Danio rerio

77 known processes

bhlhe40

basic helix-loop-helix family, member e40

(Aliases: bhlhb2,zgc:76913,wu:fm54h07,DEC1,wu:fc28a06)

bhlhe40 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hepaticobiliary system development GO:0061008 98 0.694
aging GO:0007568 2 0.675
nitrogen compound metabolic process GO:0006807 319 0.414
liver development GO:0001889 96 0.363
lipid storage GO:0019915 1 0.354
determination of left right symmetry GO:0007368 179 0.337
embryonic organ development GO:0048568 381 0.315
embryonic heart tube morphogenesis GO:0003143 108 0.313
positive regulation of biological process GO:0048518 253 0.296
specification of symmetry GO:0009799 204 0.290
locomotion GO:0040011 313 0.285
heterocycle metabolic process GO:0046483 290 0.282
regulation of biological quality GO:0065008 263 0.268
Rat
regulation of developmental process GO:0050793 247 0.234
heart looping GO:0001947 94 0.232
determination of heart left right asymmetry GO:0061371 117 0.229
cartilage development GO:0051216 96 0.227
cellular nitrogen compound metabolic process GO:0034641 290 0.219
regulation of metabolic process GO:0019222 359 0.217
regulation of multicellular organismal process GO:0051239 277 0.209
aromatic compound biosynthetic process GO:0019438 217 0.207
circadian regulation of gene expression GO:0032922 8 0.200
regulation of blood pressure GO:0008217 1 0.200
epithelial tube morphogenesis GO:0060562 148 0.198
cellular nitrogen compound biosynthetic process GO:0044271 218 0.192
cellular response to extracellular stimulus GO:0031668 2 0.184
organic cyclic compound metabolic process GO:1901360 301 0.182
oxoacid metabolic process GO:0043436 31 0.175
regulation of signaling GO:0023051 235 0.172
Rat
cell proliferation GO:0008283 80 0.171
regulation of transcription dna templated GO:0006355 213 0.168
positive regulation of cell activation GO:0050867 1 0.163
organic substance biosynthetic process GO:1901576 289 0.160
maintenance of location GO:0051235 4 0.160
cellular response to external stimulus GO:0071496 2 0.159
larval development GO:0002164 2 0.157
biosynthetic process GO:0009058 294 0.154
immune system process GO:0002376 241 0.152
regulation of response to stimulus GO:0048583 269 0.151
organelle assembly GO:0070925 110 0.136
signal transduction GO:0007165 455 0.132
positive regulation of cytokine production GO:0001819 2 0.129
organic cyclic compound biosynthetic process GO:1901362 223 0.127
growth GO:0040007 174 0.126
primitive erythrocyte differentiation GO:0060319 5 0.125
phagocytosis engulfment GO:0006911 1 0.123
regulation of endocrine process GO:0044060 2 0.123
cellular macromolecule biosynthetic process GO:0034645 224 0.121
single organism metabolic process GO:0044710 217 0.117
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.117
nucleobase containing compound metabolic process GO:0006139 274 0.116
hemopoiesis GO:0030097 183 0.110
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.108
cellular response to nutrient levels GO:0031669 2 0.105
intracellular receptor signaling pathway GO:0030522 30 0.103
positive regulation of cellular process GO:0048522 201 0.102
heart morphogenesis GO:0003007 156 0.102
regulation of circadian rhythm GO:0042752 4 0.102
Mouse Rat
carboxylic acid metabolic process GO:0019752 22 0.101
cellular response to starvation GO:0009267 1 0.092
lipid metabolic process GO:0006629 52 0.092
nucleobase containing compound biosynthetic process GO:0034654 205 0.089
skeletal system development GO:0001501 181 0.088
homeostatic process GO:0042592 142 0.088
death GO:0016265 121 0.087
positive regulation of muscle tissue development GO:1901863 1 0.087
response to bacterium GO:0009617 58 0.085
nucleic acid templated transcription GO:0097659 181 0.085
fin regeneration GO:0031101 51 0.084
blood circulation GO:0008015 87 0.083
positive regulation of transport GO:0051050 2 0.082
regulation of nucleic acid templated transcription GO:1903506 213 0.082
positive regulation of translation GO:0045727 1 0.081
heterocycle biosynthetic process GO:0018130 215 0.081
muscle structure development GO:0061061 196 0.081
small molecule metabolic process GO:0044281 77 0.080
system process GO:0003008 185 0.080
positive regulation of striated muscle cell differentiation GO:0051155 1 0.078
response to other organism GO:0051707 97 0.074
multicellular organismal metabolic process GO:0044236 2 0.073
cellular biosynthetic process GO:0044249 286 0.073
regulation of cytokine production GO:0001817 3 0.071
