Danio rerio

69 known processes

tdp2b

tyrosyl-DNA phosphodiesterase 2b

(Aliases: ttrap,ttrapl,tdp2)

tdp2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nitrogen compound metabolic process GO:0006807 319 0.307
cellular nitrogen compound metabolic process GO:0034641 290 0.300
cellular biosynthetic process GO:0044249 286 0.289
organelle organization GO:0006996 227 0.281
organic cyclic compound biosynthetic process GO:1901362 223 0.278
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.261
organic substance biosynthetic process GO:1901576 289 0.236
cellular macromolecule metabolic process GO:0044260 391 0.235
cellular aromatic compound metabolic process GO:0006725 295 0.210
biosynthetic process GO:0009058 294 0.196
regulation of primary metabolic process GO:0080090 311 0.186
macromolecule biosynthetic process GO:0009059 227 0.183
nucleic acid templated transcription GO:0097659 181 0.175
nucleobase containing compound biosynthetic process GO:0034654 205 0.171
aromatic compound biosynthetic process GO:0019438 217 0.168
determination of left right symmetry GO:0007368 179 0.154
positive regulation of cellular process GO:0048522 201 0.147
specification of symmetry GO:0009799 204 0.143
heterocycle metabolic process GO:0046483 290 0.135
cellular macromolecule biosynthetic process GO:0034645 224 0.132
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.129
regulation of nitrogen compound metabolic process GO:0051171 251 0.119
regulation of rna biosynthetic process GO:2001141 213 0.118
regulation of biosynthetic process GO:0009889 250 0.116
regulation of rna metabolic process GO:0051252 224 0.116
nucleic acid metabolic process GO:0090304 244 0.113
cellular nitrogen compound biosynthetic process GO:0044271 218 0.113
heterocycle biosynthetic process GO:0018130 215 0.106
regulation of metabolic process GO:0019222 359 0.096
regulation of transcription dna templated GO:0006355 213 0.095
rna metabolic process GO:0016070 219 0.093
regulation of nucleic acid templated transcription GO:1903506 213 0.092
regulation of gene expression GO:0010468 265 0.091
regulation of macromolecule biosynthetic process GO:0010556 225 0.090
rna biosynthetic process GO:0032774 181 0.082
regulation of cellular biosynthetic process GO:0031326 245 0.073
regulation of cellular metabolic process GO:0031323 320 0.071
regulation of macromolecule metabolic process GO:0060255 317 0.071
organic cyclic compound metabolic process GO:1901360 301 0.070
transcription dna templated GO:0006351 181 0.068
organonitrogen compound metabolic process GO:1901564 74 0.067
gene expression GO:0010467 252 0.063
nucleobase containing compound metabolic process GO:0006139 274 0.062
regulation of binding GO:0051098 3 0.054
cellular protein metabolic process GO:0044267 129 0.052
negative regulation of cellular process GO:0048523 283 0.051
multi organism process GO:0051704 134 0.050
peptidyl lysine acetylation GO:0018394 2 0.049
positive regulation of biosynthetic process GO:0009891 68 0.045
macromolecular complex subunit organization GO:0043933 74 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.043
positive regulation of biological process GO:0048518 253 0.042
protein metabolic process GO:0019538 183 0.041
spindle assembly involved in mitosis GO:0090307 1 0.039
cell morphogenesis GO:0000902 289 0.037
spindle assembly GO:0051225 2 0.037
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.036
mitotic dna integrity checkpoint GO:0044774 4 0.036
cell cycle GO:0007049 93 0.036
kidney development GO:0001822 92 0.035
cellular component assembly GO:0022607 170 0.035
response to stress GO:0006950 263 0.034
regulation of multicellular organismal development GO:2000026 223 0.034
negative regulation of biological process GO:0048519 304 0.034
meiotic chromosome segregation GO:0045132 3 0.033
maintenance of location GO:0051235 4 0.033
cellular component biogenesis GO:0044085 178 0.033
macromolecular complex assembly GO:0065003 35 0.032
negative regulation of metabolic process GO:0009892 86 0.030
regulation of signaling GO:0023051 235 0.029
protein acylation GO:0043543 3 0.029
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.029
mitotic cell cycle embryonic GO:0045448 2 0.029
cellular protein modification process GO:0006464 100 0.028
regulation of cell death GO:0010941 103 0.027
single organism metabolic process GO:0044710 217 0.027
macromolecule modification GO:0043412 111 0.027
determination of bilateral symmetry GO:0009855 204 0.026
convergent extension GO:0060026 118 0.026
microtubule organizing center organization GO:0031023 1 0.026
positive regulation of muscle organ development GO:0048636 1 0.026
phosphorus metabolic process GO:0006793 109 0.026
locomotion GO:0040011 313 0.025
positive regulation of cellular biosynthetic process GO:0031328 68 0.025
