Danio rerio

31 known processes

crb3a

crumbs homolog 3a

crb3a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
apical protein localization GO:0045176 6 0.594
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.551
medulla oblongata development GO:0021550 4 0.516
eye development GO:0001654 277 0.362
brain development GO:0007420 293 0.250
cilium assembly GO:0042384 58 0.237
cilium morphogenesis GO:0060271 85 0.226
eye photoreceptor cell development GO:0042462 30 0.214
asymmetric protein localization GO:0008105 6 0.209
regulation of cell communication GO:0010646 232 0.203
detection of visible light GO:0009584 12 0.196
cell surface receptor signaling pathway GO:0007166 325 0.191
cilium organization GO:0044782 71 0.184
signal transduction GO:0007165 455 0.178
wnt signaling pathway GO:0016055 80 0.175
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.162
renal system development GO:0072001 94 0.146
eye morphogenesis GO:0048592 144 0.139
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules GO:0007157 2 0.138
morphogenesis of an epithelium GO:0002009 333 0.137
retina development in camera type eye GO:0060041 146 0.134
single organism organelle organization GO:1902589 199 0.133
neuron development GO:0048666 262 0.132
cellular response to radiation GO:0071478 4 0.131
visual perception GO:0007601 17 0.129
regulation of signaling GO:0023051 235 0.126
negative regulation of signaling GO:0023057 96 0.125
camera type eye development GO:0043010 222 0.124
glomerulus development GO:0032835 27 0.116
swim bladder development GO:0048794 19 0.112
photoreceptor cell development GO:0042461 40 0.110
response to drug GO:0042493 3 0.110
regulation of signal transduction GO:0009966 225 0.109
sensory organ development GO:0007423 393 0.108
cell projection assembly GO:0030031 64 0.107
negative regulation of biological process GO:0048519 304 0.107
negative regulation of cell communication GO:0010648 96 0.105
pronephros development GO:0048793 69 0.105
cellular macromolecule metabolic process GO:0044260 391 0.105
regulation of canonical wnt signaling pathway GO:0060828 34 0.100
digestive tract morphogenesis GO:0048546 231 0.099
neurological system process GO:0050877 62 0.099
nephron development GO:0072006 31 0.096
photoreceptor cell differentiation GO:0046530 55 0.096
head development GO:0060322 303 0.095
renal system process GO:0003014 14 0.094
cell morphogenesis GO:0000902 289 0.093
phototransduction GO:0007602 2 0.093
establishment or maintenance of apical basal cell polarity GO:0035088 12 0.092
g protein coupled receptor signaling pathway GO:0007186 74 0.087
cellular component assembly involved in morphogenesis GO:0010927 107 0.086
cellular component biogenesis GO:0044085 178 0.085
cell projection organization GO:0030030 284 0.083
single organismal cell cell adhesion GO:0016337 29 0.081
system process GO:0003008 185 0.075
organelle assembly GO:0070925 110 0.072
protein metabolic process GO:0019538 183 0.071
rhodopsin mediated signaling pathway GO:0016056 1 0.067
aging GO:0007568 2 0.065
urogenital system development GO:0001655 97 0.064
canonical wnt signaling pathway GO:0060070 48 0.061
organelle organization GO:0006996 227 0.060
cellular response to light stimulus GO:0071482 4 0.057
central nervous system development GO:0007417 387 0.057
neuron differentiation GO:0030182 353 0.057
negative regulation of signal transduction GO:0009968 94 0.056
digestive system development GO:0055123 289 0.056
light induced release of internally sequestered calcium ion GO:0008377 1 0.053
maintenance of location GO:0051235 4 0.053
negative regulation of cellular process GO:0048523 283 0.053
organic anion transport GO:0015711 15 0.052
renal filtration GO:0097205 10 0.051
cell projection morphogenesis GO:0048858 244 0.051
retina morphogenesis in camera type eye GO:0060042 79 0.050
regulation of response to stimulus GO:0048583 269 0.050
cellular component morphogenesis GO:0032989 336 0.050
negative regulation of response to stimulus GO:0048585 104 0.049
generation of neurons GO:0048699 385 0.049
sensory organ morphogenesis GO:0090596 200 0.046
cell part morphogenesis GO:0032990 246 0.045
regulation of wnt signaling pathway GO:0030111 53 0.045
regulation of stem cell differentiation GO:2000736 4 0.043
regulation of multicellular organism growth GO:0040014 4 0.042
regulation of biological quality GO:0065008 263 0.042
muscle structure development GO:0061061 196 0.042
