Danio rerio

86 known processes

pitx3

paired-like homeodomain transcription factor 3

(Aliases: zgc:109716)

pitx3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of nucleobase containing compound metabolic process GO:0019219 250 1.000
brain development GO:0007420 293 0.999
neuron projection development GO:0031175 180 0.998
Worm Fly
cellular component morphogenesis GO:0032989 336 0.998
Worm Fly
axonogenesis GO:0007409 152 0.997
Worm
response to chemical GO:0042221 320 0.996
Worm
axon guidance GO:0007411 86 0.994
Worm
endocrine system development GO:0035270 65 0.994
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.994
Worm Fly
cell morphogenesis involved in differentiation GO:0000904 195 0.991
Worm Fly
central nervous system neuron differentiation GO:0021953 74 0.990
heterocycle biosynthetic process GO:0018130 215 0.989
response to abiotic stimulus GO:0009628 122 0.989
generation of neurons GO:0048699 385 0.987
Mouse Worm Fly
axon development GO:0061564 166 0.985
Worm
regulation of rna biosynthetic process GO:2001141 213 0.985
regulation of gene expression GO:0010468 265 0.984
cell motility GO:0048870 244 0.981
cellular nitrogen compound biosynthetic process GO:0044271 218 0.979
sensory organ development GO:0007423 393 0.978
regulation of multicellular organismal process GO:0051239 277 0.977
regulation of cellular metabolic process GO:0031323 320 0.977
neuron projection guidance GO:0097485 86 0.976
Worm
taxis GO:0042330 109 0.975
Worm
regulation of multicellular organismal development GO:2000026 223 0.972
regulation of transcription dna templated GO:0006355 213 0.971
cell surface receptor signaling pathway GO:0007166 325 0.971
sensory organ morphogenesis GO:0090596 200 0.970
Zebrafish Mouse
regulation of axonogenesis GO:0050770 32 0.969
regulation of primary metabolic process GO:0080090 311 0.969
skeletal system development GO:0001501 181 0.968
Zebrafish
developmental growth GO:0048589 166 0.968
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.967
cellular nitrogen compound metabolic process GO:0034641 290 0.967
cell projection organization GO:0030030 284 0.964
Worm Fly
embryonic organ development GO:0048568 381 0.961
Zebrafish
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.957
regulation of nitrogen compound metabolic process GO:0051171 251 0.953
digestive tract development GO:0048565 265 0.948
Zebrafish
ameboidal type cell migration GO:0001667 143 0.947
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.947
Mouse Worm
neuron projection morphogenesis GO:0048812 161 0.945
Worm Fly
positive regulation of rna metabolic process GO:0051254 59 0.945
embryonic organ morphogenesis GO:0048562 274 0.941
Zebrafish
transcription from rna polymerase ii promoter GO:0006366 80 0.940
Mouse Worm
regulation of developmental process GO:0050793 247 0.939
positive regulation of nucleic acid templated transcription GO:1903508 57 0.938
aromatic compound biosynthetic process GO:0019438 217 0.935
camera type eye development GO:0043010 222 0.932
nucleic acid templated transcription GO:0097659 181 0.932
regulation of biosynthetic process GO:0009889 250 0.929
skin development GO:0043588 54 0.927
regulation of metabolic process GO:0019222 359 0.924
positive regulation of cellular biosynthetic process GO:0031328 68 0.923
response to external stimulus GO:0009605 264 0.919
Worm
positive regulation of cellular metabolic process GO:0031325 94 0.917
nucleobase containing compound metabolic process GO:0006139 274 0.914
stem cell differentiation GO:0048863 117 0.914
camera type eye morphogenesis GO:0048593 108 0.911
Zebrafish Mouse
response to stress GO:0006950 263 0.911
embryonic limb morphogenesis GO:0030326 2 0.907
cell migration GO:0016477 237 0.907
angiogenesis GO:0001525 158 0.905
stem cell proliferation GO:0072089 4 0.905
