Danio rerio

0 known processes

smad7

MAD, mothers against decapentaplegic homolog 7 (Drosophila)

(Aliases: wu:fj60c10,madh7)

smad7 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aromatic compound biosynthetic process GO:0019438 217 0.936
Human Zebrafish Fly
ameboidal type cell migration GO:0001667 143 0.909
Zebrafish
cellular macromolecule biosynthetic process GO:0034645 224 0.896
Human Zebrafish Fly
regulation of multicellular organismal development GO:2000026 223 0.841
Zebrafish Fly
cellular aromatic compound metabolic process GO:0006725 295 0.817
Human Zebrafish Fly
biosynthetic process GO:0009058 294 0.809
Human Zebrafish Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.801
Human Zebrafish Fly
regulation of transcription dna templated GO:0006355 213 0.790
Human Zebrafish Mouse Fly
rna biosynthetic process GO:0032774 181 0.771
Human Zebrafish Fly
sensory organ development GO:0007423 393 0.760
Zebrafish
nucleic acid templated transcription GO:0097659 181 0.759
Human Zebrafish Fly
sympathetic nervous system development GO:0048485 3 0.739
regulation of primary metabolic process GO:0080090 311 0.718
Human Zebrafish Mouse Fly
cellular biosynthetic process GO:0044249 286 0.708
Human Zebrafish Fly
heterocycle biosynthetic process GO:0018130 215 0.706
Human Zebrafish Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.693
Human Zebrafish Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.683
Human Zebrafish Mouse Fly
regulation of rna metabolic process GO:0051252 224 0.682
Human Zebrafish Mouse Fly
camera type eye morphogenesis GO:0048593 108 0.680
cell motility GO:0048870 244 0.662
Zebrafish Fly
regulation of macromolecule metabolic process GO:0060255 317 0.639
Human Zebrafish Mouse Fly
organic cyclic compound metabolic process GO:1901360 301 0.636
Human Zebrafish Fly
sensory organ morphogenesis GO:0090596 200 0.600
Zebrafish
eye development GO:0001654 277 0.596
nucleic acid metabolic process GO:0090304 244 0.539
Human Zebrafish Fly
cellular macromolecule metabolic process GO:0044260 391 0.535
Human Zebrafish Mouse Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.533
Human Zebrafish Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.523
Human Zebrafish Mouse Fly
negative regulation of cellular process GO:0048523 283 0.507
Human Zebrafish Mouse Fly
regulation of gene expression GO:0010468 265 0.506
Human Zebrafish Mouse Fly
rna metabolic process GO:0016070 219 0.503
Human Zebrafish Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.478
Human Zebrafish
nitrogen compound metabolic process GO:0006807 319 0.475
Human Zebrafish Fly
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.467
Human Zebrafish Mouse Fly
regulation of rna biosynthetic process GO:2001141 213 0.459
Human Zebrafish Mouse Fly
regulation of cell differentiation GO:0045595 142 0.454
Zebrafish Fly
inner ear morphogenesis GO:0042472 63 0.454
Zebrafish
regulation of cellular biosynthetic process GO:0031326 245 0.451
Human Zebrafish Mouse Fly
regulation of cell development GO:0060284 100 0.449
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.438
Human Zebrafish Fly
transcription dna templated GO:0006351 181 0.436
Human Zebrafish Fly
ear morphogenesis GO:0042471 64 0.417
Zebrafish
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.405
Human Zebrafish Mouse Fly
head development GO:0060322 303 0.404
cell morphogenesis involved in differentiation GO:0000904 195 0.399
Fly
regulation of biosynthetic process GO:0009889 250 0.397
Human Zebrafish Mouse Fly
regulation of cell morphogenesis GO:0022604 42 0.394
brain development GO:0007420 293 0.391
neuron projection development GO:0031175 180 0.389
