Danio rerio

0 known processes

pnp5b

purine nucleoside phosphorylase 5b

(Aliases: zgc:101740)

pnp5b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.090
aging GO:0007568 2 0.063
multicellular organism growth GO:0035264 4 0.047
regulation of multicellular organism growth GO:0040014 4 0.039
positive regulation of transport GO:0051050 2 0.038
cognition GO:0050890 1 0.038
maintenance of location GO:0051235 4 0.037
mitochondrion organization GO:0007005 4 0.035
cellular response to external stimulus GO:0071496 2 0.035
positive regulation of cell cycle GO:0045787 3 0.034
nitrogen compound metabolic process GO:0006807 319 0.034
Yeast
positive regulation of catabolic process GO:0009896 4 0.033
cellular aromatic compound metabolic process GO:0006725 295 0.032
Yeast
cellular nitrogen compound metabolic process GO:0034641 290 0.032
Yeast
cellular response to nutrient levels GO:0031669 2 0.032
establishment of protein localization to organelle GO:0072594 4 0.032
nucleobase containing compound metabolic process GO:0006139 274 0.032
Yeast
autophagy GO:0006914 4 0.031
positive regulation of cellular catabolic process GO:0031331 3 0.031
gtp metabolic process GO:0046039 4 0.031
organic cyclic compound metabolic process GO:1901360 301 0.031
Yeast
cellular response to extracellular stimulus GO:0031668 2 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.030
regulation of metabolic process GO:0019222 359 0.030
positive regulation of cellular component biogenesis GO:0044089 3 0.030
heterocycle metabolic process GO:0046483 290 0.029
Yeast
regulation of cytokine production GO:0001817 3 0.029
amine metabolic process GO:0009308 2 0.028
organic substance biosynthetic process GO:1901576 289 0.028
Yeast
meiotic nuclear division GO:0007126 4 0.028
organelle fusion GO:0048284 3 0.028
phagocytosis GO:0006909 3 0.028
negative regulation of protein phosphorylation GO:0001933 4 0.028
regulation of macromolecule metabolic process GO:0060255 317 0.028
modification dependent protein catabolic process GO:0019941 3 0.028
single organism metabolic process GO:0044710 217 0.027
Yeast
guanosine containing compound metabolic process GO:1901068 4 0.027
Yeast
cellular macromolecule metabolic process GO:0044260 391 0.027
cellular protein catabolic process GO:0044257 4 0.026
gtp catabolic process GO:0006184 2 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.026
cellular response to starvation GO:0009267 1 0.026
signal transduction GO:0007165 455 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
regulation of nucleoside metabolic process GO:0009118 2 0.026
regulation of protein transport GO:0051223 3 0.026
membrane fusion GO:0061025 2 0.026
ubiquitin dependent protein catabolic process GO:0006511 3 0.026
regulation of binding GO:0051098 3 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
guanosine containing compound catabolic process GO:1901069 2 0.025
Yeast
regulation of cellular metabolic process GO:0031323 320 0.025
gene expression GO:0010467 252 0.025
regulation of protein complex assembly GO:0043254 3 0.024
lipid storage GO:0019915 1 0.024
cellular ketone metabolic process GO:0042180 11 0.024
stem cell maintenance GO:0019827 4 0.024
atp catabolic process GO:0006200 4 0.024
nucleoside monophosphate catabolic process GO:0009125 4 0.024
cellular amine metabolic process GO:0044106 2 0.023
protein import GO:0017038 3 0.023
regulation of nucleotide catabolic process GO:0030811 2 0.023
modification dependent macromolecule catabolic process GO:0043632 3 0.023
protein localization to nucleus GO:0034504 3 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
regulation of nitrogen compound metabolic process GO:0051171 251 0.023
macromolecule biosynthetic process GO:0009059 227 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
regulation of purine nucleotide catabolic process GO:0033121 2 0.023
extrinsic apoptotic signaling pathway GO:0097191 3 0.023
ribonucleoside monophosphate catabolic process GO:0009158 4 0.023
protein targeting to nucleus GO:0044744 3 0.023
positive regulation of biological process GO:0048518 253 0.023
response to stress GO:0006950 263 0.022
regulation of cellular biosynthetic process GO:0031326 245 0.022
regulation of metal ion transport GO:0010959 4 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