amine metabolic process GO:0009308 2 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.024
mitotic dna damage checkpoint GO:0044773 4 0.024
dna catabolic process GO:0006308 1 0.024
sensory organ development GO:0007423 393 0.024
small molecule metabolic process GO:0044281 77 0.024
cellular component movement GO:0006928 335 0.024
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.024
urogenital system development GO:0001655 97 0.023
blood vessel development GO:0001568 246 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.023
g2 m transition of mitotic cell cycle GO:0000086 4 0.022
regulation of multicellular organismal process GO:0051239 277 0.022
carbohydrate derivative metabolic process GO:1901135 61 0.022
pole plasm assembly GO:0007315 4 0.022
immune system development GO:0002520 191 0.021
regulation of protein ubiquitination GO:0031396 3 0.021
positive regulation of transcription dna templated GO:0045893 57 0.021
single organism organelle organization GO:1902589 199 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
regulation of cell differentiation GO:0045595 142 0.020
stem cell maintenance GO:0019827 4 0.020
camera type eye development GO:0043010 222 0.020
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.020
negative regulation of cellular biosynthetic process GO:0031327 55 0.020
cytokinesis GO:0000910 3 0.020
phosphorylation GO:0016310 69 0.020
g2 dna damage checkpoint GO:0031572 3 0.019
protein acetylation GO:0006473 2 0.019
spliceosomal snrnp assembly GO:0000387 2 0.019
regulation of apoptotic process GO:0042981 98 0.019
cellular amine metabolic process GO:0044106 2 0.019
negative regulation of dna metabolic process GO:0051053 4 0.019
mitochondrial transport GO:0006839 2 0.019
regulation of response to stimulus GO:0048583 269 0.019
regulation of molecular function GO:0065009 70 0.019
response to organic substance GO:0010033 153 0.019
kupffer s vesicle development GO:0070121 50 0.019
b cell activation GO:0042113 2 0.019
cell motility GO:0048870 244 0.018
internal protein amino acid acetylation GO:0006475 2 0.018
meiotic nuclear division GO:0007126 4 0.018
cellular response to oxygen levels GO:0071453 1 0.018
axis specification GO:0009798 43 0.018
apoptotic process GO:0006915 116 0.018
larval development GO:0002164 2 0.018
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.018
meiotic cell cycle process GO:1903046 3 0.018
hemopoiesis GO:0030097 183 0.018
immune system process GO:0002376 241 0.018
growth GO:0040007 174 0.018
positive regulation of transport GO:0051050 2 0.018
regulation of cytokine production GO:0001817 3 0.018
cell proliferation GO:0008283 80 0.017
positive regulation of nucleic acid templated transcription GO:1903508 57 0.017
negative regulation of rna biosynthetic process GO:1902679 45 0.017
dorsal ventral pattern formation GO:0009953 125 0.017
anterior posterior axis specification GO:0009948 20 0.017
negative regulation of cellular metabolic process GO:0031324 77 0.017
immunoglobulin mediated immune response GO:0016064 3 0.017
epithelial tube morphogenesis GO:0060562 148 0.016
vasculature development GO:0001944 278 0.016
embryonic organ development GO:0048568 381 0.016
peptidyl lysine dimethylation GO:0018027 1 0.016
cellular localization GO:0051641 97 0.016
mitotic sister chromatid segregation GO:0000070 6 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.015
pronephros development GO:0048793 69 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
mitochondrion organization GO:0007005 4 0.015
positive regulation of gene expression GO:0010628 71 0.015
cellular component morphogenesis GO:0032989 336 0.015
protein homooligomerization GO:0051260 3 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.015
hepaticobiliary system development GO:0061008 98 0.015
regulation of dna replication GO:0006275 3 0.015
mesoderm development GO:0007498 88 0.015
covalent chromatin modification GO:0016569 20 0.015
negative regulation of kinase activity GO:0033673 4 0.015
regulation of biological quality GO:0065008 263 0.015
cellular response to hypoxia GO:0071456 1 0.014
protein complex biogenesis GO:0070271 30 0.014
positive regulation of rna biosynthetic process GO:1902680 57 0.014
cellular ketone metabolic process GO:0042180 11 0.014
cellular response to decreased oxygen levels GO:0036294 1 0.014
positive regulation of cell cycle GO:0045787 3 0.014
eye development GO:0001654 277 0.014
cilium morphogenesis GO:0060271 85 0.014
regulation of cell proliferation GO:0042127 37 0.014
oocyte anterior posterior axis specification GO:0007314 4 0.014
protein targeting to nucleus GO:0044744 3 0.014
ribonucleotide metabolic process GO:0009259 27 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
hormone transport GO:0009914 2 0.014
