Danio rerio

0 known processes

lgi2a

leucine-rich repeat LGI family, member 2a

lgi2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.077
embryonic organ morphogenesis GO:0048562 274 0.055
central nervous system development GO:0007417 387 0.053
cell morphogenesis GO:0000902 289 0.052
heterocycle biosynthetic process GO:0018130 215 0.051
neuron differentiation GO:0030182 353 0.049
generation of neurons GO:0048699 385 0.047
response to external stimulus GO:0009605 264 0.045
cell part morphogenesis GO:0032990 246 0.044
amine metabolic process GO:0009308 2 0.043
embryonic organ development GO:0048568 381 0.043
cognition GO:0050890 1 0.042
cell projection organization GO:0030030 284 0.042
aromatic compound biosynthetic process GO:0019438 217 0.041
nitrogen compound metabolic process GO:0006807 319 0.040
cell projection morphogenesis GO:0048858 244 0.039
cellular amine metabolic process GO:0044106 2 0.039
regulation of macromolecule metabolic process GO:0060255 317 0.039
adult behavior GO:0030534 2 0.039
positive regulation of transport GO:0051050 2 0.038
regulation of multicellular organismal process GO:0051239 277 0.038
larval development GO:0002164 2 0.038
regulation of metabolic process GO:0019222 359 0.037
regulation of primary metabolic process GO:0080090 311 0.037
negative regulation of biological process GO:0048519 304 0.036
system process GO:0003008 185 0.036
camera type eye development GO:0043010 222 0.035
gene expression GO:0010467 252 0.034
sensory organ development GO:0007423 393 0.034
response to stress GO:0006950 263 0.034
maintenance of location GO:0051235 4 0.034
nucleobase containing compound biosynthetic process GO:0034654 205 0.033
regulation of cellular amino acid metabolic process GO:0006521 0 0.033
chordate embryonic development GO:0043009 271 0.033
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.032
skeletal system development GO:0001501 181 0.032
cell motility GO:0048870 244 0.032
immune system development GO:0002520 191 0.032
regulation of cellular ketone metabolic process GO:0010565 7 0.032
regulation of cellular metabolic process GO:0031323 320 0.031
organic cyclic compound biosynthetic process GO:1901362 223 0.031
cellular macromolecule metabolic process GO:0044260 391 0.031
signal transduction GO:0007165 455 0.030
locomotion GO:0040011 313 0.030
regulation of gene expression GO:0010468 265 0.030
cellular component morphogenesis GO:0032989 336 0.030
morphogenesis of an epithelium GO:0002009 333 0.029
rna metabolic process GO:0016070 219 0.029
response to drug GO:0042493 3 0.029
cellular protein catabolic process GO:0044257 4 0.029
eye development GO:0001654 277 0.028
cation transmembrane transport GO:0098655 65 0.028
heterocycle metabolic process GO:0046483 290 0.028
head development GO:0060322 303 0.028
regulation of cellular amine metabolic process GO:0033238 0 0.027
neuron projection development GO:0031175 180 0.027
positive regulation of biological process GO:0048518 253 0.027
cell morphogenesis involved in differentiation GO:0000904 195 0.027
cellular nitrogen compound metabolic process GO:0034641 290 0.027
brain development GO:0007420 293 0.027
cellular component movement GO:0006928 335 0.027
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.027
cellular nitrogen compound biosynthetic process GO:0044271 218 0.027
regulation of nitrogen compound metabolic process GO:0051171 251 0.026
regulation of binding GO:0051098 3 0.026
neuron development GO:0048666 262 0.026
multicellular organism growth GO:0035264 4 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
nucleic acid metabolic process GO:0090304 244 0.026
regulation of biological quality GO:0065008 263 0.026
nuclear migration GO:0007097 3 0.025
organic cyclic compound metabolic process GO:1901360 301 0.025
regulation of dendrite morphogenesis GO:0048814 3 0.025
regulation of multicellular organismal development GO:2000026 223 0.025
regulation of signal transduction GO:0009966 225 0.025
cell migration GO:0016477 237 0.025
skeletal system morphogenesis GO:0048705 102 0.025