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.386
Human Zebrafish Fly
otic placode formation GO:0043049 23 0.379
Zebrafish
macromolecule biosynthetic process GO:0009059 227 0.377
Human Zebrafish Fly
chordate embryonic development GO:0043009 271 0.376
axonogenesis GO:0007409 152 0.357
Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.355
regulation of macromolecule biosynthetic process GO:0010556 225 0.352
Human Zebrafish Mouse Fly
regulation of multicellular organismal process GO:0051239 277 0.347
Zebrafish Mouse Fly
regulation of binding GO:0051098 3 0.347
negative regulation of cell communication GO:0010648 96 0.339
Human Mouse Fly
neural tube development GO:0021915 62 0.331
cellular component movement GO:0006928 335 0.328
Zebrafish Fly
forebrain development GO:0030900 96 0.326
ectodermal placode morphogenesis GO:0071697 32 0.325
Zebrafish
cellular protein modification process GO:0006464 100 0.324
Human Mouse
heterocycle metabolic process GO:0046483 290 0.323
Human Zebrafish Fly
eye morphogenesis GO:0048592 144 0.322
circulatory system process GO:0003013 87 0.298
Mouse
regulation of response to stimulus GO:0048583 269 0.294
Human Zebrafish Mouse Fly
larval development GO:0002164 2 0.289
Worm Fly
blood vessel development GO:0001568 246 0.288
Zebrafish Mouse
negative regulation of biological process GO:0048519 304 0.279
Human Zebrafish Mouse Fly
cellular protein metabolic process GO:0044267 129 0.278
Human Mouse
stem cell maintenance GO:0019827 4 0.274
Fly
positive regulation of gene expression GO:0010628 71 0.272
Zebrafish
regulation of metabolic process GO:0019222 359 0.267
Human Zebrafish Mouse Fly
central nervous system development GO:0007417 387 0.255
dorsal ventral pattern formation GO:0009953 125 0.252
Zebrafish
regulation of cell communication GO:0010646 232 0.248
Human Zebrafish Mouse Fly
enzyme linked receptor protein signaling pathway GO:0007167 106 0.246
Human Zebrafish Mouse Fly
signal transduction GO:0007165 455 0.243
Human Zebrafish Mouse Fly
negative regulation of kinase activity GO:0033673 4 0.242
cell part morphogenesis GO:0032990 246 0.242
Fly
negative regulation of signal transduction GO:0009968 94 0.239
Human Mouse Fly
positive regulation of cellular metabolic process GO:0031325 94 0.236
Human Zebrafish
axon development GO:0061564 166 0.235
Fly
hatching gland development GO:0048785 3 0.227
negative regulation of bmp signaling pathway GO:0030514 13 0.226
Human Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.225
Zebrafish
regulation of cellular response to growth factor stimulus GO:0090287 35 0.224
Human Fly
cellular response to organic substance GO:0071310 105 0.219
Human Mouse Fly
regulation of apoptotic process GO:0042981 98 0.210
regulation of anatomical structure morphogenesis GO:0022603 130 0.209
Zebrafish
regulation of neurogenesis GO:0050767 87 0.209
response to chemical GO:0042221 320 0.207
Human Mouse Fly
gland development GO:0048732 143 0.207
camera type eye development GO:0043010 222 0.206
positive regulation of epithelial cell differentiation GO:0030858 2 0.200
regulation of developmental process GO:0050793 247 0.200
Zebrafish Fly
connective tissue development GO:0061448 99 0.197
nuclear transport GO:0051169 4 0.197
regulation of cellular metabolic process GO:0031323 320 0.189
Human Zebrafish Mouse Fly
locomotion GO:0040011 313 0.188
Zebrafish Fly
retina development in camera type eye GO:0060041 146 0.184
positive regulation of cellular biosynthetic process GO:0031328 68 0.183
Zebrafish
heart development GO:0007507 313 0.179
Zebrafish Mouse
positive regulation of biological process GO:0048518 253 0.175
Human Zebrafish Mouse
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.173
