Danio rerio

120 known processes

smad2

MAD homolog 2 (Drosophila)

(Aliases: wu:fj43c06,madh2,fj43c06)

smad2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule metabolic process GO:0044260 391 0.642
tube morphogenesis GO:0035239 349 0.596
Zebrafish Mouse
digestive system development GO:0055123 289 0.517
Zebrafish Mouse
convergent extension GO:0060026 118 0.509
Zebrafish
larval development GO:0002164 2 0.412
cellular carbohydrate metabolic process GO:0044262 4 0.398
regulation of cellular metabolic process GO:0031323 320 0.382
convergent extension involved in gastrulation GO:0060027 71 0.370
Zebrafish
regulation of meiotic cell cycle GO:0051445 1 0.366
Worm
gastrulation GO:0007369 208 0.354
Zebrafish Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.347
regulation of signaling GO:0023051 235 0.269
Human Zebrafish
cellular nitrogen compound metabolic process GO:0034641 290 0.263
digestive tract development GO:0048565 265 0.262
Zebrafish Mouse
cellular protein catabolic process GO:0044257 4 0.258
nitrogen compound metabolic process GO:0006807 319 0.253
cell part morphogenesis GO:0032990 246 0.251
regulation of macromolecule metabolic process GO:0060255 317 0.247
signal transduction GO:0007165 455 0.237
organic substance catabolic process GO:1901575 28 0.226
protein metabolic process GO:0019538 183 0.217
Human Mouse
digestive tract morphogenesis GO:0048546 231 0.216
Zebrafish Mouse
positive regulation of catabolic process GO:0009896 4 0.215
positive regulation of cellular catabolic process GO:0031331 3 0.212
nuclear migration GO:0007097 3 0.208
wnt signaling pathway GO:0016055 80 0.198
regionalization GO:0003002 274 0.189
Human Zebrafish Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.186
neuroblast proliferation GO:0007405 2 0.183
single organism organelle organization GO:1902589 199 0.181
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.175
cellular protein metabolic process GO:0044267 129 0.172
Human Mouse
regulation of primary metabolic process GO:0080090 311 0.165
regulation of biological quality GO:0065008 263 0.164
Mouse
cytoskeleton organization GO:0007010 96 0.162
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.160
stem cell proliferation GO:0072089 4 0.159
heart development GO:0007507 313 0.153
Zebrafish Mouse
cell morphogenesis GO:0000902 289 0.149
Mouse
microtubule based process GO:0007017 60 0.146
regulation of signal transduction GO:0009966 225 0.146
Human Zebrafish
negative regulation of biological process GO:0048519 304 0.145
oogenesis GO:0048477 14 0.145
rna biosynthetic process GO:0032774 181 0.141
regulation of nitrogen compound metabolic process GO:0051171 251 0.141
hematopoietic or lymphoid organ development GO:0048534 191 0.138
Zebrafish
rna metabolic process GO:0016070 219 0.138
nuclear division GO:0000280 23 0.137
regulation of response to stimulus GO:0048583 269 0.136
Human Zebrafish
negative regulation of response to stimulus GO:0048585 104 0.134
gene expression GO:0010467 252 0.133
immune system development GO:0002520 191 0.130
Zebrafish
central nervous system formation GO:0021556 1 0.126
mitotic nuclear division GO:0007067 18 0.126
nitric oxide biosynthetic process GO:0006809 2 0.124
retinoic acid metabolic process GO:0042573 9 0.120
apoptotic process GO:0006915 116 0.120
negative regulation of cell communication GO:0010648 96 0.117
peptidyl threonine phosphorylation GO:0018107 1 0.115
phosphate containing compound metabolic process GO:0006796 108 0.114
Human Mouse
autophagy GO:0006914 4 0.114
embryonic organ morphogenesis GO:0048562 274 0.111
Zebrafish Mouse
locomotion GO:0040011 313 0.111
Zebrafish
cellular response to organic substance GO:0071310 105 0.110
Human Mouse
regulation of cell differentiation GO:0045595 142 0.110
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.109
cell surface receptor signaling pathway GO:0007166 325 0.105
