Danio rerio

0 known processes

pde6b

phosphodiesterase 6B, cGMP-specific, rod, beta

pde6b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.063
sensory organ development GO:0007423 393 0.060
Mouse
eye development GO:0001654 277 0.057
Mouse
aging GO:0007568 2 0.056
heterocycle metabolic process GO:0046483 290 0.053
signal transduction GO:0007165 455 0.045
nuclear transport GO:0051169 4 0.043
retina development in camera type eye GO:0060041 146 0.042
Mouse
positive regulation of transport GO:0051050 2 0.041
meiotic nuclear division GO:0007126 4 0.041
camera type eye development GO:0043010 222 0.040
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.038
cellular nitrogen compound metabolic process GO:0034641 290 0.037
organic cyclic compound metabolic process GO:1901360 301 0.036
guanosine containing compound metabolic process GO:1901068 4 0.036
maintenance of location GO:0051235 4 0.035
cell surface receptor signaling pathway GO:0007166 325 0.033
eye morphogenesis GO:0048592 144 0.033
multicellular organism growth GO:0035264 4 0.033
regulation of protein transport GO:0051223 3 0.032
cellular aromatic compound metabolic process GO:0006725 295 0.031
regulation of multicellular organism growth GO:0040014 4 0.031
nucleocytoplasmic transport GO:0006913 4 0.031
positive regulation of cellular component biogenesis GO:0044089 3 0.031
regulation of establishment of protein localization GO:0070201 4 0.030
regulation of protein complex assembly GO:0043254 3 0.029
organonitrogen compound metabolic process GO:1901564 74 0.029
cellular macromolecule biosynthetic process GO:0034645 224 0.029
establishment of protein localization to organelle GO:0072594 4 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.028
amine metabolic process GO:0009308 2 0.027
regulation of cytokine production GO:0001817 3 0.027
protein localization to nucleus GO:0034504 3 0.027
regulation of meiotic cell cycle GO:0051445 1 0.027
cellular response to external stimulus GO:0071496 2 0.027
adult behavior GO:0030534 2 0.027
embryonic organ development GO:0048568 381 0.026
organelle organization GO:0006996 227 0.026
digestive tract morphogenesis GO:0048546 231 0.025
regulation of cytoplasmic transport GO:1903649 4 0.024
cellular component disassembly GO:0022411 1 0.024
wnt signaling pathway GO:0016055 80 0.024
actin polymerization or depolymerization GO:0008154 2 0.024
regulation of signal transduction GO:0009966 225 0.023
cellular amine metabolic process GO:0044106 2 0.023
regulation of intracellular protein transport GO:0033157 3 0.023
nitrogen compound metabolic process GO:0006807 319 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
regulation of protein localization to nucleus GO:1900180 2 0.023
nucleic acid metabolic process GO:0090304 244 0.022
regulation of nucleocytoplasmic transport GO:0046822 2 0.022
regulation of biological quality GO:0065008 263 0.022
tube morphogenesis GO:0035239 349 0.022
protein localization to plasma membrane GO:0072659 1 0.022
single organism nuclear import GO:1902593 3 0.022
protein targeting to nucleus GO:0044744 3 0.022
protein import GO:0017038 3 0.022
phagocytosis GO:0006909 3 0.022
positive regulation of cell cycle GO:0045787 3 0.022
stem cell proliferation GO:0072089 4 0.021
protein heterooligomerization GO:0051291 1 0.021
nuclear import GO:0051170 3 0.021
regulation of synapse organization GO:0050807 3 0.021
female gonad development GO:0008585 4 0.021
regulation of inflammatory response GO:0050727 2 0.021
female sex differentiation GO:0046660 4 0.020
heterocycle biosynthetic process GO:0018130 215 0.020
regulation of response to stimulus GO:0048583 269 0.020
regulation of dendrite development GO:0050773 3 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
organic substance biosynthetic process GO:1901576 289 0.020
cellular component biogenesis GO:0044085 178 0.020
single organism metabolic process GO:0044710 217 0.020
regulation of nucleoside metabolic process GO:0009118 2 0.020
cell part morphogenesis GO:0032990 246 0.020
regulation of stem cell differentiation GO:2000736 4 0.020
regulation of transporter activity GO:0032409 2 0.020
neuron differentiation GO:0030182 353 0.019
mitochondrion organization GO:0007005 4 0.019
regulation of reproductive process GO:2000241 4 0.019
regulation of ion transmembrane transporter activity GO:0032412 2 0.019
digestive tract development GO:0048565 265 0.019
protein polymerization GO:0051258 4 0.019
neurological system process GO:0050877 62 0.019
protein import into nucleus GO:0006606 3 0.019
cell morphogenesis GO:0000902 289 0.019
chordate embryonic development GO:0043009 271 0.019
cellular component morphogenesis GO:0032989 336 0.019
morphogenesis of an epithelium GO:0002009 333 0.019
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.019
