Danio rerio

0 known processes

trio

triple functional domain (PTPRF interacting)

(Aliases: si:dz230d15.1)

trio biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.076
maintenance of location GO:0051235 4 0.040
phagocytosis GO:0006909 3 0.038
aging GO:0007568 2 0.038
signal transduction GO:0007165 455 0.037
cell surface receptor signaling pathway GO:0007166 325 0.035
regulation of multicellular organism growth GO:0040014 4 0.035
positive regulation of cellular component biogenesis GO:0044089 3 0.035
amine metabolic process GO:0009308 2 0.034
cellular macromolecule metabolic process GO:0044260 391 0.033
positive regulation of cell cycle GO:0045787 3 0.032
cellular amine metabolic process GO:0044106 2 0.031
nitrogen compound metabolic process GO:0006807 319 0.031
positive regulation of transport GO:0051050 2 0.031
cellular nitrogen compound metabolic process GO:0034641 290 0.031
multicellular organism growth GO:0035264 4 0.030
cellular protein catabolic process GO:0044257 4 0.030
meiotic nuclear division GO:0007126 4 0.029
organic cyclic compound metabolic process GO:1901360 301 0.029
regulation of cellular metabolic process GO:0031323 320 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.028
lipid storage GO:0019915 1 0.028
extrinsic apoptotic signaling pathway GO:0097191 3 0.028
sensory organ development GO:0007423 393 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
stem cell maintenance GO:0019827 4 0.027
cellular ketone metabolic process GO:0042180 11 0.027
regulation of cellular amine metabolic process GO:0033238 0 0.026
establishment of protein localization to organelle GO:0072594 4 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
eye development GO:0001654 277 0.026
positive regulation of protein complex assembly GO:0031334 2 0.026
regulation of cytokine production GO:0001817 3 0.025
negative regulation of cellular process GO:0048523 283 0.025
regulation of cell activation GO:0050865 1 0.025
regulation of metabolic process GO:0019222 359 0.025
regulation of protein transport GO:0051223 3 0.025
regulation of signal transduction GO:0009966 225 0.025
regulation of cellular ketone metabolic process GO:0010565 7 0.025
mitochondrion organization GO:0007005 4 0.024
modification dependent macromolecule catabolic process GO:0043632 3 0.024
immune system process GO:0002376 241 0.024
cellular aromatic compound metabolic process GO:0006725 295 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.024
ribonucleoside monophosphate catabolic process GO:0009158 4 0.024
atp catabolic process GO:0006200 4 0.024
female sex differentiation GO:0046660 4 0.024
adult behavior GO:0030534 2 0.024
response to chemical GO:0042221 320 0.024
heterocycle metabolic process GO:0046483 290 0.023
organonitrogen compound metabolic process GO:1901564 74 0.023
gene expression GO:0010467 252 0.023
rna metabolic process GO:0016070 219 0.023
organic substance biosynthetic process GO:1901576 289 0.023
regulation of response to stimulus GO:0048583 269 0.023
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.022
autophagy GO:0006914 4 0.022
nucleic acid metabolic process GO:0090304 244 0.022
modification dependent protein catabolic process GO:0019941 3 0.022
positive regulation of catabolic process GO:0009896 4 0.022
cell substrate adhesion GO:0031589 4 0.022
erk1 and erk2 cascade GO:0070371 4 0.022
protein acetylation GO:0006473 2 0.022
regulation of gene expression GO:0010468 265 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
generation of neurons GO:0048699 385 0.022
heterocycle biosynthetic process GO:0018130 215 0.022
cellular response to external stimulus GO:0071496 2 0.022
proteasomal protein catabolic process GO:0010498 2 0.021
negative regulation of biological process GO:0048519 304 0.021
regulation of signaling GO:0023051 235 0.021
response to drug GO:0042493 3 0.021
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.021
regulation of primary metabolic process GO:0080090 311 0.021
nuclear transport GO:0051169 4 0.021
regulation of erk1 and erk2 cascade GO:0070372 4 0.021
hemopoiesis GO:0030097 183 0.021
oxoacid metabolic process GO:0043436 31 0.020
cellular component movement GO:0006928 335 0.020
blood vessel development GO:0001568 246 0.020
positive regulation of cytokine production GO:0001819 2 0.020
meiotic cell cycle process GO:1903046 3 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.020
regulation of reproductive process GO:2000241 4 0.020
positive regulation of secretion GO:0051047 1 0.020
nucleoside monophosphate catabolic process GO:0009125 4 0.020
gtp catabolic process GO:0006184 2 0.020
cellular response to extracellular stimulus GO:0031668 2 0.020
regulation of protein complex assembly GO:0043254 3 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
regulation of protein catabolic process GO:0042176 1 0.020
biosynthetic process GO:0009058 294 0.020
organic acid metabolic process GO:0006082 31 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.019
