Danio rerio

20 known processes

pah

phenylalanine hydroxylase

(Aliases: MGC65981,wu:fb02f10,zgc:65981,cb877)

pah biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
carboxylic acid metabolic process GO:0019752 22 0.478
Worm
alpha amino acid metabolic process GO:1901605 3 0.449
Worm
organic acid metabolic process GO:0006082 31 0.357
Worm
organic substance biosynthetic process GO:1901576 289 0.329
Zebrafish Worm
cellular amino acid metabolic process GO:0006520 7 0.309
Worm
small molecule metabolic process GO:0044281 77 0.294
Worm
response to chemical GO:0042221 320 0.279
nitrogen compound metabolic process GO:0006807 319 0.274
Zebrafish Worm
maintenance of location GO:0051235 4 0.261
response to organic substance GO:0010033 153 0.238
single organism localization GO:1902578 225 0.229
oxoacid metabolic process GO:0043436 31 0.210
Worm
single organism metabolic process GO:0044710 217 0.207
Zebrafish Mouse Worm
aging GO:0007568 2 0.197
Worm
muscle cell development GO:0055001 115 0.164
muscle structure development GO:0061061 196 0.162
single organism transport GO:0044765 206 0.161
developmental growth GO:0048589 166 0.156
striated muscle cell differentiation GO:0051146 129 0.151
lipid storage GO:0019915 1 0.150
multicellular organism growth GO:0035264 4 0.143
cellular macromolecule biosynthetic process GO:0034645 224 0.143
regulation of developmental process GO:0050793 247 0.138
regulation of macromolecule metabolic process GO:0060255 317 0.133
regulation of cell differentiation GO:0045595 142 0.132
cellular component assembly GO:0022607 170 0.130
heterocycle biosynthetic process GO:0018130 215 0.128
Zebrafish
transport GO:0006810 220 0.127
regulation of multicellular organism growth GO:0040014 4 0.125
cellular biosynthetic process GO:0044249 286 0.123
Zebrafish Worm
pyruvate metabolic process GO:0006090 1 0.119
regulation of cell communication GO:0010646 232 0.114
regulation of multicellular organismal process GO:0051239 277 0.113
death GO:0016265 121 0.112
response to endogenous stimulus GO:0009719 83 0.109
cellular component biogenesis GO:0044085 178 0.104
negative regulation of biological process GO:0048519 304 0.102
single organism organelle organization GO:1902589 199 0.100
carboxylic acid catabolic process GO:0046395 3 0.098
Worm
insulin like growth factor receptor signaling pathway GO:0048009 4 0.097
nucleic acid templated transcription GO:0097659 181 0.095
regulation of apoptotic process GO:0042981 98 0.095
biosynthetic process GO:0009058 294 0.093
Zebrafish Worm
cytoskeleton organization GO:0007010 96 0.091
cellular modified amino acid metabolic process GO:0006575 3 0.091
regulation of metabolic process GO:0019222 359 0.088
single organism biosynthetic process GO:0044711 71 0.086
Worm
heart development GO:0007507 313 0.085
cation transport GO:0006812 81 0.085
striated muscle cell development GO:0055002 108 0.084
cellular component assembly involved in morphogenesis GO:0010927 107 0.083
regulation of primary metabolic process GO:0080090 311 0.079
muscle cell differentiation GO:0042692 139 0.076
cellular localization GO:0051641 97 0.075
larval development GO:0002164 2 0.075
heterocycle metabolic process GO:0046483 290 0.074
Zebrafish Worm
fat soluble vitamin metabolic process GO:0006775 4 0.074
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.073
cellular amine metabolic process GO:0044106 2 0.071
Worm
positive regulation of biological process GO:0048518 253 0.070
locomotion GO:0040011 313 0.070
cellular aromatic compound metabolic process GO:0006725 295 0.069
Zebrafish Worm
organelle assembly GO:0070925 110 0.068
regulation of nucleic acid templated transcription GO:1903506 213 0.066
cellular component morphogenesis GO:0032989 336 0.066
nucleobase containing compound metabolic process GO:0006139 274 0.066
regulation of cellular biosynthetic process GO:0031326 245 0.065
macromolecule biosynthetic process GO:0009059 227 0.065
cellular response to organic substance GO:0071310 105 0.065
nucleic acid metabolic process GO:0090304 244 0.065
chordate embryonic development GO:0043009 271 0.065
protein metabolic process GO:0019538 183 0.064
organic acid catabolic process GO:0016054 3 0.064
Worm
proton transport GO:0015992 7 0.063
neuron differentiation GO:0030182 353 0.063
Zebrafish
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.062
alcohol biosynthetic process GO:0046165 2 0.061
regulation of response to stimulus GO:0048583 269 0.061
regulation of signaling GO:0023051 235 0.060