nucleobase containing compound metabolic process GO:0006139 274 0.025
phagocytosis GO:0006909 3 0.025
response to chemical GO:0042221 320 0.025
axonogenesis GO:0007409 152 0.025
transmission of nerve impulse GO:0019226 19 0.025
muscle structure development GO:0061061 196 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.025
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.024
modification dependent protein catabolic process GO:0019941 3 0.024
ion transmembrane transport GO:0034220 91 0.024
regulation of metal ion transport GO:0010959 4 0.024
regulation of cellular biosynthetic process GO:0031326 245 0.024
regulation of cell communication GO:0010646 232 0.024
regulation of multicellular organism growth GO:0040014 4 0.024
proteasomal protein catabolic process GO:0010498 2 0.024
regulation of reproductive process GO:2000241 4 0.024
embryonic skeletal system development GO:0048706 97 0.023
regulation of protein transport GO:0051223 3 0.023
regulation of dendrite development GO:0050773 3 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.023
cellular component biogenesis GO:0044085 178 0.023
cellular biosynthetic process GO:0044249 286 0.023
axon development GO:0061564 166 0.023
inorganic cation transmembrane transport GO:0098662 50 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.022
extrinsic apoptotic signaling pathway GO:0097191 3 0.022
regulation of membrane potential GO:0042391 23 0.022
positive regulation of cellular component biogenesis GO:0044089 3 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
cellular amino acid metabolic process GO:0006520 7 0.022
cellular response to external stimulus GO:0071496 2 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
stem cell proliferation GO:0072089 4 0.022
transmembrane transport GO:0055085 120 0.022
tube morphogenesis GO:0035239 349 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.022
regulation of reactive oxygen species metabolic process GO:2000377 2 0.022
negative regulation of cellular process GO:0048523 283 0.022
erk1 and erk2 cascade GO:0070371 4 0.022
macromolecule biosynthetic process GO:0009059 227 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.022
heart morphogenesis GO:0003007 156 0.021
neuron projection morphogenesis GO:0048812 161 0.021
cellular component assembly GO:0022607 170 0.021
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.021
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
positive regulation of catabolic process GO:0009896 4 0.020
response to nutrient GO:0007584 3 0.020
nuclear transport GO:0051169 4 0.020
cellular ketone metabolic process GO:0042180 11 0.020
cellular aromatic compound metabolic process GO:0006725 295 0.020
homeostatic process GO:0042592 142 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
regulation of response to stimulus GO:0048583 269 0.020
regulation of rna metabolic process GO:0051252 224 0.020
organic substance biosynthetic process GO:1901576 289 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.019
regulation of synapse assembly GO:0051963 3 0.019
gtp catabolic process GO:0006184 2 0.019
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.019
oxoacid metabolic process GO:0043436 31 0.019
response to carbohydrate GO:0009743 3 0.019
regulation of cytokine production GO:0001817 3 0.019
regulation of signaling GO:0023051 235 0.019
immune system process GO:0002376 241 0.019
female gonad development GO:0008585 4 0.019
positive regulation of cell cycle GO:0045787 3 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
embryonic skeletal system morphogenesis GO:0048704 93 0.019
gtp metabolic process GO:0046039 4 0.019
modification dependent macromolecule catabolic process GO:0043632 3 0.019
cell substrate adhesion GO:0031589 4 0.019
protein localization to nucleus GO:0034504 3 0.019
mitochondrion organization GO:0007005 4 0.018
heart development GO:0007507 313 0.018
single organism metabolic process GO:0044710 217 0.018
regulation of developmental process GO:0050793 247 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.018