membrane fusion GO:0061025 2 0.019
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
regulation of cell communication GO:0010646 232 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
cognition GO:0050890 1 0.019
locomotor rhythm GO:0045475 3 0.019
cellular response to nutrient levels GO:0031669 2 0.019
guanosine containing compound metabolic process GO:1901068 4 0.019
ubiquitin dependent protein catabolic process GO:0006511 3 0.019
regulation of macromolecule biosynthetic process GO:0010556 225 0.019
peptidyl lysine acetylation GO:0018394 2 0.019
camera type eye development GO:0043010 222 0.019
vasculature development GO:0001944 278 0.019
cellular component morphogenesis GO:0032989 336 0.019
neuron differentiation GO:0030182 353 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
regulation of multicellular organismal process GO:0051239 277 0.019
positive regulation of cytoskeleton organization GO:0051495 3 0.019
localization of cell GO:0051674 244 0.019
guanosine containing compound catabolic process GO:1901069 2 0.019
regulation of inflammatory response GO:0050727 2 0.019
regulation of biosynthetic process GO:0009889 250 0.019
cell part morphogenesis GO:0032990 246 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
organic cyclic compound biosynthetic process GO:1901362 223 0.019
cell morphogenesis GO:0000902 289 0.018
cytokinesis GO:0000910 3 0.018
exocytosis GO:0006887 1 0.018
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
small molecule metabolic process GO:0044281 77 0.018
leukocyte proliferation GO:0070661 1 0.018
morphogenesis of an epithelium GO:0002009 333 0.018
single organism metabolic process GO:0044710 217 0.018
gtp metabolic process GO:0046039 4 0.018
cell projection morphogenesis GO:0048858 244 0.018
immune system development GO:0002520 191 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
establishment of localization GO:0051234 244 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
regulation of biological quality GO:0065008 263 0.018
rna biosynthetic process GO:0032774 181 0.018
internal peptidyl lysine acetylation GO:0018393 2 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.018
regulation of meiotic cell cycle GO:0051445 1 0.018
regulation of macromolecule metabolic process GO:0060255 317 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
protein localization to plasma membrane GO:0072659 1 0.018
transcription dna templated GO:0006351 181 0.018
regulation of synapse organization GO:0050807 3 0.018
purine nucleoside monophosphate catabolic process GO:0009128 4 0.018
regulation of metal ion transport GO:0010959 4 0.018
embryo development ending in birth or egg hatching GO:0009792 271 0.018
adherens junction organization GO:0034332 4 0.017
digestive system development GO:0055123 289 0.017
tissue remodeling GO:0048771 4 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.017
blood vessel morphogenesis GO:0048514 216 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
regulation of binding GO:0051098 3 0.017
negative regulation of mapk cascade GO:0043409 4 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
cellular biosynthetic process GO:0044249 286 0.017
protein acylation GO:0043543 3 0.017
central nervous system development GO:0007417 387 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
tube morphogenesis GO:0035239 349 0.017
single organism localization GO:1902578 225 0.017
endosomal transport GO:0016197 2 0.017
nucleic acid templated transcription GO:0097659 181 0.017
regulation of mrna processing GO:0050684 3 0.017
positive regulation of apoptotic signaling pathway GO:2001235 1 0.017
compound eye development GO:0048749 2 0.016
mononuclear cell proliferation GO:0032943 1 0.016
single organism membrane fusion GO:0044801 2 0.016
embryonic organ development GO:0048568 381 0.016
cell projection organization GO:0030030 284 0.016
regulation of rna biosynthetic process GO:2001141 213 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
positive regulation of secretion by cell GO:1903532 1 0.016
internal protein amino acid acetylation GO:0006475 2 0.016
response to organic substance GO:0010033 153 0.016
negative regulation of kinase activity GO:0033673 4 0.016
protein localization to nucleus GO:0034504 3 0.016
muscle structure development GO:0061061 196 0.016
regulation of multicellular organismal development GO:2000026 223 0.016
double strand break repair GO:0006302 3 0.016
cell migration GO:0016477 237 0.016
protein secretion GO:0009306 1 0.016
stem cell proliferation GO:0072089 4 0.016
organelle organization GO:0006996 227 0.016
primary neural tube formation GO:0014020 1 0.016
protein metabolic process GO:0019538 183 0.016
enzyme linked receptor protein signaling pathway GO:0007167 106 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
lymphocyte proliferation GO:0046651 1 0.016
response to stress GO:0006950 263 0.016
lateral inhibition GO:0046331 1 0.016
locomotion GO:0040011 313 0.016
rna localization GO:0006403 4 0.015
