Danio rerio

76 known processes

sfpq

splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)

(Aliases: zgc:85935,wu:fa11h12,hm:zeh0027,wu:fd10f03)

sfpq biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of metabolic process GO:0019222 359 0.326
Human Mouse
regulation of multicellular organismal process GO:0051239 277 0.283
larval development GO:0002164 2 0.281
Worm
growth GO:0040007 174 0.212
Worm
regulation of multicellular organismal development GO:2000026 223 0.210
regulation of gene expression epigenetic GO:0040029 11 0.201
histone h3 k4 methylation GO:0051568 2 0.199
histone modification GO:0016570 20 0.177
Mouse
macromolecule biosynthetic process GO:0009059 227 0.172
Human Mouse
methylation GO:0032259 22 0.168
regulation of cell differentiation GO:0045595 142 0.164
regulation of nucleic acid templated transcription GO:1903506 213 0.163
Human Mouse
meiotic nuclear division GO:0007126 4 0.162
negative regulation of biological process GO:0048519 304 0.161
embryo development ending in birth or egg hatching GO:0009792 271 0.149
negative regulation of cellular process GO:0048523 283 0.148
rna metabolic process GO:0016070 219 0.147
Human Mouse
maternal determination of anterior posterior axis embryo GO:0008358 4 0.146
ribonucleoside monophosphate catabolic process GO:0009158 4 0.140
response to chemical GO:0042221 320 0.139
Human
positive regulation of biosynthetic process GO:0009891 68 0.128
regulation of multicellular organism growth GO:0040014 4 0.127
embryonic organ development GO:0048568 381 0.125
regulation of developmental process GO:0050793 247 0.124
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.122
Human Mouse
regulation of primary metabolic process GO:0080090 311 0.120
Human Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.119
Human Mouse
organic cyclic compound metabolic process GO:1901360 301 0.116
Human Mouse
skeletal muscle tissue development GO:0007519 67 0.114
muscle tissue development GO:0060537 110 0.111
organelle organization GO:0006996 227 0.110
Mouse
response to external stimulus GO:0009605 264 0.103
adult behavior GO:0030534 2 0.099
positive regulation of biological process GO:0048518 253 0.098
Human
somitogenesis GO:0001756 87 0.095
negative regulation of metabolic process GO:0009892 86 0.095
Human Mouse
mitotic cell cycle GO:0000278 64 0.095
positive regulation of cellular metabolic process GO:0031325 94 0.095
negative regulation of gene expression GO:0010629 65 0.092
Human Mouse
aromatic compound biosynthetic process GO:0019438 217 0.088
Human Mouse
activation of mapkkk activity GO:0000185 1 0.086
regulation of anatomical structure morphogenesis GO:0022603 130 0.085
3 utr mediated mrna stabilization GO:0070935 3 0.083
regulation of cellular metabolic process GO:0031323 320 0.081
Human Mouse
central nervous system development GO:0007417 387 0.081
blood vessel development GO:0001568 246 0.079
cell migration GO:0016477 237 0.078
pigmentation GO:0043473 85 0.077
regulation of cellular biosynthetic process GO:0031326 245 0.076
Human Mouse
cellular protein metabolic process GO:0044267 129 0.076
Mouse
cellular component assembly GO:0022607 170 0.076
positive regulation of dna metabolic process GO:0051054 1 0.073
regulation of transcription dna templated GO:0006355 213 0.072
Human Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.071
Human Mouse
single fertilization GO:0007338 3 0.071
cell substrate junction assembly GO:0007044 2 0.070
cellular macromolecule biosynthetic process GO:0034645 224 0.068
Human Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.068
Human Mouse
cellular macromolecule metabolic process GO:0044260 391 0.067
Human Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.066
Human Mouse
maintenance of location GO:0051235 4 0.065
regulation of gene expression GO:0010468 265 0.064
Human Mouse
striated muscle tissue development GO:0014706 110 0.063
nucleobase containing compound biosynthetic process GO:0034654 205 0.062
Human Mouse
developmental growth GO:0048589 166 0.062
protein modification process GO:0036211 100 0.062
Mouse
chromatin modification GO:0016568 21 0.061
Mouse
regulation of mrna processing GO:0050684 3 0.060
single organism organelle organization GO:1902589 199 0.060
Mouse
positive regulation of cellular component biogenesis GO:0044089 3 0.059