i kappab kinase nf kappab signaling GO:0007249 4 0.070
negative regulation of gene expression GO:0010629 65 0.069
organic acid metabolic process GO:0006082 31 0.068
response to wounding GO:0009611 116 0.067
digestive tract development GO:0048565 265 0.067
response to nutrient GO:0007584 3 0.066
regulation of heart growth GO:0060420 2 0.065
response to decreased oxygen levels GO:0036293 25 0.064
negative regulation of biological process GO:0048519 304 0.064
regulation of autophagy GO:0010506 3 0.062
embryonic organ morphogenesis GO:0048562 274 0.062
regulation of signal transduction GO:0009966 225 0.061
transport GO:0006810 220 0.060
diencephalon development GO:0021536 58 0.060
response to external stimulus GO:0009605 264 0.059
Mouse Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.058
Human Mouse Rat
single organism transport GO:0044765 206 0.058
heart development GO:0007507 313 0.057
chordate embryonic development GO:0043009 271 0.056
cellular component assembly involved in morphogenesis GO:0010927 107 0.056
response to hexose GO:0009746 3 0.056
negative regulation of protein kinase activity GO:0006469 4 0.055
endocrine process GO:0050886 2 0.055
transcription dna templated GO:0006351 181 0.055
regulation of gene expression GO:0010468 265 0.054
hormone transport GO:0009914 2 0.054
innervation GO:0060384 3 0.054
regulation of biosynthetic process GO:0009889 250 0.053
response to biotic stimulus GO:0009607 97 0.052
regulation of glial cell differentiation GO:0045685 4 0.052
regulation of cellular biosynthetic process GO:0031326 245 0.050
transcription from rna polymerase ii promoter GO:0006366 80 0.050
Human Mouse Rat
phosphate containing compound metabolic process GO:0006796 108 0.050
regulation of multicellular organism growth GO:0040014 4 0.049
single organism localization GO:1902578 225 0.049
regulation of nitrogen compound metabolic process GO:0051171 251 0.047
protein import GO:0017038 3 0.047
apoptotic process GO:0006915 116 0.047
positive regulation of striated muscle tissue development GO:0045844 1 0.047
lateral mesoderm development GO:0048368 23 0.047
nucleic acid metabolic process GO:0090304 244 0.047
regulation of tube size GO:0035150 2 0.046
response to hypoxia GO:0001666 25 0.046
developmental growth GO:0048589 166 0.046
response to organic cyclic compound GO:0014070 51 0.045
brain development GO:0007420 293 0.045
positive regulation of muscle cell differentiation GO:0051149 1 0.045
vasculature development GO:0001944 278 0.045
cellular response to organic substance GO:0071310 105 0.045
mesoderm development GO:0007498 88 0.044
regulation of localization GO:0032879 104 0.044
regulation of cell death GO:0010941 103 0.043
regulation of cell communication GO:0010646 232 0.042
Rat
response to nutrient levels GO:0031667 10 0.042
synaptic growth at neuromuscular junction GO:0051124 2 0.042
organonitrogen compound metabolic process GO:1901564 74 0.041
localization of cell GO:0051674 244 0.041
regulation of growth GO:0040008 42 0.041
regulation of cardiac muscle tissue development GO:0055024 1 0.041
regulation of macromolecule biosynthetic process GO:0010556 225 0.040
regulation of rna biosynthetic process GO:2001141 213 0.040
immune system development GO:0002520 191 0.040
oxidation reduction process GO:0055114 41 0.040
regulation of macromolecule metabolic process GO:0060255 317 0.039
toll like receptor signaling pathway GO:0002224 4 0.039
amine metabolic process GO:0009308 2 0.039
tissue remodeling GO:0048771 4 0.038
cell surface receptor signaling pathway GO:0007166 325 0.038
programmed cell death GO:0012501 119 0.037
negative regulation of kinase activity GO:0033673 4 0.037
cellular amino acid metabolic process GO:0006520 7 0.036
response to stress GO:0006950 263 0.036
smooth muscle contraction GO:0006939 2 0.036
positive regulation of immune system process GO:0002684 17 0.036
regulation of systemic arterial blood pressure GO:0003073 1 0.035
somitogenesis GO:0001756 87 0.035
mononuclear cell proliferation GO:0032943 1 0.035
cellular amide metabolic process GO:0043603 4 0.033
regulation of multicellular organismal development GO:2000026 223 0.033
blood vessel development GO:0001568 246 0.033
determination of bilateral symmetry GO:0009855 204 0.032
nuclear transport GO:0051169 4 0.032
phagocytosis GO:0006909 3 0.032
eye development GO:0001654 277 0.032
cellular carbohydrate metabolic process GO:0044262 4 0.032
erythrocyte homeostasis GO:0034101 55 0.032
