Danio rerio

64 known processes

cacna1c

calcium channel, voltage-dependent, L type, alpha 1C subunit

(Aliases: C-LTCC,isl)

cacna1c biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
skeletal system development GO:0001501 181 0.626
embryo development ending in birth or egg hatching GO:0009792 271 0.614
cation transmembrane transport GO:0098655 65 0.537
ion transmembrane transport GO:0034220 91 0.516
regulation of biological quality GO:0065008 263 0.491
Human Mouse
cellular component morphogenesis GO:0032989 336 0.421
larval development GO:0002164 2 0.397
chordate embryonic development GO:0043009 271 0.378
regulation of multicellular organism growth GO:0040014 4 0.341
cellular nitrogen compound biosynthetic process GO:0044271 218 0.337
aromatic compound biosynthetic process GO:0019438 217 0.336
multicellular organism growth GO:0035264 4 0.306
inner ear development GO:0048839 126 0.300
embryonic heart tube development GO:0035050 133 0.297
striated muscle cell differentiation GO:0051146 129 0.283
connective tissue development GO:0061448 99 0.269
embryonic skeletal system morphogenesis GO:0048704 93 0.267
hemopoiesis GO:0030097 183 0.225
cellular component biogenesis GO:0044085 178 0.211
skeletal system morphogenesis GO:0048705 102 0.210
determination of bilateral symmetry GO:0009855 204 0.198
Worm
embryonic organ development GO:0048568 381 0.189
nucleobase containing compound biosynthetic process GO:0034654 205 0.186
single organism localization GO:1902578 225 0.185
cellular component assembly GO:0022607 170 0.179
transmembrane transport GO:0055085 120 0.166
cell morphogenesis GO:0000902 289 0.149
muscle tissue development GO:0060537 110 0.146
striated muscle cell development GO:0055002 108 0.142
cartilage development GO:0051216 96 0.142
embryonic skeletal system development GO:0048706 97 0.140
muscle cell differentiation GO:0042692 139 0.138
single organism organelle organization GO:1902589 199 0.138
heart development GO:0007507 313 0.134
cellular localization GO:0051641 97 0.129
Mouse
cell migration GO:0016477 237 0.122
regulation of developmental process GO:0050793 247 0.120
Mouse
embryonic organ morphogenesis GO:0048562 274 0.118
enzyme linked receptor protein signaling pathway GO:0007167 106 0.118
myotube differentiation GO:0014902 45 0.117
myotube cell development GO:0014904 35 0.116
single organism transport GO:0044765 206 0.109
sensory organ development GO:0007423 393 0.109
immune system process GO:0002376 241 0.104
skeletal muscle tissue development GO:0007519 67 0.102
regulation of stem cell differentiation GO:2000736 4 0.094
cartilage morphogenesis GO:0060536 13 0.093
ear development GO:0043583 127 0.093
gland development GO:0048732 143 0.092
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.091
striated muscle tissue development GO:0014706 110 0.089
transport GO:0006810 220 0.089
cell motility GO:0048870 244 0.086
regulation of transcription dna templated GO:0006355 213 0.083
heterocycle biosynthetic process GO:0018130 215 0.080
digestive system development GO:0055123 289 0.077
specification of symmetry GO:0009799 204 0.077
Worm
establishment of localization GO:0051234 244 0.076
regulation of localization GO:0032879 104 0.076
regulation of response to stimulus GO:0048583 269 0.075
Worm
cardiac muscle cell development GO:0055013 20 0.073
cellular biosynthetic process GO:0044249 286 0.072
regulation of rna biosynthetic process GO:2001141 213 0.070
muscle structure development GO:0061061 196 0.070
regulation of multicellular organismal process GO:0051239 277 0.068
organelle assembly GO:0070925 110 0.067
cellular component movement GO:0006928 335 0.065
establishment of localization in cell GO:0051649 77 0.065
Mouse
inorganic cation transmembrane transport GO:0098662 50 0.064
regulation of nucleic acid templated transcription GO:1903506 213 0.062
endocrine system development GO:0035270 65 0.062
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.062
chemotaxis GO:0006935 104 0.062
regulation of cellular biosynthetic process GO:0031326 245 0.061
fin morphogenesis GO:0033334 53 0.059
positive regulation of transport GO:0051050 2 0.059
nucleobase containing compound metabolic process GO:0006139 274 0.058
developmental growth GO:0048589 166 0.057
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.055
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.054
cardiac atrium morphogenesis GO:0003209 2 0.054
cell projection organization GO:0030030 284 0.054
mesenchyme development GO:0060485 127 0.054
cell part morphogenesis GO:0032990 246 0.054
cell surface receptor signaling pathway GO:0007166 325 0.052
cognition GO:0050890 1 0.052
Mouse
regulation of biosynthetic process GO:0009889 250 0.051