ubiquitin dependent protein catabolic process GO:0006511 3 0.018
determination of bilateral symmetry GO:0009855 204 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
synaptic transmission cholinergic GO:0007271 4 0.018
biosynthetic process GO:0009058 294 0.018
muscle organ development GO:0007517 101 0.018
guanosine containing compound catabolic process GO:1901069 2 0.018
rna biosynthetic process GO:0032774 181 0.018
regulation of calcium ion transport GO:0051924 2 0.017
cation transport GO:0006812 81 0.017
digestive system development GO:0055123 289 0.017
transcription dna templated GO:0006351 181 0.017
organic acid metabolic process GO:0006082 31 0.017
anterior posterior pattern specification GO:0009952 152 0.017
regulation of tube size GO:0035150 2 0.017
blood vessel development GO:0001568 246 0.017
multicellular organismal signaling GO:0035637 22 0.017
protein metabolic process GO:0019538 183 0.017
digestive tract development GO:0048565 265 0.017
protein localization to plasma membrane GO:0072659 1 0.016
regulation of protein catabolic process GO:0042176 1 0.016
peptide metabolic process GO:0006518 1 0.016
autophagy GO:0006914 4 0.016
nucleic acid templated transcription GO:0097659 181 0.016
cellular response to reactive oxygen species GO:0034614 2 0.016
nucleocytoplasmic transport GO:0006913 4 0.016
response to uv GO:0009411 3 0.016
vasculature development GO:0001944 278 0.016
cell surface receptor signaling pathway GO:0007166 325 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
fertilization GO:0009566 3 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
notochord development GO:0030903 54 0.016
cilium morphogenesis GO:0060271 85 0.016
positive regulation of cytokine production GO:0001819 2 0.016
female sex differentiation GO:0046660 4 0.016
response to wounding GO:0009611 116 0.016
synaptic growth at neuromuscular junction GO:0051124 2 0.016
protein targeting to nucleus GO:0044744 3 0.016
regulation of sequestering of calcium ion GO:0051282 4 0.016
mitotic dna integrity checkpoint GO:0044774 4 0.015
striated muscle tissue development GO:0014706 110 0.015
gastrulation GO:0007369 208 0.015
muscle cell differentiation GO:0042692 139 0.015
development of primary female sexual characteristics GO:0046545 4 0.015
neuronal action potential GO:0019228 18 0.015
nuclear import GO:0051170 3 0.015
regulation of mrna splicing via spliceosome GO:0048024 3 0.015
forebrain cell migration GO:0021885 1 0.015
response to glucocorticoid GO:0051384 1 0.015
action potential GO:0001508 19 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
lipid storage GO:0019915 1 0.015
positive regulation of cellular process GO:0048522 201 0.015
central nervous system neuron differentiation GO:0021953 74 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.015
regulation of jak stat cascade GO:0046425 3 0.015
regulation of locomotion GO:0040012 55 0.015
endosomal transport GO:0016197 2 0.015
regulation of protein binding GO:0043393 3 0.015
regulation of biosynthetic process GO:0009889 250 0.015
hemopoiesis GO:0030097 183 0.015
localization of cell GO:0051674 244 0.015
response to hydrogen peroxide GO:0042542 3 0.015
developmental growth involved in morphogenesis GO:0060560 86 0.015
regulation of cell shape GO:0008360 1 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
regulation of macromolecule biosynthetic process GO:0010556 225 0.015
cellular response to nutrient levels GO:0031669 2 0.015
protein import into nucleus GO:0006606 3 0.015
cilium assembly GO:0042384 58 0.015
transport GO:0006810 220 0.015
cellular amide metabolic process GO:0043603 4 0.014
secondary metabolic process GO:0019748 3 0.014
protein dephosphorylation GO:0006470 3 0.014
organelle organization GO:0006996 227 0.014
meiotic nuclear division GO:0007126 4 0.014
calcium ion transport into cytosol GO:0060402 3 0.014
single fertilization GO:0007338 3 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
positive regulation of secretion GO:0051047 1 0.014
response to abiotic stimulus GO:0009628 122 0.014
neurological system process GO:0050877 62 0.014
