Danio rerio

0 known processes

psmc2

proteasome (prosome, macropain) 26S subunit, ATPase 2

(Aliases: MGC63995,zgc:63995)

psmc2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ubiquitin dependent protein catabolic process GO:0006511 3 0.935
Human Yeast
modification dependent protein catabolic process GO:0019941 3 0.927
Human Yeast
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.865
cellular protein catabolic process GO:0044257 4 0.827
Human Yeast
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.813
Human Yeast
proteasomal protein catabolic process GO:0010498 2 0.760
modification dependent macromolecule catabolic process GO:0043632 3 0.610
Human Yeast
larval development GO:0002164 2 0.481
Worm
dna templated transcription initiation GO:0006352 1 0.335
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 4 0.257
Human
rrna catabolic process GO:0016075 1 0.254
positive regulation of protein complex assembly GO:0031334 2 0.235
Yeast
cellular macromolecule metabolic process GO:0044260 391 0.218
Human Yeast
regulation of protein complex assembly GO:0043254 3 0.218
Yeast
aging GO:0007568 2 0.213
Worm
rna biosynthetic process GO:0032774 181 0.201
Yeast
embryo development ending in birth or egg hatching GO:0009792 271 0.182
Worm
protein metabolic process GO:0019538 183 0.180
Human Yeast Fly
reproduction GO:0000003 40 0.176
Worm
positive regulation of cellular component biogenesis GO:0044089 3 0.171
Yeast
meiotic cell cycle process GO:1903046 3 0.143
nucleobase containing compound biosynthetic process GO:0034654 205 0.137
Yeast
regulation of rna biosynthetic process GO:2001141 213 0.131
Yeast
gene expression GO:0010467 252 0.130
Yeast
proteolysis GO:0006508 38 0.128
Human Yeast Fly
heterocycle biosynthetic process GO:0018130 215 0.125
Yeast
cellular macromolecule biosynthetic process GO:0034645 224 0.119
Yeast
spindle assembly involved in mitosis GO:0090307 1 0.119
regulation of biosynthetic process GO:0009889 250 0.114
Yeast
regulation of macromolecule metabolic process GO:0060255 317 0.109
Yeast
response to stress GO:0006950 263 0.109
Fly
ncrna catabolic process GO:0034661 1 0.104
regulation of metabolic process GO:0019222 359 0.098
Yeast
cellular protein metabolic process GO:0044267 129 0.096
Human Yeast
cellular response to dna damage stimulus GO:0006974 24 0.095
Fly
nitrogen compound metabolic process GO:0006807 319 0.093
Human Yeast
cellular component assembly GO:0022607 170 0.092
Yeast
spindle assembly GO:0051225 2 0.090
transcription from rna polymerase ii promoter GO:0006366 80 0.088
Yeast
aromatic compound biosynthetic process GO:0019438 217 0.087
Yeast
small molecule metabolic process GO:0044281 77 0.086
Human
cellular response to stress GO:0033554 62 0.081
Fly
cellular biosynthetic process GO:0044249 286 0.079
Yeast
single fertilization GO:0007338 3 0.075
embryonic skeletal system morphogenesis GO:0048704 93 0.067
positive regulation of nucleic acid templated transcription GO:1903508 57 0.067
Yeast
protein n linked glycosylation GO:0006487 1 0.065
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.064
skeletal system development GO:0001501 181 0.061
regulation of transcription dna templated GO:0006355 213 0.061
Yeast
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.057
regulation of primary metabolic process GO:0080090 311 0.055
Yeast
protein complex biogenesis GO:0070271 30 0.055
Yeast
macromolecule biosynthetic process GO:0009059 227 0.054
Yeast
protein catabolic process GO:0030163 7 0.054
Human Yeast
atp catabolic process GO:0006200 4 0.054
Human
embryonic cranial skeleton morphogenesis GO:0048701 90 0.053
response to chemical GO:0042221 320 0.052
transcription dna templated GO:0006351 181 0.052
Yeast
cellular protein complex assembly GO:0043623 19 0.051
Yeast
negative regulation of biological process GO:0048519 304 0.051
response to external stimulus GO:0009605 264 0.051
regulation of cellular metabolic process GO:0031323 320 0.051
Yeast
meiotic nuclear division GO:0007126 4 0.051
centrosome organization GO:0051297 1 0.051
nucleic acid templated transcription GO:0097659 181 0.050
Yeast
cellular response to external stimulus GO:0071496 2 0.048
meiosis i GO:0007127 1 0.047
maintenance of location GO:0051235 4 0.047
protein localization to nucleus GO:0034504 3 0.047
heterocycle metabolic process GO:0046483 290 0.046
Human Yeast
positive regulation of molecular function GO:0044093 33 0.046
organic substance biosynthetic process GO:1901576 289 0.045
