Danio rerio

0 known processes

lrp6

low-density lipoprotein receptor-related protein 6

lrp6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ development GO:0007423 393 0.095
stem cell proliferation GO:0072089 4 0.076
posterior lateral line system development GO:0048915 46 0.066
lateral line development GO:0048882 66 0.063
mechanosensory lateral line system development GO:0048881 49 0.063
neuromast development GO:0048884 46 0.062
regulation of stem cell proliferation GO:0072091 2 0.059
lipid homeostasis GO:0055088 3 0.053
larval development GO:0002164 2 0.051
posterior lateral line development GO:0048916 38 0.050
regulation of blood pressure GO:0008217 1 0.049
regulation of nitrogen compound metabolic process GO:0051171 251 0.045
gtp catabolic process GO:0006184 2 0.041
sensory system development GO:0048880 76 0.040
regulation of multicellular organismal process GO:0051239 277 0.040
negative regulation of protein phosphorylation GO:0001933 4 0.038
cellular component movement GO:0006928 335 0.038
negative regulation of cellular process GO:0048523 283 0.037
phagocytosis GO:0006909 3 0.037
nitrogen compound metabolic process GO:0006807 319 0.035
eye development GO:0001654 277 0.034
response to chemical GO:0042221 320 0.034
cell surface receptor signaling pathway GO:0007166 325 0.033
regionalization GO:0003002 274 0.033
stem cell maintenance GO:0019827 4 0.032
regulation of reproductive process GO:2000241 4 0.032
blood vessel development GO:0001568 246 0.031
signal transduction GO:0007165 455 0.031
central nervous system development GO:0007417 387 0.031
cellular macromolecule metabolic process GO:0044260 391 0.031
positive regulation of cell cycle GO:0045787 3 0.030
organic substance biosynthetic process GO:1901576 289 0.030
organic cyclic compound metabolic process GO:1901360 301 0.030
generation of neurons GO:0048699 385 0.029
lateral line system development GO:0048925 76 0.029
retina development in camera type eye GO:0060041 146 0.028
positive regulation of transport GO:0051050 2 0.028
sensory perception of chemical stimulus GO:0007606 3 0.027
vasculature development GO:0001944 278 0.027
neuroblast proliferation GO:0007405 2 0.027
regulation of gene expression GO:0010468 265 0.027
multicellular organism growth GO:0035264 4 0.027
negative regulation of biological process GO:0048519 304 0.027
regulation of primary metabolic process GO:0080090 311 0.027
guanosine containing compound metabolic process GO:1901068 4 0.026
system process GO:0003008 185 0.026
extrinsic apoptotic signaling pathway GO:0097191 3 0.026
regulation of multicellular organism growth GO:0040014 4 0.026
olfactory lobe development GO:0021988 4 0.025
cellular nitrogen compound metabolic process GO:0034641 290 0.025
cellular component morphogenesis GO:0032989 336 0.025
guanosine containing compound catabolic process GO:1901069 2 0.025
regulation of metal ion transport GO:0010959 4 0.024
cellular ketone metabolic process GO:0042180 11 0.024
regulation of stem cell differentiation GO:2000736 4 0.024
neuron neuron synaptic transmission GO:0007270 1 0.024
regulation of cellular metabolic process GO:0031323 320 0.024
regulation of biological quality GO:0065008 263 0.023
positive regulation of stem cell proliferation GO:2000648 1 0.023
organic cyclic compound biosynthetic process GO:1901362 223 0.023
peptidyl lysine acetylation GO:0018394 2 0.023
neuron differentiation GO:0030182 353 0.023
internal peptidyl lysine acetylation GO:0018393 2 0.023
maintenance of location GO:0051235 4 0.023
regulation of cytokine production GO:0001817 3 0.023
cellular response to molecule of bacterial origin GO:0071219 3 0.022
locomotion GO:0040011 313 0.022
nucleic acid templated transcription GO:0097659 181 0.022
regulation of mrna processing GO:0050684 3 0.022
hormone secretion GO:0046879 2 0.022
regulation of biosynthetic process GO:0009889 250 0.022
cell part morphogenesis GO:0032990 246 0.022
single organism metabolic process GO:0044710 217 0.022