diencephalon development GO:0021536 58 0.905
regulation of cell fate commitment GO:0010453 22 0.904
macromolecule biosynthetic process GO:0009059 227 0.904
ear development GO:0043583 127 0.903
regulation of epithelial cell proliferation GO:0050678 3 0.897
signal transduction GO:0007165 455 0.892
Zebrafish
regulation of photoreceptor cell differentiation GO:0046532 2 0.891
rna biosynthetic process GO:0032774 181 0.891
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.885
cellular macromolecule metabolic process GO:0044260 391 0.884
cellular biosynthetic process GO:0044249 286 0.882
central nervous system development GO:0007417 387 0.880
rna metabolic process GO:0016070 219 0.873
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.868
blood vessel morphogenesis GO:0048514 216 0.862
nucleobase containing compound biosynthetic process GO:0034654 205 0.858
blood vessel development GO:0001568 246 0.852
embryonic cranial skeleton morphogenesis GO:0048701 90 0.851
Zebrafish
neuron development GO:0048666 262 0.848
Mouse Worm Fly
cell projection morphogenesis GO:0048858 244 0.843
Worm Fly
regulation of mechanoreceptor differentiation GO:0045631 1 0.840
response to wounding GO:0009611 116 0.839
neural crest cell development GO:0014032 62 0.837
regulation of macromolecule metabolic process GO:0060255 317 0.836
gene expression GO:0010467 252 0.828
embryo development ending in birth or egg hatching GO:0009792 271 0.827
Zebrafish
glial cell differentiation GO:0010001 42 0.821
forebrain neuron development GO:0021884 7 0.802
positive regulation of metabolic process GO:0009893 108 0.801
locomotion GO:0040011 313 0.794
Worm
positive regulation of biosynthetic process GO:0009891 68 0.792
cellular aromatic compound metabolic process GO:0006725 295 0.792
homeostatic process GO:0042592 142 0.792
neuron fate commitment GO:0048663 26 0.788
morphogenesis of an epithelium GO:0002009 333 0.784
Zebrafish
negative regulation of biological process GO:0048519 304 0.777
positive regulation of gene expression GO:0010628 71 0.775
sympathetic nervous system development GO:0048485 3 0.774
regulation of neurogenesis GO:0050767 87 0.764
cell part morphogenesis GO:0032990 246 0.750
Worm Fly
regulation of cell death GO:0010941 103 0.744
skeletal system morphogenesis GO:0048705 102 0.743
Zebrafish
transcription dna templated GO:0006351 181 0.742
nucleic acid metabolic process GO:0090304 244 0.742
glial cell migration GO:0008347 3 0.737
hindbrain development GO:0030902 91 0.725
regulation of anatomical structure morphogenesis GO:0022603 130 0.721
growth GO:0040007 174 0.718
morphogenesis of a branching structure GO:0001763 21 0.716
adenohypophysis development GO:0021984 15 0.706
developmental growth involved in morphogenesis GO:0060560 86 0.699
localization of cell GO:0051674 244 0.699
response to hypoxia GO:0001666 25 0.697
regulation of cellular biosynthetic process GO:0031326 245 0.697
regulation of rna metabolic process GO:0051252 224 0.682
bone development GO:0060348 14 0.680
establishment of localization in cell GO:0051649 77 0.678
forebrain generation of neurons GO:0021872 14 0.678
biosynthetic process GO:0009058 294 0.677
epidermis development GO:0008544 48 0.666
nitrogen compound metabolic process GO:0006807 319 0.662
wound healing GO:0042060 90 0.653
protein import GO:0017038 3 0.651
neural crest cell migration GO:0001755 42 0.649
ossification GO:0001503 23 0.648
sprouting angiogenesis GO:0002040 53 0.644
organic substance biosynthetic process GO:1901576 289 0.636
neuron differentiation GO:0030182 353 0.632
Mouse Worm Fly
inner ear morphogenesis GO:0042472 63 0.632
organic cyclic compound biosynthetic process GO:1901362 223 0.630
morphogenesis of an epithelial sheet GO:0002011 49 0.630
Zebrafish
regulation of biological quality GO:0065008 263 0.624