intracellular signal transduction GO:0035556 85 0.014
regulation of nucleoside metabolic process GO:0009118 2 0.014
regulation of transcription dna templated GO:0006355 213 0.014
regulation of mrna processing GO:0050684 3 0.014
cell cycle g2 m phase transition GO:0044839 4 0.014
regulation of protein import into nucleus GO:0042306 2 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
multicellular organismal response to stress GO:0033555 2 0.014
retina development in camera type eye GO:0060041 146 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
regulation of blood pressure GO:0008217 1 0.014
tissue remodeling GO:0048771 4 0.014
establishment of localization GO:0051234 244 0.014
protein import GO:0017038 3 0.014
sequestering of metal ion GO:0051238 3 0.014
regeneration GO:0031099 91 0.014
small molecule metabolic process GO:0044281 77 0.014
negative regulation of cell communication GO:0010648 96 0.014
single organism localization GO:1902578 225 0.013
regulation of programmed cell death GO:0043067 101 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
exocytosis GO:0006887 1 0.013
regulation of protein targeting GO:1903533 2 0.013
cytokinesis GO:0000910 3 0.013
regulation of synaptic plasticity GO:0048167 1 0.013
behavior GO:0007610 74 0.013
regulation of cell development GO:0060284 100 0.013
digestive tract morphogenesis GO:0048546 231 0.013
stem cell division GO:0017145 1 0.013
regulation of cell death GO:0010941 103 0.013
response to alkaloid GO:0043279 2 0.013
embryonic cranial skeleton morphogenesis GO:0048701 90 0.013
growth GO:0040007 174 0.013
regulation of nucleocytoplasmic transport GO:0046822 2 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
regulation of synapse organization GO:0050807 3 0.013
regulation of cell substrate adhesion GO:0010810 1 0.013
chemosensory behavior GO:0007635 1 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.013
cilium organization GO:0044782 71 0.013
single organism nuclear import GO:1902593 3 0.013
response to monosaccharide GO:0034284 3 0.013
regulation of cell differentiation GO:0045595 142 0.013
regulation of localization GO:0032879 104 0.013
regulation of transmembrane transport GO:0034762 18 0.013
regulation of cell activation GO:0050865 1 0.013
organelle fusion GO:0048284 3 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
cellular response to stress GO:0033554 62 0.013
astrocyte differentiation GO:0048708 1 0.013
cell matrix adhesion GO:0007160 4 0.013
regulation of purine nucleotide catabolic process GO:0033121 2 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
response to corticosteroid GO:0031960 1 0.013
cellular component disassembly GO:0022411 1 0.013
central nervous system neuron development GO:0021954 29 0.013
protein targeting to membrane GO:0006612 1 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
regulation of erk1 and erk2 cascade GO:0070372 4 0.012
hepaticobiliary system development GO:0061008 98 0.012
inorganic ion transmembrane transport GO:0098660 57 0.012
adherens junction organization GO:0034332 4 0.012
sequestering of calcium ion GO:0051208 3 0.012
muscle tissue development GO:0060537 110 0.012
mechanosensory behavior GO:0007638 2 0.012
regulation of protein complex assembly GO:0043254 3 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
membrane invagination GO:0010324 1 0.012
metal ion transport GO:0030001 58 0.012
positive regulation of myeloid cell differentiation GO:0045639 2 0.012
cellular protein modification process GO:0006464 100 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
somite development GO:0061053 96 0.012
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.012
maternal determination of anterior posterior axis embryo GO:0008358 4 0.012
muscle cell development GO:0055001 115 0.012
ear development GO:0043583 127 0.012
centrosome organization GO:0051297 1 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
olfactory bulb development GO:0021772 4 0.012
embryonic heart tube development GO:0035050 133 0.012
programmed cell death GO:0012501 119 0.012
