Danio rerio

33 known processes

pde6c

phosphodiesterase 6C, cGMP-specific, cone, alpha prime

(Aliases: zgc:73085,MGC73085)

pde6c biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
photoreceptor cell outer segment organization GO:0035845 9 0.877
single organism organelle organization GO:1902589 199 0.816
detection of light stimulus GO:0009583 12 0.810
photoreceptor cell differentiation GO:0046530 55 0.809
photoreceptor cell development GO:0042461 40 0.715
eye morphogenesis GO:0048592 144 0.693
camera type eye development GO:0043010 222 0.673
cellular component movement GO:0006928 335 0.666
sensory organ development GO:0007423 393 0.622
generation of neurons GO:0048699 385 0.610
nonmotile primary cilium assembly GO:0035058 2 0.609
retina development in camera type eye GO:0060041 146 0.594
camera type eye photoreceptor cell differentiation GO:0060219 19 0.586
signal transduction GO:0007165 455 0.564
detection of external stimulus GO:0009581 24 0.514
phototransduction visible light GO:0007603 2 0.512
eye development GO:0001654 277 0.504
sensory organ morphogenesis GO:0090596 200 0.462
tube morphogenesis GO:0035239 349 0.399
retina homeostasis GO:0001895 12 0.360
detection of abiotic stimulus GO:0009582 24 0.337
retina morphogenesis in camera type eye GO:0060042 79 0.311
eye photoreceptor cell development GO:0042462 30 0.298
camera type eye morphogenesis GO:0048593 108 0.296
eye photoreceptor cell differentiation GO:0001754 45 0.290
response to abiotic stimulus GO:0009628 122 0.273
cellular response to radiation GO:0071478 4 0.268
localization of cell GO:0051674 244 0.253
receptor recycling GO:0001881 4 0.236
system process GO:0003008 185 0.235
absorption of visible light GO:0016038 2 0.233
regulation of chemokine activity GO:1900136 3 0.224
small molecule metabolic process GO:0044281 77 0.223
central nervous system development GO:0007417 387 0.216
apical protein localization GO:0045176 6 0.209
neuron development GO:0048666 262 0.207
sensory perception GO:0007600 39 0.189
response to external stimulus GO:0009605 264 0.181
phototransduction GO:0007602 2 0.165
anatomical structure homeostasis GO:0060249 36 0.165
response to light stimulus GO:0009416 46 0.163
transmission of nerve impulse GO:0019226 19 0.159
cell migration GO:0016477 237 0.157
immune system process GO:0002376 241 0.144
phosphorus metabolic process GO:0006793 109 0.142
tissue homeostasis GO:0001894 25 0.140
establishment of endothelial blood brain barrier GO:0014045 2 0.140
regulation of smoothened signaling pathway GO:0008589 18 0.135
regulation of protein binding GO:0043393 3 0.135
regulation of localization GO:0032879 104 0.131
cellular component assembly GO:0022607 170 0.130
detection of stimulus GO:0051606 29 0.128
ameboidal type cell migration GO:0001667 143 0.127
light adaption GO:0036367 1 0.125
regulation of cell communication GO:0010646 232 0.123
locomotion GO:0040011 313 0.123
retina layer formation GO:0010842 24 0.122
brain development GO:0007420 293 0.119
aging GO:0007568 2 0.118
smoothened signaling pathway GO:0007224 30 0.118
retinal cone cell development GO:0046549 8 0.117
phosphate containing compound metabolic process GO:0006796 108 0.115
cell motility GO:0048870 244 0.114
cellular response to light stimulus GO:0071482 4 0.113
embryonic heart tube development GO:0035050 133 0.112
inositol lipid mediated signaling GO:0048017 2 0.112
regulation of binding GO:0051098 3 0.112
visual perception GO:0007601 17 0.111
multicellular organismal signaling GO:0035637 22 0.111
response to light intensity GO:0009642 1 0.110
cell surface receptor signaling pathway GO:0007166 325 0.109
spindle organization GO:0007051 5 0.109
neurological system process GO:0050877 62 0.107
cellular nitrogen compound metabolic process GO:0034641 290 0.106
neuron differentiation GO:0030182 353 0.106
organelle localization GO:0051640 49 0.104
protein desumoylation GO:0016926 1 0.102
protein complex subunit organization GO:0071822 46 0.101
embryo development ending in birth or egg hatching GO:0009792 271 0.100
organelle organization GO:0006996 227 0.100
multicellular organism growth GO:0035264 4 0.099
cellular component morphogenesis GO:0032989 336 0.098
regulation of receptor recycling GO:0001919 3 0.093
neural retina development GO:0003407 49 0.093
protein modification process GO:0036211 100 0.092