transcription from rna polymerase ii promoter GO:0006366 80 0.051
signal transduction GO:0007165 455 0.050
organic cyclic compound biosynthetic process GO:1901362 223 0.050
digestive tract morphogenesis GO:0048546 231 0.049
embryonic skeletal joint development GO:0072498 3 0.049
regulation of neurogenesis GO:0050767 87 0.048
cellular nitrogen compound metabolic process GO:0034641 290 0.047
negative regulation of gene expression GO:0010629 65 0.047
actin cytoskeleton organization GO:0030036 63 0.046
muscle organ development GO:0007517 101 0.044
stem cell proliferation GO:0072089 4 0.043
appendage development GO:0048736 80 0.043
neuron projection development GO:0031175 180 0.042
blood vessel development GO:0001568 246 0.042
regulation of growth GO:0040008 42 0.041
Mouse
regulation of gene expression GO:0010468 265 0.041
system process GO:0003008 185 0.041
positive regulation of cellular component biogenesis GO:0044089 3 0.041
negative regulation of feeding behavior GO:2000252 2 0.041
regulation of protein transport GO:0051223 3 0.040
cell proliferation GO:0008283 80 0.040
heart process GO:0003015 71 0.039
hematopoietic or lymphoid organ development GO:0048534 191 0.039
heart jogging GO:0003146 40 0.039
maintenance of location GO:0051235 4 0.039
protein complex subunit organization GO:0071822 46 0.039
ear morphogenesis GO:0042471 64 0.038
regulation of signaling GO:0023051 235 0.038
ameboidal type cell migration GO:0001667 143 0.038
neuron development GO:0048666 262 0.038
response to wounding GO:0009611 116 0.038
embryonic cranial skeleton morphogenesis GO:0048701 90 0.038
tissue homeostasis GO:0001894 25 0.037
immune system development GO:0002520 191 0.037
locomotion GO:0040011 313 0.037
generation of neurons GO:0048699 385 0.037
sensory system development GO:0048880 76 0.036
macromolecular complex assembly GO:0065003 35 0.036
behavior GO:0007610 74 0.035
Mouse Worm
blood vessel morphogenesis GO:0048514 216 0.035
regulation of organ growth GO:0046620 3 0.035
Mouse
muscle fiber development GO:0048747 52 0.034
positive regulation of transcription dna templated GO:0045893 57 0.034
myofibril assembly GO:0030239 48 0.034
protein complex assembly GO:0006461 30 0.033
embryonic heart tube morphogenesis GO:0003143 108 0.033
skeletal muscle fiber development GO:0048741 35 0.033
cell cell signaling GO:0007267 52 0.032
Mouse
regulation of metabolic process GO:0019222 359 0.032
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.032
negative regulation of transcription dna templated GO:0045892 45 0.032
fin regeneration GO:0031101 51 0.031
regulation of nervous system development GO:0051960 90 0.031
lipid storage GO:0019915 1 0.031
glial cell differentiation GO:0010001 42 0.031
regulation of reproductive process GO:2000241 4 0.031
cellular response to endogenous stimulus GO:0071495 68 0.030
regulation of cell size GO:0008361 29 0.030
determination of heart left right asymmetry GO:0061371 117 0.030
pancreas development GO:0031016 84 0.030
actin filament based process GO:0030029 64 0.030
regulation of protein complex assembly GO:0043254 3 0.029
regulation of anatomical structure morphogenesis GO:0022603 130 0.029
neuron projection morphogenesis GO:0048812 161 0.029
ion transport GO:0006811 114 0.029
protein import GO:0017038 3 0.029
neuron neuron synaptic transmission GO:0007270 1 0.028
tissue regeneration GO:0042246 74 0.028
heart looping GO:0001947 94 0.028
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
heterocycle metabolic process GO:0046483 290 0.027
regulation of cell differentiation GO:0045595 142 0.027
heart morphogenesis GO:0003007 156 0.027
metal ion transport GO:0030001 58 0.027
cell morphogenesis involved in differentiation GO:0000904 195 0.027
inner ear morphogenesis GO:0042472 63 0.027
regulation of establishment of protein localization GO:0070201 4 0.027
localization of cell GO:0051674 244 0.027
transcription dna templated GO:0006351 181 0.026
organic substance biosynthetic process GO:1901576 289 0.026
nucleic acid metabolic process GO:0090304 244 0.026
growth GO:0040007 174 0.026
Mouse
embryonic viscerocranium morphogenesis GO:0048703 52 0.026
organelle organization GO:0006996 227 0.025
negative regulation of biological process GO:0048519 304 0.025
rna metabolic process GO:0016070 219 0.025
axon guidance GO:0007411 86 0.025
protein localization to nucleus GO:0034504 3 0.025
cellular response to organic substance GO:0071310 105 0.024
cardiac cell fate commitment GO:0060911 1 0.024
cellular component assembly involved in morphogenesis GO:0010927 107 0.024
regulation of behavior GO:0050795 24 0.023
Worm
negative regulation of rna metabolic process GO:0051253 48 0.023