Yeast
regulation of cellular biosynthetic process GO:0031326 245 0.045
Yeast
cellular nitrogen compound biosynthetic process GO:0044271 218 0.044
Yeast
cellular macromolecular complex assembly GO:0034622 24 0.043
Yeast
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.043
regulation of rna metabolic process GO:0051252 224 0.043
Yeast
embryonic skeletal system development GO:0048706 97 0.042
regulation of biological quality GO:0065008 263 0.042
response to inorganic substance GO:0010035 38 0.042
transport GO:0006810 220 0.042
chordate embryonic development GO:0043009 271 0.041
negative regulation of cellular process GO:0048523 283 0.041
autophagy GO:0006914 4 0.040
nucleic acid metabolic process GO:0090304 244 0.040
Yeast
regulation of molecular function GO:0065009 70 0.040
cellular macromolecule catabolic process GO:0044265 12 0.039
Human Yeast
negative regulation of nuclear division GO:0051784 3 0.038
rna metabolic process GO:0016070 219 0.038
Yeast
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.037
Yeast
meiotic chromosome segregation GO:0045132 3 0.037
positive regulation of biological process GO:0048518 253 0.037
Yeast
catabolic process GO:0009056 32 0.036
Human Yeast
nucleoside monophosphate catabolic process GO:0009125 4 0.035
Human
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.035
Yeast
negative regulation of protein transport GO:0051224 3 0.035
regulation of cellular component organization GO:0051128 86 0.035
Yeast
regulation of multicellular organism growth GO:0040014 4 0.035
protein complex subunit organization GO:0071822 46 0.034
Yeast
positive regulation of catabolic process GO:0009896 4 0.034
Yeast
cellular response to nutrient levels GO:0031669 2 0.034
regulation of multicellular organismal process GO:0051239 277 0.034
lipid storage GO:0019915 1 0.033
organic cyclic compound biosynthetic process GO:1901362 223 0.033
Yeast
response to drug GO:0042493 3 0.033
organelle fission GO:0048285 23 0.032
regulation of developmental process GO:0050793 247 0.032
camera type eye development GO:0043010 222 0.032
cellular catabolic process GO:0044248 27 0.032
Human Yeast
regulation of binding GO:0051098 3 0.031
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.031
Human
cellular component biogenesis GO:0044085 178 0.031
Yeast
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.031
Yeast
homeostatic process GO:0042592 142 0.031
meiotic spindle organization GO:0000212 1 0.031
organic substance catabolic process GO:1901575 28 0.030
Human Yeast
regulation of protein catabolic process GO:0042176 1 0.030
Yeast
regulation of establishment of protein localization GO:0070201 4 0.030
organic cyclic compound metabolic process GO:1901360 301 0.030
Human Yeast
cellular nitrogen compound metabolic process GO:0034641 290 0.030
Human Yeast
microtubule organizing center organization GO:0031023 1 0.030
positive regulation of transcription dna templated GO:0045893 57 0.030
Yeast
cellular protein modification process GO:0006464 100 0.029
positive regulation of cellular catabolic process GO:0031331 3 0.029
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.029
Yeast
regulation of stem cell proliferation GO:0072091 2 0.029
protein modification by small protein removal GO:0070646 1 0.028
regulation of nucleic acid templated transcription GO:1903506 213 0.028
Yeast
immune system process GO:0002376 241 0.028
membrane fusion GO:0061025 2 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.027
Yeast
positive regulation of gene expression GO:0010628 71 0.027
Yeast
single organism organelle organization GO:1902589 199 0.027
locomotion GO:0040011 313 0.027
cellular response to chemical stimulus GO:0070887 157 0.027
single organism localization GO:1902578 225 0.027
sister chromatid segregation GO:0000819 6 0.026
positive regulation of macromolecule metabolic process GO:0010604 93 0.026
Yeast
meiosis ii GO:0007135 1 0.026
single organism transport GO:0044765 206 0.025
positive regulation of cellular process GO:0048522 201 0.025
Yeast
multicellular organism growth GO:0035264 4 0.025
sensory organ development GO:0007423 393 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
macromolecular complex assembly GO:0065003 35 0.025
Yeast
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.025
regulation of inflammatory response GO:0050727 2 0.025
positive regulation of cellular metabolic process GO:0031325 94 0.025
Yeast