cell morphogenesis GO:0000902 289 0.091
positive regulation of map kinase activity GO:0043406 3 0.090
stem cell division GO:0017145 1 0.089
heterocycle metabolic process GO:0046483 290 0.088
single organism metabolic process GO:0044710 217 0.087
detection of visible light GO:0009584 12 0.085
establishment of endothelial barrier GO:0061028 3 0.085
nucleocytoplasmic transport GO:0006913 4 0.084
cellular component biogenesis GO:0044085 178 0.082
negative regulation of biological process GO:0048519 304 0.080
negative regulation of protein phosphorylation GO:0001933 4 0.074
neuronal action potential GO:0019228 18 0.072
regulation of cellular amine metabolic process GO:0033238 0 0.072
nucleobase containing compound metabolic process GO:0006139 274 0.071
negative regulation of cell cell adhesion mediated by cadherin GO:2000048 2 0.071
neuron neuron synaptic transmission GO:0007270 1 0.070
cellular protein modification process GO:0006464 100 0.068
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.067
axon ensheathment in central nervous system GO:0032291 2 0.066
regulation of biological quality GO:0065008 263 0.065
cytoskeleton organization GO:0007010 96 0.064
establishment of organelle localization GO:0051656 45 0.063
cell part morphogenesis GO:0032990 246 0.063
sensory perception of light stimulus GO:0050953 19 0.063
cell cell adhesion mediated by cadherin GO:0044331 5 0.063
regulation of guanylate cyclase activity GO:0031282 6 0.063
light absorption GO:0016037 2 0.061
larval development GO:0002164 2 0.061
regulation of metabolic process GO:0019222 359 0.061
establishment of localization GO:0051234 244 0.061
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.060
sensory perception of chemical stimulus GO:0007606 3 0.060
neuroblast proliferation GO:0007405 2 0.060
cellular macromolecule metabolic process GO:0044260 391 0.059
cgmp metabolic process GO:0046068 7 0.059
purine nucleotide metabolic process GO:0006163 27 0.058
atp catabolic process GO:0006200 4 0.058
organophosphate metabolic process GO:0019637 37 0.053
positive regulation of cgmp biosynthetic process GO:0030828 6 0.053
positive regulation of cellular process GO:0048522 201 0.052
retinal cone cell differentiation GO:0042670 12 0.052
cell projection organization GO:0030030 284 0.052
cyclic nucleotide metabolic process GO:0009187 18 0.052
cortical cytoskeleton organization GO:0030865 1 0.051
mitotic cell cycle process GO:1903047 48 0.051
stem cell proliferation GO:0072089 4 0.050
ribonucleotide biosynthetic process GO:0009260 20 0.050
photoreceptor cell fate commitment GO:0046552 1 0.050
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.049
heart development GO:0007507 313 0.048
single organism transport GO:0044765 206 0.048
establishment of localization in cell GO:0051649 77 0.048
ribose phosphate metabolic process GO:0019693 27 0.047
cell projection morphogenesis GO:0048858 244 0.047
nuclear transport GO:0051169 4 0.047
microtubule based process GO:0007017 60 0.046
cellular amino acid metabolic process GO:0006520 7 0.046
establishment of blood brain barrier GO:0060856 2 0.046
protein metabolic process GO:0019538 183 0.046
transport GO:0006810 220 0.046
regulation of signal transduction GO:0009966 225 0.045
cell migration involved in gastrulation GO:0042074 79 0.045
negative regulation of response to stimulus GO:0048585 104 0.045
homeostatic process GO:0042592 142 0.043
regulation of signaling GO:0023051 235 0.042
protein modification by small protein removal GO:0070646 1 0.042
medulla oblongata development GO:0021550 4 0.042
organic cyclic compound metabolic process GO:1901360 301 0.041
purine containing compound biosynthetic process GO:0072522 20 0.041
protein complex assembly GO:0006461 30 0.041
establishment of spindle localization GO:0051293 12 0.041
biosynthetic process GO:0009058 294 0.041
cellular component disassembly GO:0022411 1 0.041
rho protein signal transduction GO:0007266 5 0.040
digestive tract development GO:0048565 265 0.040
meiotic nuclear division GO:0007126 4 0.040
purine nucleotide biosynthetic process GO:0006164 20 0.039
cellular amine metabolic process GO:0044106 2 0.039
positive regulation of biological process GO:0048518 253 0.039
ear development GO:0043583 127 0.038
determination of bilateral symmetry GO:0009855 204 0.038