regulation of protein targeting GO:1903533 2 0.023
carbohydrate derivative biosynthetic process GO:1901137 43 0.023
floor plate morphogenesis GO:0033505 12 0.023
cellular response to hormone stimulus GO:0032870 39 0.023
regulation of cell projection organization GO:0031344 44 0.023
reactive oxygen species metabolic process GO:0072593 6 0.022
organic substance transport GO:0071702 58 0.022
Mouse
aorta morphogenesis GO:0035909 3 0.022
cellular macromolecule metabolic process GO:0044260 391 0.022
morphogenesis of an epithelium GO:0002009 333 0.022
response to external stimulus GO:0009605 264 0.022
Zebrafish
neuron differentiation GO:0030182 353 0.022
regulation of rna metabolic process GO:0051252 224 0.022
regulation of cytokine production GO:0001817 3 0.021
reproductive process GO:0022414 40 0.021
Worm
regulation of synapse organization GO:0050807 3 0.021
small molecule metabolic process GO:0044281 77 0.021
negative regulation of signaling GO:0023057 96 0.021
negative regulation of cellular process GO:0048523 283 0.021
regulation of cellular metabolic process GO:0031323 320 0.021
cellular response to oxygen levels GO:0071453 1 0.021
positive regulation of nucleic acid templated transcription GO:1903508 57 0.020
neurological system process GO:0050877 62 0.020
Zebrafish Mouse
endocrine pancreas development GO:0031018 27 0.020
circulatory system process GO:0003013 87 0.020
regulation of transport GO:0051049 45 0.020
cytoskeleton organization GO:0007010 96 0.020
digestive tract development GO:0048565 265 0.019
pectoral fin development GO:0033339 50 0.019
regulation of protein import into nucleus GO:0042306 2 0.019
dorsal ventral pattern formation GO:0009953 125 0.019
cellular aromatic compound metabolic process GO:0006725 295 0.019
cytokinesis GO:0000910 3 0.019
regulation of protein catabolic process GO:0042176 1 0.019
angiogenesis GO:0001525 158 0.019
extracellular structure organization GO:0043062 27 0.019
carbohydrate homeostasis GO:0033500 1 0.019
Mouse
response to alkaloid GO:0043279 2 0.019
sensory organ morphogenesis GO:0090596 200 0.019
gene expression GO:0010467 252 0.019
multi organism process GO:0051704 134 0.019
Worm
rna biosynthetic process GO:0032774 181 0.019
embryonic neurocranium morphogenesis GO:0048702 15 0.019
lateral line development GO:0048882 66 0.018
muscle organ morphogenesis GO:0048644 8 0.018
nuclear transport GO:0051169 4 0.018
cardiogenic plate morphogenesis GO:0003142 1 0.018
nitrogen compound metabolic process GO:0006807 319 0.018
biosynthetic process GO:0009058 294 0.018
response to nitrogen compound GO:1901698 19 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.018
positive regulation of nervous system development GO:0051962 25 0.018
endoplasmic reticulum unfolded protein response GO:0030968 2 0.018
cell cycle process GO:0022402 53 0.018
regulation of multicellular organismal development GO:2000026 223 0.017
reproduction GO:0000003 40 0.017
Worm
convergent extension GO:0060026 118 0.017
regulation of transmembrane transport GO:0034762 18 0.017
fin development GO:0033333 77 0.017
response to stress GO:0006950 263 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
regulation of cell communication GO:0010646 232 0.017
hatching GO:0035188 4 0.017
vasculature development GO:0001944 278 0.016
regulation of cellular component organization GO:0051128 86 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.016
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.016
fertilization GO:0009566 3 0.016
regulation of neuron differentiation GO:0045664 56 0.016
positive regulation of developmental process GO:0051094 50 0.016
protein targeting to nucleus GO:0044744 3 0.016
single organism metabolic process GO:0044710 217 0.016
somitogenesis GO:0001756 87 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.015
regionalization GO:0003002 274 0.015
cardiac muscle tissue morphogenesis GO:0055008 7 0.015
response to endogenous stimulus GO:0009719 83 0.015
eye morphogenesis GO:0048592 144 0.015
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.015
regulation of transporter activity GO:0032409 2 0.015
multi organism reproductive process GO:0044703 36 0.015
Worm
cardiac chamber morphogenesis GO:0003206 12 0.015
gastrulation GO:0007369 208 0.015
homeostatic process GO:0042592 142 0.015
Human Mouse
negative regulation of developmental process GO:0051093 65 0.015
inorganic ion transmembrane transport GO:0098660 57 0.015
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 2 0.015
regulation of signal transduction GO:0009966 225 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.014
cation transport GO:0006812 81 0.014
stem cell maintenance GO:0019827 4 0.014