protein acetylation GO:0006473 2 0.058
oocyte anterior posterior axis specification GO:0007314 4 0.058
negative regulation of cellular catabolic process GO:0031330 3 0.058
multicellular organism growth GO:0035264 4 0.058
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.058
Human Mouse
pole plasm assembly GO:0007315 4 0.057
biosynthetic process GO:0009058 294 0.057
Human Mouse
nuclear pore organization GO:0006999 2 0.056
retina development in camera type eye GO:0060041 146 0.056
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.055
nitrogen compound metabolic process GO:0006807 319 0.055
Human Mouse
purine nucleoside monophosphate catabolic process GO:0009128 4 0.055
positive regulation of metabolic process GO:0009893 108 0.055
rna stabilization GO:0043489 4 0.054
stem cell differentiation GO:0048863 117 0.054
morphogenesis of an epithelium GO:0002009 333 0.053
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.053
heterocycle metabolic process GO:0046483 290 0.053
Human Mouse
heart development GO:0007507 313 0.052
chromatin organization GO:0006325 22 0.051
Mouse
nucleic acid templated transcription GO:0097659 181 0.051
Human Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.051
Human Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.050
synaptic growth at neuromuscular junction GO:0051124 2 0.050
establishment of localization GO:0051234 244 0.050
heterocycle biosynthetic process GO:0018130 215 0.050
Human Mouse
anterior posterior pattern specification GO:0009952 152 0.050
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.048
macromolecule methylation GO:0043414 19 0.048
eye development GO:0001654 277 0.047
neuronal stem cell maintenance GO:0097150 2 0.047
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.047
cellular nitrogen compound metabolic process GO:0034641 290 0.047
Human Mouse
rna transport GO:0050658 2 0.046
regulation of dna templated transcription elongation GO:0032784 3 0.046
organelle fission GO:0048285 23 0.045
positive regulation of chromatin modification GO:1903310 1 0.045
sarcomerogenesis GO:0048769 4 0.045
regulation of meiotic cell cycle GO:0051445 1 0.044
heart morphogenesis GO:0003007 156 0.044
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.044
fertilization GO:0009566 3 0.044
cell cycle GO:0007049 93 0.044
vasculature development GO:0001944 278 0.044
modification of morphology or physiology of other organism GO:0035821 4 0.044
cellular component biogenesis GO:0044085 178 0.044
localization of cell GO:0051674 244 0.043
neuron differentiation GO:0030182 353 0.041
cytoskeleton organization GO:0007010 96 0.041
blood vessel morphogenesis GO:0048514 216 0.040
digestive tract development GO:0048565 265 0.040
organic cyclic compound biosynthetic process GO:1901362 223 0.040
Human Mouse
internal peptidyl lysine acetylation GO:0018393 2 0.040
histone methylation GO:0016571 13 0.039
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.039
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.039
organic substance biosynthetic process GO:1901576 289 0.039
Human Mouse
gene silencing by rna GO:0031047 4 0.039
atp catabolic process GO:0006200 4 0.038
peptidyl lysine acetylation GO:0018394 2 0.038
regulation of cell death GO:0010941 103 0.038
Human
generation of neurons GO:0048699 385 0.038
regulation of rna metabolic process GO:0051252 224 0.037
Human Mouse
cellular protein modification process GO:0006464 100 0.037
Mouse
positive regulation of cellular biosynthetic process GO:0031328 68 0.037
lipid storage GO:0019915 1 0.037
embryonic heart tube morphogenesis GO:0003143 108 0.037
cellular component morphogenesis GO:0032989 336 0.036
segmentation GO:0035282 97 0.036
negative regulation of cellular biosynthetic process GO:0031327 55 0.036
Human Mouse
transmembrane transport GO:0055085 120 0.036
regulation of cellular component organization GO:0051128 86 0.036
protein metabolic process GO:0019538 183 0.035
Mouse
internal protein amino acid acetylation GO:0006475 2 0.035
mitotic g2 dna damage checkpoint GO:0007095 3 0.035
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:0000462 1 0.035
regulation of protein catabolic process GO:0042176 1 0.035
dsrna fragmentation GO:0031050 1 0.035
nucleic acid transport GO:0050657 2 0.034
