Danio rerio

171 known processes

smad5

MAD homolog 5 (Drosophila)

(Aliases: wu:fb67b04,madh5,sb:cb400,mad,fb67b04,smd5,SBN)

smad5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hematopoietic or lymphoid organ development GO:0048534 191 0.963
Zebrafish Mouse
gastrulation GO:0007369 208 0.939
embryonic organ development GO:0048568 381 0.933
embryonic organ morphogenesis GO:0048562 274 0.930
digestive tract development GO:0048565 265 0.918
convergent extension GO:0060026 118 0.901
cellular macromolecule metabolic process GO:0044260 391 0.885
hemopoiesis GO:0030097 183 0.882
Zebrafish Mouse
regulation of biological quality GO:0065008 263 0.837
Mouse Fly
regionalization GO:0003002 274 0.807
transcription dna templated GO:0006351 181 0.807
tube morphogenesis GO:0035239 349 0.806
heart development GO:0007507 313 0.789
regulation of gene expression GO:0010468 265 0.757
fin morphogenesis GO:0033334 53 0.734
digestive tract morphogenesis GO:0048546 231 0.730
nitrogen compound metabolic process GO:0006807 319 0.715
determination of bilateral symmetry GO:0009855 204 0.702
regulation of signaling GO:0023051 235 0.697
rna metabolic process GO:0016070 219 0.696
signal transduction GO:0007165 455 0.676
regulation of biosynthetic process GO:0009889 250 0.639
epithelial tube morphogenesis GO:0060562 148 0.620
rna biosynthetic process GO:0032774 181 0.612
regulation of signal transduction GO:0009966 225 0.601
regulation of response to stimulus GO:0048583 269 0.578
cell surface receptor signaling pathway GO:0007166 325 0.557
digestive system development GO:0055123 289 0.554
regulation of rna metabolic process GO:0051252 224 0.524
organic cyclic compound biosynthetic process GO:1901362 223 0.518
regulation of nucleic acid templated transcription GO:1903506 213 0.512
nucleobase containing compound metabolic process GO:0006139 274 0.511
chordate embryonic development GO:0043009 271 0.502
regulation of metabolic process GO:0019222 359 0.496
specification of symmetry GO:0009799 204 0.495
medial fin morphogenesis GO:0035141 14 0.489
heterocycle biosynthetic process GO:0018130 215 0.473
cellular nitrogen compound metabolic process GO:0034641 290 0.470
embryonic heart tube development GO:0035050 133 0.467
biosynthetic process GO:0009058 294 0.465
organic cyclic compound metabolic process GO:1901360 301 0.454
transcription from rna polymerase ii promoter GO:0006366 80 0.445
heterocycle metabolic process GO:0046483 290 0.445
gene expression GO:0010467 252 0.438
neuron projection morphogenesis GO:0048812 161 0.431
regulation of nitrogen compound metabolic process GO:0051171 251 0.430
regulation of macromolecule metabolic process GO:0060255 317 0.427
convergent extension involved in gastrulation GO:0060027 71 0.418
embryonic heart tube morphogenesis GO:0003143 108 0.417
oocyte development GO:0048599 14 0.405
Zebrafish
immune system development GO:0002520 191 0.401
Zebrafish Mouse
wnt signaling pathway GO:0016055 80 0.393
nucleic acid metabolic process GO:0090304 244 0.389
regulation of multicellular organismal development GO:2000026 223 0.386
regulation of cellular metabolic process GO:0031323 320 0.382
morphogenesis of an epithelium GO:0002009 333 0.378
spindle assembly involved in female meiosis GO:0007056 1 0.376
cellular macromolecule catabolic process GO:0044265 12 0.361
regulation of transcription dna templated GO:0006355 213 0.360
macromolecule biosynthetic process GO:0009059 227 0.348
regulation of protein catabolic process GO:0042176 1 0.345
homeostatic process GO:0042592 142 0.343
Mouse
positive regulation of protein deacetylation GO:0090312 1 0.343
positive regulation of catabolic process GO:0009896 4 0.341
dorsal ventral pattern formation GO:0009953 125 0.336
aromatic compound biosynthetic process GO:0019438 217 0.329
cell motility GO:0048870 244 0.324
spindle assembly GO:0051225 2 0.322