macromolecular complex subunit organization GO:0043933 74 0.169
cell surface receptor signaling pathway GO:0007166 325 0.168
Human Zebrafish Mouse Fly
ectodermal placode development GO:0071696 37 0.163
Zebrafish
positive regulation of cellular process GO:0048522 201 0.161
Human Zebrafish Mouse
neuron projection morphogenesis GO:0048812 161 0.153
Fly
neuron differentiation GO:0030182 353 0.152
Fly
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.149
Human Zebrafish
positive regulation of programmed cell death GO:0043068 29 0.148
death GO:0016265 121 0.146
vasculature development GO:0001944 278 0.144
Zebrafish Mouse
transcription from rna polymerase ii promoter GO:0006366 80 0.142
Human Zebrafish Fly
blood vessel morphogenesis GO:0048514 216 0.141
Zebrafish Mouse
immune system process GO:0002376 241 0.140
Zebrafish
positive regulation of nucleic acid templated transcription GO:1903508 57 0.139
Zebrafish
regulation of programmed cell death GO:0043067 101 0.139
embryonic skeletal system development GO:0048706 97 0.135
negative regulation of cellular metabolic process GO:0031324 77 0.134
Human Zebrafish Mouse
cell migration GO:0016477 237 0.133
Zebrafish Fly
otic vesicle formation GO:0030916 27 0.131
Zebrafish
amine metabolic process GO:0009308 2 0.131
negative regulation of protein phosphorylation GO:0001933 4 0.130
Human Mouse
cell projection organization GO:0030030 284 0.129
Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.128
Human Zebrafish Fly
muscle structure development GO:0061061 196 0.127
Mouse Fly
myotube cell development GO:0014904 35 0.126
regulation of cell proliferation GO:0042127 37 0.126
positive regulation of macromolecule metabolic process GO:0010604 93 0.124
Human Zebrafish
skeletal system morphogenesis GO:0048705 102 0.124
morphogenesis of an epithelium GO:0002009 333 0.122
Zebrafish Fly
intracellular signal transduction GO:0035556 85 0.121
Human Zebrafish Fly
neuron development GO:0048666 262 0.118
Fly
specification of symmetry GO:0009799 204 0.117
Zebrafish
cellular response to chemical stimulus GO:0070887 157 0.117
Human Mouse Fly
response to external stimulus GO:0009605 264 0.116
Worm Fly
generation of neurons GO:0048699 385 0.116
Fly
embryonic organ development GO:0048568 381 0.114
Zebrafish
embryonic organ morphogenesis GO:0048562 274 0.113
Zebrafish
localization of cell GO:0051674 244 0.112
Zebrafish Fly
negative regulation of cell proliferation GO:0008285 8 0.110
cell growth GO:0016049 57 0.110
Fly
muscle tissue development GO:0060537 110 0.108
Mouse
negative regulation of phosphate metabolic process GO:0045936 13 0.108
Human Mouse
positive regulation of transcription dna templated GO:0045893 57 0.107
Zebrafish
gene expression GO:0010467 252 0.107
Human Zebrafish Fly
angiogenesis GO:0001525 158 0.107
wnt signaling pathway GO:0016055 80 0.104
negative regulation of protein kinase activity GO:0006469 4 0.103
otic vesicle morphogenesis GO:0071600 34 0.103
Zebrafish
ectodermal placode formation GO:0060788 26 0.102
Zebrafish
embryonic cranial skeleton morphogenesis GO:0048701 90 0.101
cartilage development GO:0051216 96 0.099
protein metabolic process GO:0019538 183 0.096
Human Mouse
regulation of proteolysis GO:0030162 24 0.095
Human
protein localization to nucleus GO:0034504 3 0.093
gastrulation GO:0007369 208 0.092
Zebrafish
melanocyte differentiation GO:0030318 26 0.092
retina morphogenesis in camera type eye GO:0060042 79 0.091
response to organic substance GO:0010033 153 0.091
Human Mouse Fly
negative regulation of macromolecule metabolic process GO:0010605 76 0.091
Human Zebrafish Mouse
response to growth factor GO:0070848 39 0.090
Human Mouse Fly