Human Zebrafish Mouse
oocyte development GO:0048599 14 0.104
response to chemical GO:0042221 320 0.101
Human Mouse
response to abiotic stimulus GO:0009628 122 0.101
brain development GO:0007420 293 0.100
cell migration involved in gastrulation GO:0042074 79 0.100
Zebrafish
regulation of metabolic process GO:0019222 359 0.099
embryo development ending in birth or egg hatching GO:0009792 271 0.097
Mouse
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.097
spindle assembly GO:0051225 2 0.095
cell death GO:0008219 121 0.094
negative regulation of cellular process GO:0048523 283 0.094
growth GO:0040007 174 0.094
Mouse Worm
regulation of macromolecule biosynthetic process GO:0010556 225 0.093
stem cell maintenance GO:0019827 4 0.093
positive regulation of biological process GO:0048518 253 0.091
reactive oxygen species biosynthetic process GO:1903409 1 0.090
microtubule cytoskeleton organization GO:0000226 33 0.090
adherens junction maintenance GO:0034334 2 0.090
modification dependent macromolecule catabolic process GO:0043632 3 0.090
meiotic nuclear division GO:0007126 4 0.089
establishment of organelle localization GO:0051656 45 0.088
cellular protein modification process GO:0006464 100 0.088
Human Mouse
negative regulation of signaling GO:0023057 96 0.087
cellular component biogenesis GO:0044085 178 0.085
Human
cell fate commitment GO:0045165 99 0.085
Mouse
negative regulation of gene expression GO:0010629 65 0.085
heterocycle biosynthetic process GO:0018130 215 0.085
regulation of developmental process GO:0050793 247 0.085
pronuclear migration GO:0035046 1 0.084
phosphorus metabolic process GO:0006793 109 0.083
Human Mouse
organic cyclic compound metabolic process GO:1901360 301 0.083
regulation of calcium dependent cell cell adhesion GO:0046586 1 0.083
central nervous system development GO:0007417 387 0.082
negative regulation of cellular metabolic process GO:0031324 77 0.081
nucleobase containing compound metabolic process GO:0006139 274 0.080
maintenance of location GO:0051235 4 0.080
catabolic process GO:0009056 32 0.080
establishment of localization GO:0051234 244 0.077
Mouse
peptidyl serine phosphorylation GO:0018105 1 0.077
positive regulation of oocyte development GO:0060282 1 0.076
intracellular signal transduction GO:0035556 85 0.076
regulation of cell death GO:0010941 103 0.075
proteasomal protein catabolic process GO:0010498 2 0.075
cellular component assembly GO:0022607 170 0.075
Human
cellular nitrogen compound biosynthetic process GO:0044271 218 0.074
ameboidal type cell migration GO:0001667 143 0.073
Zebrafish
response to stress GO:0006950 263 0.073
cell cycle GO:0007049 93 0.072
Worm
regulation of carbohydrate metabolic process GO:0006109 4 0.072
heterocycle metabolic process GO:0046483 290 0.072
enzyme linked receptor protein signaling pathway GO:0007167 106 0.071
Human Zebrafish Mouse
single organism localization GO:1902578 225 0.070
Mouse
single organism reproductive process GO:0044702 40 0.070
cellular component morphogenesis GO:0032989 336 0.070
Mouse
regulation of mrna processing GO:0050684 3 0.069
response to oxidative stress GO:0006979 11 0.069
regulation of molecular function GO:0065009 70 0.068
Mouse
phagocytosis GO:0006909 3 0.068
negative regulation of smoothened signaling pathway GO:0045879 6 0.068
cell cycle process GO:0022402 53 0.068
Worm
mitotic cell cycle GO:0000278 64 0.067
Worm
cellular catabolic process GO:0044248 27 0.067
establishment of spindle localization GO:0051293 12 0.067
phosphorylation GO:0016310 69 0.067
Human Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.066
Mouse
response to endogenous stimulus GO:0009719 83 0.065
Human Mouse
histone phosphorylation GO:0016572 2 0.064
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.064
positive regulation of cellular process GO:0048522 201 0.063
meiotic cell cycle process GO:1903046 3 0.063