olfactory bulb development GO:0021772 4 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.022
regulation of cellular ketone metabolic process GO:0010565 7 0.022
gtp metabolic process GO:0046039 4 0.022
somatic stem cell maintenance GO:0035019 1 0.022
establishment of protein localization to organelle GO:0072594 4 0.022
eye morphogenesis GO:0048592 144 0.021
internal protein amino acid acetylation GO:0006475 2 0.021
cellular response to external stimulus GO:0071496 2 0.021
dorsal ventral pattern formation GO:0009953 125 0.021
lipid storage GO:0019915 1 0.021
organonitrogen compound metabolic process GO:1901564 74 0.021
mononuclear cell proliferation GO:0032943 1 0.021
camera type eye development GO:0043010 222 0.021
homeostasis of number of cells within a tissue GO:0048873 4 0.021
cellular biosynthetic process GO:0044249 286 0.020
cellular response to lipopolysaccharide GO:0071222 3 0.020
heterocycle metabolic process GO:0046483 290 0.020
cellular aromatic compound metabolic process GO:0006725 295 0.020
hypothalamus cell differentiation GO:0021979 4 0.020
sensory organ morphogenesis GO:0090596 200 0.020
posterior lateral line neuromast development GO:0048919 20 0.020
amine metabolic process GO:0009308 2 0.020
protein import GO:0017038 3 0.020
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.020
rna biosynthetic process GO:0032774 181 0.020
gene expression GO:0010467 252 0.020
heterocycle biosynthetic process GO:0018130 215 0.020
biosynthetic process GO:0009058 294 0.019
organelle organization GO:0006996 227 0.019
nucleic acid metabolic process GO:0090304 244 0.019
cellular macromolecule biosynthetic process GO:0034645 224 0.019
macromolecule biosynthetic process GO:0009059 227 0.019
response to external stimulus GO:0009605 264 0.019
cellular response to biotic stimulus GO:0071216 3 0.019
nucleobase containing compound metabolic process GO:0006139 274 0.019
negative regulation of kinase activity GO:0033673 4 0.019
cell morphogenesis GO:0000902 289 0.018
regulation of signaling GO:0023051 235 0.018
regulation of developmental process GO:0050793 247 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
regulation of signal transduction GO:0009966 225 0.018
cellular component disassembly GO:0022411 1 0.018
brain development GO:0007420 293 0.018
peptide transport GO:0015833 1 0.018
secondary metabolic process GO:0019748 3 0.018
protein acylation GO:0043543 3 0.018
segmentation GO:0035282 97 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
regulation of synapse assembly GO:0051963 3 0.018
retina morphogenesis in camera type eye GO:0060042 79 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
negative regulation of chemotaxis GO:0050922 4 0.018
small molecule metabolic process GO:0044281 77 0.018
regulation of cellular biosynthetic process GO:0031326 245 0.017
cellular protein catabolic process GO:0044257 4 0.017
regulation of epithelial cell proliferation GO:0050678 3 0.017
protein acetylation GO:0006473 2 0.017
aging GO:0007568 2 0.017
cellular response to nutrient levels GO:0031669 2 0.017
skeletal system development GO:0001501 181 0.017
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.017
cell projection organization GO:0030030 284 0.017
cell motility GO:0048870 244 0.017
liver development GO:0001889 96 0.017
regulation of meiotic cell cycle GO:0051445 1 0.017
head development GO:0060322 303 0.017
hormone transport GO:0009914 2 0.017
regulation of rna metabolic process GO:0051252 224 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
regulation of response to stimulus GO:0048583 269 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
ribonucleoside monophosphate catabolic process GO:0009158 4 0.017
protein localization to nucleus GO:0034504 3 0.017
response to carbohydrate GO:0009743 3 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
cellular amine metabolic process GO:0044106 2 0.017
cellular carbohydrate metabolic process GO:0044262 4 0.017
somite development GO:0061053 96 0.017