negative regulation of metabolic process GO:0009892 86 0.089
Human Zebrafish Mouse
regulation of axonogenesis GO:0050770 32 0.088
negative regulation of rna metabolic process GO:0051253 48 0.087
Human Zebrafish
stem cell development GO:0048864 82 0.086
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.085
Human Zebrafish
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.083
Human Zebrafish Mouse Fly
response to stress GO:0006950 263 0.083
Human
enteric nervous system development GO:0048484 12 0.083
regulation of neuron differentiation GO:0045664 56 0.082
phosphorylation GO:0016310 69 0.082
Human Mouse Fly
regulation of signal transduction GO:0009966 225 0.080
Human Zebrafish Mouse Fly
regulation of catalytic activity GO:0050790 55 0.079
Human
collagen metabolic process GO:0032963 2 0.079
hindbrain development GO:0030902 91 0.079
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.079
Human Zebrafish
ganglion development GO:0061548 5 0.076
palate development GO:0060021 8 0.075
Zebrafish
regulation of cell death GO:0010941 103 0.075
negative regulation of cell cycle GO:0045786 14 0.075
negative regulation of developmental process GO:0051093 65 0.075
Fly
single organism nuclear import GO:1902593 3 0.074
retina layer formation GO:0010842 24 0.074
negative regulation of catalytic activity GO:0043086 21 0.074
Human
positive regulation of apoptotic process GO:0043065 29 0.073
regulation of nervous system development GO:0051960 90 0.072
Fly
cell projection morphogenesis GO:0048858 244 0.071
Fly
apoptotic process GO:0006915 116 0.070
negative regulation of transcription dna templated GO:0045892 45 0.069
Human Zebrafish
homeostatic process GO:0042592 142 0.069
macromolecule modification GO:0043412 111 0.068
Human Mouse
bmp signaling pathway GO:0030509 52 0.067
Human Zebrafish Mouse Fly
cellular amine metabolic process GO:0044106 2 0.066
protein targeting to nucleus GO:0044744 3 0.066
stem cell differentiation GO:0048863 117 0.066
Fly
determination of left right symmetry GO:0007368 179 0.064
Zebrafish
immune response GO:0006955 28 0.064
somatic stem cell maintenance GO:0035019 1 0.064
developmental growth GO:0048589 166 0.063
Fly
cellular component morphogenesis GO:0032989 336 0.063
Fly
cell proliferation GO:0008283 80 0.063
primary neural tube formation GO:0014020 1 0.063
lateral inhibition GO:0046331 1 0.063
positive regulation of metabolic process GO:0009893 108 0.062
Human Zebrafish
behavior GO:0007610 74 0.062
Worm
axon guidance GO:0007411 86 0.062
Fly
skeletal system development GO:0001501 181 0.061
signal transduction by p53 class mediator GO:0072331 13 0.060
regulation of epithelial to mesenchymal transition GO:0010717 3 0.060
cell morphogenesis GO:0000902 289 0.060
Fly
regulation of cellular protein metabolic process GO:0032268 52 0.060
Human Mouse
central nervous system myelin formation GO:0032289 1 0.060
negative regulation of nucleic acid templated transcription GO:1903507 45 0.059
Human Zebrafish
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.059
Fly
nephron morphogenesis GO:0072028 2 0.059
convergent extension GO:0060026 118 0.059
Zebrafish
photoreceptor cell differentiation GO:0046530 55 0.058
cell cycle arrest GO:0007050 1 0.058
cellular protein catabolic process GO:0044257 4 0.058
Human
regulation of protein metabolic process GO:0051246 56 0.057
Human Mouse
positive regulation of rna biosynthetic process GO:1902680 57 0.056
Zebrafish
hemopoiesis GO:0030097 183 0.056
Zebrafish
epidermal cell differentiation GO:0009913 36 0.056
lens morphogenesis in camera type eye GO:0002089 7 0.055
regulation of canonical wnt signaling pathway GO:0060828 34 0.055
epidermal cell fate specification GO:0009957 4 0.054