regulation of nucleoside metabolic process GO:0009118 2 0.038
cellular biosynthetic process GO:0044249 286 0.038
single organism localization GO:1902578 225 0.037
carbohydrate derivative metabolic process GO:1901135 61 0.037
asymmetric protein localization GO:0008105 6 0.037
regulation of cellular ketone metabolic process GO:0010565 7 0.037
embryonic axis specification GO:0000578 12 0.035
determination of left right symmetry GO:0007368 179 0.035
regulation of multicellular organismal process GO:0051239 277 0.035
head development GO:0060322 303 0.035
muscle structure development GO:0061061 196 0.035
spindle localization GO:0051653 12 0.035
morphogenesis of an epithelial sheet GO:0002011 49 0.033
positive regulation of transport GO:0051050 2 0.033
maintenance of location GO:0051235 4 0.033
nuclear migration GO:0007097 3 0.033
g protein coupled receptor signaling pathway GO:0007186 74 0.033
intracellular signal transduction GO:0035556 85 0.032
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.032
neurotransmitter transport GO:0006836 2 0.031
regulation of establishment of protein localization GO:0070201 4 0.031
regulation of primary metabolic process GO:0080090 311 0.031
establishment of mitotic spindle orientation GO:0000132 10 0.031
nucleotide metabolic process GO:0009117 28 0.031
positive regulation of metabolic process GO:0009893 108 0.031
hematopoietic or lymphoid organ development GO:0048534 191 0.031
regulation of catalytic activity GO:0050790 55 0.031
growth GO:0040007 174 0.031
amine metabolic process GO:0009308 2 0.030
regulation of inflammatory response GO:0050727 2 0.030
renal filtration GO:0097205 10 0.030
response to drug GO:0042493 3 0.030
rhodopsin mediated signaling pathway GO:0016056 1 0.030
morphogenesis of an epithelium GO:0002009 333 0.030
positive regulation of guanylate cyclase activity GO:0031284 6 0.030
regulation of cytoplasmic transport GO:1903649 4 0.030
nitrogen compound metabolic process GO:0006807 319 0.029
action potential GO:0001508 19 0.029
chordate embryonic development GO:0043009 271 0.029
regulation of sequestering of calcium ion GO:0051282 4 0.028
establishment of synaptic vesicle localization GO:0097480 1 0.028
single organismal cell cell adhesion GO:0016337 29 0.028
specification of symmetry GO:0009799 204 0.028
nucleobase containing small molecule metabolic process GO:0055086 32 0.028
cellular nitrogen compound biosynthetic process GO:0044271 218 0.028
response to radiation GO:0009314 51 0.028
macromolecule modification GO:0043412 111 0.027
cilium morphogenesis GO:0060271 85 0.027
regulation of protein transport GO:0051223 3 0.027
response to stress GO:0006950 263 0.026
cortical actin cytoskeleton organization GO:0030866 1 0.026
angiogenesis GO:0001525 158 0.026
regulation of locomotion GO:0040012 55 0.026
multicellular organismal response to stress GO:0033555 2 0.026
establishment of spindle orientation GO:0051294 10 0.025
regulation of intracellular protein transport GO:0033157 3 0.025
regulation of multicellular organism growth GO:0040014 4 0.025
nuclear export GO:0051168 1 0.025
pyruvate metabolic process GO:0006090 1 0.025
positive regulation of axon extension involved in axon guidance GO:0048842 1 0.025
macromolecular complex subunit organization GO:0043933 74 0.025
negative regulation of epithelial cell proliferation GO:0050680 1 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
heterocycle biosynthetic process GO:0018130 215 0.025
regulation of neurotransmitter secretion GO:0046928 1 0.025
guanosine containing compound catabolic process GO:1901069 2 0.024
establishment or maintenance of cell polarity GO:0007163 29 0.024
fatty acid elongation GO:0030497 1 0.024
negative regulation of cellular process GO:0048523 283 0.024
macromolecular complex assembly GO:0065003 35 0.024
negative regulation of defense response GO:0031348 2 0.024
hemopoiesis GO:0030097 183 0.024
regulation of chemotaxis GO:0050920 18 0.024
embryonic pattern specification GO:0009880 44 0.024
macromolecule localization GO:0033036 54 0.024
cell cycle process GO:0022402 53 0.023
single organism biosynthetic process GO:0044711 71 0.023
gtp catabolic process GO:0006184 2 0.023
cyclic nucleotide biosynthetic process GO:0009190 18 0.023
regulation of macromolecule metabolic process GO:0060255 317 0.023
pronuclear migration GO:0035046 1 0.022
