Danio rerio

0 known processes

hmgb1b

high-mobility group box 1b

(Aliases: MGC165618,wu:fb13a05,wu:fa96c07,zgc:165618)

hmgb1b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
3 utr mediated mrna stabilization GO:0070935 3 0.959
regulation of binding GO:0051098 3 0.546
Human
rna stabilization GO:0043489 4 0.533
b cell differentiation GO:0030183 1 0.357
extrinsic apoptotic signaling pathway GO:0097191 3 0.343
regulation of nuclease activity GO:0032069 1 0.341
nucleic acid templated transcription GO:0097659 181 0.292
Human Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.234
Human Mouse
negative regulation of leukocyte differentiation GO:1902106 1 0.208
response to cold GO:0009409 4 0.201
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.197
Human
organic cyclic compound metabolic process GO:1901360 301 0.184
Human Mouse
regulation of transcription dna templated GO:0006355 213 0.176
Human Mouse
regulation of rna biosynthetic process GO:2001141 213 0.174
Human Mouse
regulation of gene expression GO:0010468 265 0.148
Human Mouse
positive regulation of cell cycle GO:0045787 3 0.132
spermatid differentiation GO:0048515 2 0.126
organic cyclic compound biosynthetic process GO:1901362 223 0.113
Human Mouse
regulation of cellular metabolic process GO:0031323 320 0.111
Human Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.110
Human
regulation of mrna splicing via spliceosome GO:0048024 3 0.106
cellular macromolecule biosynthetic process GO:0034645 224 0.104
Human Mouse
response to external stimulus GO:0009605 264 0.104
response to uv GO:0009411 3 0.103
myeloid cell differentiation GO:0030099 86 0.100
Mouse
regulation of nitrogen compound metabolic process GO:0051171 251 0.100
Human Mouse
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.098
positive regulation of nuclease activity GO:0032075 1 0.096
muscle structure development GO:0061061 196 0.094
response to other organism GO:0051707 97 0.090
response to external biotic stimulus GO:0043207 97 0.089
response to vitamin GO:0033273 3 0.089
cellular component movement GO:0006928 335 0.087
negative regulation of myeloid cell differentiation GO:0045638 1 0.085
cellular component biogenesis GO:0044085 178 0.080
Human
cellular nitrogen compound biosynthetic process GO:0044271 218 0.078
Human Mouse
macromolecule biosynthetic process GO:0009059 227 0.077
Human Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.076
Human Mouse
positive regulation of transport GO:0051050 2 0.073
negative regulation of rna biosynthetic process GO:1902679 45 0.072
Human
nucleobase containing compound biosynthetic process GO:0034654 205 0.071
Human Mouse
regulation of neural precursor cell proliferation GO:2000177 3 0.068
cytoskeleton dependent cytokinesis GO:0061640 3 0.065
aromatic compound biosynthetic process GO:0019438 217 0.064
Human Mouse
nucleic acid metabolic process GO:0090304 244 0.063
Human Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.062
Human Mouse
melanin metabolic process GO:0006582 2 0.062
response to chemical GO:0042221 320 0.061
Mouse
cell proliferation GO:0008283 80 0.061
organelle organization GO:0006996 227 0.060
cell cycle process GO:0022402 53 0.058
regulation of cell activation GO:0050865 1 0.058
b cell activation GO:0042113 2 0.058
organic substance biosynthetic process GO:1901576 289 0.054
Human Mouse
smoothened signaling pathway GO:0007224 30 0.054
negative regulation of ras protein signal transduction GO:0046580 1 0.054
response to temperature stimulus GO:0009266 15 0.054
startle response GO:0001964 4 0.053
negative regulation of biosynthetic process GO:0009890 55 0.051
Human
biosynthetic process GO:0009058 294 0.051
Human Mouse
regulation of erythrocyte differentiation GO:0045646 2 0.050
regulation of cellular biosynthetic process GO:0031326 245 0.050
Human Mouse
regulation of myeloid cell differentiation GO:0045637 8 0.049
Mouse
regulation of multicellular organismal development GO:2000026 223 0.048
Mouse
rna transport GO:0050658 2 0.047
negative regulation of cellular biosynthetic process GO:0031327 55 0.046
Human
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.045
Human
