Danio rerio

7 known processes

chek2

CHK2 checkpoint homolog (S. pombe)

(Aliases: fa66f08,zgc:55865,wu:fa66f08)

chek2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular nitrogen compound metabolic process GO:0034641 290 0.328
Human Fly
regulation of dna replication GO:0006275 3 0.173
Human
double strand break repair via homologous recombination GO:0000724 1 0.111
organic cyclic compound metabolic process GO:1901360 301 0.109
Human Fly
nitrogen compound metabolic process GO:0006807 319 0.102
Human Fly
larval development GO:0002164 2 0.097
cellular biosynthetic process GO:0044249 286 0.086
Human Fly
dna alkylation GO:0006305 8 0.079
organelle organization GO:0006996 227 0.078
Human Worm
dna catabolic process GO:0006308 1 0.078
transcription dna templated GO:0006351 181 0.076
Human Fly
gene expression GO:0010467 252 0.075
Human Fly
regulation of gene expression GO:0010468 265 0.074
Human Fly
mitotic dna integrity checkpoint GO:0044774 4 0.072
Human Fly
recombinational repair GO:0000725 1 0.070
response to chemical GO:0042221 320 0.064
dna metabolic process GO:0006259 27 0.058
Human Fly
microtubule organizing center organization GO:0031023 1 0.055
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.054
Human Fly
nucleobase containing compound metabolic process GO:0006139 274 0.053
Human Fly
positive regulation of catabolic process GO:0009896 4 0.047
negative regulation of histone methylation GO:0031061 1 0.047
locomotion GO:0040011 313 0.046
g2 m transition of mitotic cell cycle GO:0000086 4 0.046
Human
immunoglobulin mediated immune response GO:0016064 3 0.045
response to biotic stimulus GO:0009607 97 0.045
regulation of multicellular organism growth GO:0040014 4 0.045
neuron development GO:0048666 262 0.044
positive regulation of chromatin modification GO:1903310 1 0.043
biosynthetic process GO:0009058 294 0.042
Human Fly
meiotic chromosome segregation GO:0045132 3 0.041
Worm
positive regulation of cell cycle GO:0045787 3 0.041
regulation of dna metabolic process GO:0051052 11 0.041
Human Fly
oocyte maturation GO:0001556 4 0.040
cellular nitrogen compound biosynthetic process GO:0044271 218 0.040
Human Fly
regulation of transcription dna templated GO:0006355 213 0.039
Human Fly
regulation of chromosome segregation GO:0051983 1 0.039
regulation of protein ubiquitination GO:0031396 3 0.039
organic cyclic compound biosynthetic process GO:1901362 223 0.038
Human Fly
cell cycle g2 m phase transition GO:0044839 4 0.038
Human
organic substance biosynthetic process GO:1901576 289 0.038
Human Fly
cell cycle GO:0007049 93 0.038
Human Worm Fly
mitotic recombination GO:0006312 2 0.037
heterocycle metabolic process GO:0046483 290 0.037
Human Fly
double strand break repair GO:0006302 3 0.036
Human
positive regulation of histone modification GO:0031058 1 0.036
histone phosphorylation GO:0016572 2 0.036
cellular macromolecule metabolic process GO:0044260 391 0.035
Human Fly
response to external stimulus GO:0009605 264 0.035
cellular macromolecule biosynthetic process GO:0034645 224 0.035
Human Fly
regulation of protein catabolic process GO:0042176 1 0.035
Human
cellular aromatic compound metabolic process GO:0006725 295 0.035
Human Fly
signal transduction GO:0007165 455 0.034
Human Mouse Fly
negative regulation of chromosome organization GO:2001251 1 0.034
nucleic acid metabolic process GO:0090304 244 0.033
Human Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.032
Human Fly
aromatic compound biosynthetic process GO:0019438 217 0.032
Human Fly
regulation of metabolic process GO:0019222 359 0.032
Human Fly
dna modification GO:0006304 8 0.032
positive regulation of cellular catabolic process GO:0031331 3 0.032
negative regulation of mitosis GO:0045839 3 0.031
establishment of localization GO:0051234 244 0.031
reciprocal dna recombination GO:0035825 1 0.031
dna methylation GO:0006306 8 0.031
protein metabolic process GO:0019538 183 0.031
Human Fly
modification dependent protein catabolic process GO:0019941 3 0.030
rna metabolic process GO:0016070 219 0.030
Human Fly
regulation of rna metabolic process GO:0051252 224 0.029
Human Fly
response to uv GO:0009411 3 0.029
dna methylation or demethylation GO:0044728 8 0.028
sex determination GO:0007530 1 0.027