cell migration involved in gastrulation GO:0042074 79 0.321
stem cell division GO:0017145 1 0.314
Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.314
regulation of establishment of protein localization GO:0070201 4 0.298
cellular aromatic compound metabolic process GO:0006725 295 0.295
embryonic epithelial tube formation GO:0001838 17 0.282
regulation of protein import into nucleus GO:0042306 2 0.269
determination of heart left right asymmetry GO:0061371 117 0.269
dorsal convergence GO:0060030 14 0.268
sexual reproduction GO:0019953 36 0.266
Zebrafish Mouse Fly
organic substance biosynthetic process GO:1901576 289 0.264
nuclear import GO:0051170 3 0.262
cell projection morphogenesis GO:0048858 244 0.259
cellular macromolecule biosynthetic process GO:0034645 224 0.258
cellular component assembly GO:0022607 170 0.256
Fly
determination of left right symmetry GO:0007368 179 0.244
cellular component movement GO:0006928 335 0.240
regulation of multicellular organism growth GO:0040014 4 0.240
Worm
nuclear transport GO:0051169 4 0.238
blood vessel morphogenesis GO:0048514 216 0.234
cell cycle GO:0007049 93 0.232
Worm Fly
cellular component biogenesis GO:0044085 178 0.232
Fly
positive regulation of synaptic growth at neuromuscular junction GO:0045887 1 0.229
Fly
cellular protein modification process GO:0006464 100 0.220
Mouse
regulation of developmental process GO:0050793 247 0.219
regulation of anatomical structure morphogenesis GO:0022603 130 0.216
regulation of localization GO:0032879 104 0.213
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.212
regulation of protein transport GO:0051223 3 0.211
endocardial cushion formation GO:0003272 2 0.211
epithelial tube formation GO:0072175 19 0.202
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.202
positive regulation of chromatin modification GO:1903310 1 0.201
cellular protein metabolic process GO:0044267 129 0.200
Mouse
negative regulation of response to stimulus GO:0048585 104 0.199
immune system process GO:0002376 241 0.198
Zebrafish Mouse
single organism localization GO:1902578 225 0.196
establishment of protein localization to organelle GO:0072594 4 0.195
dorsal ventral neural tube patterning GO:0021904 1 0.192
protein localization to nucleus GO:0034504 3 0.189
regulation of nervous system development GO:0051960 90 0.187
Fly
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.186
macromolecule catabolic process GO:0009057 15 0.184
odontogenesis GO:0042476 9 0.180
positive regulation of map kinase activity GO:0043406 3 0.171
germ line stem cell division GO:0042078 1 0.169
Fly
regulation of dna replication GO:0006275 3 0.167
phosphate containing compound metabolic process GO:0006796 108 0.165
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.163
anterior posterior pattern specification GO:0009952 152 0.161
Fly
meiotic spindle organization GO:0000212 1 0.160
mesoderm morphogenesis GO:0048332 51 0.158
stem cell proliferation GO:0072089 4 0.155
negative regulation of cellular process GO:0048523 283 0.153
Zebrafish Worm Fly
intracellular signal transduction GO:0035556 85 0.153
Zebrafish
response to organic substance GO:0010033 153 0.152
Mouse Fly
ossification GO:0001503 23 0.151
Mouse
mesoderm formation GO:0001707 43 0.151
cellular biosynthetic process GO:0044249 286 0.149
single organism nuclear import GO:1902593 3 0.149
regulation of cellular biosynthetic process GO:0031326 245 0.148
enzyme linked receptor protein signaling pathway GO:0007167 106 0.144
positive regulation of cell cycle GO:0045787 3 0.144
Worm
localization of cell GO:0051674 244 0.141
smoothened signaling pathway GO:0007224 30 0.140
caudal fin morphogenesis GO:0035143 7 0.140
protein import into nucleus GO:0006606 3 0.140
regulation of multicellular organismal process GO:0051239 277 0.138
odontogenesis of dentin containing tooth GO:0042475 1 0.137
neuroblast proliferation GO:0007405 2 0.136