regulation of biomineral tissue development GO:0070167 2 0.054
negative regulation of signaling GO:0023057 96 0.054
Human Mouse Fly
heart morphogenesis GO:0003007 156 0.054
Zebrafish Mouse
defense response GO:0006952 47 0.053
regulation of epithelial cell proliferation GO:0050678 3 0.053
determination of ventral identity GO:0048264 21 0.053
Zebrafish
neuroblast proliferation GO:0007405 2 0.053
female gonad development GO:0008585 4 0.053
central nervous system neuron differentiation GO:0021953 74 0.052
somite development GO:0061053 96 0.052
digestive system development GO:0055123 289 0.052
Zebrafish Fly
regulation of cellular ketone metabolic process GO:0010565 7 0.051
positive regulation of cell differentiation GO:0045597 30 0.051
Zebrafish
single organism metabolic process GO:0044710 217 0.051
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.051
skin development GO:0043588 54 0.050
positive regulation of developmental process GO:0051094 50 0.050
Zebrafish
neural plate regionalization GO:0060897 10 0.049
skeletal muscle fiber development GO:0048741 35 0.049
female sex differentiation GO:0046660 4 0.049
peripheral nervous system development GO:0007422 55 0.048
regulation of cell shape GO:0008360 1 0.047
ossification GO:0001503 23 0.047
hematopoietic or lymphoid organ development GO:0048534 191 0.047
Zebrafish
growth GO:0040007 174 0.046
Fly
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.046
sex determination GO:0007530 1 0.046
embryonic heart tube development GO:0035050 133 0.045
Zebrafish
regulation of wnt signaling pathway GO:0030111 53 0.045
negative regulation of wnt signaling pathway GO:0030178 30 0.045
regulation of cytokine production GO:0001817 3 0.045
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.044
Human
nucleocytoplasmic transport GO:0006913 4 0.044
brain morphogenesis GO:0048854 18 0.043
regulation of signal transduction by p53 class mediator GO:1901796 9 0.043
protein modification process GO:0036211 100 0.043
Human Mouse
positive regulation of response to stimulus GO:0048584 80 0.043
regulation of biological quality GO:0065008 263 0.043
Human Fly
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.043
Human Mouse Fly
striated muscle tissue development GO:0014706 110 0.042
Mouse
positive regulation of rna metabolic process GO:0051254 59 0.042
Zebrafish
neural plate pattern specification GO:0060896 12 0.041
motor neuron axon guidance GO:0008045 23 0.041
neuron projection guidance GO:0097485 86 0.041
Fly
regulation of growth GO:0040008 42 0.041
Fly
regulation of cell cycle GO:0051726 52 0.041
regulation of phosphorus metabolic process GO:0051174 43 0.041
Human Mouse Fly
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.040
photoreceptor cell fate commitment GO:0046552 1 0.040
chemotaxis GO:0006935 104 0.040
Fly
cell cycle GO:0007049 93 0.040
regulation of cellular amino acid metabolic process GO:0006521 0 0.040
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.039
cell migration involved in gastrulation GO:0042074 79 0.039
Zebrafish
retinal ganglion cell axon guidance GO:0031290 35 0.039
Fly
regulation of phosphate metabolic process GO:0019220 43 0.039
Human Mouse Fly
embryonic eye morphogenesis GO:0048048 30 0.039
establishment of protein localization to organelle GO:0072594 4 0.038
neural crest cell differentiation GO:0014033 72 0.038
sister chromatid cohesion GO:0007062 2 0.038
protein import into nucleus GO:0006606 3 0.038
cranial ganglion development GO:0061550 3 0.037
phosphate containing compound metabolic process GO:0006796 108 0.037
Human Mouse Fly
negative regulation of apoptotic process GO:0043066 55 0.037
positive regulation of endothelial cell differentiation GO:0045603 2 0.037