cellular response to nutrient levels GO:0031669 2 0.014
developmental programmed cell death GO:0010623 4 0.014
cytosolic calcium ion transport GO:0060401 3 0.014
single fertilization GO:0007338 3 0.014
organism emergence from protective structure GO:0071684 4 0.014
taxis GO:0042330 109 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
neurotransmitter transport GO:0006836 2 0.014
regulation of neuron migration GO:2001222 2 0.014
appendage morphogenesis GO:0035107 56 0.014
negative regulation of reproductive process GO:2000242 3 0.013
wound healing GO:0042060 90 0.013
myeloid cell differentiation GO:0030099 86 0.013
regulation of heart contraction GO:0008016 32 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
phagocytosis GO:0006909 3 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
lateral line system development GO:0048925 76 0.013
outflow tract morphogenesis GO:0003151 1 0.013
aorta development GO:0035904 4 0.013
regulation of circadian rhythm GO:0042752 4 0.013
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
negative regulation of signal transduction GO:0009968 94 0.013
leukocyte proliferation GO:0070661 1 0.013
macromolecular complex subunit organization GO:0043933 74 0.013
calcium ion transmembrane transport GO:0070588 13 0.013
eye development GO:0001654 277 0.013
macromolecule biosynthetic process GO:0009059 227 0.012
protein complex biogenesis GO:0070271 30 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
biomineral tissue development GO:0031214 13 0.012
positive regulation of cell cycle GO:0045787 3 0.012
bmp signaling pathway GO:0030509 52 0.012
regulation of system process GO:0044057 40 0.012
collagen metabolic process GO:0032963 2 0.012
monocarboxylic acid catabolic process GO:0072329 3 0.012
astrocyte differentiation GO:0048708 1 0.012
embryonic pattern specification GO:0009880 44 0.012
axon development GO:0061564 166 0.012
mesoderm development GO:0007498 88 0.012
pectoral fin morphogenesis GO:0035138 29 0.012
compound eye development GO:0048749 2 0.012
positive regulation of bmp signaling pathway GO:0030513 10 0.012
single organism cellular localization GO:1902580 46 0.012
regulation of primary metabolic process GO:0080090 311 0.012
response to organic substance GO:0010033 153 0.012
muscle cell development GO:0055001 115 0.012
meiotic nuclear division GO:0007126 4 0.012
ventricular cardiac muscle tissue development GO:0003229 3 0.012
actomyosin structure organization GO:0031032 53 0.012
positive regulation of cell division GO:0051781 2 0.012
cardiocyte differentiation GO:0035051 44 0.012
positive regulation of alcohol biosynthetic process GO:1902932 1 0.012
regulation of protein localization to nucleus GO:1900180 2 0.011
positive regulation of biological process GO:0048518 253 0.011
cellular macromolecule biosynthetic process GO:0034645 224 0.011
regulation of locomotion GO:0040012 55 0.011
cardiac ventricle formation GO:0003211 1 0.011
organic cyclic compound metabolic process GO:1901360 301 0.011
cellular response to unfolded protein GO:0034620 2 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
calcium ion transport into cytosol GO:0060402 3 0.011
bmp signaling pathway involved in heart development GO:0061312 15 0.011
tube morphogenesis GO:0035239 349 0.011
hormone secretion GO:0046879 2 0.011
Mouse
regulation of oocyte development GO:0060281 3 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
startle response GO:0001964 4 0.011
negative regulation of defense response GO:0031348 2 0.011
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.011
spemann organizer formation at the embryonic shield GO:0060063 2 0.011
oxoacid metabolic process GO:0043436 31 0.011
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.010
mechanoreceptor differentiation GO:0042490 37 0.010
protein localization GO:0008104 40 0.010
post embryonic morphogenesis GO:0009886 4 0.010
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.010
organ growth GO:0035265 12 0.010
Mouse
negative regulation of cell differentiation GO:0045596 46 0.010
detection of external stimulus GO:0009581 24 0.010
Zebrafish
single organism nuclear import GO:1902593 3 0.010
actin polymerization or depolymerization GO:0008154 2 0.010
floor plate formation GO:0021508 12 0.010

cacna1c disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.106
disease of anatomical entity DOID:7 0 0.038
Human
bone development disease DOID:0080006 0 0.024
bone disease DOID:0080001 0 0.024
musculoskeletal system disease DOID:17 0 0.024
connective tissue disease DOID:65 0 0.024
cardiovascular system disease DOID:1287 0 0.018
Human
disease of mental health DOID:150 0 0.010
developmental disorder of mental health DOID:0060037 0 0.010