aging GO:0007568 2 0.034
rna localization GO:0006403 4 0.034
signal transduction GO:0007165 455 0.034
Human
digestive tract morphogenesis GO:0048546 231 0.034
ion transport GO:0006811 114 0.033
response to biotic stimulus GO:0009607 97 0.033
transport GO:0006810 220 0.033
hematopoietic or lymphoid organ development GO:0048534 191 0.032
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.032
Human Mouse
regulation of cell proliferation GO:0042127 37 0.032
rna biosynthetic process GO:0032774 181 0.031
Human Mouse
gene silencing GO:0016458 4 0.031
negative regulation of rna metabolic process GO:0051253 48 0.030
Human Mouse
cell matrix adhesion GO:0007160 4 0.030
dna modification GO:0006304 8 0.030
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.029
amine metabolic process GO:0009308 2 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.029
Human Mouse
stem cell development GO:0048864 82 0.029
negative regulation of biosynthetic process GO:0009890 55 0.029
Human Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.028
Human Mouse
exocytosis GO:0006887 1 0.028
regulation of biosynthetic process GO:0009889 250 0.028
Human Mouse
stem cell maintenance GO:0019827 4 0.028
brain development GO:0007420 293 0.028
chordate embryonic development GO:0043009 271 0.028
pore complex assembly GO:0046931 2 0.027
extrinsic apoptotic signaling pathway GO:0097191 3 0.027
regulation of cell development GO:0060284 100 0.027
determination of left right symmetry GO:0007368 179 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.027
positive regulation of cellular process GO:0048522 201 0.027
Human
adherens junction organization GO:0034332 4 0.027
cardiac muscle myosin thick filament assembly GO:0071690 1 0.026
sensory organ morphogenesis GO:0090596 200 0.026
negative regulation of ras protein signal transduction GO:0046580 1 0.026
system process GO:0003008 185 0.026
Fly
regulation of synapse assembly GO:0051963 3 0.025
macromolecule localization GO:0033036 54 0.025
camera type eye development GO:0043010 222 0.025
sensory perception of light stimulus GO:0050953 19 0.025
Fly
multi organism cellular process GO:0044764 2 0.025
establishment of protein localization to organelle GO:0072594 4 0.024
mitotic dna integrity checkpoint GO:0044774 4 0.024
regulation of cellular protein catabolic process GO:1903362 1 0.024
embryonic heart tube development GO:0035050 133 0.024
positive regulation of transport GO:0051050 2 0.023
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.023
cellular amine metabolic process GO:0044106 2 0.023
viral process GO:0016032 1 0.023
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.023
immune system process GO:0002376 241 0.023
alternative mrna splicing via spliceosome GO:0000380 1 0.023
Human
cytokinesis GO:0000910 3 0.023
regulation of nervous system development GO:0051960 90 0.023
regulation of metal ion transport GO:0010959 4 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
mitotic nuclear division GO:0007067 18 0.022
cell projection organization GO:0030030 284 0.022
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.022
regionalization GO:0003002 274 0.022
regulation of organelle assembly GO:1902115 4 0.022
muscle cell development GO:0055001 115 0.022
mesenchymal cell development GO:0014031 78 0.022
retina morphogenesis in camera type eye GO:0060042 79 0.022
cellular response to dsrna GO:0071359 1 0.022
positive regulation of neuron apoptotic process GO:0043525 1 0.022
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.022
Human Mouse
transcription dna templated GO:0006351 181 0.021
Human Mouse
covalent chromatin modification GO:0016569 20 0.021
Mouse
intracellular signal transduction GO:0035556 85 0.021
Human
reproduction GO:0000003 40 0.021
Worm Fly
sensory organ development GO:0007423 393 0.021
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.021
positive regulation of rna biosynthetic process GO:1902680 57 0.020
protein alkylation GO:0008213 13 0.020
nucleobase containing compound transport GO:0015931 2 0.020
transcription from rna polymerase ii promoter GO:0006366 80 0.020
Human
single organism metabolic process GO:0044710 217 0.020
Mouse
cellular component movement GO:0006928 335 0.020
regulation of organelle organization GO:0033043 29 0.020