development of primary female sexual characteristics GO:0046545 4 0.017
single fertilization GO:0007338 3 0.017
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.016
chemosensory behavior GO:0007635 1 0.016
stem cell division GO:0017145 1 0.016
negative regulation of sequestering of calcium ion GO:0051283 4 0.016
somatic cell dna recombination GO:0016444 1 0.016
anterior posterior pattern specification GO:0009952 152 0.016
synaptic growth at neuromuscular junction GO:0051124 2 0.016
protein import into nucleus GO:0006606 3 0.016
organic acid metabolic process GO:0006082 31 0.016
canonical wnt signaling pathway GO:0060070 48 0.016
single organism nuclear import GO:1902593 3 0.016
hepaticobiliary system development GO:0061008 98 0.016
positive regulation of catabolic process GO:0009896 4 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
response to hexose GO:0009746 3 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
response to monosaccharide GO:0034284 3 0.016
response to drug GO:0042493 3 0.016
leukocyte proliferation GO:0070661 1 0.016
tissue remodeling GO:0048771 4 0.016
regulation of sodium ion transport GO:0002028 2 0.016
regulation of cell communication GO:0010646 232 0.015
transcription dna templated GO:0006351 181 0.015
regulation of nucleotide catabolic process GO:0030811 2 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
regulation of carbohydrate metabolic process GO:0006109 4 0.015
regulation of gtp catabolic process GO:0033124 2 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
regulation of hormone secretion GO:0046883 2 0.015
regulation of metabolic process GO:0019222 359 0.015
positive regulation of cellular component biogenesis GO:0044089 3 0.015
establishment of localization GO:0051234 244 0.015
carbohydrate biosynthetic process GO:0016051 1 0.015
regulation of establishment of protein localization GO:0070201 4 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
localization of cell GO:0051674 244 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.015
cell projection morphogenesis GO:0048858 244 0.015
fertilization GO:0009566 3 0.015
sequestering of calcium ion GO:0051208 3 0.015
regulation of macromolecule biosynthetic process GO:0010556 225 0.015
positive regulation of reproductive process GO:2000243 2 0.015
pharyngeal muscle development GO:0043282 4 0.015
neurotransmitter transport GO:0006836 2 0.015
regulation of gtpase activity GO:0043087 2 0.015
positive regulation of secretion GO:0051047 1 0.015
digestive system development GO:0055123 289 0.015
nuclear transport GO:0051169 4 0.015
posterior lateral line neuromast deposition GO:0048922 5 0.015
chordate embryonic development GO:0043009 271 0.015
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.015
positive regulation of cellular catabolic process GO:0031331 3 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
regulation of blood vessel size GO:0050880 2 0.015
camera type eye morphogenesis GO:0048593 108 0.014
neuromast primordium migration GO:0048883 12 0.014
adherens junction organization GO:0034332 4 0.014
regulation of cytoplasmic transport GO:1903649 4 0.014
proteasomal protein catabolic process GO:0010498 2 0.014
macromolecular complex disassembly GO:0032984 1 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
immune system development GO:0002520 191 0.014
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.014
angiogenesis GO:0001525 158 0.014
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.014
compound eye development GO:0048749 2 0.014
blood vessel morphogenesis GO:0048514 216 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
sequestering of metal ion GO:0051238 3 0.014
protein dephosphorylation GO:0006470 3 0.014
rna metabolic process GO:0016070 219 0.014
membrane fusion GO:0061025 2 0.014
female gonad development GO:0008585 4 0.014
carbohydrate homeostasis GO:0033500 1 0.014
embryonic organ morphogenesis GO:0048562 274 0.014
regulation of protein catabolic process GO:0042176 1 0.014