viral process GO:0016032 1 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
recombinational repair GO:0000725 1 0.014
protein complex assembly GO:0006461 30 0.014
protein modification process GO:0036211 100 0.014
positive regulation of cellular catabolic process GO:0031331 3 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
positive regulation of cytokine production GO:0001819 2 0.014
oxoacid metabolic process GO:0043436 31 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
cell surface receptor signaling pathway GO:0007166 325 0.014
internal peptidyl lysine acetylation GO:0018393 2 0.014
positive regulation of translation GO:0045727 1 0.014
determination of heart left right asymmetry GO:0061371 117 0.014
cell killing GO:0001906 2 0.014
blood vessel morphogenesis GO:0048514 216 0.014
ovarian follicle development GO:0001541 2 0.014
negative regulation of transcription dna templated GO:0045892 45 0.014
fertilization GO:0009566 3 0.014
regulation of cell cycle GO:0051726 52 0.013
anterior posterior pattern specification GO:0009952 152 0.013
spermatid development GO:0007286 2 0.013
heart development GO:0007507 313 0.013
response to abiotic stimulus GO:0009628 122 0.013
negative regulation of dna replication GO:0008156 2 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
maternal determination of anterior posterior axis embryo GO:0008358 4 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.013
response to external stimulus GO:0009605 264 0.013
positive regulation of metabolic process GO:0009893 108 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
nuclear transport GO:0051169 4 0.012
atp catabolic process GO:0006200 4 0.012
centrosome cycle GO:0007098 1 0.012
cell projection morphogenesis GO:0048858 244 0.012
cellular response to organic substance GO:0071310 105 0.012
regulation of reproductive process GO:2000241 4 0.012
spermatid differentiation GO:0048515 2 0.012
response to bacterium GO:0009617 58 0.012
organic acid metabolic process GO:0006082 31 0.012
microtubule based process GO:0007017 60 0.012
embryonic digestive tract development GO:0048566 4 0.012
response to monosaccharide GO:0034284 3 0.012
response to uv GO:0009411 3 0.012
developmental growth GO:0048589 166 0.012
gamete generation GO:0007276 33 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
septum transversum development GO:0003343 4 0.012
cardiocyte differentiation GO:0035051 44 0.012
specification of axis polarity GO:0065001 4 0.011
chromatin organization GO:0006325 22 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.011
cell projection organization GO:0030030 284 0.011
killing of cells of other organism GO:0031640 1 0.011
regulation of cell communication GO:0010646 232 0.011
positive regulation of muscle tissue development GO:1901863 1 0.011
central nervous system development GO:0007417 387 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
positive regulation of cell activation GO:0050867 1 0.011
cell death GO:0008219 121 0.011
negative regulation of gene expression GO:0010629 65 0.011
regulation of establishment of protein localization GO:0070201 4 0.011
rna localization GO:0006403 4 0.011
multicellular organism reproduction GO:0032504 35 0.011
aging GO:0007568 2 0.011
regulation of developmental process GO:0050793 247 0.011
regulation of signal transduction GO:0009966 225 0.011
interspecies interaction between organisms GO:0044419 4 0.011
establishment of protein localization to organelle GO:0072594 4 0.011
negative regulation of protein kinase activity GO:0006469 4 0.011
organelle assembly GO:0070925 110 0.011
cell part morphogenesis GO:0032990 246 0.011
localization of cell GO:0051674 244 0.011
regulation of cell activation GO:0050865 1 0.011
cardiac atrium development GO:0003230 4 0.011
retina development in camera type eye GO:0060041 146 0.011
renal system development GO:0072001 94 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
appendage morphogenesis GO:0035107 56 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
negative regulation of mitosis GO:0045839 3 0.010
cell substrate junction assembly GO:0007044 2 0.010
dna methylation or demethylation GO:0044728 8 0.010
negative regulation of signaling GO:0023057 96 0.010
signal transduction GO:0007165 455 0.010
response to carbohydrate GO:0009743 3 0.010
regulation of nucleoside metabolic process GO:0009118 2 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
cellular response to radiation GO:0071478 4 0.010
regionalization GO:0003002 274 0.010
modification dependent protein catabolic process GO:0019941 3 0.010
peptide transport GO:0015833 1 0.010
neuron differentiation GO:0030182 353 0.010
positive regulation of multi organism process GO:0043902 3 0.010

tdp2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
nervous system disease DOID:863 0 0.011