positive regulation of cytokine production GO:0001819 2 0.019
rna metabolic process GO:0016070 219 0.018
inositol lipid mediated signaling GO:0048017 2 0.018
small molecule metabolic process GO:0044281 77 0.018
immune system development GO:0002520 191 0.018
phagocytosis engulfment GO:0006911 1 0.018
transcription dna templated GO:0006351 181 0.018
regulation of transmembrane transporter activity GO:0022898 2 0.018
negative regulation of protein phosphorylation GO:0001933 4 0.018
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
camera type eye morphogenesis GO:0048593 108 0.018
development of primary female sexual characteristics GO:0046545 4 0.018
regulation of cellular ketone metabolic process GO:0010565 7 0.018
muscle cell differentiation GO:0042692 139 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
locomotor rhythm GO:0045475 3 0.017
muscle structure development GO:0061061 196 0.017
lipid storage GO:0019915 1 0.017
secondary metabolic process GO:0019748 3 0.017
spermatid development GO:0007286 2 0.017
meiotic cell cycle process GO:1903046 3 0.017
cell fate commitment GO:0045165 99 0.017
regulation of protein targeting GO:1903533 2 0.017
negative regulation of protein transport GO:0051224 3 0.017
cilium organization GO:0044782 71 0.017
lymphocyte proliferation GO:0046651 1 0.017
response to drug GO:0042493 3 0.017
cellular carbohydrate metabolic process GO:0044262 4 0.017
medulla oblongata development GO:0021550 4 0.017
sensory organ morphogenesis GO:0090596 200 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
proteasomal protein catabolic process GO:0010498 2 0.017
cytokinesis GO:0000910 3 0.017
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.017
transport GO:0006810 220 0.017
regulation of protein import into nucleus GO:0042306 2 0.016
regulation of binding GO:0051098 3 0.016
cellular biosynthetic process GO:0044249 286 0.016
angiogenesis GO:0001525 158 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
response to stress GO:0006950 263 0.016
gene expression GO:0010467 252 0.016
cell projection organization GO:0030030 284 0.016
protein homooligomerization GO:0051260 3 0.016
immune system process GO:0002376 241 0.016
cellular component assembly GO:0022607 170 0.016
positive regulation of biological process GO:0048518 253 0.016
peptidyl lysine acetylation GO:0018394 2 0.016
actin filament polymerization GO:0030041 2 0.016
water transport GO:0006833 15 0.016
regulation of neural precursor cell proliferation GO:2000177 3 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
single organism organelle organization GO:1902589 199 0.016
protein acetylation GO:0006473 2 0.016
regulation of protein polymerization GO:0032271 2 0.016
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.015
system process GO:0003008 185 0.015
phosphate containing compound metabolic process GO:0006796 108 0.015
nucleobase containing compound biosynthetic process GO:0034654 205 0.015
rna localization GO:0006403 4 0.015
stem cell maintenance GO:0019827 4 0.015
regulation of cell communication GO:0010646 232 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.015
striated muscle cell development GO:0055002 108 0.015
establishment of synaptic vesicle localization GO:0097480 1 0.015
positive regulation of notch signaling pathway GO:0045747 3 0.015
phosphorus metabolic process GO:0006793 109 0.015
regulation of dna replication GO:0006275 3 0.015
regulation of metal ion transport GO:0010959 4 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
single organism transport GO:0044765 206 0.015
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.015
biosynthetic process GO:0009058 294 0.015
stem cell division GO:0017145 1 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
positive regulation of catabolic process GO:0009896 4 0.015
cellular response to radiation GO:0071478 4 0.015
mononuclear cell proliferation GO:0032943 1 0.015
cellular amino acid metabolic process GO:0006520 7 0.015
regulation of cell projection assembly GO:0060491 4 0.015
response to chemical GO:0042221 320 0.015
internal protein amino acid acetylation GO:0006475 2 0.015
cellular nitrogen compound biosynthetic process GO:0044271 218 0.015
cell substrate adhesion GO:0031589 4 0.015
protein complex disassembly GO:0043241 1 0.015
negative regulation of defense response GO:0031348 2 0.015
fertilization GO:0009566 3 0.015
phototransduction GO:0007602 2 0.014
gastrulation GO:0007369 208 0.014
regulation of cellular metabolic process GO:0031323 320 0.014
cellular protein metabolic process GO:0044267 129 0.014
regulation of protein catabolic process GO:0042176 1 0.014
regulation of metabolic process GO:0019222 359 0.014
chemosensory behavior GO:0007635 1 0.014
hematopoietic or lymphoid organ development GO:0048534 191 0.014
response to external stimulus GO:0009605 264 0.014
Mouse