g2 m transition of mitotic cell cycle GO:0000086 4 0.062
response to organic substance GO:0010033 153 0.062
Human Mouse
negative regulation of apoptotic process GO:0043066 55 0.061
negative regulation of metabolic process GO:0009892 86 0.060
modification dependent protein catabolic process GO:0019941 3 0.060
death GO:0016265 121 0.060
cell cycle g2 m phase transition GO:0044839 4 0.059
regulation of intracellular signal transduction GO:1902531 57 0.059
guanosine containing compound catabolic process GO:1901069 2 0.058
multicellular organism growth GO:0035264 4 0.057
Worm
regulation of transcription dna templated GO:0006355 213 0.057
ubiquitin dependent protein catabolic process GO:0006511 3 0.057
regulation of cell communication GO:0010646 232 0.056
Human Zebrafish
regulation of oocyte development GO:0060281 3 0.056
nitric oxide metabolic process GO:0046209 2 0.056
extrinsic apoptotic signaling pathway GO:0097191 3 0.056
morphogenesis of an epithelium GO:0002009 333 0.056
Zebrafish
reproductive process GO:0022414 40 0.055
regulation of protein catabolic process GO:0042176 1 0.055
regulation of gtp catabolic process GO:0033124 2 0.055
regulation of establishment of protein localization GO:0070201 4 0.055
organic cyclic compound biosynthetic process GO:1901362 223 0.054
organelle organization GO:0006996 227 0.054
embryonic organ development GO:0048568 381 0.054
Zebrafish Mouse
neuron differentiation GO:0030182 353 0.054
chordate embryonic development GO:0043009 271 0.054
Mouse
positive regulation of molecular function GO:0044093 33 0.054
cellular macromolecule biosynthetic process GO:0034645 224 0.052
gtp catabolic process GO:0006184 2 0.052
transport GO:0006810 220 0.052
Mouse
lipid homeostasis GO:0055088 3 0.052
regulation of purine nucleotide catabolic process GO:0033121 2 0.051
regulation of retinoic acid biosynthetic process GO:1900052 6 0.050
localization of cell GO:0051674 244 0.050
Zebrafish
hemopoiesis GO:0030097 183 0.049
Zebrafish
single organism metabolic process GO:0044710 217 0.049
regulation of nucleotide catabolic process GO:0030811 2 0.049
nuclear transport GO:0051169 4 0.048
gland development GO:0048732 143 0.048
nucleus localization GO:0051647 8 0.048
organonitrogen compound metabolic process GO:1901564 74 0.048
chromosome organization GO:0051276 31 0.048
generation of neurons GO:0048699 385 0.048
cellular component movement GO:0006928 335 0.047
Zebrafish
histone modification GO:0016570 20 0.047
macromolecule biosynthetic process GO:0009059 227 0.047
regulation of nucleoside metabolic process GO:0009118 2 0.047
nucleocytoplasmic transport GO:0006913 4 0.046
neuron projection morphogenesis GO:0048812 161 0.045
cellular response to endogenous stimulus GO:0071495 68 0.045
Human Mouse
regulation of apoptotic process GO:0042981 98 0.045
pharyngeal muscle development GO:0043282 4 0.045
regulation of response to nutrient levels GO:0032107 1 0.045
aging GO:0007568 2 0.044
cellular response to chemical stimulus GO:0070887 157 0.044
Human Mouse
oocyte maturation GO:0001556 4 0.044
response to external stimulus GO:0009605 264 0.044
g1 s transition of mitotic cell cycle GO:0000082 1 0.043
negative regulation of calcium dependent cell cell adhesion GO:0046588 1 0.043
sensory organ development GO:0007423 393 0.043
Zebrafish
neuroblast differentiation GO:0014016 1 0.043
endoderm development GO:0007492 49 0.043
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.042
programmed cell death GO:0012501 119 0.042
spindle localization GO:0051653 12 0.041
cellular response to external stimulus GO:0071496 2 0.041
endodermal cell fate determination GO:0007493 2 0.041
protein complex subunit organization GO:0071822 46 0.041
Human
retinoic acid biosynthetic process GO:0002138 6 0.040
negative regulation of molecular function GO:0044092 23 0.040
regulation of phosphate metabolic process GO:0019220 43 0.040