positive regulation of immune effector process GO:0002699 3 0.032
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.031
response to external biotic stimulus GO:0043207 97 0.031
macromolecule biosynthetic process GO:0009059 227 0.030
protein secretion GO:0009306 1 0.030
regulation of inflammatory response GO:0050727 2 0.030
leukocyte proliferation GO:0070661 1 0.030
head development GO:0060322 303 0.030
response to temperature stimulus GO:0009266 15 0.029
positive regulation of cellular biosynthetic process GO:0031328 68 0.029
muscle organ development GO:0007517 101 0.029
specification of organ identity GO:0010092 2 0.028
endocardial cushion formation GO:0003272 2 0.028
circulatory system process GO:0003013 87 0.028
positive regulation of rna biosynthetic process GO:1902680 57 0.028
regionalization GO:0003002 274 0.028
multicellular organism growth GO:0035264 4 0.028
muscle cell differentiation GO:0042692 139 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
neuron differentiation GO:0030182 353 0.027
positive regulation of defense response GO:0031349 9 0.027
zymogen activation GO:0031638 3 0.027
multicellular organismal homeostasis GO:0048871 29 0.027
hormone secretion GO:0046879 2 0.027
myeloid cell differentiation GO:0030099 86 0.026
generation of neurons GO:0048699 385 0.026
response to endogenous stimulus GO:0009719 83 0.026
response to drug GO:0042493 3 0.026
membrane invagination GO:0010324 1 0.026
regulation of cell differentiation GO:0045595 142 0.026
hindbrain development GO:0030902 91 0.026
cell migration GO:0016477 237 0.025
cellular aromatic compound metabolic process GO:0006725 295 0.025
aorta development GO:0035904 4 0.025
hematopoietic or lymphoid organ development GO:0048534 191 0.025
cellular response to oxygen levels GO:0071453 1 0.025
membrane repolarization GO:0086009 2 0.024
cellular amine metabolic process GO:0044106 2 0.024
establishment of protein localization to organelle GO:0072594 4 0.024
protein targeting to nucleus GO:0044744 3 0.024
primitive hemopoiesis GO:0060215 27 0.024
negative regulation of secretion by cell GO:1903531 2 0.023
defense response GO:0006952 47 0.023
regulation of carbohydrate metabolic process GO:0006109 4 0.023
positive regulation of cellular metabolic process GO:0031325 94 0.023
response to oxygen levels GO:0070482 25 0.023
regulation of primary metabolic process GO:0080090 311 0.023
striated muscle tissue development GO:0014706 110 0.023
lipid localization GO:0010876 11 0.023
regulation of system process GO:0044057 40 0.023
cellular response to lipid GO:0071396 39 0.023
negative regulation of metabolic process GO:0009892 86 0.023
regulation of programmed cell death GO:0043067 101 0.023
regulation of blood vessel size GO:0050880 2 0.022
regulation of blood circulation GO:1903522 32 0.022
regulation of defense response GO:0031347 14 0.022
regulation of hormone levels GO:0010817 21 0.022
ectodermal cell fate specification GO:0001715 2 0.022
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.022
positive regulation of metabolic process GO:0009893 108 0.022
regulation of protein metabolic process GO:0051246 56 0.022
negative regulation of cell differentiation GO:0045596 46 0.022
positive regulation of cell death GO:0010942 29 0.022
cellular response to biotic stimulus GO:0071216 3 0.022
tissue regeneration GO:0042246 74 0.022
embryonic skeletal joint morphogenesis GO:0060272 3 0.022
negative regulation of cell death GO:0060548 60 0.022
embryo development ending in birth or egg hatching GO:0009792 271 0.021
digestive system development GO:0055123 289 0.021
regulation of striated muscle tissue development GO:0016202 6 0.021
positive regulation of blood circulation GO:1903524 2 0.021
bmp signaling pathway GO:0030509 52 0.021
regulation of collagen metabolic process GO:0010712 2 0.021
regulation of response to biotic stimulus GO:0002831 2 0.021
negative regulation of cellular process GO:0048523 283 0.021
response to alkaloid GO:0043279 2 0.021
mesenchyme development GO:0060485 127 0.021
regulation of cell activation GO:0050865 1 0.021
rna metabolic process GO:0016070 219 0.021
response to chemical GO:0042221 320 0.021
single organism organelle organization GO:1902589 199 0.020
rna biosynthetic process GO:0032774 181 0.020
multi organism process GO:0051704 134 0.020
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.020
cellular protein catabolic process GO:0044257 4 0.020
cellular protein metabolic process GO:0044267 129 0.020