negative regulation of response to stimulus GO:0048585 104 0.036
Human Mouse Fly
neuroepithelial cell differentiation GO:0060563 26 0.036
startle response GO:0001964 4 0.036
muscle organ development GO:0007517 101 0.035
Mouse Fly
positive regulation of cellular component biogenesis GO:0044089 3 0.035
cellular amino acid metabolic process GO:0006520 7 0.035
cell cycle process GO:0022402 53 0.035
glucose homeostasis GO:0042593 1 0.035
cellular response to extracellular stimulus GO:0031668 2 0.034
gliogenesis GO:0042063 45 0.034
regulation of organ growth GO:0046620 3 0.034
epithelial tube morphogenesis GO:0060562 148 0.034
Zebrafish Fly
determination of bilateral symmetry GO:0009855 204 0.034
Zebrafish
protein import GO:0017038 3 0.033
embryonic camera type eye development GO:0031076 29 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.033
Human
regulation of oocyte development GO:0060281 3 0.033
Zebrafish
nuclear import GO:0051170 3 0.033
cell cycle g1 s phase transition GO:0044843 1 0.033
negative regulation of epithelial cell proliferation GO:0050680 1 0.033
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.033
Human Zebrafish
cell death GO:0008219 121 0.032
epithelial cell differentiation GO:0030855 116 0.032
programmed cell death GO:0012501 119 0.032
synaptic growth at neuromuscular junction GO:0051124 2 0.032
Fly
regulation of response to nutrient levels GO:0032107 1 0.032
meiotic nuclear division GO:0007126 4 0.031
regulation of chondrocyte differentiation GO:0032330 1 0.031
fibroblast growth factor receptor signaling pathway GO:0008543 22 0.031
heart looping GO:0001947 94 0.031
Zebrafish
positive regulation of signal transduction GO:0009967 56 0.030
myotube differentiation GO:0014902 45 0.030
epidermis development GO:0008544 48 0.030
tube morphogenesis GO:0035239 349 0.030
Zebrafish Fly
embryonic camera type eye morphogenesis GO:0048596 19 0.030
determination of heart left right asymmetry GO:0061371 117 0.030
Zebrafish
blood circulation GO:0008015 87 0.030
Mouse
negative regulation of chromosome organization GO:2001251 1 0.030
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.029
regionalization GO:0003002 274 0.029
Zebrafish Fly
regulation of cell projection organization GO:0031344 44 0.028
positive regulation of cellular protein metabolic process GO:0032270 22 0.028
Human
cellular ketone metabolic process GO:0042180 11 0.028
regulation of protein binding GO:0043393 3 0.028
developmental programmed cell death GO:0010623 4 0.028
regulation of signaling GO:0023051 235 0.028
Human Zebrafish Mouse Fly
odontogenesis of dentin containing tooth GO:0042475 1 0.028
lens development in camera type eye GO:0002088 22 0.027
development of primary female sexual characteristics GO:0046545 4 0.027
rhythmic process GO:0048511 21 0.027
synaptic target recognition GO:0008039 1 0.027
small gtpase mediated signal transduction GO:0007264 8 0.027
regulation of cellular amine metabolic process GO:0033238 0 0.027
endoderm development GO:0007492 49 0.026
developmental cell growth GO:0048588 52 0.026
chromosome organization GO:0051276 31 0.026
hepaticobiliary system development GO:0061008 98 0.026
regulation of mapk cascade GO:0043408 14 0.025
multicellular organismal metabolic process GO:0044236 2 0.025
modification dependent macromolecule catabolic process GO:0043632 3 0.025
Human
cellular response to nutrient levels GO:0031669 2 0.025
positive regulation of cell communication GO:0010647 56 0.025
biomineral tissue development GO:0031214 13 0.025
protein modification by small protein conjugation or removal GO:0070647 14 0.025
Human
central nervous system myelination GO:0022010 2 0.025