mitotic cell cycle process GO:1903047 48 0.040
muscle structure development GO:0061061 196 0.040
cell growth GO:0016049 57 0.039
nucleic acid templated transcription GO:0097659 181 0.039
isoprenoid biosynthetic process GO:0008299 7 0.039
cell projection morphogenesis GO:0048858 244 0.039
regulation of programmed cell death GO:0043067 101 0.038
regulation of protein targeting GO:1903533 2 0.038
centrosome cycle GO:0007098 1 0.038
regulation of localization GO:0032879 104 0.038
chromatin modification GO:0016568 21 0.038
negative regulation of signal transduction GO:0009968 94 0.038
gastrulation with mouth forming second GO:0001702 44 0.038
negative regulation of catabolic process GO:0009895 3 0.038
regulation of reactive oxygen species metabolic process GO:2000377 2 0.037
regulation of synapse organization GO:0050807 3 0.037
peptidyl threonine modification GO:0018210 1 0.037
response to radiation GO:0009314 51 0.037
peptidyl serine modification GO:0018209 2 0.037
apoptotic signaling pathway GO:0097190 23 0.036
macromolecule catabolic process GO:0009057 15 0.036
ear development GO:0043583 127 0.035
Zebrafish
regulation of multicellular organism growth GO:0040014 4 0.035
Worm
negative regulation of cellular biosynthetic process GO:0031327 55 0.035
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.035
negative regulation of collateral sprouting GO:0048671 2 0.035
developmental growth GO:0048589 166 0.035
Mouse Worm
negative regulation of mapk cascade GO:0043409 4 0.035
guanosine containing compound metabolic process GO:1901068 4 0.034
rna processing GO:0006396 25 0.034
hepaticobiliary system development GO:0061008 98 0.034
protein localization to nucleus GO:0034504 3 0.034
head development GO:0060322 303 0.034
regulation of rna biosynthetic process GO:2001141 213 0.034
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.033
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.032
cell proliferation GO:0008283 80 0.032
macromolecular complex subunit organization GO:0043933 74 0.032
Human
developmental growth involved in morphogenesis GO:0060560 86 0.031
gtp metabolic process GO:0046039 4 0.031
cellular response to nutrient levels GO:0031669 2 0.031
organelle assembly GO:0070925 110 0.031
ear morphogenesis GO:0042471 64 0.031
Zebrafish
cell cycle g1 s phase transition GO:0044843 1 0.031
regulation of cellular component organization GO:0051128 86 0.030
Mouse
regulation of nucleocytoplasmic transport GO:0046822 2 0.030
neuron projection development GO:0031175 180 0.030
spermatid development GO:0007286 2 0.030
homeostatic process GO:0042592 142 0.030
protein modification process GO:0036211 100 0.030
Human Mouse
epiboly GO:0090504 41 0.030
regulation of vitamin metabolic process GO:0030656 6 0.029
regulation of autophagy GO:0010506 3 0.029
regulation of gene expression GO:0010468 265 0.029
regulation of wnt signaling pathway GO:0030111 53 0.029
blood vessel morphogenesis GO:0048514 216 0.029
Zebrafish
diterpenoid biosynthetic process GO:0016102 7 0.029
regulation of nucleic acid templated transcription GO:1903506 213 0.029
mitotic dna integrity checkpoint GO:0044774 4 0.029
sensory organ morphogenesis GO:0090596 200 0.029
Zebrafish
synaptic growth at neuromuscular junction GO:0051124 2 0.029
regulation of response to extracellular stimulus GO:0032104 1 0.028
biosynthetic process GO:0009058 294 0.028
forebrain development GO:0030900 96 0.028
regulation of rna metabolic process GO:0051252 224 0.028
positive regulation of nucleoside metabolic process GO:0045979 1 0.028
centrosome organization GO:0051297 1 0.028
negative regulation of wnt signaling pathway GO:0030178 30 0.028
response to fluid shear stress GO:0034405 2 0.028
germ line stem cell division GO:0042078 1 0.028
negative regulation of protein phosphorylation GO:0001933 4 0.028
cellular biosynthetic process GO:0044249 286 0.028
organelle localization GO:0051640 49 0.027