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.024
regulation of protein localization to nucleus GO:1900180 2 0.023
nucleobase containing compound metabolic process GO:0006139 274 0.023
Human Yeast
cell projection morphogenesis GO:0048858 244 0.023
mitotic sister chromatid segregation GO:0000070 6 0.023
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.023
Yeast
cell fate commitment GO:0045165 99 0.023
macromolecule catabolic process GO:0009057 15 0.023
Human Yeast
positive regulation of biosynthetic process GO:0009891 68 0.023
Yeast
death GO:0016265 121 0.022
regulation of response to stimulus GO:0048583 269 0.022
cellular amine metabolic process GO:0044106 2 0.022
protein polymerization GO:0051258 4 0.021
pole plasm assembly GO:0007315 4 0.021
mitotic nuclear division GO:0007067 18 0.021
regulation of chromosome segregation GO:0051983 1 0.021
multicellular organismal reproductive process GO:0048609 35 0.021
negative regulation of neural precursor cell proliferation GO:2000178 1 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
fertilization GO:0009566 3 0.020
dna templated transcription elongation GO:0006354 3 0.020
mitotic cell cycle GO:0000278 64 0.020
amine metabolic process GO:0009308 2 0.020
mitotic dna integrity checkpoint GO:0044774 4 0.020
programmed cell death GO:0012501 119 0.020
regulation of protein transport GO:0051223 3 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
Human
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
Yeast
regionalization GO:0003002 274 0.019
protein complex assembly GO:0006461 30 0.019
Yeast
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.019
cell death GO:0008219 121 0.019
neuroblast proliferation GO:0007405 2 0.019
oocyte development GO:0048599 14 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
stem cell division GO:0017145 1 0.018
lens development in camera type eye GO:0002088 22 0.018
organelle assembly GO:0070925 110 0.018
positive regulation of rna biosynthetic process GO:1902680 57 0.018
Yeast
apoptotic process GO:0006915 116 0.018
negative regulation of synapse assembly GO:0051964 2 0.018
regulation of meiotic cell cycle GO:0051445 1 0.018
oocyte anterior posterior axis specification GO:0007314 4 0.018
establishment of localization GO:0051234 244 0.018
apoptotic process involved in development GO:1902742 2 0.018
golgi vesicle transport GO:0048193 3 0.018
positive regulation of cellular biosynthetic process GO:0031328 68 0.018
Yeast
dna repair GO:0006281 6 0.018
eye development GO:0001654 277 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
blood vessel development GO:0001568 246 0.018
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.018
neuron differentiation GO:0030182 353 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
Human
nucleocytoplasmic transport GO:0006913 4 0.017
protein dephosphorylation GO:0006470 3 0.017
embryonic organ development GO:0048568 381 0.017
single organism metabolic process GO:0044710 217 0.017
Human
regulation of dna templated transcription elongation GO:0032784 3 0.017
mitotic cell cycle process GO:1903047 48 0.017
macromolecular complex subunit organization GO:0043933 74 0.017
Yeast
protein import GO:0017038 3 0.017
developmental programmed cell death GO:0010623 4 0.017
kidney development GO:0001822 92 0.017
negative regulation of metabolic process GO:0009892 86 0.017
double strand break repair via homologous recombination GO:0000724 1 0.016
positive regulation of cell cycle GO:0045787 3 0.016
phosphorus metabolic process GO:0006793 109 0.016
Human
skeletal system morphogenesis GO:0048705 102 0.016
response to glucose GO:0009749 3 0.016
embryonic organ morphogenesis GO:0048562 274 0.016
regulation of cellular protein catabolic process GO:1903362 1 0.016
tissue remodeling GO:0048771 4 0.016
developmental growth GO:0048589 166 0.016
double strand break repair GO:0006302 3 0.016
cellular response to starvation GO:0009267 1 0.016
organelle organization GO:0006996 227 0.016
response to other organism GO:0051707 97 0.016
regulation of protein ubiquitination GO:0031396 3 0.016
response to nutrient GO:0007584 3 0.016
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.016
regulation of response to stress GO:0080134 36 0.016
protein stabilization GO:0050821 2 0.016
ribonucleotide metabolic process GO:0009259 27 0.016
Human
mitotic g2 dna damage checkpoint GO:0007095 3 0.015
nuclear division GO:0000280 23 0.015
multi organism process GO:0051704 134 0.015
