic process GO:0006082 31 0.024
gtp catabolic process GO:0006184 2 0.024
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.024
negative regulation of signaling GO:0023057 96 0.024
chemotaxis GO:0006935 104 0.024
regulation of cell proliferation GO:0042127 37 0.024
regulation of cytokine production GO:0001817 3 0.024
regulation of proteolysis GO:0030162 24 0.024
protein targeting to nucleus GO:0044744 3 0.024
organic substance transport GO:0071702 58 0.023
nucleic acid transport GO:0050657 2 0.023
oxoacid metabolic process GO:0043436 31 0.023
response to hydrogen peroxide GO:0042542 3 0.023
cellular macromolecule metabolic process GO:0044260 391 0.023
direct ossification GO:0036072 3 0.023
modification dependent protein catabolic process GO:0019941 3 0.023
reactive oxygen species metabolic process GO:0072593 6 0.023
hemopoiesis GO:0030097 183 0.023
catabolic process GO:0009056 32 0.023
synaptic vesicle recycling GO:0036465 1 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
negative regulation of cell death GO:0060548 60 0.023
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.022
protein acetylation GO:0006473 2 0.022
axon regeneration GO:0031103 14 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
nuclear import GO:0051170 3 0.021
rna localization GO:0006403 4 0.021
regulation of developmental process GO:0050793 247 0.021
regulation of binding GO:0051098 3 0.021
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
cofactor metabolic process GO:0051186 15 0.021
response to ethanol GO:0045471 6 0.021
establishment of protein localization to organelle GO:0072594 4 0.021
gamete generation GO:0007276 33 0.021
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
cellular component morphogenesis GO:0032989 336 0.021
response to bacterium GO:0009617 58 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
response to glucose GO:0009749 3 0.020
cellular component movement GO:0006928 335 0.020
negative regulation of apoptotic process GO:0043066 55 0.020
carboxylic acid catabolic process GO:0046395 3 0.020
positive regulation of inflammatory response GO:0050729 1 0.020
small molecule catabolic process GO:0044282 3 0.020
regulation of protein import into nucleus GO:0042306 2 0.020
modification dependent macromolecule catabolic process GO:0043632 3 0.019
growth GO:0040007 174 0.019
removal of superoxide radicals GO:0019430 2 0.019
gtp metabolic process GO:0046039 4 0.019
regulation of reactive oxygen species metabolic process GO:2000377 2 0.019
cytoskeleton dependent cytokinesis GO:0061640 3 0.019
neuron development GO:0048666 262 0.019
response to molecule of bacterial origin GO:0002237 14 0.019
positive regulation of nucleoside metabolic process GO:0045979 1 0.019
cell substrate junction assembly GO:0007044 2 0.019
cellular macromolecule catabolic process GO:0044265 12 0.019
meiotic nuclear division GO:0007126 4 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
regulation of cell differentiation GO:0045595 142 0.019
cellular amide metabolic process GO:0043603 4 0.019
guanosine containing compound catabolic process GO:1901069 2 0.019
nucleobase containing compound metabolic process GO:0006139 274 0.019
cellular response to external stimulus GO:0071496 2 0.018
regulation of cellular metabolic process GO:0031323 320 0.018
regulation of cellular protein catabolic process GO:1903362 1 0.018
regulation of primary metabolic process GO:0080090 311 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
negative regulation of programmed cell death GO:0043069 58 0.018
enzyme linked receptor protein signaling pathway GO:0007167 106 0.018
response to carbohydrate GO:0009743 3 0.018
positive regulation of striated muscle cell differentiation GO:0051155 1 0.018
single organism catabolic process GO:0044712 13 0.018
positive regulation of proteolysis GO:0045862 10 0.018
response to hexose GO:0009746 3 0.018
gastrulation with mouth forming second GO:0001702 44 0.018
regulation of hormone secretion GO:0046883 2 0.018
regulation of transporter activity GO:0032409 2 0.018
regulation of localization GO:0032879 104 0.017
porphyrin containing compound metabolic process GO:0006778 10 0.017
reactive oxygen species biosynthetic process GO:1903409 1 0.017
positive regulation of cell communication GO:0010647 56 0.017
taxis GO:0042330 109 0.017
striated muscle tissue development GO:0014706 110 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