tube closure GO:0060606 1 0.025
positive regulation of catabolic process GO:0009896 4 0.025
Human
fin development GO:0033333 77 0.025
regulation of erk1 and erk2 cascade GO:0070372 4 0.024
positive regulation of multicellular organismal process GO:0051240 52 0.024
Zebrafish
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.024
response to vitamin GO:0033273 3 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.024
Zebrafish
taxis GO:0042330 109 0.024
Fly
negative regulation of biosynthetic process GO:0009890 55 0.024
Human Zebrafish
guanosine containing compound catabolic process GO:1901069 2 0.024
negative regulation of intracellular signal transduction GO:1902532 22 0.024
urogenital system development GO:0001655 97 0.024
Mouse Fly
organic acid metabolic process GO:0006082 31 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.023
Human
neural precursor cell proliferation GO:0061351 20 0.023
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.023
Human Zebrafish Mouse Fly
negative regulation of mapk cascade GO:0043409 4 0.023
proteolysis GO:0006508 38 0.023
Human
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.023
Zebrafish
regulation of hydrolase activity GO:0051336 28 0.022
regulation of kinase activity GO:0043549 15 0.022
cell substrate adhesion GO:0031589 4 0.022
stem cell division GO:0017145 1 0.022
regulation of cell migration GO:0030334 40 0.022
negative regulation of molecular function GO:0044092 23 0.022
Human
negative regulation of cell development GO:0010721 26 0.022
oligodendrocyte development GO:0014003 7 0.022
positive regulation of cytoskeleton organization GO:0051495 3 0.022
negative regulation of rna biosynthetic process GO:1902679 45 0.022
Human Zebrafish
cell fate commitment GO:0045165 99 0.022
skeletal muscle organ development GO:0060538 78 0.022
nephron epithelium morphogenesis GO:0072088 1 0.022
positive regulation of signaling GO:0023056 56 0.022
regulation of skeletal muscle tissue development GO:0048641 4 0.021
optic placode formation involved in camera type eye formation GO:0046619 3 0.021
regulation of establishment of protein localization GO:0070201 4 0.021
maintenance of location GO:0051235 4 0.021
fin morphogenesis GO:0033334 53 0.021
myeloid cell development GO:0061515 32 0.021
Zebrafish
negative regulation of phosphorylation GO:0042326 6 0.021
Human Mouse
response to oxygen levels GO:0070482 25 0.021
regulation of intracellular signal transduction GO:1902531 57 0.021
axonal defasciculation GO:0007414 2 0.020
pigmentation GO:0043473 85 0.020
Worm
regulation of protein complex assembly GO:0043254 3 0.020
protein acylation GO:0043543 3 0.020
mitotic cell cycle GO:0000278 64 0.020
regulation of transferase activity GO:0051338 16 0.020
Human
regulation of bmp signaling pathway GO:0030510 39 0.020
Human Zebrafish Mouse
striated muscle cell differentiation GO:0051146 129 0.020
negative regulation of cell differentiation GO:0045596 46 0.020
Fly
mesenchyme development GO:0060485 127 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.020
multicellular organismal macromolecule metabolic process GO:0044259 2 0.020
single organism transport GO:0044765 206 0.019
meiotic cell cycle process GO:1903046 3 0.019
negative regulation of gene expression GO:0010629 65 0.019
Human Zebrafish
negative regulation of mitosis GO:0045839 3 0.019
regulation of cell motility GO:2000145 46 0.019
ovulation cycle GO:0042698 2 0.019
positive regulation of chromosome organization GO:2001252 1 0.019
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.019
developmental growth involved in morphogenesis GO:0060560 86 0.019
Fly
renal tubule morphogenesis GO:0061333 1 0.019
Fly