b cell activation GO:0042113 2 0.026
embryo development ending in birth or egg hatching GO:0009792 271 0.026
Worm
negative regulation of metabolic process GO:0009892 86 0.026
Human
regulation of histone h3 k9 methylation GO:0051570 2 0.026
chromatin organization GO:0006325 22 0.025
macromolecule biosynthetic process GO:0009059 227 0.024
Human Fly
response to organic substance GO:0010033 153 0.023
nucleobase containing compound biosynthetic process GO:0034654 205 0.023
Human Fly
programmed cell death GO:0012501 119 0.023
Human Mouse Fly
regulation of macromolecule metabolic process GO:0060255 317 0.023
Human Fly
pancreas development GO:0031016 84 0.022
histone modification GO:0016570 20 0.022
neuron differentiation GO:0030182 353 0.022
cell cycle g1 s phase transition GO:0044843 1 0.022
sensory organ development GO:0007423 393 0.022
cellular response to chemical stimulus GO:0070887 157 0.021
b cell mediated immunity GO:0019724 3 0.021
growth GO:0040007 174 0.021
dna biosynthetic process GO:0071897 3 0.021
regulation of apoptotic process GO:0042981 98 0.021
Fly
regulation of rna biosynthetic process GO:2001141 213 0.021
Human Fly
regulation of protein import into nucleus GO:0042306 2 0.020
neuroblast fate commitment GO:0014017 1 0.020
meiosis i GO:0007127 1 0.019
histone h3 k4 methylation GO:0051568 2 0.019
response to stress GO:0006950 263 0.019
g1 s transition of mitotic cell cycle GO:0000082 1 0.019
peptidyl serine phosphorylation GO:0018105 1 0.018
regulation of macromolecule biosynthetic process GO:0010556 225 0.018
Human Fly
vasculature development GO:0001944 278 0.018
intracellular mrna localization GO:0008298 1 0.018
rna localization GO:0006403 4 0.018
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.018
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.018
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.018
Human
male meiosis GO:0007140 2 0.018
negative regulation of cellular process GO:0048523 283 0.018
Human Fly
multicellular organism growth GO:0035264 4 0.017
response to drug GO:0042493 3 0.017
regulation of binding GO:0051098 3 0.017
microtubule based process GO:0007017 60 0.017
Human
stem cell maintenance GO:0019827 4 0.017
centrosome organization GO:0051297 1 0.017
regulation of histone methylation GO:0031060 3 0.017
meiosis ii GO:0007135 1 0.017
mitotic cell cycle embryonic GO:0045448 2 0.017
immunoglobulin production GO:0002377 1 0.017
transport GO:0006810 220 0.017
methylation GO:0032259 22 0.017
phagocytosis GO:0006909 3 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.016
Fly
covalent chromatin modification GO:0016569 20 0.016
cellular component movement GO:0006928 335 0.016
gtp catabolic process GO:0006184 2 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
establishment of protein localization to organelle GO:0072594 4 0.016
somatic cell dna recombination GO:0016444 1 0.016
single organism metabolic process GO:0044710 217 0.016
Human Fly
macromolecule modification GO:0043412 111 0.016
Human Fly
positive regulation of cellular metabolic process GO:0031325 94 0.016
Human Fly
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.016
regulation of biosynthetic process GO:0009889 250 0.016
Human Fly
protein modification process GO:0036211 100 0.016
Human Fly
adult behavior GO:0030534 2 0.015
cell morphogenesis GO:0000902 289 0.015
heart development GO:0007507 313 0.015
organelle fission GO:0048285 23 0.015
Human Worm
meiotic cell cycle process GO:1903046 3 0.015
Worm
macromolecule localization GO:0033036 54 0.015
response to endogenous stimulus GO:0009719 83 0.015
leukocyte proliferation GO:0070661 1 0.015
negative regulation of dna replication GO:0008156 2 0.015
Human
chromosome organization GO:0051276 31 0.015
regulation of gene silencing GO:0060968 1 0.015
multi organism process GO:0051704 134 0.015
Fly
cellular response to oxygen levels GO:0071453 1 0.015
positive regulation of chromosome organization GO:2001252 1 0.015
g2 dna damage checkpoint GO:0031572 3 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
negative regulation of biological process GO:0048519 304 0.014
Human Fly
negative regulation of dna metabolic process GO:0051053 4 0.014
Human
dna recombination GO:0006310 5 0.014
cellular protein modification process GO:0006464 100 0.014