determination of left right asymmetry in diencephalon GO:0035462 4 0.135
cell division GO:0051301 20 0.134
Fly
negative regulation of signal transduction GO:0009968 94 0.133
cellular response to chemical stimulus GO:0070887 157 0.131
Mouse Fly
regulation of intracellular protein transport GO:0033157 3 0.131
regulation of synapse assembly GO:0051963 3 0.131
Fly
meiotic nuclear division GO:0007126 4 0.129
protein targeting to nucleus GO:0044744 3 0.129
oxoacid metabolic process GO:0043436 31 0.127
regulation of primary metabolic process GO:0080090 311 0.126
regulation of cellular protein catabolic process GO:1903362 1 0.123
gamete generation GO:0007276 33 0.122
Zebrafish Mouse Fly
medial fin development GO:0033338 16 0.121
heart morphogenesis GO:0003007 156 0.121
negative regulation of developmental process GO:0051093 65 0.119
Fly
regulation of protein ubiquitination GO:0031396 3 0.119
positive regulation of cellular process GO:0048522 201 0.118
regulation of cell communication GO:0010646 232 0.117
developmental growth involved in morphogenesis GO:0060560 86 0.116
negative regulation of multicellular organismal process GO:0051241 69 0.116
skeletal system development GO:0001501 181 0.114
Mouse
nephron tubule morphogenesis GO:0072078 1 0.112
primary neural tube formation GO:0014020 1 0.111
ubiquitin dependent protein catabolic process GO:0006511 3 0.110
single organism transport GO:0044765 206 0.109
protein metabolic process GO:0019538 183 0.109
Mouse
negative regulation of cellular catabolic process GO:0031330 3 0.109
developmental growth GO:0048589 166 0.108
Worm Fly
establishment of localization in cell GO:0051649 77 0.108
regulation of nucleocytoplasmic transport GO:0046822 2 0.107
erythrocyte differentiation GO:0030218 54 0.105
Mouse
regulation of smoothened signaling pathway GO:0008589 18 0.105
spindle assembly involved in meiosis GO:0090306 1 0.105
axis specification GO:0009798 43 0.105
determination of ventral identity GO:0048264 21 0.104
cell cycle g1 s phase transition GO:0044843 1 0.104
Fly
embryonic hemopoiesis GO:0035162 53 0.103
caudal fin development GO:0033336 9 0.102
regulation of protein targeting GO:1903533 2 0.102
head development GO:0060322 303 0.101
meiosis i GO:0007127 1 0.101
response to organic cyclic compound GO:0014070 51 0.100
Mouse
regulation of protein localization to nucleus GO:1900180 2 0.100
neural tube development GO:0021915 62 0.099
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.098
taxis GO:0042330 109 0.097
Fly
axial mesoderm formation GO:0048320 4 0.096
anatomical structure arrangement GO:0048532 2 0.096
determination of dorsal ventral asymmetry GO:0048262 34 0.096
organic substance transport GO:0071702 58 0.095
regulation of cell projection organization GO:0031344 44 0.095
smoothened signaling pathway involved in dorsal ventral neural tube patterning GO:0060831 1 0.095
regulation of establishment of planar polarity GO:0090175 4 0.095
nucleobase containing compound biosynthetic process GO:0034654 205 0.095
locomotion GO:0040011 313 0.093
modification dependent protein catabolic process GO:0019941 3 0.092
axis elongation GO:0003401 31 0.092
nucleocytoplasmic transport GO:0006913 4 0.091
negative regulation of catabolic process GO:0009895 3 0.091
regulation of canonical wnt signaling pathway GO:0060828 34 0.091
macromolecule modification GO:0043412 111 0.089
Mouse
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.089
regulation of epithelial cell proliferation GO:0050678 3 0.088
single organism metabolic process GO:0044710 217 0.087
positive regulation of biological process GO:0048518 253 0.086
reproduction GO:0000003 40 0.085
Zebrafish Mouse Worm Fly
stem cell maintenance GO:0019827 4 0.084
Fly
multicellular organism growth GO:0035264 4 0.084
Worm
regulation of calcium dependent cell cell adhesion GO:0046586 1 0.084
cell projection organization GO:0030030 284 0.083