pancreas development GO:0031016 84 0.020
regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 1 0.020
regeneration GO:0031099 91 0.020
single organism biosynthetic process GO:0044711 71 0.020
response to extracellular stimulus GO:0009991 10 0.020
embryonic heart tube development GO:0035050 133 0.020
camera type eye development GO:0043010 222 0.019
central nervous system development GO:0007417 387 0.019
cellular response to chemical stimulus GO:0070887 157 0.019
positive regulation of cell cycle GO:0045787 3 0.019
single organism carbohydrate metabolic process GO:0044723 12 0.019
regulation of cellular component organization GO:0051128 86 0.019
g1 s transition of mitotic cell cycle GO:0000082 1 0.019
regulation of dna templated transcription in response to stress GO:0043620 0 0.019
negative regulation of signal transduction GO:0009968 94 0.019
positive regulation of response to external stimulus GO:0032103 9 0.019
collagen metabolic process GO:0032963 2 0.019
cell motility GO:0048870 244 0.019
response to corticosteroid GO:0031960 1 0.018
cell death GO:0008219 121 0.018
cation transport GO:0006812 81 0.018
connective tissue development GO:0061448 99 0.018
lipid homeostasis GO:0055088 3 0.018
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.018
negative regulation of cellular metabolic process GO:0031324 77 0.018
positive regulation of innate immune response GO:0045089 8 0.017
cellular response to decreased oxygen levels GO:0036294 1 0.017
regulation of rna metabolic process GO:0051252 224 0.017
angiogenesis GO:0001525 158 0.017
organelle organization GO:0006996 227 0.017
organonitrogen compound biosynthetic process GO:1901566 47 0.017
protein metabolic process GO:0019538 183 0.017
single organism nuclear import GO:1902593 3 0.017
monocarboxylic acid metabolic process GO:0032787 17 0.017
morphogenesis of an epithelium GO:0002009 333 0.017
eye photoreceptor cell development GO:0042462 30 0.017
dorsal ventral pattern formation GO:0009953 125 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
hindbrain morphogenesis GO:0021575 22 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
negative regulation of cell communication GO:0010648 96 0.016
cellular component disassembly GO:0022411 1 0.016
regulation of organ growth GO:0046620 3 0.016
gene expression GO:0010467 252 0.016
cellular macromolecule metabolic process GO:0044260 391 0.016
negative regulation of blood circulation GO:1903523 2 0.016
positive regulation of cellular component biogenesis GO:0044089 3 0.016
immune response activating signal transduction GO:0002757 5 0.016
wound healing GO:0042060 90 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
chemical homeostasis GO:0048878 49 0.016
cellular component morphogenesis GO:0032989 336 0.016
retina development in camera type eye GO:0060041 146 0.016
lymphocyte proliferation GO:0046651 1 0.016
regulation of anatomical structure size GO:0090066 33 0.015
negative regulation of mesodermal cell fate specification GO:0042662 3 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
ectodermal cell differentiation GO:0010668 2 0.015
regulation of muscle tissue development GO:1901861 6 0.015
insulin like growth factor receptor signaling pathway GO:0048009 4 0.015
positive regulation of cell communication GO:0010647 56 0.015
autophagy GO:0006914 4 0.015
response to acid chemical GO:0001101 17 0.015
b cell activation GO:0042113 2 0.015
peptide transport GO:0015833 1 0.015
cerebellar granular layer development GO:0021681 3 0.015
skeletal muscle organ development GO:0060538 78 0.015
carbohydrate metabolic process GO:0005975 12 0.015
immune effector process GO:0002252 23 0.015
negative regulation of map kinase activity GO:0043407 2 0.015
endocardial cushion development GO:0003197 6 0.015
mitochondrion organization GO:0007005 4 0.015
neuron projection guidance GO:0097485 86 0.015
negative regulation of mitosis GO:0045839 3 0.015
cellular protein modification process GO:0006464 100 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
response to organic substance GO:0010033 153 0.015
sensory organ development GO:0007423 393 0.014
cell substrate adhesion GO:0031589 4 0.014
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.014
cation transmembrane transport GO:0098655 65 0.014
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.014
protein stabilization GO:0050821 2 0.014
carbohydrate derivative metabolic process GO:1901135 61 0.014
septum transversum development GO:0003343 4 0.014