Human Fly
sister chromatid cohesion GO:0007062 2 0.014
developmental process involved in reproduction GO:0003006 27 0.014
Fly
cytokinesis GO:0000910 3 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
organic acid metabolic process GO:0006082 31 0.013
hatching GO:0035188 4 0.013
heterocycle biosynthetic process GO:0018130 215 0.013
Human Fly
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
Human
cellular amino acid metabolic process GO:0006520 7 0.013
reciprocal meiotic recombination GO:0007131 1 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
cell part morphogenesis GO:0032990 246 0.013
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.013
chordate embryonic development GO:0043009 271 0.013
organism emergence from protective structure GO:0071684 4 0.013
neuron projection morphogenesis GO:0048812 161 0.013
chromosome organization involved in meiosis GO:0070192 1 0.013
regulation of gene expression epigenetic GO:0040029 11 0.013
germ cell development GO:0007281 22 0.013
Fly
morphogenesis of an epithelium GO:0002009 333 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
sensory organ morphogenesis GO:0090596 200 0.012
response to external biotic stimulus GO:0043207 97 0.012
oxoacid metabolic process GO:0043436 31 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
Human
negative regulation of cellular metabolic process GO:0031324 77 0.012
Human
negative regulation of cytoplasmic transport GO:1903650 2 0.012
heme metabolic process GO:0042168 9 0.012
reproduction GO:0000003 40 0.012
Worm Fly
somatic stem cell maintenance GO:0035019 1 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
regulation of protein complex assembly GO:0043254 3 0.012
nucleic acid templated transcription GO:0097659 181 0.012
Human Fly
regulation of mitotic cell cycle phase transition GO:1901990 8 0.012
Human Fly
negative regulation of protein transport GO:0051224 3 0.012
determination of left right symmetry GO:0007368 179 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
response to amino acid GO:0043200 2 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
reproductive process GO:0022414 40 0.011
Fly
centrosome cycle GO:0007098 1 0.011
cellular response to stress GO:0033554 62 0.011
negative regulation of nuclear division GO:0051784 3 0.011
single organism organelle organization GO:1902589 199 0.011
Human
regulation of cellular protein catabolic process GO:1903362 1 0.011
cell projection morphogenesis GO:0048858 244 0.011
amine metabolic process GO:0009308 2 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
phosphorus metabolic process GO:0006793 109 0.011
Human Fly
cellular response to hypoxia GO:0071456 1 0.011
anterior posterior pattern specification GO:0009952 152 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
Human Fly
cellular amine metabolic process GO:0044106 2 0.011
negative regulation of protein localization to nucleus GO:1900181 2 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
rna biosynthetic process GO:0032774 181 0.011
Human Fly
apoptotic process GO:0006915 116 0.011
Human Mouse Fly
negative regulation of protein import into nucleus GO:0042308 2 0.011
aging GO:0007568 2 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
regulation of nucleotide catabolic process GO:0030811 2 0.010
cellular component morphogenesis GO:0032989 336 0.010
urogenital system development GO:0001655 97 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
regionalization GO:0003002 274 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
Human
gtp metabolic process GO:0046039 4 0.010
cellular protein catabolic process GO:0044257 4 0.010
Human

chek2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.078
Human
disease of cellular proliferation DOID:14566 0 0.078
Human
immune system disease DOID:2914 0 0.028
disease of anatomical entity DOID:7 0 0.028
bone marrow disease DOID:4961 0 0.028
hematopoietic system disease DOID:74 0 0.028
large intestine cancer DOID:5672 0 0.027
gastrointestinal system cancer DOID:3119 0 0.027
intestinal cancer DOID:10155 0 0.027
organ system cancer DOID:0050686 0 0.027
Human
colorectal cancer DOID:9256 0 0.027
nervous system disease DOID:863 0 0.013
disease of metabolism DOID:0014667 0 0.011