Yeast
cytokinesis GO:0000910 3 0.022
response to chemical GO:0042221 320 0.022
establishment of localization GO:0051234 244 0.022
aromatic compound biosynthetic process GO:0019438 217 0.022
Yeast
regulation of reproductive process GO:2000241 4 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
purine nucleoside monophosphate catabolic process GO:0009128 4 0.022
regulation of synaptic plasticity GO:0048167 1 0.022
small molecule metabolic process GO:0044281 77 0.022
Yeast
response to external stimulus GO:0009605 264 0.022
nucleocytoplasmic transport GO:0006913 4 0.021
nuclear transport GO:0051169 4 0.021
adult behavior GO:0030534 2 0.021
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.021
cellular macromolecule biosynthetic process GO:0034645 224 0.021
negative regulation of protein kinase activity GO:0006469 4 0.021
single organism nuclear import GO:1902593 3 0.020
single organism membrane fusion GO:0044801 2 0.020
organelle organization GO:0006996 227 0.020
stem cell proliferation GO:0072089 4 0.020
heterocycle biosynthetic process GO:0018130 215 0.020
Yeast
transport GO:0006810 220 0.020
protein import into nucleus GO:0006606 3 0.020
tissue remodeling GO:0048771 4 0.020
compound eye development GO:0048749 2 0.020
regulation of gene expression GO:0010468 265 0.020
regulation of cell communication GO:0010646 232 0.020
neuron development GO:0048666 262 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
cellular biosynthetic process GO:0044249 286 0.020
Yeast
positive regulation of nucleoside metabolic process GO:0045979 1 0.020
cellular nitrogen compound biosynthetic process GO:0044271 218 0.020
Yeast
embryonic organ development GO:0048568 381 0.020
cellular carbohydrate metabolic process GO:0044262 4 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.020
nuclear import GO:0051170 3 0.020
regulation of meiotic cell cycle GO:0051445 1 0.020
regulation of gtp catabolic process GO:0033124 2 0.020
oxoacid metabolic process GO:0043436 31 0.020
sensory organ development GO:0007423 393 0.020
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.019
response to drug GO:0042493 3 0.019
chordate embryonic development GO:0043009 271 0.019
negative regulation of biological process GO:0048519 304 0.019
positive regulation of protein complex assembly GO:0031334 2 0.019
neuron differentiation GO:0030182 353 0.019
cell projection morphogenesis GO:0048858 244 0.019
embryo development ending in birth or egg hatching GO:0009792 271 0.019
golgi vesicle transport GO:0048193 3 0.019
exocytosis GO:0006887 1 0.019
regulation of response to stimulus GO:0048583 269 0.019
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
morphogenesis of an epithelium GO:0002009 333 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
response to nutrient GO:0007584 3 0.019
regulation of biological quality GO:0065008 263 0.019
regulation of protein catabolic process GO:0042176 1 0.019
generation of neurons GO:0048699 385 0.019
endosomal transport GO:0016197 2 0.019
locomotion GO:0040011 313 0.018
biosynthetic process GO:0009058 294 0.018
Yeast
meiotic cell cycle process GO:1903046 3 0.018
rna metabolic process GO:0016070 219 0.018
transcription dna templated GO:0006351 181 0.018
protein secretion GO:0009306 1 0.018
response to carbohydrate GO:0009743 3 0.018
negative regulation of cellular process GO:0048523 283 0.018
regulation of cell activation GO:0050865 1 0.018
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
cellular component morphogenesis GO:0032989 336 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.018
carboxylic acid metabolic process GO:0019752 22 0.018
central nervous system development GO:0007417 387 0.018
organic acid metabolic process GO:0006082 31 0.018
single organism localization GO:1902578 225 0.018
macroautophagy GO:0016236 1 0.018
regulation of biosynthetic process GO:0009889 250 0.018
cell projection organization GO:0030030 284 0.018
peptidyl serine phosphorylation GO:0018105 1 0.018
head development GO:0060322 303 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.018
regulation of synapse organization GO:0050807 3 0.017
positive regulation of cellular process GO:0048522 201 0.017