positive regulation of metabolic process GO:0009893 108 0.015
Yeast
regulation of peptidase activity GO:0052547 23 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
signal transduction GO:0007165 455 0.015
chromosome organization involved in meiosis GO:0070192 1 0.015
protein homooligomerization GO:0051260 3 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
organic acid metabolic process GO:0006082 31 0.015
stem cell proliferation GO:0072089 4 0.015
dna biosynthetic process GO:0071897 3 0.015
lipid catabolic process GO:0016042 4 0.015
cell death in response to oxidative stress GO:0036473 2 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
centrosome duplication GO:0051298 1 0.015
negative regulation of immune response GO:0050777 2 0.015
regulation of response to external stimulus GO:0032101 31 0.014
cellular localization GO:0051641 97 0.014
regulation of proteolysis GO:0030162 24 0.014
protein modification process GO:0036211 100 0.014
hatching GO:0035188 4 0.014
regulation of endopeptidase activity GO:0052548 23 0.014
regulation of cell activation GO:0050865 1 0.014
regulation of cell communication GO:0010646 232 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
regulation of apoptotic process GO:0042981 98 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.013
cell morphogenesis GO:0000902 289 0.013
positive regulation of histone modification GO:0031058 1 0.013
gene silencing by rna GO:0031047 4 0.013
response to glucocorticoid GO:0051384 1 0.013
response to biotic stimulus GO:0009607 97 0.013
response to organic substance GO:0010033 153 0.013
ion homeostasis GO:0050801 41 0.013
response to external biotic stimulus GO:0043207 97 0.013
macroautophagy GO:0016236 1 0.013
eye morphogenesis GO:0048592 144 0.012
oxoacid metabolic process GO:0043436 31 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
positive regulation of peptidase activity GO:0010952 10 0.012
thermosensory behavior GO:0040040 1 0.012
cell division GO:0051301 20 0.012
positive regulation of chromosome organization GO:2001252 1 0.012
female sex differentiation GO:0046660 4 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
chromosome organization GO:0051276 31 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
regulation of sodium ion transport GO:0002028 2 0.012
regulation of response to oxidative stress GO:1902882 2 0.012
neuron development GO:0048666 262 0.012
regulation of reproductive process GO:2000241 4 0.012
cellular component morphogenesis GO:0032989 336 0.012
negative regulation of defense response GO:0031348 2 0.011
negative regulation of intracellular protein transport GO:0090317 3 0.011
negative regulation of cellular metabolic process GO:0031324 77 0.011
regulation of synapse organization GO:0050807 3 0.011
negative regulation of mitosis GO:0045839 3 0.011
blood vessel morphogenesis GO:0048514 216 0.011
nuclear transport GO:0051169 4 0.011
regulation of nitrogen compound metabolic process GO:0051171 251 0.011
Yeast
mitochondrion organization GO:0007005 4 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
neuron projection morphogenesis GO:0048812 161 0.011
generation of neurons GO:0048699 385 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
cellular homeostasis GO:0019725 26 0.011
organism emergence from protective structure GO:0071684 4 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
protein targeting to nucleus GO:0044744 3 0.011
angiogenesis GO:0001525 158 0.011
protein complex disassembly GO:0043241 1 0.011
gamete generation GO:0007276 33 0.011
positive regulation of dna metabolic process GO:0051054 1 0.010
regulation of protein metabolic process GO:0051246 56 0.010
Yeast
macromolecular complex disassembly GO:0032984 1 0.010
response to wounding GO:0009611 116 0.010
regulation of gene expression GO:0010468 265 0.010
Yeast
cell motility GO:0048870 244 0.010
cytoplasm organization GO:0007028 4 0.010
cellular aromatic compound metabolic process GO:0006725 295 0.010
Human Yeast
chemical homeostasis GO:0048878 49 0.010
establishment of protein localization to organelle GO:0072594 4 0.010

psmc2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.058
nervous system disease DOID:863 0 0.016
disease of cellular proliferation DOID:14566 0 0.014
motor neuron disease DOID:231 0 0.014
central nervous system disease DOID:331 0 0.014
amyotrophic lateral sclerosis DOID:332 0 0.014
neurodegenerative disease DOID:1289 0 0.014