signal transduction GO:0007165 455 0.060
embryo development ending in birth or egg hatching GO:0009792 271 0.060
Worm
response to hormone GO:0009725 48 0.060
cellular nitrogen compound biosynthetic process GO:0044271 218 0.060
Zebrafish
regulation of cellular metabolic process GO:0031323 320 0.059
positive regulation of cellular process GO:0048522 201 0.059
regulation of rna biosynthetic process GO:2001141 213 0.059
cell death GO:0008219 121 0.058
immune system process GO:0002376 241 0.058
regulation of nitrogen compound metabolic process GO:0051171 251 0.057
gene expression GO:0010467 252 0.056
actin filament based process GO:0030029 64 0.056
embryonic organ development GO:0048568 381 0.053
cellular ketone metabolic process GO:0042180 11 0.052
muscle tissue development GO:0060537 110 0.052
response to stress GO:0006950 263 0.050
Worm
neurotransmitter transport GO:0006836 2 0.050
macromolecular complex subunit organization GO:0043933 74 0.050
regulation of biosynthetic process GO:0009889 250 0.050
carbohydrate biosynthetic process GO:0016051 1 0.050
actomyosin structure organization GO:0031032 53 0.049
cellular carbohydrate metabolic process GO:0044262 4 0.048
macromolecular complex assembly GO:0065003 35 0.048
establishment of localization GO:0051234 244 0.048
regulation of growth GO:0040008 42 0.047
growth GO:0040007 174 0.044
cell cell signaling GO:0007267 52 0.044
myofibril assembly GO:0030239 48 0.044
regulation of biological quality GO:0065008 263 0.042
embryonic organ morphogenesis GO:0048562 274 0.042
negative regulation of macromolecule metabolic process GO:0010605 76 0.041
actin cytoskeleton organization GO:0030036 63 0.041
striated muscle tissue development GO:0014706 110 0.040
programmed cell death GO:0012501 119 0.039
amine metabolic process GO:0009308 2 0.039
Worm
cellular macromolecule metabolic process GO:0044260 391 0.038
regulation of macromolecule biosynthetic process GO:0010556 225 0.038
branched chain amino acid metabolic process GO:0009081 1 0.038
axonogenesis GO:0007409 152 0.038
cellular amide metabolic process GO:0043603 4 0.037
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.037
negative regulation of cellular process GO:0048523 283 0.037
neuron projection morphogenesis GO:0048812 161 0.036
cellular nitrogen compound metabolic process GO:0034641 290 0.036
Zebrafish Worm
positive regulation of transport GO:0051050 2 0.036
regulation of cell death GO:0010941 103 0.035
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.035
organic cyclic compound metabolic process GO:1901360 301 0.035
Zebrafish Worm
cell projection morphogenesis GO:0048858 244 0.035
regulation of rna metabolic process GO:0051252 224 0.034
polyol metabolic process GO:0019751 1 0.033
axon development GO:0061564 166 0.033
ion transmembrane transport GO:0034220 91 0.033
protein localization to plasma membrane GO:0072659 1 0.032
response to glucose GO:0009749 3 0.032
chemosensory behavior GO:0007635 1 0.031
organonitrogen compound metabolic process GO:1901564 74 0.031
Zebrafish Worm
regulation of axonogenesis GO:0050770 32 0.031
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.031
regulation of anatomical structure morphogenesis GO:0022603 130 0.030
regulation of developmental growth GO:0048638 38 0.030
neuron development GO:0048666 262 0.030
ion transport GO:0006811 114 0.029
cellular response to chemical stimulus GO:0070887 157 0.029
response to hexose GO:0009746 3 0.029
regulation of programmed cell death GO:0043067 101 0.029
central nervous system development GO:0007417 387 0.029
Zebrafish
organic cyclic compound biosynthetic process GO:1901362 223 0.029
Zebrafish Worm
transcription from rna polymerase ii promoter GO:0006366 80 0.029
organelle organization GO:0006996 227 0.028
positive regulation of catabolic process GO:0009896 4 0.028
regulation of cell development GO:0060284 100 0.028
regulation of synaptic plasticity GO:0048167 1 0.028
autophagy GO:0006914 4 0.027
monocarboxylic acid metabolic process GO:0032787 17 0.027
cellular response to organic cyclic compound GO:0071407 38 0.026
aromatic compound biosynthetic process GO:0019438 217 0.026
Zebrafish Worm
cellular lipid metabolic process GO:0044255 36 0.026
protein homooligomerization GO:0051260 3 0.026
regulation of localization GO:0032879 104 0.025
response to alkaloid GO:0043279 2 0.025
regulation of multicellular organismal development GO:2000026 223 0.025
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.025