regulation of primary metabolic process GO:0080090 311 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
Yeast
cellular component movement GO:0006928 335 0.017
regulation of rna metabolic process GO:0051252 224 0.017
muscle structure development GO:0061061 196 0.017
cell substrate adhesion GO:0031589 4 0.017
organic cyclic compound biosynthetic process GO:1901362 223 0.017
Yeast
cellular component disassembly GO:0022411 1 0.017
eye development GO:0001654 277 0.017
positive regulation of secretion by cell GO:1903532 1 0.017
regulation of protein targeting GO:1903533 2 0.017
protein metabolic process GO:0019538 183 0.017
positive regulation of secretion GO:0051047 1 0.017
vasculature development GO:0001944 278 0.017
rna localization GO:0006403 4 0.017
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
regulation of nucleocytoplasmic transport GO:0046822 2 0.017
regulation of gtpase activity GO:0043087 2 0.016
cytoskeleton dependent cytokinesis GO:0061640 3 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.016
system process GO:0003008 185 0.016
regulation of transcription dna templated GO:0006355 213 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
cell cycle g1 s phase transition GO:0044843 1 0.016
positive regulation of gtpase activity GO:0043547 1 0.016
immune system process GO:0002376 241 0.016
neurotransmitter transport GO:0006836 2 0.016
neurotransmitter secretion GO:0007269 2 0.016
single organism transport GO:0044765 206 0.016
regulation of signaling GO:0023051 235 0.016
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.016
regulation of dendrite development GO:0050773 3 0.016
nucleic acid templated transcription GO:0097659 181 0.016
mitochondrial transport GO:0006839 2 0.016
regulation of mrna processing GO:0050684 3 0.016
transmembrane transport GO:0055085 120 0.016
g1 s transition of mitotic cell cycle GO:0000082 1 0.016
cellular lipid catabolic process GO:0044242 3 0.016
nucleic acid metabolic process GO:0090304 244 0.016
cellular response to radiation GO:0071478 4 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.015
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.015
positive regulation of apoptotic signaling pathway GO:2001235 1 0.015
protein localization to plasma membrane GO:0072659 1 0.015
regulation of signal transduction GO:0009966 225 0.015
lipid catabolic process GO:0016042 4 0.015
regulation of developmental process GO:0050793 247 0.015
adherens junction organization GO:0034332 4 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.015
negative regulation of kinase activity GO:0033673 4 0.015
cellular response to chemical stimulus GO:0070887 157 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
cell morphogenesis GO:0000902 289 0.015
germ line stem cell maintenance GO:0030718 2 0.015
peptidyl serine modification GO:0018209 2 0.015
negative regulation of mapk cascade GO:0043409 4 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
tube morphogenesis GO:0035239 349 0.015
primary neural tube formation GO:0014020 1 0.015
regionalization GO:0003002 274 0.015
protein acetylation GO:0006473 2 0.014
rna biosynthetic process GO:0032774 181 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
cellular component assembly GO:0022607 170 0.014
regulation of transporter activity GO:0032409 2 0.014
macromolecular complex disassembly GO:0032984 1 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.014
locomotor rhythm GO:0045475 3 0.014
spermatid differentiation GO:0048515 2 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
protein polyubiquitination GO:0000209 4 0.014
homeostatic process GO:0042592 142 0.014
meiotic chromosome segregation GO:0045132 3 0.014
lymphocyte proliferation GO:0046651 1 0.014
response to topologically incorrect protein GO:0035966 2 0.014
neuron neuron synaptic transmission GO:0007270 1 0.014
apoptotic process GO:0006915 116 0.014
intracellular signal transduction GO:0035556 85 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
small molecule catabolic process GO:0044282 3 0.014
regulation of cell shape GO:0008360 1 0.014
establishment of synaptic vesicle localization GO:0097480 1 0.014
synaptic vesicle localization GO:0097479 1 0.014
regulation of autophagy GO:0010506 3 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