tissue regeneration GO:0042246 74 0.017
negative regulation of response to stimulus GO:0048585 104 0.017
synaptic vesicle transport GO:0048489 1 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
peptide transport GO:0015833 1 0.017
fatty acid elongation GO:0030497 1 0.017
response to stress GO:0006950 263 0.017
single organism carbohydrate metabolic process GO:0044723 12 0.017
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.017
cell projection morphogenesis GO:0048858 244 0.017
neuroblast proliferation GO:0007405 2 0.016
positive regulation of cytokine production GO:0001819 2 0.016
peptide metabolic process GO:0006518 1 0.016
nucleobase containing compound transport GO:0015931 2 0.016
muscle structure development GO:0061061 196 0.016
regulation of transmembrane transporter activity GO:0022898 2 0.016
positive regulation of signal transduction GO:0009967 56 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
cellular response to molecule of bacterial origin GO:0071219 3 0.016
regulation of muscle contraction GO:0006937 3 0.016
positive regulation of secretion by cell GO:1903532 1 0.016
cellular catabolic process GO:0044248 27 0.016
positive regulation of response to stimulus GO:0048584 80 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
regulation of peptidase activity GO:0052547 23 0.016
regulation of ion transmembrane transporter activity GO:0032412 2 0.016
regulation of production of molecular mediator of immune response GO:0002700 1 0.016
regulation of signal transduction GO:0009966 225 0.016
localization of cell GO:0051674 244 0.016
gene expression GO:0010467 252 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.015
monoamine transport GO:0015844 1 0.015
transmembrane transport GO:0055085 120 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.015
response to ph GO:0009268 2 0.015
positive regulation of cellular process GO:0048522 201 0.015
response to lipid GO:0033993 60 0.015
regulation of protein transport GO:0051223 3 0.015
response to other organism GO:0051707 97 0.015
cell morphogenesis involved in differentiation GO:0000904 195 0.015
meiotic chromosome segregation GO:0045132 3 0.015
cellular modified amino acid metabolic process GO:0006575 3 0.015
regulation of cell motility GO:2000145 46 0.015
positive regulation of cell activation GO:0050867 1 0.015
rna transport GO:0050658 2 0.015
organelle organization GO:0006996 227 0.014
biosynthetic process GO:0009058 294 0.014
innate immune response GO:0045087 13 0.014
response to abiotic stimulus GO:0009628 122 0.014
cell migration GO:0016477 237 0.014
response to unfolded protein GO:0006986 2 0.014
immune response GO:0006955 28 0.014
response to vitamin GO:0033273 3 0.014
i kappab kinase nf kappab signaling GO:0007249 4 0.014
neurotransmitter transport GO:0006836 2 0.014
organelle assembly GO:0070925 110 0.014
hematopoietic or lymphoid organ development GO:0048534 191 0.014
regulation of endopeptidase activity GO:0052548 23 0.014
response to inorganic substance GO:0010035 38 0.014
regulation of reproductive process GO:2000241 4 0.014
immune effector process GO:0002252 23 0.014
cellular component maintenance GO:0043954 3 0.014
cellular response to nutrient levels GO:0031669 2 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
positive regulation of cell death GO:0010942 29 0.013
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
protein acylation GO:0043543 3 0.013
adherens junction organization GO:0034332 4 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
negative regulation of cell communication GO:0010648 96 0.013
membrane hyperpolarization GO:0060081 1 0.013
response to corticosteroid GO:0031960 1 0.013
regulation of protein targeting GO:1903533 2 0.013
regulation of neurotransmitter transport GO:0051588 1 0.013
positive regulation of signaling GO:0023056 56 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
positive regulation of secretion GO:0051047 1 0.013
amino acid transport GO:0006865 2 0.013
cell part morphogenesis GO:0032990 246 0.013
lymphocyte proliferation GO:0046651 1 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
regulation of cellular component organization GO:0051128 86 0.013
establishment of rna localization GO:0051236 3 0.013
hormone transport GO:0009914 2 0.013
meiotic cell cycle process GO:1903046 3 0.013
cellular response to reactive oxygen species GO:0034614 2 0.013