peptidyl lysine acetylation GO:0018394 2 0.045
negative regulation of gene expression GO:0010629 65 0.045
Human
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.045
regulation of immune system process GO:0002682 34 0.045
Mouse
signal transduction GO:0007165 455 0.044
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.044
regulation of response to stimulus GO:0048583 269 0.043
negative regulation of signaling GO:0023057 96 0.042
regulation of mrna stability GO:0043488 4 0.042
cellular component morphogenesis GO:0032989 336 0.042
alternative mrna splicing via spliceosome GO:0000380 1 0.042
negative regulation of rna metabolic process GO:0051253 48 0.042
Human
eye development GO:0001654 277 0.041
Mouse
regulation of biosynthetic process GO:0009889 250 0.041
Human Mouse
mitotic cell cycle process GO:1903047 48 0.040
cellular response to chemical stimulus GO:0070887 157 0.040
mitotic cytokinesis GO:0000281 3 0.040
regulation of oligodendrocyte differentiation GO:0048713 1 0.040
negative regulation of biological process GO:0048519 304 0.040
Human Mouse
spermatid development GO:0007286 2 0.040
positive regulation of neural precursor cell proliferation GO:2000179 1 0.039
cognition GO:0050890 1 0.038
nucleic acid transport GO:0050657 2 0.037
cellular biosynthetic process GO:0044249 286 0.036
Human Mouse
muscle tissue development GO:0060537 110 0.036
cell cycle GO:0007049 93 0.035
embryonic digestive tract development GO:0048566 4 0.035
striated muscle tissue development GO:0014706 110 0.035
rna splicing GO:0008380 16 0.034
cellular response to organic substance GO:0071310 105 0.034
cell surface receptor signaling pathway GO:0007166 325 0.033
rna metabolic process GO:0016070 219 0.033
Human Mouse
regulation of apoptotic process GO:0042981 98 0.033
Human
cytokinesis GO:0000910 3 0.033
larval development GO:0002164 2 0.032
axon development GO:0061564 166 0.032
nuclear body organization GO:0030575 2 0.032
regulation of cell communication GO:0010646 232 0.032
sensory organ development GO:0007423 393 0.031
Mouse
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.031
regulation of endothelial cell proliferation GO:0001936 1 0.031
female gonad development GO:0008585 4 0.030
embryonic digestive tract morphogenesis GO:0048557 3 0.030
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.029
regulation of epithelial cell proliferation GO:0050678 3 0.029
heterocycle biosynthetic process GO:0018130 215 0.028
Human Mouse
regulation of programmed cell death GO:0043067 101 0.028
Human
determination of left right symmetry GO:0007368 179 0.028
single organism organelle organization GO:1902589 199 0.028
cellular response to molecule of bacterial origin GO:0071219 3 0.028
establishment of rna localization GO:0051236 3 0.028
hemopoiesis GO:0030097 183 0.027
Mouse
stem cell proliferation GO:0072089 4 0.027
positive regulation of biological process GO:0048518 253 0.027
Human Mouse
regulation of reproductive process GO:2000241 4 0.027
signal transduction in absence of ligand GO:0038034 1 0.027
cell part morphogenesis GO:0032990 246 0.027
erythrocyte differentiation GO:0030218 54 0.026
stem cell maintenance GO:0019827 4 0.026
chemotaxis GO:0006935 104 0.026
response to lipid GO:0033993 60 0.026
Mouse
mrna stabilization GO:0048255 4 0.026
protein acylation GO:0043543 3 0.026
cellular response to lipid GO:0071396 39 0.026
positive regulation of multi organism process GO:0043902 3 0.026
regulation of protein binding GO:0043393 3 0.026
megakaryocyte differentiation GO:0030219 1 0.025
positive regulation of reproductive process GO:2000243 2 0.025
protein acetylation GO:0006473 2 0.025
adult behavior GO:0030534 2 0.025
cell projection organization GO:0030030 284 0.025
hematopoietic progenitor cell differentiation GO:0002244 23 0.025
regulation of nucleic acid templated transcription GO:1903506 213 0.024
Human Mouse
sister chromatid cohesion GO:0007062 2 0.024
negative regulation of cellular process GO:0048523 283 0.024
Human
regulation of nucleotide catabolic process GO:0030811 2 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
positive regulation of immune effector process GO:0002699 3 0.023