Zebrafish
cellular component movement GO:0006928 335 0.623
Worm
inner ear receptor cell differentiation GO:0060113 29 0.622
muscle cell development GO:0055001 115 0.597
striated muscle cell differentiation GO:0051146 129 0.593
regulation of cell development GO:0060284 100 0.588
patterning of blood vessels GO:0001569 15 0.588
positive regulation of neural precursor cell proliferation GO:2000179 1 0.583
keratinocyte differentiation GO:0030216 0 0.579
positive regulation of cell fate commitment GO:0010455 1 0.571
motor neuron axon guidance GO:0008045 23 0.569
renal system development GO:0072001 94 0.562
response to organic substance GO:0010033 153 0.557
inner ear receptor cell fate commitment GO:0060120 4 0.555
forebrain development GO:0030900 96 0.553
immune system development GO:0002520 191 0.549
regulation of nervous system development GO:0051960 90 0.545
organophosphate metabolic process GO:0019637 37 0.542
neuron fate specification GO:0048665 20 0.540
regulation of signal transduction GO:0009966 225 0.537
regulation of developmental growth GO:0048638 38 0.533
regulation of locomotion GO:0040012 55 0.528
Worm
positive regulation of cellular component movement GO:0051272 11 0.526
auditory receptor cell differentiation GO:0042491 15 0.524
regulation of phosphorus metabolic process GO:0051174 43 0.520
peripheral nervous system development GO:0007422 55 0.516
positive regulation of transcription dna templated GO:0045893 57 0.515
epithelial tube morphogenesis GO:0060562 148 0.509
phosphorus metabolic process GO:0006793 109 0.499
hematopoietic progenitor cell differentiation GO:0002244 23 0.497
apoptotic process GO:0006915 116 0.489
gland development GO:0048732 143 0.481
endocrine process GO:0050886 2 0.470
tube morphogenesis GO:0035239 349 0.469
regulation of cell shape GO:0008360 1 0.466
response to oxygen levels GO:0070482 25 0.463
auditory receptor cell fate commitment GO:0009912 4 0.463
positive regulation of rna biosynthetic process GO:1902680 57 0.462
response to inorganic substance GO:0010035 38 0.461
neuroblast differentiation GO:0014016 1 0.461
positive regulation of stem cell proliferation GO:2000648 1 0.457
sequestering of metal ion GO:0051238 3 0.457
eye development GO:0001654 277 0.451
nephron epithelium morphogenesis GO:0072088 1 0.448
epidermal cell differentiation GO:0009913 36 0.446
forebrain neuron differentiation GO:0021879 14 0.444
proximal distal pattern formation GO:0009954 1 0.441
digestive tract morphogenesis GO:0048546 231 0.440
branching morphogenesis of an epithelial tube GO:0048754 15 0.439
endothelial cell migration GO:0043542 19 0.435
regulation of glial cell differentiation GO:0045685 4 0.426
appendage morphogenesis GO:0035107 56 0.425
establishment of localization GO:0051234 244 0.424
programmed cell death GO:0012501 119 0.418
organic cyclic compound metabolic process GO:1901360 301 0.416
cell morphogenesis GO:0000902 289 0.416
Worm Fly
regulation of multicellular organism growth GO:0040014 4 0.413
cell fate commitment GO:0045165 99 0.409
response to endogenous stimulus GO:0009719 83 0.401
ribonucleotide metabolic process GO:0009259 27 0.401
chordate embryonic development GO:0043009 271 0.394
Zebrafish
positive regulation of epithelial cell proliferation GO:0050679 1 0.393
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.392
Mouse Worm
positive regulation of nervous system development GO:0051962 25 0.391
glial cell development GO:0021782 20 0.388
muscle cell differentiation GO:0042692 139 0.371
positive regulation of cell motility GO:2000147 11 0.371
regulation of ossification GO:0030278 5 0.370
negative regulation of programmed cell death GO:0043069 58 0.367
cell growth GO:0016049 57 0.366
regulation of nucleic acid templated transcription GO:1903506 213 0.365