retinal pigment epithelium development GO:0003406 8 0.022
meiotic cell cycle process GO:1903046 3 0.022
single fertilization GO:0007338 3 0.022
positive regulation of cellular metabolic process GO:0031325 94 0.022
phosphorylation GO:0016310 69 0.022
enzyme linked receptor protein signaling pathway GO:0007167 106 0.022
cellular localization GO:0051641 97 0.021
phagocytosis GO:0006909 3 0.021
glycerophospholipid biosynthetic process GO:0046474 1 0.021
protein complex biogenesis GO:0070271 30 0.021
synapsis GO:0007129 1 0.021
synaptic vesicle endocytosis GO:0048488 1 0.021
thermosensory behavior GO:0040040 1 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.021
nucleobase containing compound biosynthetic process GO:0034654 205 0.021
cyclic purine nucleotide metabolic process GO:0052652 18 0.021
cellular ketone metabolic process GO:0042180 11 0.020
neuron projection development GO:0031175 180 0.020
convergent extension GO:0060026 118 0.020
androgen metabolic process GO:0008209 2 0.020
regulation of cellular component organization GO:0051128 86 0.020
gene expression GO:0010467 252 0.020
retinal cell programmed cell death GO:0046666 2 0.020
response to chemical GO:0042221 320 0.020
polyol metabolic process GO:0019751 1 0.020
synaptic vesicle localization GO:0097479 1 0.020
purine ribonucleotide metabolic process GO:0009150 27 0.020
regulation of nucleocytoplasmic transport GO:0046822 2 0.019
regulation of cellular metabolic process GO:0031323 320 0.019
ribosome assembly GO:0042255 1 0.019
response to amphetamine GO:0001975 1 0.019
myeloid cell development GO:0061515 32 0.019
digestive system development GO:0055123 289 0.019
response to amine GO:0014075 1 0.019
organonitrogen compound biosynthetic process GO:1901566 47 0.019
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 8 0.019
immune system development GO:0002520 191 0.019
activation of mapk activity GO:0000187 3 0.019
regulation of gtp catabolic process GO:0033124 2 0.019
embryonic organ development GO:0048568 381 0.018
rna metabolic process GO:0016070 219 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
positive regulation of response to stimulus GO:0048584 80 0.018
spindle assembly GO:0051225 2 0.018
negative regulation of signaling GO:0023057 96 0.018
positive regulation of cell communication GO:0010647 56 0.018
glomerular filtration GO:0003094 6 0.018
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.018
actin filament based process GO:0030029 64 0.018
glial cell differentiation GO:0010001 42 0.018
cell adhesion GO:0007155 40 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
regulation of response to stimulus GO:0048583 269 0.017
photoreceptor cell maintenance GO:0045494 11 0.017
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
purine nucleoside monophosphate catabolic process GO:0009128 4 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.017
nuclear division GO:0000280 23 0.017
regulation of cellular component movement GO:0051270 55 0.017
regulation of dendrite morphogenesis GO:0048814 3 0.017
calcium mediated signaling GO:0019722 2 0.016
vitamin a metabolic process GO:0006776 1 0.016
regulation of cellular biosynthetic process GO:0031326 245 0.016
negative regulation of signal transduction GO:0009968 94 0.016
regulation of cgmp biosynthetic process GO:0030826 6 0.016
cell cycle GO:0007049 93 0.016
single organism cell adhesion GO:0098602 29 0.016
negative regulation of kinase activity GO:0033673 4 0.016
cellular aromatic compound metabolic process GO:0006725 295 0.016
embryonic heart tube morphogenesis GO:0003143 108 0.015
positive regulation of signaling GO:0023056 56 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
auditory receptor cell fate determination GO:0042668 2 0.015
microtubule cytoskeleton organization GO:0000226 33 0.015
establishment of mitotic spindle localization GO:0040001 12 0.015
regulation of nucleotide catabolic process GO:0030811 2 0.015
locomotor rhythm GO:0045475 3 0.015
protein phosphorylation GO:0006468 47 0.015
cytokinesis GO:0000910 3 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.015
cellular component assembly involved in morphogenesis GO:0010927 107 0.015
regulation of dna replication GO:0006275 3 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
lamellipodium organization GO:0097581 1 0.014
mitotic cell cycle GO:0000278 64 0.014