regulation of endothelial cell differentiation GO:0045601 3 0.019
cellular response to endogenous stimulus GO:0071495 68 0.019
Human Mouse Fly
embryonic viscerocranium morphogenesis GO:0048703 52 0.019
stem cell proliferation GO:0072089 4 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
protein destabilization GO:0031648 1 0.019
forebrain neuron fate commitment GO:0021877 1 0.019
otic vesicle development GO:0071599 42 0.019
Zebrafish
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.018
covalent chromatin modification GO:0016569 20 0.018
notch signaling pathway GO:0007219 35 0.018
immune system development GO:0002520 191 0.018
Zebrafish
adult behavior GO:0030534 2 0.018
positive regulation of cell death GO:0010942 29 0.018
mesenchymal cell development GO:0014031 78 0.018
negative regulation of cell cycle process GO:0010948 9 0.018
regulation of histone deacetylation GO:0031063 2 0.018
regulation of vascular permeability GO:0043114 5 0.018
regulation of bone mineralization GO:0030500 2 0.017
convergent extension involved in gastrulation GO:0060027 71 0.017
Zebrafish
positive regulation of immune system process GO:0002684 17 0.017
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.017
regulation of organ morphogenesis GO:2000027 35 0.017
Zebrafish
meiosis i GO:0007127 1 0.017
eye photoreceptor cell development GO:0042462 30 0.017
regulation of protein transport GO:0051223 3 0.017
response to abiotic stimulus GO:0009628 122 0.017
regulation of muscle organ development GO:0048634 9 0.017
Fly
appendage development GO:0048736 80 0.017
Fly
histone deacetylation GO:0016575 2 0.017
neurological system process GO:0050877 62 0.017
erk1 and erk2 cascade GO:0070371 4 0.017
cellular modified amino acid metabolic process GO:0006575 3 0.017
macromolecule catabolic process GO:0009057 15 0.017
Human
smoothened signaling pathway GO:0007224 30 0.017
negative regulation of map kinase activity GO:0043407 2 0.017
positive regulation of neurogenesis GO:0050769 24 0.016
positive regulation of protein metabolic process GO:0051247 23 0.016
Human
regulation of ossification GO:0030278 5 0.016
chromatin organization GO:0006325 22 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
regulation of phosphorylation GO:0042325 26 0.016
Human Mouse Fly
bone morphogenesis GO:0060349 11 0.016
regulation of system process GO:0044057 40 0.016
Mouse
digestive tract development GO:0048565 265 0.016
Zebrafish Fly
regulation of cellular component organization GO:0051128 86 0.016
Fly
regulation of skeletal muscle fiber development GO:0048742 2 0.016
regulation of gastrulation GO:0010470 24 0.016
regulation of carbohydrate metabolic process GO:0006109 4 0.016
negative regulation of programmed cell death GO:0043069 58 0.015
regulation of localization GO:0032879 104 0.015
nephron tubule morphogenesis GO:0072078 1 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
endothelial cell migration GO:0043542 19 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
positive regulation of apoptotic signaling pathway GO:2001235 1 0.015
positive regulation of cell cycle GO:0045787 3 0.015
cellular localization GO:0051641 97 0.015
Human
positive regulation of glial cell differentiation GO:0045687 1 0.015
embryonic limb morphogenesis GO:0030326 2 0.015
negative regulation of mitotic cell cycle GO:0045930 11 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.015
nose development GO:0043584 3 0.015

smad7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.022
bone disease DOID:0080001 0 0.022
disease of anatomical entity DOID:7 0 0.022
dysostosis DOID:1934 0 0.022
musculoskeletal system disease DOID:17 0 0.022
connective tissue disease DOID:65 0 0.022