brain development GO:0007420 293 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.025
response to carbohydrate GO:0009743 3 0.024
cellular macromolecular complex assembly GO:0034622 24 0.024
gtp metabolic process GO:0046039 4 0.024
positive regulation of secretion GO:0051047 1 0.024
response to external stimulus GO:0009605 264 0.024
cell morphogenesis GO:0000902 289 0.024
regulation of gene expression GO:0010468 265 0.024
rna metabolic process GO:0016070 219 0.023
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.023
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.023
cell morphogenesis involved in differentiation GO:0000904 195 0.023
response to abiotic stimulus GO:0009628 122 0.023
cell surface receptor signaling pathway GO:0007166 325 0.022
establishment of blood brain barrier GO:0060856 2 0.022
cellular response to endogenous stimulus GO:0071495 68 0.022
positive regulation of cellular catabolic process GO:0031331 3 0.022
negative regulation of gene expression GO:0010629 65 0.022
lipid metabolic process GO:0006629 52 0.022
cell part morphogenesis GO:0032990 246 0.021
lipid oxidation GO:0034440 1 0.021
lipid catabolic process GO:0016042 4 0.021
organic substance transport GO:0071702 58 0.021
synaptic growth at neuromuscular junction GO:0051124 2 0.021
rna biosynthetic process GO:0032774 181 0.021
immune system development GO:0002520 191 0.020
ear development GO:0043583 127 0.020
response to drug GO:0042493 3 0.020
regulation of signal transduction GO:0009966 225 0.020
blood coagulation GO:0007596 12 0.020
synaptic transmission cholinergic GO:0007271 4 0.020
sensory organ development GO:0007423 393 0.020
regulation of cellular amine metabolic process GO:0033238 0 0.019
localization of cell GO:0051674 244 0.019
protein complex biogenesis GO:0070271 30 0.019
response to organic cyclic compound GO:0014070 51 0.019
positive regulation of developmental process GO:0051094 50 0.019
cellular protein metabolic process GO:0044267 129 0.018
small molecule catabolic process GO:0044282 3 0.018
Worm
cardiocyte differentiation GO:0035051 44 0.018
pancreas development GO:0031016 84 0.018
intracellular transport GO:0046907 32 0.018
regulation of gtpase activity GO:0043087 2 0.018
protein complex assembly GO:0006461 30 0.018
regulation of nucleotide catabolic process GO:0030811 2 0.018
gland development GO:0048732 143 0.018
vesicle mediated transport GO:0016192 22 0.018
regulation of cell shape GO:0008360 1 0.017
taxis GO:0042330 109 0.017
blood vessel development GO:0001568 246 0.017
regulation of carbohydrate metabolic process GO:0006109 4 0.017
myosin filament assembly GO:0031034 6 0.017
tissue regeneration GO:0042246 74 0.017
regulation of transcription dna templated GO:0006355 213 0.017
response to corticosteroid GO:0031960 1 0.016
positive regulation of cellular metabolic process GO:0031325 94 0.016
female sex differentiation GO:0046660 4 0.016
oxidation reduction process GO:0055114 41 0.016
Zebrafish Mouse Worm
trabecula formation GO:0060343 2 0.016
establishment of protein localization to organelle GO:0072594 4 0.016
regulation of protein transport GO:0051223 3 0.016
cellular amino acid biosynthetic process GO:0008652 2 0.016
Worm
vitamin a metabolic process GO:0006776 1 0.016
guanosine containing compound metabolic process GO:1901068 4 0.016
renal absorption GO:0070293 1 0.016
mononuclear cell proliferation GO:0032943 1 0.016
regulation of carbohydrate biosynthetic process GO:0043255 1 0.016
tube morphogenesis GO:0035239 349 0.016
response to transition metal nanoparticle GO:1990267 28 0.015
camera type eye development GO:0043010 222 0.015
positive regulation of carbohydrate metabolic process GO:0045913 1 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
nuclear import GO:0051170 3 0.015
protein complex subunit organization GO:0071822 46 0.015
catechol containing compound metabolic process GO:0009712 2 0.015
Zebrafish
gtp catabolic process GO:0006184 2 0.015
cellular component movement GO:0006928 335 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
small molecule biosynthetic process GO:0044283 16 0.015
Worm
intracellular signal transduction GO:0035556 85 0.015
macromolecule localization GO:0033036 54 0.015
leukocyte proliferation GO:0070661 1 0.014
regulation of reproductive process GO:2000241 4 0.014
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.014
response to monosaccharide GO:0034284 3 0.014
regulation of cell activation GO:0050865 1 0.014