stem cell development GO:0048864 82 0.365
negative regulation of cellular process GO:0048523 283 0.354
mesenchyme development GO:0060485 127 0.350
regulation of macromolecule biosynthetic process GO:0010556 225 0.348
myotube differentiation GO:0014902 45 0.347
carbohydrate derivative metabolic process GO:1901135 61 0.347
positive regulation of locomotion GO:0040017 14 0.347
embryonic skeletal system morphogenesis GO:0048704 93 0.345
Zebrafish
mesenchymal cell development GO:0014031 78 0.343
central nervous system neuron axonogenesis GO:0021955 18 0.341
cellular response to chemical stimulus GO:0070887 157 0.340
response to oxygen containing compound GO:1901700 55 0.340
response to oxidative stress GO:0006979 11 0.339
negative regulation of apoptotic process GO:0043066 55 0.336
neuroblast fate commitment GO:0014017 1 0.328
intracellular signal transduction GO:0035556 85 0.321
heart morphogenesis GO:0003007 156 0.318
ectodermal placode morphogenesis GO:0071697 32 0.318
hepaticobiliary system development GO:0061008 98 0.318
dopaminergic neuron differentiation GO:0071542 14 0.317
Mouse
morphogenesis of a branching epithelium GO:0061138 16 0.313
regulation of molecular function GO:0065009 70 0.309
heterocycle metabolic process GO:0046483 290 0.307
phosphate containing compound metabolic process GO:0006796 108 0.306
cell proliferation GO:0008283 80 0.294
cilium assembly GO:0042384 58 0.293
epiboly GO:0090504 41 0.291
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.289
compound eye development GO:0048749 2 0.288
cellular protein metabolic process GO:0044267 129 0.287
regulation of inner ear receptor cell differentiation GO:2000980 1 0.286
neuroblast proliferation GO:0007405 2 0.286
enzyme linked receptor protein signaling pathway GO:0007167 106 0.285
developmental cell growth GO:0048588 52 0.285
neuron migration GO:0001764 22 0.284
epithelial cell morphogenesis GO:0003382 2 0.282
cellular response to organic substance GO:0071310 105 0.278
regulation of cell morphogenesis GO:0022604 42 0.277
negative regulation of epithelial cell proliferation GO:0050680 1 0.276
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.274
nephron epithelium development GO:0072009 16 0.274
regulation of cell growth GO:0001558 29 0.274
maintenance of location GO:0051235 4 0.273
bone morphogenesis GO:0060349 11 0.271
regulation of catalytic activity GO:0050790 55 0.270
response to other organism GO:0051707 97 0.270
regulation of heart growth GO:0060420 2 0.270
tissue regeneration GO:0042246 74 0.269
cranial nerve morphogenesis GO:0021602 15 0.269
epithelial cell development GO:0002064 42 0.266
regulation of organ growth GO:0046620 3 0.266
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.262
system process GO:0003008 185 0.262
Zebrafish
eye morphogenesis GO:0048592 144 0.261
Zebrafish Mouse
vasculature development GO:0001944 278 0.261
peripheral nervous system neuron differentiation GO:0048934 28 0.257
heart development GO:0007507 313 0.255
Zebrafish
regulation of neuron migration GO:2001222 2 0.254
nuclear transport GO:0051169 4 0.253
striated muscle cell development GO:0055002 108 0.253
cellular catabolic process GO:0044248 27 0.249
neuron projection extension GO:1990138 45 0.248
embryonic camera type eye development GO:0031076 29 0.247
Zebrafish
regeneration GO:0031099 91 0.246
negative regulation of gene expression GO:0010629 65 0.245
ear morphogenesis GO:0042471 64 0.245
venous blood vessel morphogenesis GO:0048845 3 0.243
epithelial cell differentiation GO:0030855 116 0.240
Mouse
regulation of sequestering of calcium ion GO:0051282 4 0.238
regulation of cell size GO:0008361 29 0.238
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.237
regulation of protein transport GO:0051223 3 0.236
cellular response to endogenous stimulus GO:0071495 68 0.235