cellular protein catabolic process GO:0044257 4 0.082
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.081
generation of neurons GO:0048699 385 0.081
tube formation GO:0035148 25 0.081
neuron differentiation GO:0030182 353 0.080
synaptic growth at neuromuscular junction GO:0051124 2 0.079
Fly
regulation of response to stress GO:0080134 36 0.079
regulation of protein binding GO:0043393 3 0.079
cellular amine metabolic process GO:0044106 2 0.078
regulation of vitamin metabolic process GO:0030656 6 0.078
response to chemical GO:0042221 320 0.078
Mouse Fly
single organism reproductive process GO:0044702 40 0.078
Zebrafish Mouse Fly
fin development GO:0033333 77 0.077
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.077
segmentation GO:0035282 97 0.077
Fly
meiotic cell cycle process GO:1903046 3 0.076
cellular nitrogen compound biosynthetic process GO:0044271 218 0.076
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.076
positive regulation of synapse assembly GO:0051965 1 0.075
Fly
reproductive process GO:0022414 40 0.075
Zebrafish Mouse Worm Fly
protein import GO:0017038 3 0.074
cellular catabolic process GO:0044248 27 0.072
regulation of bmp signaling pathway GO:0030510 39 0.071
central nervous system development GO:0007417 387 0.071
cellular response to nutrient levels GO:0031669 2 0.071
regulation of biomineral tissue development GO:0070167 2 0.070
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.069
Fly
response to oxygen containing compound GO:1901700 55 0.069
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.068
Zebrafish Mouse Fly
single organism organelle organization GO:1902589 199 0.068
mitotic cell cycle process GO:1903047 48 0.067
Fly
positive regulation of biosynthetic process GO:0009891 68 0.065
larval development GO:0002164 2 0.065
single organismal cell cell adhesion GO:0016337 29 0.065
regulation of wnt signaling pathway GO:0030111 53 0.064
response to stress GO:0006950 263 0.064
regulation of cytoplasmic transport GO:1903649 4 0.064
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.063
embryonic skeletal system development GO:0048706 97 0.063
adherens junction organization GO:0034332 4 0.063
negative regulation of dna replication GO:0008156 2 0.062
regulation of cell growth GO:0001558 29 0.061
negative regulation of signaling GO:0023057 96 0.060
oocyte construction GO:0007308 5 0.060
skeletal system morphogenesis GO:0048705 102 0.060
proteasomal protein catabolic process GO:0010498 2 0.060
macromolecular complex subunit organization GO:0043933 74 0.060
endocardial cushion morphogenesis GO:0003203 3 0.059
erythrocyte homeostasis GO:0034101 55 0.059
Mouse
negative regulation of gene expression GO:0010629 65 0.059
Zebrafish Fly
positive regulation of histone deacetylation GO:0031065 1 0.058
protein localization GO:0008104 40 0.057
positive regulation of cellular component biogenesis GO:0044089 3 0.056
Fly
response to biotic stimulus GO:0009607 97 0.056
convergent extension involved in axis elongation GO:0060028 26 0.055
mrna metabolic process GO:0016071 20 0.055
cellular response to stress GO:0033554 62 0.055
regulation of apoptotic process GO:0042981 98 0.055
small molecule metabolic process GO:0044281 77 0.054
proepicardium development GO:0003342 4 0.053
amine metabolic process GO:0009308 2 0.053
skin morphogenesis GO:0043589 7 0.052
negative regulation of biological process GO:0048519 304 0.051
Zebrafish Worm Fly
segment polarity determination GO:0007367 1 0.050
regulation of mrna processing GO:0050684 3 0.050
blood vessel development GO:0001568 246 0.050
negative regulation of nervous system development GO:0051961 22 0.050
neural tube patterning GO:0021532 33 0.049
embryonic cranial skeleton morphogenesis GO:0048701 90 0.049
regulation of neurogenesis GO:0050767 87 0.048
establishment of localization GO:0051234 244 0.048