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.014
adult behavior GO:0030534 2 0.014
embryonic organ development GO:0048568 381 0.014
regulation of ph GO:0006885 3 0.014
regulation of muscle contraction GO:0006937 3 0.014
positive regulation of cytokine production GO:0001819 2 0.014
cellular response to starvation GO:0009267 1 0.014
tube morphogenesis GO:0035239 349 0.013
macromolecule modification GO:0043412 111 0.013
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.013
protein localization to plasma membrane GO:0072659 1 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
neuron development GO:0048666 262 0.013
regulation of mrna splicing via spliceosome GO:0048024 3 0.013
taxis GO:0042330 109 0.013
immune system process GO:0002376 241 0.013
membrane invagination GO:0010324 1 0.013
autophagy GO:0006914 4 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
muscle fiber development GO:0048747 52 0.013
protein homooligomerization GO:0051260 3 0.013
nephron tubule morphogenesis GO:0072078 1 0.013
phagocytosis engulfment GO:0006911 1 0.013
regulation of cell activation GO:0050865 1 0.013
positive regulation of notch signaling pathway GO:0045747 3 0.013
gland development GO:0048732 143 0.013
positive regulation of biological process GO:0048518 253 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
regulation of protein transport GO:0051223 3 0.013
somatic muscle development GO:0007525 4 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
cellular response to radiation GO:0071478 4 0.013
modification dependent macromolecule catabolic process GO:0043632 3 0.013
protein complex disassembly GO:0043241 1 0.013
regulation of dendrite morphogenesis GO:0048814 3 0.013
developmental growth GO:0048589 166 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
cognition GO:0050890 1 0.012
response to uv GO:0009411 3 0.012
nuclear migration GO:0007097 3 0.012
positive regulation of immune effector process GO:0002699 3 0.012
neuron projection development GO:0031175 180 0.012
meiotic nuclear division GO:0007126 4 0.012
protein heterooligomerization GO:0051291 1 0.012
forebrain regionalization GO:0021871 4 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.012
female sex differentiation GO:0046660 4 0.012
regulation of circadian rhythm GO:0042752 4 0.012
cell migration GO:0016477 237 0.012
circulatory system process GO:0003013 87 0.012
response to glucose GO:0009749 3 0.012
release of sequestered calcium ion into cytosol GO:0051209 3 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
negative chemotaxis GO:0050919 1 0.012
connective tissue development GO:0061448 99 0.012
growth GO:0040007 174 0.012
single organism organelle organization GO:1902589 199 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
axonogenesis GO:0007409 152 0.012
negative regulation of stem cell differentiation GO:2000737 2 0.012
posterior lateral line neuromast primordium migration GO:0048920 12 0.012
positive regulation of myeloid cell differentiation GO:0045639 2 0.012
adipose tissue development GO:0060612 1 0.012
mesenchyme development GO:0060485 127 0.012
production of molecular mediator of immune response GO:0002440 2 0.012
cell cycle g1 s phase transition GO:0044843 1 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
nuclear import GO:0051170 3 0.012
somitogenesis GO:0001756 87 0.012
regulation of transcription dna templated GO:0006355 213 0.012
b cell activation GO:0042113 2 0.012
glucose homeostasis GO:0042593 1 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
blood circulation GO:0008015 87 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
cell cycle arrest GO:0007050 1 0.012
organism emergence from protective structure GO:0071684 4 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
activation of mapk activity GO:0000187 3 0.012
regulation of membrane potential GO:0042391 23 0.012
negative regulation of cytokine production GO:0001818 1 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.011