aromatic compound biosynthetic process GO:0019438 217 0.027
cellular response to starvation GO:0009267 1 0.027
erythrocyte differentiation GO:0030218 54 0.027
nucleoside monophosphate catabolic process GO:0009125 4 0.027
erythrocyte homeostasis GO:0034101 55 0.027
establishment of localization in cell GO:0051649 77 0.027
Mouse
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.027
negative regulation of programmed cell death GO:0043069 58 0.027
positive regulation of synapse assembly GO:0051965 1 0.027
cellular localization GO:0051641 97 0.027
Mouse
establishment of endothelial barrier GO:0061028 3 0.026
nucleobase containing compound biosynthetic process GO:0034654 205 0.026
sexual reproduction GO:0019953 36 0.026
determination of bilateral symmetry GO:0009855 204 0.026
Human Zebrafish
cellular response to stress GO:0033554 62 0.026
striated muscle cell differentiation GO:0051146 129 0.026
macromolecule modification GO:0043412 111 0.026
Human Mouse
nucleic acid metabolic process GO:0090304 244 0.026
positive regulation of cellular metabolic process GO:0031325 94 0.026
Human Zebrafish Mouse
negative regulation of developmental process GO:0051093 65 0.026
anterior posterior pattern specification GO:0009952 152 0.026
Mouse
establishment of cell polarity GO:0030010 18 0.025
axonogenesis GO:0007409 152 0.025
negative regulation of reproductive process GO:2000242 3 0.025
carboxylic acid metabolic process GO:0019752 22 0.025
reactive oxygen species metabolic process GO:0072593 6 0.025
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.025
myeloid cell differentiation GO:0030099 86 0.025
Zebrafish
oocyte differentiation GO:0009994 14 0.024
regulation of gtpase activity GO:0043087 2 0.024
regulation of biosynthetic process GO:0009889 250 0.024
neuron development GO:0048666 262 0.024
inner ear development GO:0048839 126 0.024
Zebrafish
regulation of response to stress GO:0080134 36 0.024
response to oxygen containing compound GO:1901700 55 0.024
Human Mouse
transcription dna templated GO:0006351 181 0.024
negative regulation of biosynthetic process GO:0009890 55 0.024
regulation of phosphorylation GO:0042325 26 0.024
regulation of binding GO:0051098 3 0.024
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.024
establishment or maintenance of cell polarity GO:0007163 29 0.024
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.024
Human Zebrafish Mouse
developmental maturation GO:0021700 34 0.023
multi organism process GO:0051704 134 0.023
developmental process involved in reproduction GO:0003006 27 0.023
amine metabolic process GO:0009308 2 0.023
immune system process GO:0002376 241 0.023
Zebrafish
sensory system development GO:0048880 76 0.023
ribonucleotide metabolic process GO:0009259 27 0.023
mitochondrion organization GO:0007005 4 0.023
eye development GO:0001654 277 0.023
regulation of cell cycle GO:0051726 52 0.023
Worm
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.022
regulation of organelle organization GO:0033043 29 0.022
diencephalon development GO:0021536 58 0.022
regulation of reproductive process GO:2000241 4 0.022
single fertilization GO:0007338 3 0.022
negative regulation of cell differentiation GO:0045596 46 0.022
gamete generation GO:0007276 33 0.022
regulation of circadian rhythm GO:0042752 4 0.022
epithelial cell differentiation GO:0030855 116 0.022
fertilization GO:0009566 3 0.022
synaptic vesicle transport GO:0048489 1 0.022
positive regulation of stress activated mapk cascade GO:0032874 3 0.022
heart jogging GO:0003146 40 0.022
Zebrafish
biological adhesion GO:0022610 40 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
Human Zebrafish Mouse
cellular response to molecule of bacterial origin GO:0071219 3 0.021
positive regulation of map kinase activity GO:0043406 3 0.021
epithelial tube morphogenesis GO:0060562 148 0.021
Zebrafish