heterocycle biosynthetic process GO:0018130 215 0.041
proteasomal protein catabolic process GO:0010498 2 0.041
cellular response to extracellular stimulus GO:0031668 2 0.040
establishment of localization GO:0051234 244 0.040
cell cell adhesion GO:0098609 6 0.040
locomotion GO:0040011 313 0.040
kidney development GO:0001822 92 0.038
phototransduction visible light GO:0007603 2 0.037
notch signaling pathway GO:0007219 35 0.037
striated muscle cell differentiation GO:0051146 129 0.037
multicellular organismal homeostasis GO:0048871 29 0.037
sensory perception of light stimulus GO:0050953 19 0.036
smoothened signaling pathway GO:0007224 30 0.036
glomerular filtration GO:0003094 6 0.035
multicellular organism growth GO:0035264 4 0.035
biological adhesion GO:0022610 40 0.035
cellular component assembly GO:0022607 170 0.035
cellular response to external stimulus GO:0071496 2 0.035
cellular response to nutrient levels GO:0031669 2 0.034
regulation of macromolecule metabolic process GO:0060255 317 0.034
cellular nitrogen compound biosynthetic process GO:0044271 218 0.034
muscle cell differentiation GO:0042692 139 0.034
regulation of metabolic process GO:0019222 359 0.034
regulation of binding GO:0051098 3 0.033
cellular component disassembly GO:0022411 1 0.033
liver development GO:0001889 96 0.032
phosphorus metabolic process GO:0006793 109 0.032
positive regulation of cellular process GO:0048522 201 0.032
heterocycle metabolic process GO:0046483 290 0.032
ion transport GO:0006811 114 0.032
cognition GO:0050890 1 0.032
cell motility GO:0048870 244 0.031
single organism transport GO:0044765 206 0.031
regulation of muscle contraction GO:0006937 3 0.031
positive regulation of cellular component biogenesis GO:0044089 3 0.031
muscle cell development GO:0055001 115 0.031
cellular component movement GO:0006928 335 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.030
embryonic heart tube development GO:0035050 133 0.030
digestive tract development GO:0048565 265 0.030
detection of abiotic stimulus GO:0009582 24 0.030
negative regulation of wnt signaling pathway GO:0030178 30 0.029
eye photoreceptor cell differentiation GO:0001754 45 0.029
neurotransmitter secretion GO:0007269 2 0.029
regulation of establishment of protein localization GO:0070201 4 0.029
regulation of carbohydrate metabolic process GO:0006109 4 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.028
aromatic compound biosynthetic process GO:0019438 217 0.028
determination of bilateral symmetry GO:0009855 204 0.027
regulation of primary metabolic process GO:0080090 311 0.027
macromolecule modification GO:0043412 111 0.027
response to abiotic stimulus GO:0009628 122 0.027
camera type eye morphogenesis GO:0048593 108 0.026
regulation of response to nutrient levels GO:0032107 1 0.026
cell migration GO:0016477 237 0.026
regulation of molecular function GO:0065009 70 0.026
cellular nitrogen compound metabolic process GO:0034641 290 0.026
single organism metabolic process GO:0044710 217 0.025
compound eye development GO:0048749 2 0.025
regulation of protein binding GO:0043393 3 0.025
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.025
cellular response to starvation GO:0009267 1 0.025
nitrogen compound metabolic process GO:0006807 319 0.024
carbon dioxide transport GO:0015670 3 0.024
apoptotic process GO:0006915 116 0.024
nucleocytoplasmic transport GO:0006913 4 0.024
ubiquitin dependent protein catabolic process GO:0006511 3 0.024
protein secretion GO:0009306 1 0.024
establishment of synaptic vesicle localization GO:0097480 1 0.024
hormone transport GO:0009914 2 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.024
positive regulation of cell cycle GO:0045787 3 0.024
cellular aromatic compound metabolic process GO:0006725 295 0.023
regulation of neurotransmitter transport GO:0051588 1 0.022
transport GO:0006810 220 0.022
gland development GO:0048732 143 0.022
actin polymerization or depolymerization GO:0008154 2 0.022
response to external stimulus GO:0009605 264 0.022
establishment or maintenance of cell polarity GO:0007163 29 0.022
vasculature development GO:0001944 278 0.022
immune system process GO:0002376 241 0.022
cell substrate adherens junction assembly GO:0007045 1 0.022
localization of cell GO:0051674 244 0.022
regulation of cellular metabolic process GO:0031323 320 0.022
cellular protein catabolic process GO:0044257 4 0.022
adult behavior GO:0030534 2 0.021
regulation of hormone secretion GO:0046883 2 0.021