centrosome duplication GO:0051298 1 0.048
female meiotic division GO:0007143 2 0.048
determination of left right asymmetry in nervous system GO:0035545 4 0.047
regulation of chromosome segregation GO:0051983 1 0.047
sensory organ development GO:0007423 393 0.047
endodermal cell fate determination GO:0007493 2 0.047
vasculature development GO:0001944 278 0.046
growth GO:0040007 174 0.046
Worm Fly
endodermal cell differentiation GO:0035987 19 0.046
Fly
ventral spinal cord interneuron specification GO:0021521 3 0.046
nephron epithelium morphogenesis GO:0072088 1 0.046
negative regulation of metabolic process GO:0009892 86 0.045
Zebrafish Fly
cell proliferation involved in heart morphogenesis GO:0061323 2 0.045
modification dependent macromolecule catabolic process GO:0043632 3 0.045
cilium morphogenesis GO:0060271 85 0.045
regulation of cellular ketone metabolic process GO:0010565 7 0.045
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.045
Zebrafish
negative regulation of rna metabolic process GO:0051253 48 0.044
Zebrafish
negative regulation of molecular function GO:0044092 23 0.044
negative regulation of cytoplasmic transport GO:1903650 2 0.043
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.043
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.043
Zebrafish
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.043
Zebrafish
organonitrogen compound metabolic process GO:1901564 74 0.043
endodermal cell fate commitment GO:0001711 18 0.043
Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.042
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.042
cell part morphogenesis GO:0032990 246 0.042
response to growth factor GO:0070848 39 0.042
Mouse Fly
regulation of cell division GO:0051302 12 0.042
negative regulation of cell division GO:0051782 4 0.042
protein modification process GO:0036211 100 0.041
Mouse
embryonic pattern specification GO:0009880 44 0.041
regulation of wnt signaling pathway involved in heart development GO:0003307 2 0.041
g1 s transition of mitotic cell cycle GO:0000082 1 0.041
Fly
protein processing GO:0016485 12 0.041
regulation of developmental growth GO:0048638 38 0.040
Worm Fly
regulation of epithelial to mesenchymal transition GO:0010717 3 0.040
negative regulation of neural precursor cell proliferation GO:2000178 1 0.040
embryonic axis specification GO:0000578 12 0.039
tissue regeneration GO:0042246 74 0.038
gastrulation with mouth forming second GO:0001702 44 0.038
glucose homeostasis GO:0042593 1 0.038
tube closure GO:0060606 1 0.038
positive regulation of transcription dna templated GO:0045893 57 0.038
neuron development GO:0048666 262 0.038
kidney development GO:0001822 92 0.038
Mouse
maintenance of location GO:0051235 4 0.037
microtubule organizing center organization GO:0031023 1 0.037
catabolic process GO:0009056 32 0.037
neural tube formation GO:0001841 16 0.037
response to wounding GO:0009611 116 0.036
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.036
protein phosphorylation GO:0006468 47 0.036
Mouse
regulation of synapse organization GO:0050807 3 0.036
Fly
mesenchymal cell proliferation GO:0010463 1 0.036
cell maturation GO:0048469 23 0.036
specification of axis polarity GO:0065001 4 0.036
morphogenesis of an epithelial fold GO:0060571 1 0.035
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.035
regulation of neuron projection development GO:0010975 40 0.035
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.035
appendage development GO:0048736 80 0.035
Fly
regulation of histone deacetylation GO:0031063 2 0.034
cell proliferation in dorsal spinal cord GO:0010456 2 0.034
cell morphogenesis GO:0000902 289 0.034
organic substance catabolic process GO:1901575 28 0.033
regulation of cell development GO:0060284 100 0.033
Zebrafish
regulation of growth GO:0040008 42 0.033
Worm Fly
protein polyubiquitination GO:0000209 4 0.033
heart jogging GO:0003146 40 0.033