cgmp biosynthetic process GO:0006182 7 0.014
purine containing compound metabolic process GO:0072521 29 0.014
actomyosin structure organization GO:0031032 53 0.014
anterior posterior pattern specification GO:0009952 152 0.014
establishment of melanosome localization GO:0032401 19 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
axon ensheathment GO:0008366 18 0.014
ensheathment of neurons GO:0007272 18 0.014
neurotransmitter secretion GO:0007269 2 0.014
positive regulation of cell cycle GO:0045787 3 0.013
neural tube formation GO:0001841 16 0.013
cilium organization GO:0044782 71 0.013
epithelial cell development GO:0002064 42 0.013
olfactory lobe development GO:0021988 4 0.013
synaptic vesicle transport GO:0048489 1 0.013
intestinal epithelial structure maintenance GO:0060729 7 0.013
ribonucleotide metabolic process GO:0009259 27 0.013
cell fate commitment GO:0045165 99 0.013
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.013
fertilization GO:0009566 3 0.013
digestive tract morphogenesis GO:0048546 231 0.013
programmed cell death GO:0012501 119 0.012
cellular lipid metabolic process GO:0044255 36 0.012
transcription dna templated GO:0006351 181 0.012
regulation of membrane potential GO:0042391 23 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
developmental programmed cell death GO:0010623 4 0.012
protein complex disassembly GO:0043241 1 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
regulation of intracellular signal transduction GO:1902531 57 0.012
response to uv GO:0009411 3 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.012
regulation of cgmp metabolic process GO:0030823 6 0.012
multicellular organismal homeostasis GO:0048871 29 0.012
developmental growth GO:0048589 166 0.012
regulation of cell migration GO:0030334 40 0.012
regulation of organelle assembly GO:1902115 4 0.012
regulation of phosphate metabolic process GO:0019220 43 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
detection of light stimulus involved in visual perception GO:0050908 7 0.012
centrosome duplication GO:0051298 1 0.011
cell death GO:0008219 121 0.011
protein heterooligomerization GO:0051291 1 0.011
vesicle mediated transport GO:0016192 22 0.011
forebrain morphogenesis GO:0048853 6 0.011
sensory perception of sound GO:0007605 9 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
lateral line ganglion development GO:0048890 2 0.011
carbohydrate homeostasis GO:0033500 1 0.011
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.011
forebrain anterior posterior pattern specification GO:0021797 3 0.011
regulation of cell cell adhesion GO:0022407 13 0.011
homeostasis of number of cells within a tissue GO:0048873 4 0.011
cell substrate adherens junction assembly GO:0007045 1 0.011
positive regulation of protein complex assembly GO:0031334 2 0.011
wnt signaling pathway GO:0016055 80 0.011
cellular response to reactive oxygen species GO:0034614 2 0.011
reflex GO:0060004 2 0.011
actin cytoskeleton organization GO:0030036 63 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
gastrulation with mouth forming second GO:0001702 44 0.011
fatty acid transport GO:0015908 1 0.011
phosphatidylinositol metabolic process GO:0046488 7 0.011
death GO:0016265 121 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
inner ear development GO:0048839 126 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
positive regulation of cell division GO:0051781 2 0.010
cell proliferation GO:0008283 80 0.010
cellular protein complex disassembly GO:0043624 1 0.010
regulation of dendrite development GO:0050773 3 0.010
cellular response to oxygen levels GO:0071453 1 0.010
negative regulation of catabolic process GO:0009895 3 0.010

pde6c disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
retinal disease DOID:5679 0 0.720
sensory system disease DOID:0050155 0 0.720
disease of anatomical entity DOID:7 0 0.720
eye and adnexa disease DOID:1492 0 0.720
nervous system disease DOID:863 0 0.720
eye disease DOID:5614 0 0.720
retinal degeneration DOID:8466 0 0.116
retinitis pigmentosa DOID:10584 0 0.116
physical disorder DOID:0080015 0 0.012
congenital nervous system abnormality DOID:2490 0 0.012
neuromuscular disease DOID:440 0 0.011
charcot marie tooth disease DOID:10595 0 0.011
neuropathy DOID:870 0 0.011
musculoskeletal system disease DOID:17 0 0.011