regulation of cell activation GO:0050865 1 0.014
protein secretion GO:0009306 1 0.014
positive regulation of protein complex assembly GO:0031334 2 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
membrane invagination GO:0010324 1 0.014
digestive system development GO:0055123 289 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
regulation of mrna processing GO:0050684 3 0.014
astrocyte differentiation GO:0048708 1 0.014
regulation of autophagy GO:0010506 3 0.014
autophagy GO:0006914 4 0.014
sensory perception of chemical stimulus GO:0007606 3 0.014
gtp catabolic process GO:0006184 2 0.014
determination of heart left right asymmetry GO:0061371 117 0.014
neurotransmitter transport GO:0006836 2 0.014
regulation of sodium ion transport GO:0002028 2 0.014
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
macromolecule biosynthetic process GO:0009059 227 0.014
organic acid metabolic process GO:0006082 31 0.014
regulation of signaling GO:0023051 235 0.014
developmental programmed cell death GO:0010623 4 0.014
rna biosynthetic process GO:0032774 181 0.014
single organism localization GO:1902578 225 0.014
cellular ketone metabolic process GO:0042180 11 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.013
establishment of localization GO:0051234 244 0.013
nuclear migration GO:0007097 3 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
gtp metabolic process GO:0046039 4 0.013
hemopoiesis GO:0030097 183 0.013
response to amino acid GO:0043200 2 0.013
response to uv GO:0009411 3 0.013
protein acylation GO:0043543 3 0.013
guanosine containing compound catabolic process GO:1901069 2 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
cell matrix adhesion GO:0007160 4 0.013
negative regulation of kinase activity GO:0033673 4 0.013
negative regulation of catabolic process GO:0009895 3 0.013
endosomal transport GO:0016197 2 0.013
protein complex localization GO:0031503 1 0.013
negative regulation of dna metabolic process GO:0051053 4 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
synaptic vesicle localization GO:0097479 1 0.013
regulation of blood vessel size GO:0050880 2 0.013
regulation of biosynthetic process GO:0009889 250 0.013
negative regulation of cytokine production GO:0001818 1 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
adherens junction organization GO:0034332 4 0.013
centrosome organization GO:0051297 1 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
leukocyte proliferation GO:0070661 1 0.013
regulation of tube size GO:0035150 2 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
cellular response to starvation GO:0009267 1 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
synaptic vesicle transport GO:0048489 1 0.012
single fertilization GO:0007338 3 0.012
convergent extension GO:0060026 118 0.012
regulation of calcium ion transport GO:0051924 2 0.012
cognition GO:0050890 1 0.012
regulation of blood pressure GO:0008217 1 0.012
maternal determination of anterior posterior axis embryo GO:0008358 4 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
macromolecular complex disassembly GO:0032984 1 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
generation of neurons GO:0048699 385 0.012
negative regulation of synapse assembly GO:0051964 2 0.012
positive regulation of protein polymerization GO:0032273 2 0.012
peptide transport GO:0015833 1 0.012
catechol containing compound metabolic process GO:0009712 2 0.012
homeostatic process GO:0042592 142 0.012
multi organism process GO:0051704 134 0.012
smooth muscle contraction GO:0006939 2 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
response to radiation GO:0009314 51 0.012
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.012
organelle assembly GO:0070925 110 0.012
regulation of organelle assembly GO:1902115 4 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
regulation of wnt signaling pathway GO:0030111 53 0.012
modification dependent protein catabolic process GO:0019941 3 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
microtubule organizing center organization GO:0031023 1 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
vacuolar transport GO:0007034 2 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
regulation of dna templated transcription elongation GO:0032784 3 0.012
cellular lipid catabolic process GO:0044242 3 0.012
negative regulation of cellular process GO:0048523 283 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
response to unfolded protein GO:0006986 2 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
central nervous system development GO:0007417 387 0.012
nuclear export GO:0051168 1 0.012
nucleic acid templated transcription GO:0097659 181 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
negative regulation of biological process GO:0048519 304 0.012