regulation of intracellular protein transport GO:0033157 3 0.021
cellular response to extracellular stimulus GO:0031668 2 0.021
establishment or maintenance of bipolar cell polarity GO:0061245 12 0.021
single organism membrane fusion GO:0044801 2 0.021
negative regulation of macromolecule metabolic process GO:0010605 76 0.021
cell motility GO:0048870 244 0.021
Zebrafish
protein localization to plasma membrane GO:0072659 1 0.021
cellular amide metabolic process GO:0043603 4 0.021
positive regulation of transport GO:0051050 2 0.021
cell migration involved in heart development GO:0060973 22 0.021
nuclear import GO:0051170 3 0.021
germ line stem cell maintenance GO:0030718 2 0.021
meiosis i GO:0007127 1 0.021
negative regulation of protein localization to nucleus GO:1900181 2 0.020
chromatin organization GO:0006325 22 0.020
carbohydrate derivative metabolic process GO:1901135 61 0.020
microtubule organizing center organization GO:0031023 1 0.020
cellular response to reactive oxygen species GO:0034614 2 0.020
cell migration GO:0016477 237 0.020
Zebrafish
regulation of phosphorus metabolic process GO:0051174 43 0.020
regulation of dendrite development GO:0050773 3 0.020
cellular response to oxygen levels GO:0071453 1 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
regulation of protein localization to nucleus GO:1900180 2 0.020
wound healing GO:0042060 90 0.019
regulation of glucose transport GO:0010827 1 0.019
positive regulation of apoptotic signaling pathway GO:2001235 1 0.019
positive regulation of biosynthetic process GO:0009891 68 0.019
Human Zebrafish Mouse
regulation of mitochondrion organization GO:0010821 1 0.019
meiotic chromosome segregation GO:0045132 3 0.019
cellular macromolecule catabolic process GO:0044265 12 0.019
oxoacid metabolic process GO:0043436 31 0.019
angioblast cell migration involved in selective angioblast sprouting GO:0035475 4 0.019
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.019
response to uv GO:0009411 3 0.019
positive regulation of gtpase activity GO:0043547 1 0.019
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.019
response to wounding GO:0009611 116 0.019
blood circulation GO:0008015 87 0.018
liver development GO:0001889 96 0.018
positive regulation of metabolic process GO:0009893 108 0.018
Human Zebrafish Mouse
negative regulation of cell cycle phase transition GO:1901988 5 0.018
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 11 0.018
formation of primary germ layer GO:0001704 62 0.018
Mouse
spindle organization GO:0007051 5 0.018
regulation of isoprenoid metabolic process GO:0019747 6 0.018
positive regulation of chromatin modification GO:1903310 1 0.018
regulation of cellular protein metabolic process GO:0032268 52 0.018
glucose import GO:0046323 2 0.018
multicellular organism reproduction GO:0032504 35 0.018
response to light stimulus GO:0009416 46 0.018
skeletal system development GO:0001501 181 0.018
Mouse
lipid storage GO:0019915 1 0.018
activation of mapk activity GO:0000187 3 0.018
establishment of spindle orientation GO:0051294 10 0.018
regulation of multicellular organismal process GO:0051239 277 0.018
adherens junction organization GO:0034332 4 0.017
membrane invagination GO:0010324 1 0.017
regulation of protein metabolic process GO:0051246 56 0.017
system process GO:0003008 185 0.017
neuron projection extension GO:1990138 45 0.017
actin filament based process GO:0030029 64 0.017
regulation of cell development GO:0060284 100 0.017
negative regulation of cell death GO:0060548 60 0.017
cellular amine metabolic process GO:0044106 2 0.017
phagocytosis engulfment GO:0006911 1 0.017
septum transversum development GO:0003343 4 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.017
camera type eye development GO:0043010 222 0.017
establishment of apical basal cell polarity GO:0035089 2 0.017
regulation of microtubule cytoskeleton organization GO:0070507 3 0.017