heart looping GO:0001947 94 0.023
regulation of signal transduction GO:0009966 225 0.023
development of primary female sexual characteristics GO:0046545 4 0.023
retina layer formation GO:0010842 24 0.023
positive regulation of nucleotide catabolic process GO:0030813 1 0.023
negative regulation of programmed cell death GO:0043069 58 0.022
mitochondrion organization GO:0007005 4 0.022
female germ line stem cell maintenance GO:0036099 1 0.022
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.022
Human
multi organism process GO:0051704 134 0.022
negative regulation of signal transduction GO:0009968 94 0.022
gtp metabolic process GO:0046039 4 0.022
organic acid metabolic process GO:0006082 31 0.022
nucleus organization GO:0006997 7 0.022
neuroblast proliferation GO:0007405 2 0.021
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.021
cellular response to external stimulus GO:0071496 2 0.021
positive chemotaxis GO:0050918 5 0.021
regulation of myelination GO:0031641 1 0.021
regulation of production of molecular mediator of immune response GO:0002700 1 0.021
negative regulation of response to stimulus GO:0048585 104 0.020
covalent chromatin modification GO:0016569 20 0.020
translational initiation GO:0006413 3 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
Human Mouse
protein localization to plasma membrane GO:0072659 1 0.020
head development GO:0060322 303 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
Human Mouse
response to glucocorticoid GO:0051384 1 0.020
Mouse
rna export from nucleus GO:0006405 1 0.019
determination of bilateral symmetry GO:0009855 204 0.019
regulation of mrna processing GO:0050684 3 0.019
negative regulation of apoptotic process GO:0043066 55 0.019
negative regulation of transcription dna templated GO:0045892 45 0.019
Human
response to virus GO:0009615 21 0.019
cilium morphogenesis GO:0060271 85 0.019
meiotic nuclear division GO:0007126 4 0.019
cell cycle g1 s phase transition GO:0044843 1 0.018
meiotic cell cycle process GO:1903046 3 0.018
embryonic organ development GO:0048568 381 0.018
negative regulation of cell communication GO:0010648 96 0.018
cytoskeleton organization GO:0007010 96 0.018
aorta development GO:0035904 4 0.018
mrna metabolic process GO:0016071 20 0.018
guanosine containing compound metabolic process GO:1901068 4 0.017
cellular response to oxygen containing compound GO:1901701 20 0.017
ubiquitin dependent protein catabolic process GO:0006511 3 0.017
immunoglobulin production GO:0002377 1 0.017
positive regulation of hydrolase activity GO:0051345 13 0.017
Human
regulation of muscle contraction GO:0006937 3 0.017
atrioventricular valve development GO:0003171 11 0.017
brain morphogenesis GO:0048854 18 0.017
cell projection morphogenesis GO:0048858 244 0.017
epithelial cell differentiation GO:0030855 116 0.017
negative regulation of cell death GO:0060548 60 0.016
oxidation reduction process GO:0055114 41 0.016
Mouse
modification of morphology or physiology of other organism GO:0035821 4 0.016
regulation of response to biotic stimulus GO:0002831 2 0.016
cellular response to organic cyclic compound GO:0071407 38 0.016
regulation of macromolecule biosynthetic process GO:0010556 225 0.016
Human Mouse
negative regulation of nucleic acid templated transcription GO:1903507 45 0.016
Human
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
neural retina development GO:0003407 49 0.016
positive regulation of cellular metabolic process GO:0031325 94 0.016
Human Mouse
positive regulation of cellular catabolic process GO:0031331 3 0.016
Mouse
stem cell development GO:0048864 82 0.016
internal peptidyl lysine acetylation GO:0018393 2 0.016
positive regulation of striated muscle cell differentiation GO:0051155 1 0.016
regulation of cell cycle GO:0051726 52 0.016
negative regulation of metabolic process GO:0009892 86 0.016
Human
hematopoietic or lymphoid organ development GO:0048534 191 0.016
Mouse
dorsal ventral pattern formation GO:0009953 125 0.016
microtubule based process GO:0007017 60 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.015
Human Mouse
histone modification GO:0016570 20 0.015