striated muscle cell differentiation GO:0051146 129 0.011
golgi vesicle transport GO:0048193 3 0.011
germ line stem cell maintenance GO:0030718 2 0.011
homeostatic process GO:0042592 142 0.011
g protein coupled receptor signaling pathway GO:0007186 74 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
regulation of calcium ion transport GO:0051924 2 0.011
oxoacid metabolic process GO:0043436 31 0.011
regulation of organ growth GO:0046620 3 0.011
forebrain development GO:0030900 96 0.011
erk1 and erk2 cascade GO:0070371 4 0.011
branching morphogenesis of a nerve GO:0048755 4 0.011
response to organic substance GO:0010033 153 0.011
protein stabilization GO:0050821 2 0.011
regulation of inflammatory response GO:0050727 2 0.011
response to alkaloid GO:0043279 2 0.011
negative regulation of developmental process GO:0051093 65 0.011
lymphocyte proliferation GO:0046651 1 0.011
regulation of cell differentiation GO:0045595 142 0.011
alcohol biosynthetic process GO:0046165 2 0.011
sprouting angiogenesis GO:0002040 53 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
endocrine process GO:0050886 2 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
meiotic cell cycle process GO:1903046 3 0.011
mitochondrion organization GO:0007005 4 0.011
transport GO:0006810 220 0.011
endosomal transport GO:0016197 2 0.011
skeletal system morphogenesis GO:0048705 102 0.011
positive regulation of epithelial cell proliferation GO:0050679 1 0.011
heart development GO:0007507 313 0.011
atp catabolic process GO:0006200 4 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
wnt signaling pathway GO:0016055 80 0.011
single organism localization GO:1902578 225 0.011
regulation of protein complex disassembly GO:0043244 1 0.011
glucose import GO:0046323 2 0.011
melanin metabolic process GO:0006582 2 0.011
negative regulation of reproductive process GO:2000242 3 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
positive regulation of gtpase activity GO:0043547 1 0.011
nephron morphogenesis GO:0072028 2 0.011
small molecule catabolic process GO:0044282 3 0.010
calcium ion transport into cytosol GO:0060402 3 0.010
actin mediated cell contraction GO:0070252 1 0.010
exocytosis GO:0006887 1 0.010
establishment of endothelial barrier GO:0061028 3 0.010
mesenchymal cell proliferation GO:0010463 1 0.010
regulation of neurotransmitter transport GO:0051588 1 0.010
regulation of intracellular protein transport GO:0033157 3 0.010
muscle structure development GO:0061061 196 0.010
regulation of sequestering of calcium ion GO:0051282 4 0.010
forebrain cell migration GO:0021885 1 0.010
cytosolic calcium ion transport GO:0060401 3 0.010
regulation of carbohydrate biosynthetic process GO:0043255 1 0.010
rna localization GO:0006403 4 0.010
transcription from rna polymerase ii promoter GO:0006366 80 0.010
pancreas development GO:0031016 84 0.010
protein depolymerization GO:0051261 1 0.010
positive regulation of multi organism process GO:0043902 3 0.010
energy reserve metabolic process GO:0006112 2 0.010
post embryonic organ development GO:0048569 4 0.010
regulation of ion transmembrane transporter activity GO:0032412 2 0.010
regulation of cell shape GO:0008360 1 0.010
regulation of nucleocytoplasmic transport GO:0046822 2 0.010
regulation of systemic arterial blood pressure GO:0003073 1 0.010
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.010
positive regulation of epithelial cell migration GO:0010634 2 0.010
regulation of dendrite development GO:0050773 3 0.010

lrp6 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
musculoskeletal system disease DOID:17 0 0.043
sensory system disease DOID:0050155 0 0.030
eye and adnexa disease DOID:1492 0 0.030
nervous system disease DOID:863 0 0.030
eye disease DOID:5614 0 0.030
connective tissue disease DOID:65 0 0.017
bone disease DOID:0080001 0 0.016
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
disease of metabolism DOID:0014667 0 0.013
retinal disease DOID:5679 0 0.012