positive regulation of gene expression GO:0010628 71 0.020
nucleoside monophosphate catabolic process GO:0009125 4 0.020
response to wounding GO:0009611 116 0.019
protein acylation GO:0043543 3 0.019
single organism localization GO:1902578 225 0.019
positive regulation of dna templated transcription elongation GO:0032786 1 0.019
tube morphogenesis GO:0035239 349 0.019
response to uv GO:0009411 3 0.019
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
Human Mouse
regulation of epithelial cell proliferation GO:0050678 3 0.019
heart looping GO:0001947 94 0.019
regulation of synapse organization GO:0050807 3 0.019
heart contraction GO:0060047 71 0.019
cell differentiation in spinal cord GO:0021515 40 0.018
positive regulation of chromosome organization GO:2001252 1 0.018
epithelial cell morphogenesis GO:0003382 2 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
locomotory behavior GO:0007626 34 0.018
regulation of neurogenesis GO:0050767 87 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.018
macromolecular complex assembly GO:0065003 35 0.018
negative regulation of rna splicing GO:0033119 1 0.018
regulation of skeletal muscle fiber development GO:0048742 2 0.018
cellular ketone metabolic process GO:0042180 11 0.018
spermatid differentiation GO:0048515 2 0.018
cellular protein catabolic process GO:0044257 4 0.017
positive regulation of macromolecule metabolic process GO:0010604 93 0.017
cellular response to external stimulus GO:0071496 2 0.017
skeletal muscle organ development GO:0060538 78 0.017
g2 m transition of mitotic cell cycle GO:0000086 4 0.017
axonogenesis GO:0007409 152 0.017
cell motility GO:0048870 244 0.017
ion transmembrane transport GO:0034220 91 0.017
gene expression GO:0010467 252 0.016
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 7 0.016
negative regulation of chromosome organization GO:2001251 1 0.016
positive regulation of synapse assembly GO:0051965 1 0.016
positive regulation of cellular protein metabolic process GO:0032270 22 0.016
negative regulation of transcription dna templated GO:0045892 45 0.016
Human Mouse
negative regulation of cell death GO:0060548 60 0.016
protein complex subunit organization GO:0071822 46 0.016
neuron projection extension GO:1990138 45 0.016
dna templated transcription elongation GO:0006354 3 0.016
regulation of cell activation GO:0050865 1 0.016
developmental growth involved in morphogenesis GO:0060560 86 0.016
membrane repolarization GO:0086009 2 0.016
cellular localization GO:0051641 97 0.016
rhythmic process GO:0048511 21 0.016
Mouse
somite development GO:0061053 96 0.016
interspecies interaction between organisms GO:0044419 4 0.016
regulation of protein complex assembly GO:0043254 3 0.016
regulation of epidermis development GO:0045682 2 0.016
response to organic substance GO:0010033 153 0.016
behavior GO:0007610 74 0.015
Fly
positive regulation of histone modification GO:0031058 1 0.015
regulation of cellular protein metabolic process GO:0032268 52 0.015
posttranscriptional gene silencing GO:0016441 3 0.015
convergent extension GO:0060026 118 0.015
locomotion GO:0040011 313 0.015
ear development GO:0043583 127 0.015
regulation of oligodendrocyte differentiation GO:0048713 1 0.015
establishment of rna localization GO:0051236 3 0.015
cardiac atrium development GO:0003230 4 0.015
protein complex biogenesis GO:0070271 30 0.015
cellular biosynthetic process GO:0044249 286 0.015
Human Mouse
posttranscriptional regulation of gene expression GO:0010608 14 0.015
determination of heart left right asymmetry GO:0061371 117 0.015
positive regulation of chromosome segregation GO:0051984 1 0.015
regulation of growth GO:0040008 42 0.015
histone deacetylation GO:0016575 2 0.015
Mouse
embryonic digestive tract morphogenesis GO:0048557 3 0.014
neurological system process GO:0050877 62 0.014
Fly
negative regulation of nuclear division GO:0051784 3 0.014
negative regulation of catabolic process GO:0009895 3 0.014
regulation of developmental growth GO:0048638 38 0.014
neural crest cell differentiation GO:0014033 72 0.014
foregut morphogenesis GO:0007440 4 0.014
adherens junction assembly GO:0034333 1 0.014
mitotic g2 m transition checkpoint GO:0044818 3 0.014
cell junction organization GO:0034330 11 0.014