chordate embryonic development GO:0043009 271 0.015
regulation of neural precursor cell proliferation GO:2000177 3 0.015
head development GO:0060322 303 0.015
regulation of synapse assembly GO:0051963 3 0.015
macromolecule biosynthetic process GO:0009059 227 0.015
response to uv GO:0009411 3 0.015
positive regulation of cell adhesion GO:0045785 1 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
germ line stem cell maintenance GO:0030718 2 0.015
regulation of rna metabolic process GO:0051252 224 0.015
positive regulation of biological process GO:0048518 253 0.015
protein import GO:0017038 3 0.015
nuclear import GO:0051170 3 0.015
negative regulation of catabolic process GO:0009895 3 0.015
peptidyl serine modification GO:0018209 2 0.015
transcription from rna polymerase ii promoter GO:0006366 80 0.015
regulation of autophagy GO:0010506 3 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
phagocytosis engulfment GO:0006911 1 0.015
regionalization GO:0003002 274 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
negative regulation of sequestering of calcium ion GO:0051283 4 0.015
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.015
angiogenesis GO:0001525 158 0.015
regulation of cellular biosynthetic process GO:0031326 245 0.015
negative regulation of mitosis GO:0045839 3 0.015
sequestering of metal ion GO:0051238 3 0.015
lipid homeostasis GO:0055088 3 0.014
protein dephosphorylation GO:0006470 3 0.014
cell motility GO:0048870 244 0.014
membrane invagination GO:0010324 1 0.014
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
regulation of developmental process GO:0050793 247 0.014
microtubule organizing center organization GO:0031023 1 0.014
signal transduction in absence of ligand GO:0038034 1 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
negative regulation of cytokine production GO:0001818 1 0.014
protein polymerization GO:0051258 4 0.014
cytokinetic process GO:0032506 2 0.014
stem cell division GO:0017145 1 0.014
neuron development GO:0048666 262 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
regulation of transcription dna templated GO:0006355 213 0.014
fertilization GO:0009566 3 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
regulation of nucleotide catabolic process GO:0030811 2 0.014
positive regulation of immune effector process GO:0002699 3 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
anterior posterior pattern specification GO:0009952 152 0.014
peptidyl serine phosphorylation GO:0018105 1 0.014
digestive tract development GO:0048565 265 0.014
heart development GO:0007507 313 0.014
cellular component disassembly GO:0022411 1 0.014
regulation of protein ubiquitination GO:0031396 3 0.014
regulation of oocyte development GO:0060281 3 0.014
nuclear export GO:0051168 1 0.013
cellular protein metabolic process GO:0044267 129 0.013
single organism transport GO:0044765 206 0.013
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.013
retina development in camera type eye GO:0060041 146 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
protein targeting to nucleus GO:0044744 3 0.013
positive regulation of cellular process GO:0048522 201 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
transport GO:0006810 220 0.013
protein import into nucleus GO:0006606 3 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
single organism organelle organization GO:1902589 199 0.013
small molecule catabolic process GO:0044282 3 0.013
cell cycle arrest GO:0007050 1 0.013
cellular response to starvation GO:0009267 1 0.013
brain development GO:0007420 293 0.013
development of primary female sexual characteristics GO:0046545 4 0.013
programmed cell death GO:0012501 119 0.013
regulation of jak stat cascade GO:0046425 3 0.013
regulation of dna replication GO:0006275 3 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
release of sequestered calcium ion into cytosol GO:0051209 3 0.013
skeletal system development GO:0001501 181 0.013
regulation of cell substrate adhesion GO:0010810 1 0.013
developmental programmed cell death GO:0010623 4 0.013
mitotic cytokinesis GO:0000281 3 0.013
cell death GO:0008219 121 0.012
recombinational repair GO:0000725 1 0.012
chemosensory behavior GO:0007635 1 0.012
spermatid differentiation GO:0048515 2 0.012
response to corticosteroid GO:0031960 1 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
single fertilization GO:0007338 3 0.012
cytosolic calcium ion transport GO:0060401 3 0.012
regulation of response to extracellular stimulus GO:0032104 1 0.012
centrosome duplication GO:0051298 1 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.012
organelle fusion GO:0048284 3 0.012
sensory organ morphogenesis GO:0090596 200 0.012
protein homooligomerization GO:0051260 3 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
positive regulation of cell activation GO:0050867 1 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
striated muscle tissue development GO:0014706 110 0.012
cellular response to oxygen levels GO:0071453 1 0.012