connective tissue development GO:0061448 99 0.235
cell substrate adhesion GO:0031589 4 0.235
respiratory system development GO:0060541 5 0.233
neurological system process GO:0050877 62 0.233
hair cell differentiation GO:0035315 32 0.227
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.227
regulation of calcium ion transport GO:0051924 2 0.222
regulation of cell substrate adhesion GO:0010810 1 0.220
regulation of organ morphogenesis GO:2000027 35 0.219
response to reactive oxygen species GO:0000302 5 0.217
positive regulation of cellular process GO:0048522 201 0.216
positive regulation of macromolecule metabolic process GO:0010604 93 0.216
regulation of neuron differentiation GO:0045664 56 0.212
embryonic viscerocranium morphogenesis GO:0048703 52 0.209
Zebrafish
regulation of cell fate specification GO:0042659 20 0.208
digestive system development GO:0055123 289 0.207
Zebrafish
gastrulation GO:0007369 208 0.202
oligodendrocyte differentiation GO:0048709 23 0.202
olfactory placode development GO:0071698 12 0.201
nucleocytoplasmic transport GO:0006913 4 0.199
positive regulation of cell cycle GO:0045787 3 0.198
cellular localization GO:0051641 97 0.195
phenol containing compound metabolic process GO:0018958 5 0.194
positive regulation of cell migration GO:0030335 11 0.194
small molecule metabolic process GO:0044281 77 0.192
regulation of reactive oxygen species metabolic process GO:2000377 2 0.190
gliogenesis GO:0042063 45 0.190
cell death GO:0008219 121 0.189
death GO:0016265 121 0.189
anatomical structure homeostasis GO:0060249 36 0.185
purine ribonucleotide metabolic process GO:0009150 27 0.184
chemotaxis GO:0006935 104 0.182
Worm
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.182
inner ear development GO:0048839 126 0.182
muscle structure development GO:0061061 196 0.180
negative regulation of gliogenesis GO:0014014 1 0.180
intracellular transport GO:0046907 32 0.178
anterior commissure morphogenesis GO:0021960 3 0.178
primary neural tube formation GO:0014020 1 0.177
lateral line nerve glial cell development GO:0048937 6 0.176
regulation of blood circulation GO:1903522 32 0.175
tissue migration GO:0090130 37 0.171
head morphogenesis GO:0060323 8 0.170
Zebrafish
endocardium formation GO:0060214 1 0.169
forebrain neuron fate commitment GO:0021877 1 0.167
cellular macromolecule localization GO:0070727 21 0.166
protein targeting to nucleus GO:0044744 3 0.166
single organism metabolic process GO:0044710 217 0.166
neural precursor cell proliferation GO:0061351 20 0.165
regulation of stem cell proliferation GO:0072091 2 0.163
specification of symmetry GO:0009799 204 0.162
Zebrafish
thyroid gland development GO:0030878 12 0.162
larval development GO:0002164 2 0.161
nucleoside phosphate metabolic process GO:0006753 28 0.160
single organism localization GO:1902578 225 0.157
aorta morphogenesis GO:0035909 3 0.156
cellular macromolecule biosynthetic process GO:0034645 224 0.156
body morphogenesis GO:0010171 16 0.155
Zebrafish
signal transduction in absence of ligand GO:0038034 1 0.155
response to decreased oxygen levels GO:0036293 25 0.153
embryonic camera type eye formation GO:0060900 10 0.152
Zebrafish
gabaergic neuron differentiation GO:0097154 2 0.152
Worm
regulation of epidermis development GO:0045682 2 0.151
face morphogenesis GO:0060325 6 0.150
Zebrafish
negative regulation of cellular metabolic process GO:0031324 77 0.150
head development GO:0060322 303 0.150
nephron development GO:0072006 31 0.149
regulation of dna replication GO:0006275 3 0.149
negative regulation of angiogenesis GO:0016525 7 0.148
establishment of protein localization to organelle GO:0072594 4 0.148
fin regeneration GO:0031101 51 0.147
glial cell fate commitment GO:0021781 6 0.147
metencephalon development GO:0022037 27 0.147