transport GO:0006810 220 0.033
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.033
regulation of dna metabolic process GO:0051052 11 0.033
histone deacetylation GO:0016575 2 0.033
protein complex biogenesis GO:0070271 30 0.033
negative regulation of cell communication GO:0010648 96 0.033
negative regulation of cell death GO:0060548 60 0.032
wnt signaling pathway involved in somitogenesis GO:0090244 2 0.032
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.032
positive regulation of transport GO:0051050 2 0.032
negative regulation of embryonic development GO:0045992 11 0.032
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.032
regulation of cell aging GO:0090342 1 0.031
reciprocal meiotic recombination GO:0007131 1 0.031
nucleic acid templated transcription GO:0097659 181 0.031
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.031
negative regulation of calcium dependent cell cell adhesion GO:0046588 1 0.031
protein localization to microtubule cytoskeleton GO:0072698 1 0.031
meiotic chromosome segregation GO:0045132 3 0.031
regulation of stem cell differentiation GO:2000736 4 0.031
erythrocyte maturation GO:0043249 8 0.031
regulation of molecular function GO:0065009 70 0.031
death GO:0016265 121 0.030
angiogenesis GO:0001525 158 0.030
protein maturation GO:0051604 12 0.030
male meiosis GO:0007140 2 0.030
axon development GO:0061564 166 0.030
regulation of transport GO:0051049 45 0.030
muscle cell differentiation GO:0042692 139 0.030
proximal distal pattern formation GO:0009954 1 0.029
positive regulation of dna metabolic process GO:0051054 1 0.029
heart looping GO:0001947 94 0.029
macromolecular complex assembly GO:0065003 35 0.029
cellular amino acid metabolic process GO:0006520 7 0.029
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.029
Zebrafish
positive regulation of cellular amine metabolic process GO:0033240 0 0.029
mesenchyme morphogenesis GO:0072132 5 0.029
regulation of cell morphogenesis GO:0022604 42 0.029
negative regulation of reproductive process GO:2000242 3 0.029
peptidyl serine phosphorylation GO:0018105 1 0.029
oocyte axis specification GO:0007309 5 0.029
unidimensional cell growth GO:0009826 5 0.029
negative regulation of protein transport GO:0051224 3 0.029
response to drug GO:0042493 3 0.028
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.028
lipid storage GO:0019915 1 0.028
defense response to fungus GO:0050832 2 0.028
oocyte differentiation GO:0009994 14 0.028
Zebrafish
insulin like growth factor receptor signaling pathway GO:0048009 4 0.027
cellular ketone metabolic process GO:0042180 11 0.027
positive regulation of gene expression GO:0010628 71 0.027
striated muscle cell differentiation GO:0051146 129 0.027
blastoderm segmentation GO:0007350 6 0.027
Fly
protein complex assembly GO:0006461 30 0.027
cardiac atrium development GO:0003230 4 0.026
actin filament based process GO:0030029 64 0.026
kidney morphogenesis GO:0060993 15 0.026
regulation of binding GO:0051098 3 0.026
peptidyl tyrosine dephosphorylation GO:0035335 1 0.026
centrosome cycle GO:0007098 1 0.026
negative regulation of protein kinase activity GO:0006469 4 0.026
adherens junction maintenance GO:0034334 2 0.026
regulation of protein metabolic process GO:0051246 56 0.025
olfactory bulb development GO:0021772 4 0.025
regulation of cell cycle GO:0051726 52 0.025
Worm Fly
proteolysis GO:0006508 38 0.025
epidermis morphogenesis GO:0048730 4 0.025
endodermal digestive tract morphogenesis GO:0061031 2 0.025
negative regulation of cell differentiation GO:0045596 46 0.025
Fly
multi organism process GO:0051704 134 0.025
Zebrafish Mouse Fly
regulation of cell death GO:0010941 103 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
rhombomere 5 morphogenesis GO:0021664 1 0.025
fin regeneration GO:0031101 51 0.025
cytoskeleton organization GO:0007010 96 0.025
mesoderm development GO:0007498 88 0.025