cellular response to lipopolysaccharide GO:0071222 3 0.014
sequestering of metal ion GO:0051238 3 0.014
negative regulation of catabolic process GO:0009895 3 0.014
double strand break repair GO:0006302 3 0.014
regulation of synapse assembly GO:0051963 3 0.014
female gonad development GO:0008585 4 0.014
regulation of sequestering of calcium ion GO:0051282 4 0.014
protein complex disassembly GO:0043241 1 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
phagocytosis engulfment GO:0006911 1 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
synaptic vesicle transport GO:0048489 1 0.014
positive regulation of cytokine production GO:0001819 2 0.014
single fertilization GO:0007338 3 0.014
digestive system development GO:0055123 289 0.013
alcohol biosynthetic process GO:0046165 2 0.013
carboxylic acid catabolic process GO:0046395 3 0.013
fertilization GO:0009566 3 0.013
chemosensory behavior GO:0007635 1 0.013
peptidyl lysine acetylation GO:0018394 2 0.013
growth GO:0040007 174 0.013
female sex differentiation GO:0046660 4 0.013
positive regulation of translation GO:0045727 1 0.013
nucleic acid transport GO:0050657 2 0.013
secondary metabolic process GO:0019748 3 0.013
regulation of stem cell proliferation GO:0072091 2 0.013
cellular component biogenesis GO:0044085 178 0.013
ion transport GO:0006811 114 0.013
developmental growth GO:0048589 166 0.013
tube closure GO:0060606 1 0.013
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.013
interspecies interaction between organisms GO:0044419 4 0.013
carbohydrate homeostasis GO:0033500 1 0.013
protein homooligomerization GO:0051260 3 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.013
mononuclear cell proliferation GO:0032943 1 0.013
negative regulation of protein transport GO:0051224 3 0.013
organic acid catabolic process GO:0016054 3 0.013
leukocyte proliferation GO:0070661 1 0.013
peptide transport GO:0015833 1 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.013
internal protein amino acid acetylation GO:0006475 2 0.013
cell migration GO:0016477 237 0.013
membrane invagination GO:0010324 1 0.013
microtubule organizing center organization GO:0031023 1 0.013
cellular amide metabolic process GO:0043603 4 0.013
regulation of protein complex disassembly GO:0043244 1 0.013
regulation of calcium ion transport GO:0051924 2 0.013
spermatid development GO:0007286 2 0.013
regulation of organelle assembly GO:1902115 4 0.013
response to hydrogen peroxide GO:0042542 3 0.012
antimicrobial humoral response GO:0019730 2 0.012
negative regulation of nuclear division GO:0051784 3 0.012
negative regulation of map kinase activity GO:0043407 2 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
peptide metabolic process GO:0006518 1 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
sequestering of calcium ion GO:0051208 3 0.012
single organism organelle organization GO:1902589 199 0.012
response to uv GO:0009411 3 0.012
regulation of nucleic acid templated transcription GO:1903506 213 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
centrosome organization GO:0051297 1 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
cell death GO:0008219 121 0.012
death GO:0016265 121 0.012
stem cell division GO:0017145 1 0.012
response to monosaccharide GO:0034284 3 0.012
developmental programmed cell death GO:0010623 4 0.012
cell part morphogenesis GO:0032990 246 0.012
protein acylation GO:0043543 3 0.012
blood vessel development GO:0001568 246 0.012
erk1 and erk2 cascade GO:0070371 4 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
phosphorus metabolic process GO:0006793 109 0.012
Yeast
lipid oxidation GO:0034440 1 0.012
cell motility GO:0048870 244 0.012
response to glucose GO:0009749 3 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
multi organism process GO:0051704 134 0.012
rna modification GO:0009451 2 0.012
blood vessel morphogenesis GO:0048514 216 0.012
amino acid transport GO:0006865 2 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
mitotic dna damage checkpoint GO:0044773 4 0.012
response to other organism GO:0051707 97 0.012
protein polymerization GO:0051258 4 0.012
hormone secretion GO:0046879 2 0.012
response to hexose GO:0009746 3 0.012