spermatid development GO:0007286 2 0.012
female gonad development GO:0008585 4 0.012
inositol lipid mediated signaling GO:0048017 2 0.012
regulation of gtpase activity GO:0043087 2 0.012
death GO:0016265 121 0.012
sequestering of calcium ion GO:0051208 3 0.012
actin polymerization or depolymerization GO:0008154 2 0.012
single organism nuclear import GO:1902593 3 0.012
regulation of cell shape GO:0008360 1 0.012
neuron projection morphogenesis GO:0048812 161 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
cellular response to organic substance GO:0071310 105 0.012
glucose homeostasis GO:0042593 1 0.012
tube closure GO:0060606 1 0.012
golgi vesicle transport GO:0048193 3 0.012
response to carbohydrate GO:0009743 3 0.012
phosphorus metabolic process GO:0006793 109 0.012
response to nutrient GO:0007584 3 0.012
regulation of dendrite development GO:0050773 3 0.012
macromolecule modification GO:0043412 111 0.012
response to monosaccharide GO:0034284 3 0.012
system process GO:0003008 185 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
calcium ion transport into cytosol GO:0060402 3 0.012
regulation of calcium ion transport GO:0051924 2 0.012
secondary metabolic process GO:0019748 3 0.012
response to hexose GO:0009746 3 0.012
convergent extension GO:0060026 118 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
actin filament polymerization GO:0030041 2 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
phosphate containing compound metabolic process GO:0006796 108 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.011
cell matrix adhesion GO:0007160 4 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
organic acid catabolic process GO:0016054 3 0.011
intracellular mrna localization GO:0008298 1 0.011
response to endogenous stimulus GO:0009719 83 0.011
carbohydrate homeostasis GO:0033500 1 0.011
protein heterooligomerization GO:0051291 1 0.011
ion transmembrane transport GO:0034220 91 0.011
negative regulation of nuclear division GO:0051784 3 0.011
gastrulation GO:0007369 208 0.011
axonogenesis GO:0007409 152 0.011
erythrocyte homeostasis GO:0034101 55 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
determination of bilateral symmetry GO:0009855 204 0.011
b cell activation GO:0042113 2 0.011
nucleic acid transport GO:0050657 2 0.011
negative regulation of defense response GO:0031348 2 0.011
cell substrate junction assembly GO:0007044 2 0.011
viral process GO:0016032 1 0.011
negative regulation of signal transduction GO:0009968 94 0.011
neurotransmitter transport GO:0006836 2 0.011
intracellular signal transduction GO:0035556 85 0.011
protein polyubiquitination GO:0000209 4 0.011
response to external stimulus GO:0009605 264 0.011
membrane lipid biosynthetic process GO:0046467 2 0.011
digestive tract morphogenesis GO:0048546 231 0.011
protein modification process GO:0036211 100 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
cellular response to radiation GO:0071478 4 0.011
interspecies interaction between organisms GO:0044419 4 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
muscle cell differentiation GO:0042692 139 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
macromolecular complex disassembly GO:0032984 1 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
macroautophagy GO:0016236 1 0.011
cellular response to hypoxia GO:0071456 1 0.011
multi organism cellular process GO:0044764 2 0.011
regulation of protein localization to nucleus GO:1900180 2 0.010
positive regulation of translation GO:0045727 1 0.010
developmental growth GO:0048589 166 0.010
regulation of wound healing GO:0061041 2 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
cellular protein modification process GO:0006464 100 0.010
centrosome organization GO:0051297 1 0.010
regulation of protein import into nucleus GO:0042306 2 0.010
production of molecular mediator of immune response GO:0002440 2 0.010
meiotic chromosome segregation GO:0045132 3 0.010
regulation of protein localization to plasma membrane GO:1903076 1 0.010
protein complex disassembly GO:0043241 1 0.010
regulation of protein targeting GO:1903533 2 0.010
eye morphogenesis GO:0048592 144 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.010
negative regulation of protein transport GO:0051224 3 0.010
somatic muscle development GO:0007525 4 0.010
cortical cytoskeleton organization GO:0030865 1 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
regulation of apoptotic process GO:0042981 98 0.010
regulation of dendrite morphogenesis GO:0048814 3 0.010
response to hydrogen peroxide GO:0042542 3 0.010
response to ketone GO:1901654 1 0.010
wnt signaling pathway GO:0016055 80 0.010

trio disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
organ system cancer DOID:0050686 0 0.020
musculoskeletal system disease DOID:17 0 0.020
disease of metabolism DOID:0014667 0 0.017
nervous system disease DOID:863 0 0.017
immune system disease DOID:2914 0 0.014
connective tissue disease DOID:65 0 0.010
muscular disease DOID:0080000 0 0.010