urogenital system development GO:0001655 97 0.025
Mouse Fly
regulation of protein deacetylation GO:0090311 2 0.025
chromosome organization GO:0051276 31 0.024
cell migration GO:0016477 237 0.024
negative regulation of nuclear division GO:0051784 3 0.024
regulation of cellular response to growth factor stimulus GO:0090287 35 0.024
microtubule based process GO:0007017 60 0.024
embryonic skeletal system morphogenesis GO:0048704 93 0.024
cartilage development GO:0051216 96 0.024
Mouse
brain development GO:0007420 293 0.024
kidney epithelium development GO:0072073 23 0.024
Mouse
cellular response to organic cyclic compound GO:0071407 38 0.024
Mouse
embryonic limb morphogenesis GO:0030326 2 0.024
anterior posterior axis specification GO:0009948 20 0.023
spindle assembly involved in mitosis GO:0090307 1 0.023
cell morphogenesis involved in differentiation GO:0000904 195 0.023
negative regulation of signal transduction by p53 class mediator GO:1901797 8 0.023
biological adhesion GO:0022610 40 0.023
negative regulation of protein import into nucleus GO:0042308 2 0.023
organelle organization GO:0006996 227 0.023
forebrain regionalization GO:0021871 4 0.023
microtubule polymerization or depolymerization GO:0031109 3 0.023
organic acid metabolic process GO:0006082 31 0.023
regulation of anatomical structure size GO:0090066 33 0.022
lateral mesoderm development GO:0048368 23 0.022
renal system development GO:0072001 94 0.022
Mouse Fly
phosphorylation GO:0016310 69 0.022
Mouse
positive regulation of chromosome organization GO:2001252 1 0.022
regulation of eye photoreceptor cell development GO:0042478 2 0.022
septum transversum development GO:0003343 4 0.022
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.022
Fly
positive regulation of multi organism process GO:0043902 3 0.022
Zebrafish
regulation of axon extension GO:0030516 24 0.022
prechordal plate formation GO:0021501 3 0.021
regulation of cellular response to stress GO:0080135 20 0.021
cellular response to transforming growth factor beta stimulus GO:0071560 7 0.021
Mouse Fly
neutrophil mediated immunity GO:0002446 1 0.021
germ cell development GO:0007281 22 0.021
Zebrafish Mouse Fly
positive regulation of neuron apoptotic process GO:0043525 1 0.021
neutrophil extravasation GO:0072672 1 0.021
stem cell development GO:0048864 82 0.021
Fly
organism emergence from protective structure GO:0071684 4 0.021
response to antibiotic GO:0046677 1 0.021
regulation of bone mineralization GO:0030500 2 0.021
regulation of mitochondrion organization GO:0010821 1 0.021
digestive tract mesoderm development GO:0007502 1 0.021
leukocyte homeostasis GO:0001776 2 0.020
immune effector process GO:0002252 23 0.020
posttranscriptional regulation of gene expression GO:0010608 14 0.020
regulation of organ morphogenesis GO:2000027 35 0.020
positive regulation of cell adhesion GO:0045785 1 0.020
establishment of monopolar cell polarity GO:0061162 2 0.020
cell aging GO:0007569 2 0.020
muscle structure development GO:0061061 196 0.020
regulation of cellular localization GO:0060341 12 0.020
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.020
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.020
ion transmembrane transport GO:0034220 91 0.020
heart field specification GO:0003128 1 0.020

smad5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
colon carcinoma DOID:1520 0 0.335
large intestine cancer DOID:5672 0 0.335
colon cancer DOID:219 0 0.335
gastrointestinal system cancer DOID:3119 0 0.335
intestinal cancer DOID:10155 0 0.335
cancer DOID:162 0 0.335
disease of cellular proliferation DOID:14566 0 0.335
organ system cancer DOID:0050686 0 0.335
colorectal cancer DOID:9256 0 0.335
disease of anatomical entity DOID:7 0 0.105
benign neoplasm DOID:0060072 0 0.055
thoracic cancer DOID:5093 0 0.024
breast cancer DOID:1612 0 0.023
nervous system disease DOID:863 0 0.023