biosynthetic process GO:0009058 294 0.021
synaptic vesicle localization GO:0097479 1 0.021
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.021
neural nucleus development GO:0048857 15 0.021
embryonic organ development GO:0048568 381 0.021
regulation of cellular protein metabolic process GO:0032268 52 0.021
gastrulation GO:0007369 208 0.021
response to light stimulus GO:0009416 46 0.021
positive regulation of catabolic process GO:0009896 4 0.021
response to inorganic substance GO:0010035 38 0.021
detection of stimulus GO:0051606 29 0.021
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 11 0.021
protein polymerization GO:0051258 4 0.021
photoreceptor cell outer segment organization GO:0035845 9 0.021
adherens junction organization GO:0034332 4 0.020
positive regulation of transport GO:0051050 2 0.020
programmed cell death GO:0012501 119 0.020
cellular response to molecule of bacterial origin GO:0071219 3 0.020
neurotransmitter transport GO:0006836 2 0.020
regulation of protein complex assembly GO:0043254 3 0.020
regulation of nitrogen compound metabolic process GO:0051171 251 0.020
nuclear transport GO:0051169 4 0.020
protein import into nucleus GO:0006606 3 0.020
chemotaxis GO:0006935 104 0.020
response to uv GO:0009411 3 0.020
response to monosaccharide GO:0034284 3 0.019
macromolecule localization GO:0033036 54 0.019
gene expression GO:0010467 252 0.019
response to chemical GO:0042221 320 0.019
protein import GO:0017038 3 0.019
organonitrogen compound metabolic process GO:1901564 74 0.019
protein complex disassembly GO:0043241 1 0.019
exocytosis GO:0006887 1 0.019
peptidyl serine phosphorylation GO:0018105 1 0.019
positive regulation of cellular catabolic process GO:0031331 3 0.019
positive regulation of epithelial cell migration GO:0010634 2 0.018
amino acid transport GO:0006865 2 0.018
sequestering of calcium ion GO:0051208 3 0.018
negative regulation of protein phosphorylation GO:0001933 4 0.018
organic cyclic compound metabolic process GO:1901360 301 0.018
regulation of cell activation GO:0050865 1 0.018
regulation of gene expression GO:0010468 265 0.018
positive regulation of secretion by cell GO:1903532 1 0.018
cell matrix adhesion GO:0007160 4 0.018
sequestering of metal ion GO:0051238 3 0.018
establishment of endothelial barrier GO:0061028 3 0.017
single organism nuclear import GO:1902593 3 0.017
positive regulation of protein complex assembly GO:0031334 2 0.017
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.017
regulation of protein transport GO:0051223 3 0.017
modification dependent macromolecule catabolic process GO:0043632 3 0.017
positive regulation of cell matrix adhesion GO:0001954 1 0.017
epithelial cell morphogenesis GO:0003382 2 0.017
nucleic acid metabolic process GO:0090304 244 0.017
heart morphogenesis GO:0003007 156 0.017
homeostasis of number of cells within a tissue GO:0048873 4 0.017
chordate embryonic development GO:0043009 271 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
regulation of tube size GO:0035150 2 0.017
establishment of protein localization to organelle GO:0072594 4 0.017
single organism cell adhesion GO:0098602 29 0.017
protein localization to plasma membrane GO:0072659 1 0.016
positive regulation of secretion GO:0051047 1 0.016
sensory perception GO:0007600 39 0.016
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.016
positive regulation of biological process GO:0048518 253 0.016
heart development GO:0007507 313 0.016
determination of heart left right asymmetry GO:0061371 117 0.016
cation transport GO:0006812 81 0.016
guanosine containing compound catabolic process GO:1901069 2 0.016
cell substrate adhesion GO:0031589 4 0.016
response to hexose GO:0009746 3 0.016
transmembrane transport GO:0055085 120 0.016
determination of left right symmetry GO:0007368 179 0.016
ion transmembrane transport GO:0034220 91 0.016
myelination in peripheral nervous system GO:0022011 4 0.016
rna metabolic process GO:0016070 219 0.016
hematopoietic or lymphoid organ development GO:0048534 191 0.016
protein complex localization GO:0031503 1 0.016
macromolecular complex subunit organization GO:0043933 74 0.016
hepaticobiliary system development GO:0061008 98 0.016
regulation of localization GO:0032879 104 0.016
regulation of epithelial cell proliferation GO:0050678 3 0.016
positive regulation of cell communication GO:0010647 56 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