positive regulation of cell cycle GO:0045787 3 0.014
hemidesmosome assembly GO:0031581 1 0.014
regulation of signaling GO:0023051 235 0.014
Human
response to stress GO:0006950 263 0.014
regulation of production of molecular mediator of immune response GO:0002700 1 0.014
oxoacid metabolic process GO:0043436 31 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
cell aging GO:0007569 2 0.014
compound eye development GO:0048749 2 0.014
midbrain development GO:0030901 28 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.013
circadian rhythm GO:0007623 19 0.013
Mouse
regulation of cell morphogenesis GO:0022604 42 0.013
muscle cell differentiation GO:0042692 139 0.013
regulation of sarcomere organization GO:0060297 2 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
central nervous system neuron differentiation GO:0021953 74 0.013
regulation of cell shape GO:0008360 1 0.013
response to inorganic substance GO:0010035 38 0.013
response to other organism GO:0051707 97 0.013
intracellular mrna localization GO:0008298 1 0.013
cation transmembrane transport GO:0098655 65 0.013
axon extension GO:0048675 45 0.013
blood circulation GO:0008015 87 0.013
cell substrate adherens junction assembly GO:0007045 1 0.013
response to drug GO:0042493 3 0.013
nuclear migration GO:0007097 3 0.013
mitotic cell cycle process GO:1903047 48 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
protein localization GO:0008104 40 0.013
cell cycle process GO:0022402 53 0.012
protein complex localization GO:0031503 1 0.012
pigment cell differentiation GO:0050931 38 0.012
regulation of intracellular signal transduction GO:1902531 57 0.012
Human
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
heart process GO:0003015 71 0.012
protein secretion GO:0009306 1 0.012
positive regulation of catabolic process GO:0009896 4 0.012
germ line stem cell maintenance GO:0030718 2 0.012
positive regulation of protein metabolic process GO:0051247 23 0.012
cell part morphogenesis GO:0032990 246 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
glial cell differentiation GO:0010001 42 0.012
positive regulation of transcription dna templated GO:0045893 57 0.012
death GO:0016265 121 0.012
Human
regulation of reproductive process GO:2000241 4 0.012
g protein coupled receptor signaling pathway GO:0007186 74 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
Human Mouse
regulation of protein transport GO:0051223 3 0.011
regulation of mrna stability GO:0043488 4 0.011
carboxylic acid metabolic process GO:0019752 22 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
hematopoietic stem cell differentiation GO:0060218 20 0.011
organic acid metabolic process GO:0006082 31 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
positive regulation of epithelial cell migration GO:0010634 2 0.011
cardiac muscle tissue development GO:0048738 48 0.011
calcium ion import GO:0070509 4 0.011
regulation of establishment of protein localization GO:0070201 4 0.011
regulation of intracellular protein transport GO:0033157 3 0.011
cell surface receptor signaling pathway GO:0007166 325 0.010
regulation of neural precursor cell proliferation GO:2000177 3 0.010
neuroblast proliferation GO:0007405 2 0.010
circulatory system process GO:0003013 87 0.010
regulation of biological quality GO:0065008 263 0.010
exocrine pancreas development GO:0031017 28 0.010
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.010
positive regulation of translation GO:0045727 1 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.010
tongue morphogenesis GO:0043587 3 0.010
macromolecule modification GO:0043412 111 0.010
Mouse
polarized epithelial cell differentiation GO:0030859 4 0.010
production of small rna involved in gene silencing by rna GO:0070918 1 0.010
neuromuscular synaptic transmission GO:0007274 2 0.010
carbohydrate biosynthetic process GO:0016051 1 0.010

sfpq disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
motor neuron disease DOID:231 0 0.026
central nervous system disease DOID:331 0 0.026
amyotrophic lateral sclerosis DOID:332 0 0.026
disease of anatomical entity DOID:7 0 0.026
neurodegenerative disease DOID:1289 0 0.026
nervous system disease DOID:863 0 0.026
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.015
physical disorder DOID:0080015 0 0.011