purine nucleoside monophosphate catabolic process GO:0009128 4 0.015
positive regulation of epithelial cell differentiation GO:0030858 2 0.015
regulation of molecular function GO:0065009 70 0.015
Human Mouse
ribosomal small subunit biogenesis GO:0042274 2 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
central nervous system neuron differentiation GO:0021953 74 0.015
cell cycle g2 m phase transition GO:0044839 4 0.015
embryonic cranial skeleton morphogenesis GO:0048701 90 0.015
death GO:0016265 121 0.015
Human
negative regulation of cellular metabolic process GO:0031324 77 0.015
Human
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.015
Human Mouse
central nervous system development GO:0007417 387 0.014
response to oxygen containing compound GO:1901700 55 0.014
internal protein amino acid acetylation GO:0006475 2 0.014
regulation of signaling GO:0023051 235 0.014
regulation of rna splicing GO:0043484 8 0.014
positive regulation of response to stimulus GO:0048584 80 0.014
exocrine pancreas development GO:0031017 28 0.014
locomotion GO:0040011 313 0.014
neuron development GO:0048666 262 0.014
ribose phosphate metabolic process GO:0019693 27 0.014
viral process GO:0016032 1 0.013
cell death GO:0008219 121 0.013
Human
actin polymerization or depolymerization GO:0008154 2 0.013
response to biotic stimulus GO:0009607 97 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
Mouse
response to organic cyclic compound GO:0014070 51 0.013
Mouse
mitotic cell cycle embryonic GO:0045448 2 0.013
nucleotide metabolic process GO:0009117 28 0.013
astrocyte differentiation GO:0048708 1 0.013
regulation of catalytic activity GO:0050790 55 0.013
Human Mouse
mesenchymal cell proliferation GO:0010463 1 0.013
positive regulation of secretion GO:0051047 1 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
cellular response to oxygen levels GO:0071453 1 0.013
cellular macromolecule metabolic process GO:0044260 391 0.012
Human Mouse
growth GO:0040007 174 0.012
rna localization GO:0006403 4 0.012
positive regulation of carbohydrate metabolic process GO:0045913 1 0.012
Mouse
chromatin modification GO:0016568 21 0.012
dendrite guidance GO:0070983 0 0.012
dorsal aorta development GO:0035907 4 0.012
intra s dna damage checkpoint GO:0031573 1 0.012
response to organic substance GO:0010033 153 0.012
Mouse
endomembrane system organization GO:0010256 13 0.012
small molecule catabolic process GO:0044282 3 0.012
retinal cell programmed cell death GO:0046666 2 0.012
leukocyte differentiation GO:0002521 25 0.012
positive regulation of gastrulation GO:2000543 2 0.012
regulation of intracellular protein transport GO:0033157 3 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
mesenchyme development GO:0060485 127 0.011
response to hexose GO:0009746 3 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
camera type eye development GO:0043010 222 0.011
positive regulation of neuron apoptotic process GO:0043525 1 0.011
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.011
atp catabolic process GO:0006200 4 0.010
regulation of cytoplasmic transport GO:1903649 4 0.010
microtubule cytoskeleton organization GO:0000226 33 0.010
lateral inhibition GO:0046331 1 0.010
cellular component assembly GO:0022607 170 0.010
Human
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.010
nucleobase containing compound transport GO:0015931 2 0.010
cardiac atrium morphogenesis GO:0003209 2 0.010
carbohydrate derivative metabolic process GO:1901135 61 0.010
cell death in response to oxidative stress GO:0036473 2 0.010
response to endogenous stimulus GO:0009719 83 0.010
Mouse

hmgb1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
physical disorder DOID:0080015 0 0.111
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
congenital nervous system abnormality DOID:2490 0 0.017
lissencephaly DOID:0050453 0 0.012
organ system cancer DOID:0050686 0 0.011
motor neuron disease DOID:231 0 0.011
central nervous system disease DOID:331 0 0.011
amyotrophic lateral sclerosis DOID:332 0 0.011
disease of anatomical entity DOID:7 0 0.011
neurodegenerative disease DOID:1289 0 0.011
nervous system disease DOID:863 0 0.011