neurotransmitter secretion GO:0007269 2 0.012
spermatid differentiation GO:0048515 2 0.012
negative regulation of secretion by cell GO:1903531 2 0.012
response to biotic stimulus GO:0009607 97 0.012
atp catabolic process GO:0006200 4 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
cell projection assembly GO:0030031 64 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
protein modification process GO:0036211 100 0.011
interspecies interaction between organisms GO:0044419 4 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
positive regulation of myeloid cell differentiation GO:0045639 2 0.011
ovulation cycle GO:0042698 2 0.011
olfactory lobe development GO:0021988 4 0.011
ventricular cardiac muscle tissue development GO:0003229 3 0.011
cellular response to nutrient levels GO:0031669 2 0.011
amino acid transport GO:0006865 2 0.011
regulation of protein complex disassembly GO:0043244 1 0.011
phosphatidylinositol mediated signaling GO:0048015 2 0.011
smoothened signaling pathway GO:0007224 30 0.011
intracellular mrna localization GO:0008298 1 0.011
regulation of primary metabolic process GO:0080090 311 0.011
cell migration GO:0016477 237 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
positive regulation of cell activation GO:0050867 1 0.011
blood vessel morphogenesis GO:0048514 216 0.011
positive regulation of secretion GO:0051047 1 0.011
dopamine metabolic process GO:0042417 2 0.011
protein localization GO:0008104 40 0.011
regulation of cell shape GO:0008360 1 0.011
muscle cell development GO:0055001 115 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.011
lamellipodium organization GO:0097581 1 0.011
oxoacid metabolic process GO:0043436 31 0.011
heart morphogenesis GO:0003007 156 0.011
ion transmembrane transport GO:0034220 91 0.011
aromatic compound biosynthetic process GO:0019438 217 0.011
neuron development GO:0048666 262 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
response to topologically incorrect protein GO:0035966 2 0.011
regulation of gtpase activity GO:0043087 2 0.011
b cell activation GO:0042113 2 0.011
neuroblast fate commitment GO:0014017 1 0.011
cytoplasm organization GO:0007028 4 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
determination of bilateral symmetry GO:0009855 204 0.011
regulation of sequestering of calcium ion GO:0051282 4 0.011
regionalization GO:0003002 274 0.011
somatic muscle development GO:0007525 4 0.011
cellular protein catabolic process GO:0044257 4 0.011
positive regulation of inflammatory response GO:0050729 1 0.011
cell projection morphogenesis GO:0048858 244 0.011
actin cytoskeleton organization GO:0030036 63 0.011
regulation of muscle contraction GO:0006937 3 0.011
cilium assembly GO:0042384 58 0.011
regulation of endothelial cell proliferation GO:0001936 1 0.011
rna 3 end processing GO:0031123 2 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
visual perception GO:0007601 17 0.011
embryonic heart tube development GO:0035050 133 0.011
regulation of cell matrix adhesion GO:0001952 1 0.011
lipid homeostasis GO:0055088 3 0.011
positive regulation of cell division GO:0051781 2 0.010
meiotic chromosome segregation GO:0045132 3 0.010
i kappab kinase nf kappab signaling GO:0007249 4 0.010
regulation of cell substrate adhesion GO:0010810 1 0.010
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010
golgi vesicle transport GO:0048193 3 0.010
ovulation cycle process GO:0022602 2 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
ameboidal type cell migration GO:0001667 143 0.010
heart looping GO:0001947 94 0.010
positive regulation of reproductive process GO:2000243 2 0.010
positive regulation of multi organism process GO:0043902 3 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.010
protein metabolic process GO:0019538 183 0.010
negative regulation of epithelial cell proliferation GO:0050680 1 0.010
production of molecular mediator of immune response GO:0002440 2 0.010
optomotor response GO:0071632 1 0.010
spindle assembly GO:0051225 2 0.010
convergent extension involved in gastrulation GO:0060027 71 0.010
negative regulation of secretion GO:0051048 2 0.010
synaptic vesicle endocytosis GO:0048488 1 0.010
determination of left right symmetry GO:0007368 179 0.010
toll like receptor signaling pathway GO:0002224 4 0.010
single organism cellular localization GO:1902580 46 0.010

pde6b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.134
sensory system disease DOID:0050155 0 0.038
eye and adnexa disease DOID:1492 0 0.038
nervous system disease DOID:863 0 0.038
retinal disease DOID:5679 0 0.033
eye disease DOID:5614 0 0.033
immune system disease DOID:2914 0 0.018
musculoskeletal system disease DOID:17 0 0.015
retinal degeneration DOID:8466 0 0.013
cardiovascular system disease DOID:1287 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011