hemopoiesis GO:0030097 183 0.016
cell aging GO:0007569 2 0.016
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
protein localization GO:0008104 40 0.016
embryonic organ morphogenesis GO:0048562 274 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
myeloid cell differentiation GO:0030099 86 0.015
maintenance of epithelial cell apical basal polarity GO:0045199 5 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
gas transport GO:0015669 3 0.015
regulation of apoptotic process GO:0042981 98 0.015
peptide transport GO:0015833 1 0.015
mononuclear cell proliferation GO:0032943 1 0.015
monoamine transport GO:0015844 1 0.015
regulation of blood vessel size GO:0050880 2 0.015
tissue homeostasis GO:0001894 25 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
cell adhesion GO:0007155 40 0.015
nuclear import GO:0051170 3 0.015
response to topologically incorrect protein GO:0035966 2 0.015
long chain fatty acid metabolic process GO:0001676 1 0.015
larval development GO:0002164 2 0.015
positive regulation of cell substrate adhesion GO:0010811 1 0.015
alpha amino acid metabolic process GO:1901605 3 0.015
organic substance biosynthetic process GO:1901576 289 0.015
regulation of sequestering of calcium ion GO:0051282 4 0.015
synaptic vesicle transport GO:0048489 1 0.015
establishment of localization in cell GO:0051649 77 0.015
angiogenesis GO:0001525 158 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
light absorption GO:0016037 2 0.014
neural tube formation GO:0001841 16 0.014
gtp catabolic process GO:0006184 2 0.014
regulation of protein complex disassembly GO:0043244 1 0.014
polarized epithelial cell differentiation GO:0030859 4 0.014
carbohydrate homeostasis GO:0033500 1 0.014
locomotor rhythm GO:0045475 3 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.014
amine metabolic process GO:0009308 2 0.014
macromolecular complex disassembly GO:0032984 1 0.014
protein targeting to nucleus GO:0044744 3 0.014
positive regulation of cell division GO:0051781 2 0.014
regulation of sodium ion transport GO:0002028 2 0.014
blood circulation GO:0008015 87 0.014
phagocytosis GO:0006909 3 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
histone h3 k4 methylation GO:0051568 2 0.014
immune system development GO:0002520 191 0.014
neuronal stem cell maintenance GO:0097150 2 0.013
muscle organ development GO:0007517 101 0.013
cellular localization GO:0051641 97 0.013
protein localization to nucleus GO:0034504 3 0.013
rna biosynthetic process GO:0032774 181 0.013
regulation of protein targeting GO:1903533 2 0.013
regulation of circadian rhythm GO:0042752 4 0.013
regulation of calcium ion transport GO:0051924 2 0.013
cellular response to organic substance GO:0071310 105 0.013
phosphorylation GO:0016310 69 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
embryonic skeletal system development GO:0048706 97 0.013
circulatory system process GO:0003013 87 0.013
entrainment of circadian clock by photoperiod GO:0043153 1 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
establishment or maintenance of polarity of embryonic epithelium GO:0016332 2 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
regulation of notch signaling pathway GO:0008593 16 0.013
hindbrain development GO:0030902 91 0.013
regulation of cell death GO:0010941 103 0.013
response to transition metal nanoparticle GO:1990267 28 0.013
cellular response to xenobiotic stimulus GO:0071466 35 0.013
organelle fusion GO:0048284 3 0.013
tube morphogenesis GO:0035239 349 0.013
regulation of autophagy GO:0010506 3 0.013
positive regulation of blood circulation GO:1903524 2 0.013
developmental growth involved in morphogenesis GO:0060560 86 0.012
small molecule metabolic process GO:0044281 77 0.012
rhythmic process GO:0048511 21 0.012
negative regulation of cytokine production GO:0001818 1 0.012
actin mediated cell contraction GO:0070252 1 0.012
negative regulation of cell death GO:0060548 60 0.012
regulation of metal ion transport GO:0010959 4 0.012
regulation of cell differentiation GO:0045595 142 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.012
embryonic limb morphogenesis GO:0030326 2 0.012
smooth muscle contraction GO:0006939 2 0.012
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.012
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
response to radiation GO:0009314 51 0.012
negative regulation of kinase activity GO:0033673 4 0.012
peptidyl serine modification GO:0018209 2 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.012