negative regulation of intracellular protein transport GO:0090317 3 0.012
localization of cell GO:0051674 244 0.012
cellular response to light stimulus GO:0071482 4 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
neuroblast proliferation GO:0007405 2 0.011
regulation of exocytosis GO:0017157 1 0.011
regulation of protein binding GO:0043393 3 0.011
signal transduction in absence of ligand GO:0038034 1 0.011
regulation of jak stat cascade GO:0046425 3 0.011
camera type eye development GO:0043010 222 0.011
regulation of blood pressure GO:0008217 1 0.011
regulation of neurotransmitter secretion GO:0046928 1 0.011
negative regulation of sequestering of calcium ion GO:0051283 4 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
sensory organ morphogenesis GO:0090596 200 0.011
nuclear export GO:0051168 1 0.011
negative regulation of cytokine production GO:0001818 1 0.011
immune system development GO:0002520 191 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
lateral inhibition GO:0046331 1 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
ion transmembrane transport GO:0034220 91 0.011
hemopoiesis GO:0030097 183 0.011
heart development GO:0007507 313 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
response to corticosteroid GO:0031960 1 0.011
regulation of inflammatory response GO:0050727 2 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
centrosome cycle GO:0007098 1 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.011
translational initiation GO:0006413 3 0.011
nucleobase containing compound transport GO:0015931 2 0.011
intracellular mrna localization GO:0008298 1 0.011
regulation of circadian rhythm GO:0042752 4 0.011
digestive tract development GO:0048565 265 0.011
cell matrix adhesion GO:0007160 4 0.011
brain development GO:0007420 293 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
cellular protein metabolic process GO:0044267 129 0.011
negative regulation of reproductive process GO:2000242 3 0.011
regulation of epithelial cell proliferation GO:0050678 3 0.011
apoptotic process involved in development GO:1902742 2 0.011
regulation of neuronal synaptic plasticity GO:0048168 1 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
regulation of response to nutrient levels GO:0032107 1 0.011
er to golgi vesicle mediated transport GO:0006888 1 0.011
organism emergence from protective structure GO:0071684 4 0.011
glucose homeostasis GO:0042593 1 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
regulation of organ growth GO:0046620 3 0.011
rna transport GO:0050658 2 0.011
cytoplasm organization GO:0007028 4 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
development of primary female sexual characteristics GO:0046545 4 0.010
axon development GO:0061564 166 0.010
negative regulation of metabolic process GO:0009892 86 0.010
phosphate containing compound metabolic process GO:0006796 108 0.010
Yeast
protein dephosphorylation GO:0006470 3 0.010
mitotic dna integrity checkpoint GO:0044774 4 0.010
positive regulation of cytoskeleton organization GO:0051495 3 0.010
monocarboxylic acid catabolic process GO:0072329 3 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
b cell activation GO:0042113 2 0.010
protein stabilization GO:0050821 2 0.010
fatty acid oxidation GO:0019395 1 0.010
regulation of cell substrate adhesion GO:0010810 1 0.010
endoplasmic reticulum unfolded protein response GO:0030968 2 0.010
striated muscle tissue development GO:0014706 110 0.010
negative regulation of multi organism process GO:0043901 3 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
mitotic cytokinesis GO:0000281 3 0.010
macromolecule modification GO:0043412 111 0.010
double strand break repair via homologous recombination GO:0000724 1 0.010
peptidyl threonine phosphorylation GO:0018107 1 0.010
negative regulation of stem cell differentiation GO:2000737 2 0.010
positive regulation of cell division GO:0051781 2 0.010
establishment of rna localization GO:0051236 3 0.010

pnp5b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.016
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
musculoskeletal system disease DOID:17 0 0.014
organ system cancer DOID:0050686 0 0.014
disease of metabolism DOID:0014667 0 0.014
immune system disease DOID:2914 0 0.010