synaptic vesicle transport GO:0048489 1 0.012
meiotic cell cycle process GO:1903046 3 0.012
protein heterooligomerization GO:0051291 1 0.012
connective tissue development GO:0061448 99 0.012
cellular protein metabolic process GO:0044267 129 0.012
regionalization GO:0003002 274 0.012
sensory perception of pain GO:0019233 1 0.012
negative regulation of kinase activity GO:0033673 4 0.012
peptidyl serine modification GO:0018209 2 0.012
protein stabilization GO:0050821 2 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
olfactory lobe development GO:0021988 4 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
sensory perception of chemical stimulus GO:0007606 3 0.011
response to endogenous stimulus GO:0009719 83 0.011
regulation of neurogenesis GO:0050767 87 0.011
actin filament based movement GO:0030048 1 0.011
macromolecule modification GO:0043412 111 0.011
cellular response to radiation GO:0071478 4 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
myeloid cell differentiation GO:0030099 86 0.011
developmental programmed cell death GO:0010623 4 0.011
protein acylation GO:0043543 3 0.011
regulation of gtp catabolic process GO:0033124 2 0.011
enzyme linked receptor protein signaling pathway GO:0007167 106 0.011
specification of symmetry GO:0009799 204 0.011
phosphorus metabolic process GO:0006793 109 0.011
gland development GO:0048732 143 0.011
cell cycle arrest GO:0007050 1 0.011
liver development GO:0001889 96 0.011
positive regulation of metabolic process GO:0009893 108 0.011
establishment of protein localization to plasma membrane GO:0090002 1 0.011
antimicrobial humoral response GO:0019730 2 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
regulation of blood vessel size GO:0050880 2 0.011
regulation of neuron differentiation GO:0045664 56 0.011
regulation of intracellular protein transport GO:0033157 3 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
forebrain development GO:0030900 96 0.011
regulation of inflammatory response GO:0050727 2 0.011
single organism membrane fusion GO:0044801 2 0.011
locomotory behavior GO:0007626 34 0.011
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.010
positive regulation of apoptotic signaling pathway GO:2001235 1 0.010
positive regulation of leukocyte differentiation GO:1902107 1 0.010
positive regulation of multicellular organismal process GO:0051240 52 0.010
stem cell maintenance GO:0019827 4 0.010
nuclear export GO:0051168 1 0.010
smooth muscle contraction GO:0006939 2 0.010
determination of left right symmetry GO:0007368 179 0.010
negative regulation of catabolic process GO:0009895 3 0.010
embryonic hemopoiesis GO:0035162 53 0.010
inositol lipid mediated signaling GO:0048017 2 0.010
positive regulation of epithelial cell migration GO:0010634 2 0.010
regulation of systemic arterial blood pressure GO:0003073 1 0.010
regulation of anatomical structure morphogenesis GO:0022603 130 0.010
peptidyl lysine acetylation GO:0018394 2 0.010
negative regulation of cytokine production GO:0001818 1 0.010
microtubule organizing center organization GO:0031023 1 0.010
sensory system development GO:0048880 76 0.010
post golgi vesicle mediated transport GO:0006892 1 0.010
developmental growth GO:0048589 166 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.010
neuromuscular synaptic transmission GO:0007274 2 0.010
atp catabolic process GO:0006200 4 0.010
rna localization GO:0006403 4 0.010
sensory organ morphogenesis GO:0090596 200 0.010
response to organic substance GO:0010033 153 0.010
organelle assembly GO:0070925 110 0.010
response to hexose GO:0009746 3 0.010
multi organism process GO:0051704 134 0.010
b cell activation GO:0042113 2 0.010

lgi2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
immune system disease DOID:2914 0 0.018
cardiovascular system disease DOID:1287 0 0.017
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
nervous system disease DOID:863 0 0.016
organ system cancer DOID:0050686 0 0.013
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
disease of metabolism DOID:0014667 0 0.013