skeletal system morphogenesis GO:0048705 102 0.012
response to glucose GO:0009749 3 0.012
regulation of membrane potential GO:0042391 23 0.012
actin filament based movement GO:0030048 1 0.012
circadian sleep wake cycle sleep GO:0050802 1 0.012
regulation of reproductive process GO:2000241 4 0.012
spermatid differentiation GO:0048515 2 0.012
neuroblast proliferation GO:0007405 2 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
response to light intensity GO:0009642 1 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
macromolecule biosynthetic process GO:0009059 227 0.012
hormone secretion GO:0046879 2 0.012
adherens junction assembly GO:0034333 1 0.012
cellular protein complex disassembly GO:0043624 1 0.012
circadian sleep wake cycle GO:0042745 2 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
regulation of protein localization to nucleus GO:1900180 2 0.011
protein depolymerization GO:0051261 1 0.011
signal transduction in absence of ligand GO:0038034 1 0.011
peptidyl threonine modification GO:0018210 1 0.011
stem cell proliferation GO:0072089 4 0.011
autophagy GO:0006914 4 0.011
glial cell proliferation GO:0014009 4 0.011
positive regulation of wnt signaling pathway GO:0030177 13 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
striated muscle cell development GO:0055002 108 0.011
cell death GO:0008219 121 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.011
response to stress GO:0006950 263 0.011
positive regulation of synapse assembly GO:0051965 1 0.011
morphogenesis of an epithelial sheet GO:0002011 49 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
regulation of blood pressure GO:0008217 1 0.011
regulation of endothelial cell proliferation GO:0001936 1 0.011
cell substrate junction assembly GO:0007044 2 0.011
regulation of myotube differentiation GO:0010830 2 0.011
actin filament polymerization GO:0030041 2 0.011
positive regulation of cytokine production GO:0001819 2 0.011
positive regulation of inflammatory response GO:0050729 1 0.011
cellular biosynthetic process GO:0044249 286 0.011
positive regulation of glucose transport GO:0010828 1 0.011
b cell activation GO:0042113 2 0.011
multicellular organismal signaling GO:0035637 22 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
chemosensory behavior GO:0007635 1 0.011
establishment of blood brain barrier GO:0060856 2 0.011
muscle organ morphogenesis GO:0048644 8 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
response to alkaloid GO:0043279 2 0.011
cellular protein modification process GO:0006464 100 0.011
regionalization GO:0003002 274 0.011
single organism biosynthetic process GO:0044711 71 0.011
centrosome organization GO:0051297 1 0.011
neuron neuron synaptic transmission GO:0007270 1 0.011
positive regulation of metabolic process GO:0009893 108 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
regulation of intracellular protein transport GO:0033157 3 0.010
inner ear development GO:0048839 126 0.010
positive regulation of protein polymerization GO:0032273 2 0.010
anatomical structure homeostasis GO:0060249 36 0.010
nuclear migration GO:0007097 3 0.010
negative regulation of notch signaling pathway GO:0045746 6 0.010
skeletal system development GO:0001501 181 0.010
regulation of protein polymerization GO:0032271 2 0.010
multi organism cellular process GO:0044764 2 0.010
positive regulation of cell activation GO:0050867 1 0.010
lymphocyte proliferation GO:0046651 1 0.010
gtp metabolic process GO:0046039 4 0.010
regulation of cell migration GO:0030334 40 0.010
lipid catabolic process GO:0016042 4 0.010
regulation of biosynthetic process GO:0009889 250 0.010
regulation of cellular ketone metabolic process GO:0010565 7 0.010
regulation of inflammatory response GO:0050727 2 0.010
positive regulation of cellular metabolic process GO:0031325 94 0.010
taxis GO:0042330 109 0.010
regulation of neurotransmitter secretion GO:0046928 1 0.010
protein modification process GO:0036211 100 0.010
transcription dna templated GO:0006351 181 0.010
behavior GO:0007610 74 0.010

crb3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.107
nervous system disease DOID:863 0 0.044
sensory system disease DOID:0050155 0 0.020
eye and adnexa disease DOID:1492 0 0.020
eye disease DOID:5614 0 0.020
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
immune system disease DOID:2914 0 0.011
musculoskeletal system disease DOID:17 0 0.010