single organism membrane organization GO:0044802 20 0.013
internal protein amino acid acetylation GO:0006475 2 0.013
single organism reproductive process GO:0044702 40 0.013
wound healing GO:0042060 90 0.012
cleavage furrow formation GO:0036089 2 0.012
regulation of sodium ion transport GO:0002028 2 0.012
cytokinetic process GO:0032506 2 0.012
cellular localization GO:0051641 97 0.012
myeloid leukocyte migration GO:0097529 12 0.012
response to axon injury GO:0048678 14 0.012
protein targeting to vacuole GO:0006623 1 0.012
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.012
cellular response to superoxide GO:0071451 2 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
post golgi vesicle mediated transport GO:0006892 1 0.012
atp catabolic process GO:0006200 4 0.012
ion homeostasis GO:0050801 41 0.012
regeneration GO:0031099 91 0.012
adult behavior GO:0030534 2 0.012
hemoglobin biosynthetic process GO:0042541 8 0.012
cation transport GO:0006812 81 0.012
protein localization to vacuole GO:0072665 1 0.012
nitrogen compound transport GO:0071705 23 0.012
regulation of carbohydrate biosynthetic process GO:0043255 1 0.012
peptidyl serine modification GO:0018209 2 0.012
activation of mapk activity GO:0000187 3 0.012
calcium ion transport into cytosol GO:0060402 3 0.011
cellular extravasation GO:0045123 1 0.011
positive regulation of wound healing GO:0090303 1 0.011
cytokinesis GO:0000910 3 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
phagocytosis GO:0006909 3 0.011
defense response to fungus GO:0050832 2 0.011
regulation of gene expression GO:0010468 265 0.011
golgi vesicle transport GO:0048193 3 0.011
reproductive process GO:0022414 40 0.011
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.011
cellular aromatic compound metabolic process GO:0006725 295 0.011
cell proliferation GO:0008283 80 0.011
regulation of cysteine type endopeptidase activity GO:2000116 21 0.011
astrocyte differentiation GO:0048708 1 0.011
cellular response to organic substance GO:0071310 105 0.011
synaptic vesicle localization GO:0097479 1 0.011
cellular biosynthetic process GO:0044249 286 0.011
positive regulation of cellular extravasation GO:0002693 1 0.011
neuron projection morphogenesis GO:0048812 161 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of molecular function GO:0044093 33 0.011
regulation of anatomical structure size GO:0090066 33 0.011
regulation of lipid catabolic process GO:0050994 2 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
compound eye development GO:0048749 2 0.011
negative regulation of multi organism process GO:0043901 3 0.010
regulation of locomotion GO:0040012 55 0.010
regulation of protein localization to plasma membrane GO:1903076 1 0.010
cellular ketone metabolic process GO:0042180 11 0.010
regulation of membrane potential GO:0042391 23 0.010
carbohydrate homeostasis GO:0033500 1 0.010
organic acid catabolic process GO:0016054 3 0.010
embryonic heart tube development GO:0035050 133 0.010
response to organic cyclic compound GO:0014070 51 0.010
carbohydrate derivative metabolic process GO:1901135 61 0.010
muscle tissue development GO:0060537 110 0.010
heterocycle metabolic process GO:0046483 290 0.010
regulation of cellular component movement GO:0051270 55 0.010
ovulation cycle GO:0042698 2 0.010
regulation of calcium ion transport GO:0051924 2 0.010
homeostatic process GO:0042592 142 0.010
protein localization to nucleus GO:0034504 3 0.010
metal ion transport GO:0030001 58 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
multicellular organismal homeostasis GO:0048871 29 0.010
reproduction GO:0000003 40 0.010
negative regulation of chemotaxis GO:0050922 4 0.010
negative regulation of signal transduction GO:0009968 94 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
fatty acid beta oxidation GO:0006635 1 0.010
homeostasis of number of cells within a tissue GO:0048873 4 0.010
negative regulation of reproductive process GO:2000242 3 0.010
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.010
regulation of wound healing GO:0061041 2 0.010

ctsz disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.112
inherited metabolic disorder DOID:655 0 0.112
disease of anatomical entity DOID:7 0 0.077
nervous system disease DOID:863 0 0.053
immune system disease DOID:2914 0 0.021
amyloidosis DOID:9120 0 0.012
acquired metabolic disease DOID:0060158 0 0.012
hematopoietic system disease DOID:74 0 0.010