regulation of catalytic activity GO:0050790 55 0.017
rna localization GO:0006403 4 0.017
lipid catabolic process GO:0016042 4 0.016
rna 3 end processing GO:0031123 2 0.016
protein phosphorylation GO:0006468 47 0.016
Human Mouse
single organism cellular localization GO:1902580 46 0.016
neural precursor cell proliferation GO:0061351 20 0.016
regulation of anatomical structure morphogenesis GO:0022603 130 0.016
Zebrafish Mouse
dorsal ventral pattern formation GO:0009953 125 0.016
Human Zebrafish
organic acid metabolic process GO:0006082 31 0.016
cellular ketone metabolic process GO:0042180 11 0.016
meiotic spindle organization GO:0000212 1 0.016
glucose homeostasis GO:0042593 1 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
regulation of mitotic cell cycle GO:0007346 25 0.015
Worm
female gamete generation GO:0007292 14 0.015
regulation of synaptic plasticity GO:0048167 1 0.015
regulation of stem cell differentiation GO:2000736 4 0.015
Mouse
protein import GO:0017038 3 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
negative regulation of translation GO:0017148 1 0.015
fin development GO:0033333 77 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.015
single organism cell adhesion GO:0098602 29 0.015
peptide metabolic process GO:0006518 1 0.015
nuclear export GO:0051168 1 0.015
lateral line development GO:0048882 66 0.015
canonical wnt signaling pathway GO:0060070 48 0.015
mrna 3 end processing GO:0031124 2 0.014
stem cell division GO:0017145 1 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
regulation of immune system process GO:0002682 34 0.014
positive regulation of programmed cell death GO:0043068 29 0.014
proteolysis GO:0006508 38 0.014
lateral line system development GO:0048925 76 0.014
regulation of sodium ion transport GO:0002028 2 0.014
negative regulation of protein import into nucleus GO:0042308 2 0.014
pronephros development GO:0048793 69 0.014
cytoskeleton dependent cytokinesis GO:0061640 3 0.014
cell aging GO:0007569 2 0.014
development of primary female sexual characteristics GO:0046545 4 0.014
positive regulation of lipid metabolic process GO:0045834 1 0.014
atp catabolic process GO:0006200 4 0.014
cell projection organization GO:0030030 284 0.014
protein targeting to nucleus GO:0044744 3 0.014
negative regulation of cellular catabolic process GO:0031330 3 0.014
anterior posterior axis specification GO:0009948 20 0.014
mapk cascade GO:0000165 18 0.014
regulation of ras gtpase activity GO:0032318 2 0.014
embryonic pattern specification GO:0009880 44 0.014
posttranscriptional regulation of gene expression GO:0010608 14 0.014
positive regulation of macromolecule metabolic process GO:0010604 93 0.014
Human Zebrafish Mouse
regulation of cell shape GO:0008360 1 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
blood vessel development GO:0001568 246 0.013
Zebrafish
stem cell differentiation GO:0048863 117 0.013
Mouse
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
fin morphogenesis GO:0033334 53 0.013
negative regulation of defense response GO:0031348 2 0.013
regulation of protein transport GO:0051223 3 0.013
negative regulation of kinase activity GO:0033673 4 0.013
response to ionizing radiation GO:0010212 6 0.013
establishment of mitotic spindle localization GO:0040001 12 0.013
mrna processing GO:0006397 14 0.013
spindle assembly involved in mitosis GO:0090307 1 0.013
response to alkaloid GO:0043279 2 0.013
axon development GO:0061564 166 0.013
cellular component disassembly GO:0022411 1 0.013
regulation of mapk cascade GO:0043408 14 0.013
regulation of erythrocyte differentiation GO:0045646 2 0.013
regulation of proteolysis GO:0030162 24 0.013
female gonad development GO:0008585 4 0.013

smad2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.046
cancer DOID:162 0 0.030
organ system cancer DOID:0050686 0 0.021
disease of anatomical entity DOID:7 0 0.017