nephron morphogenesis GO:0072028 2 0.147
ras protein signal transduction GO:0007265 7 0.146
response to radiation GO:0009314 51 0.144
kidney development GO:0001822 92 0.141
response to biotic stimulus GO:0009607 97 0.139
extrinsic apoptotic signaling pathway GO:0097191 3 0.137
nephron tubule morphogenesis GO:0072078 1 0.134
axon regeneration GO:0031103 14 0.134
regulation of cell proliferation GO:0042127 37 0.134
central nervous system neuron development GO:0021954 29 0.133
response to external biotic stimulus GO:0043207 97 0.132
response to lipid GO:0033993 60 0.132
hematopoietic or lymphoid organ development GO:0048534 191 0.132
lateral inhibition GO:0046331 1 0.130
regulation of signaling GO:0023051 235 0.130
immune system process GO:0002376 241 0.129
regulation of gastrulation GO:0010470 24 0.129
renal tubule morphogenesis GO:0061333 1 0.129
urogenital system development GO:0001655 97 0.128
positive regulation of cell fate specification GO:0042660 1 0.128
embryonic heart tube development GO:0035050 133 0.128
Zebrafish
neuron death GO:0070997 21 0.127
specification of organ identity GO:0010092 2 0.123
ectodermal placode development GO:0071696 37 0.122
regulation of apoptotic process GO:0042981 98 0.122
protein import into nucleus GO:0006606 3 0.121
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.121
foregut morphogenesis GO:0007440 4 0.120
regulation of programmed cell death GO:0043067 101 0.120
rhombomere development GO:0021546 19 0.120
proteolysis GO:0006508 38 0.119
aorta development GO:0035904 4 0.118
regulation of hydrolase activity GO:0051336 28 0.117
central nervous system myelination GO:0022010 2 0.116
defense response GO:0006952 47 0.115
retina development in camera type eye GO:0060041 146 0.115
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.115
cellular protein catabolic process GO:0044257 4 0.115
negative regulation of transcription dna templated GO:0045892 45 0.114
regulation of endodermal cell differentiation GO:1903224 15 0.112
mesenchymal cell differentiation GO:0048762 87 0.112
neuronal action potential GO:0019228 18 0.109
chemical homeostasis GO:0048878 49 0.109
cellular component assembly involved in morphogenesis GO:0010927 107 0.109
regulation of myotube differentiation GO:0010830 2 0.109
response to light stimulus GO:0009416 46 0.108
otic vesicle development GO:0071599 42 0.108
negative regulation of endothelial cell migration GO:0010596 1 0.107
ectodermal placode formation GO:0060788 26 0.107
regulation of establishment of protein localization GO:0070201 4 0.106
regulation of localization GO:0032879 104 0.106
astrocyte differentiation GO:0048708 1 0.106
cellular response to external stimulus GO:0071496 2 0.106
regulation of dna templated transcription in response to stress GO:0043620 0 0.106
organ growth GO:0035265 12 0.105
cell fate specification GO:0001708 68 0.104
lipid storage GO:0019915 1 0.103
nucleotide metabolic process GO:0009117 28 0.103
negative regulation of biosynthetic process GO:0009890 55 0.103
epithelial tube formation GO:0072175 19 0.103
response to uv GO:0009411 3 0.102
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.101
limbic system development GO:0021761 16 0.101
negative regulation of nervous system development GO:0051961 22 0.101
positive regulation of developmental process GO:0051094 50 0.100
negative regulation of multicellular organismal process GO:0051241 69 0.100
positive regulation of molecular function GO:0044093 33 0.100
positive regulation of striated muscle cell differentiation GO:0051155 1 0.099
cellular component disassembly GO:0022411 1 0.099
negative regulation of cell death GO:0060548 60 0.099
neuroblast fate determination GO:0007400 1 0.098
mechanoreceptor differentiation GO:0042490 37 0.098