positive regulation of secretion by cell GO:1903532 1 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
digestive tract morphogenesis GO:0048546 231 0.014
pigmentation GO:0043473 85 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.014
monovalent inorganic cation transport GO:0015672 42 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
establishment of protein localization to plasma membrane GO:0090002 1 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.013
regulation of nervous system development GO:0051960 90 0.013
skeletal system morphogenesis GO:0048705 102 0.013
negative regulation of cell death GO:0060548 60 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
hormone biosynthetic process GO:0042446 3 0.013
regulation of synapse assembly GO:0051963 3 0.013
epithelial cell migration GO:0010631 25 0.013
phagocytosis GO:0006909 3 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
epithelial cell differentiation GO:0030855 116 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
negative regulation of signal transduction GO:0009968 94 0.013
positive regulation of cell activation GO:0050867 1 0.013
striated muscle myosin thick filament assembly GO:0071688 6 0.013
energy reserve metabolic process GO:0006112 2 0.013
generation of neurons GO:0048699 385 0.013
Zebrafish
organic hydroxy compound transport GO:0015850 14 0.013
cell proliferation GO:0008283 80 0.012
glucose homeostasis GO:0042593 1 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
glycerolipid biosynthetic process GO:0045017 1 0.012
transmembrane transport GO:0055085 120 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
phosphorus metabolic process GO:0006793 109 0.012
lymphocyte proliferation GO:0046651 1 0.012
membrane invagination GO:0010324 1 0.012
positive regulation of multicellular organismal process GO:0051240 52 0.012
intracellular receptor signaling pathway GO:0030522 30 0.012
cellular response to hormone stimulus GO:0032870 39 0.012
endosomal transport GO:0016197 2 0.012
carbohydrate homeostasis GO:0033500 1 0.012
protein import into nucleus GO:0006606 3 0.012
system process GO:0003008 185 0.012
digestive tract mesoderm development GO:0007502 1 0.012
neuroblast proliferation GO:0007405 2 0.012
vestibular receptor cell differentiation GO:0060114 3 0.012
digestive system development GO:0055123 289 0.012
embryonic hemopoiesis GO:0035162 53 0.012
multicellular organismal signaling GO:0035637 22 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.011
negative regulation of developmental process GO:0051093 65 0.011
protein import GO:0017038 3 0.011
neuron projection development GO:0031175 180 0.011
regulation of autophagy GO:0010506 3 0.011
macromolecule modification GO:0043412 111 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
cell migration GO:0016477 237 0.011
fatty acid transport GO:0015908 1 0.011
negative regulation of signaling GO:0023057 96 0.011
cellular response to oxygen containing compound GO:1901701 20 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
cellular protein complex assembly GO:0043623 19 0.011
vitamin a biosynthetic process GO:0035238 1 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
cellular aldehyde metabolic process GO:0006081 4 0.011
sulfur compound metabolic process GO:0006790 13 0.011
negative regulation of protein phosphorylation GO:0001933 4 0.011
neurotransmitter secretion GO:0007269 2 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
mrna 3 end processing GO:0031124 2 0.011
protein localization to nucleus GO:0034504 3 0.011
regulation of hormone levels GO:0010817 21 0.011
response to oxygen containing compound GO:1901700 55 0.011
chemotaxis GO:0006935 104 0.011
taurine metabolic process GO:0019530 1 0.011
trabecula morphogenesis GO:0061383 2 0.010
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.010
s adenosylmethionine metabolic process GO:0046500 1 0.010
regulation of neurogenesis GO:0050767 87 0.010
response to glucocorticoid GO:0051384 1 0.010
cell matrix adhesion GO:0007160 4 0.010
negative chemotaxis GO:0050919 1 0.010
cardiac muscle tissue development GO:0048738 48 0.010
single organism nuclear import GO:1902593 3 0.010
negative regulation of cell communication GO:0010648 96 0.010

pah disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.018
amino acid metabolic disorder DOID:9252 0 0.018
inherited metabolic disorder DOID:655 0 0.018
bone disease DOID:0080001 0 0.013
disease of anatomical entity DOID:7 0 0.013
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.013