endocardial cushion morphogenesis GO:0003203 3 0.014
cardiac chamber formation GO:0003207 4 0.014
positive regulation of multicellular organismal process GO:0051240 52 0.014
positive regulation of gliogenesis GO:0014015 2 0.014
enzyme linked receptor protein signaling pathway GO:0007167 106 0.014
common bile duct development GO:0061009 13 0.014
negative regulation of dna metabolic process GO:0051053 4 0.014
nuclear import GO:0051170 3 0.014
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.014
cellular response to hypoxia GO:0071456 1 0.013
interspecies interaction between organisms GO:0044419 4 0.013
cellular component movement GO:0006928 335 0.013
positive regulation of nucleic acid templated transcription GO:1903508 57 0.013
positive regulation of signal transduction GO:0009967 56 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
wnt signaling pathway GO:0016055 80 0.013
macromolecular complex assembly GO:0065003 35 0.013
positive regulation of leukocyte mediated immunity GO:0002705 1 0.013
response to monosaccharide GO:0034284 3 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.013
regulation of hormone secretion GO:0046883 2 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
regulation of cytoplasmic transport GO:1903649 4 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.012
erythrocyte differentiation GO:0030218 54 0.012
lateral inhibition GO:0046331 1 0.012
carbohydrate homeostasis GO:0033500 1 0.012
hormone biosynthetic process GO:0042446 3 0.012
heart growth GO:0060419 7 0.012
gland development GO:0048732 143 0.012
multi organism cellular process GO:0044764 2 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.012
response to vitamin GO:0033273 3 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
regulation of cellular metabolic process GO:0031323 320 0.012
regulation of apoptotic process GO:0042981 98 0.012
fin development GO:0033333 77 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
negative regulation of cytokine production GO:0001818 1 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
response to inorganic substance GO:0010035 38 0.012
protein import into nucleus GO:0006606 3 0.012
response to glucose GO:0009749 3 0.012
multicellular organismal macromolecule metabolic process GO:0044259 2 0.012
regulation of cellular ketone metabolic process GO:0010565 7 0.012
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.011
kupffer s vesicle development GO:0070121 50 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
collagen biosynthetic process GO:0032964 2 0.011
nucleocytoplasmic transport GO:0006913 4 0.011
modification of morphology or physiology of other organism GO:0035821 4 0.011
regulation of neural precursor cell proliferation GO:2000177 3 0.011
cell killing GO:0001906 2 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
ion transport GO:0006811 114 0.011
neuron development GO:0048666 262 0.011
amide biosynthetic process GO:0043604 1 0.011
lipid biosynthetic process GO:0008610 22 0.011
embryonic skeletal system development GO:0048706 97 0.011
branched chain amino acid metabolic process GO:0009081 1 0.011
regulation of molecular function GO:0065009 70 0.011
Human
regulation of multicellular organismal metabolic process GO:0044246 2 0.011
cell aging GO:0007569 2 0.011
protein localization to nucleus GO:0034504 3 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
determination of liver left right asymmetry GO:0071910 11 0.011
ph reduction GO:0045851 1 0.011
viral process GO:0016032 1 0.011
response to metal ion GO:0010038 34 0.010
transmembrane transport GO:0055085 120 0.010
hemostasis GO:0007599 13 0.010
renal system process involved in regulation of blood volume GO:0001977 1 0.010
negative regulation of protein transport GO:0051224 3 0.010
positive regulation of nuclease activity GO:0032075 1 0.010
odontogenesis of dentin containing tooth GO:0042475 1 0.010
inner ear development GO:0048839 126 0.010
intracellular signal transduction GO:0035556 85 0.010
photoreceptor cell fate commitment GO:0046552 1 0.010
cardiac atrium development GO:0003230 4 0.010
regulation of cell migration GO:0030334 40 0.010

bhlhe40 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.067
disease of anatomical entity DOID:7 0 0.037
inherited metabolic disorder DOID:655 0 0.026
cardiovascular system disease DOID:1287 0 0.020
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.014
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.013