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.097
regulation of skeletal muscle fiber development GO:0048742 2 0.097
activation of mapk activity GO:0000187 3 0.097
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.096
epithelial cell proliferation GO:0050673 17 0.096
notch signaling pathway GO:0007219 35 0.095
determination of bilateral symmetry GO:0009855 204 0.095
Zebrafish
hindbrain morphogenesis GO:0021575 22 0.094
axon ensheathment GO:0008366 18 0.094
axonogenesis involved in innervation GO:0060385 1 0.092
divalent inorganic cation homeostasis GO:0072507 22 0.092
response to bacterium GO:0009617 58 0.092
positive regulation of apoptotic signaling pathway GO:2001235 1 0.091
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.091
mesenchymal cell proliferation GO:0010463 1 0.091
cytosolic calcium ion transport GO:0060401 3 0.090
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.090
retina morphogenesis in camera type eye GO:0060042 79 0.089
cellular protein localization GO:0034613 20 0.089
regulation of growth GO:0040008 42 0.089
branching morphogenesis of a nerve GO:0048755 4 0.089
habenula development GO:0021986 9 0.088
stem cell division GO:0017145 1 0.088
circulatory system process GO:0003013 87 0.087
Zebrafish
cartilage development GO:0051216 96 0.087
embryonic eye morphogenesis GO:0048048 30 0.087
Zebrafish
regulation of heart rate GO:0002027 5 0.087
pancreas development GO:0031016 84 0.086
positive regulation of cell development GO:0010720 25 0.086
extracellular structure organization GO:0043062 27 0.086
cardiac muscle tissue development GO:0048738 48 0.086
regulation of cell motility GO:2000145 46 0.085
cellular protein modification process GO:0006464 100 0.085
tissue remodeling GO:0048771 4 0.084
ventral spinal cord development GO:0021517 35 0.084
response to hydrogen peroxide GO:0042542 3 0.084
negative regulation of sequestering of calcium ion GO:0051283 4 0.083
nucleobase containing small molecule metabolic process GO:0055086 32 0.083
lateral line ganglion development GO:0048890 2 0.083
cellular response to lipid GO:0071396 39 0.083
embryonic skeletal system development GO:0048706 97 0.082
Zebrafish
pituitary gland development GO:0021983 16 0.081
negative regulation of macromolecule metabolic process GO:0010605 76 0.081
blood circulation GO:0008015 87 0.081
Zebrafish
actin filament based movement GO:0030048 1 0.080
response to mechanical stimulus GO:0009612 24 0.079
regulation of cytoplasmic transport GO:1903649 4 0.079
neural crest cell differentiation GO:0014033 72 0.079
embryonic camera type eye morphogenesis GO:0048596 19 0.079
Zebrafish
cell type specific apoptotic process GO:0097285 22 0.078
muscle tissue development GO:0060537 110 0.077
otic vesicle morphogenesis GO:0071600 34 0.076
negative regulation of cell proliferation GO:0008285 8 0.076
organonitrogen compound metabolic process GO:1901564 74 0.075
protein complex subunit organization GO:0071822 46 0.075
nuclear import GO:0051170 3 0.074
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.073
outflow tract morphogenesis GO:0003151 1 0.073
regulation of cellular component movement GO:0051270 55 0.072
multicellular organismal signaling GO:0035637 22 0.072
face development GO:0060324 8 0.072
Zebrafish
regulation of axon extension GO:0030516 24 0.072
ion homeostasis GO:0050801 41 0.072
positive regulation of secretion by cell GO:1903532 1 0.071
heart contraction GO:0060047 71 0.071
auditory receptor cell fate specification GO:0042667 2 0.071
negative regulation of epithelial cell migration GO:0010633 1 0.071

pitx3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.659
Human
musculoskeletal system disease DOID:17 0 0.659
connective tissue disease DOID:65 0 0.659
bone disease DOID:0080001 0 0.316
bone development disease DOID:0080006 0 0.261