Danio rerio

52 known processes

actn2

actinin, alpha 2

(Aliases: MGC123223,wu:fd44c03,zgc:123223)

actn2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
muscle cell development GO:0055001 115 0.989
skeletal muscle organ development GO:0060538 78 0.987
striated muscle cell development GO:0055002 108 0.985
actomyosin structure organization GO:0031032 53 0.980
striated muscle cell differentiation GO:0051146 129 0.973
muscle structure development GO:0061061 196 0.924
muscle organ development GO:0007517 101 0.867
cellular component assembly involved in morphogenesis GO:0010927 107 0.850
skeletal muscle tissue development GO:0007519 67 0.832
muscle fiber development GO:0048747 52 0.801
heart development GO:0007507 313 0.796
organelle assembly GO:0070925 110 0.783
cellular component assembly GO:0022607 170 0.781
myofibril assembly GO:0030239 48 0.777
organelle organization GO:0006996 227 0.772
muscle cell differentiation GO:0042692 139 0.760
cell projection organization GO:0030030 284 0.754
Human
cellular component biogenesis GO:0044085 178 0.737
skeletal muscle fiber development GO:0048741 35 0.715
actin filament based process GO:0030029 64 0.710
muscle tissue development GO:0060537 110 0.709
myotube cell development GO:0014904 35 0.704
myotube differentiation GO:0014902 45 0.649
adult behavior GO:0030534 2 0.641
Fly
actin cytoskeleton organization GO:0030036 63 0.597
striated muscle tissue development GO:0014706 110 0.588
regulation of muscle contraction GO:0006937 3 0.571
cellular component morphogenesis GO:0032989 336 0.558
muscle contraction GO:0006936 18 0.544
Mouse
single organism organelle organization GO:1902589 199 0.525
anatomical structure homeostasis GO:0060249 36 0.483
larval development GO:0002164 2 0.474
chordate embryonic development GO:0043009 271 0.414
ion transmembrane transport GO:0034220 91 0.403
Human
behavior GO:0007610 74 0.387
Fly
blood circulation GO:0008015 87 0.383
cell cycle GO:0007049 93 0.383
Worm
embryonic heart tube development GO:0035050 133 0.332
muscle system process GO:0003012 20 0.314
Mouse
locomotion GO:0040011 313 0.310
embryo development ending in birth or egg hatching GO:0009792 271 0.285
Worm
locomotory behavior GO:0007626 34 0.274
Fly
single organism localization GO:1902578 225 0.272
Human
cardiac muscle cell development GO:0055013 20 0.268
sarcomere organization GO:0045214 26 0.246
cytoskeleton organization GO:0007010 96 0.224
signal transduction GO:0007165 455 0.218
Mouse
transport GO:0006810 220 0.215
Human
establishment of localization GO:0051234 244 0.211
Human
actin mediated cell contraction GO:0070252 1 0.204
regulation of actin filament based movement GO:1903115 1 0.195
catabolic process GO:0009056 32 0.194
Worm
multicellular organismal reproductive process GO:0048609 35 0.193
regulation of cell matrix adhesion GO:0001952 1 0.191
response to chemical GO:0042221 320 0.190
aging GO:0007568 2 0.187
cellular component movement GO:0006928 335 0.187
regulation of metabolic process GO:0019222 359 0.179
Mouse
heart looping GO:0001947 94 0.178
ribonucleoside monophosphate catabolic process GO:0009158 4 0.177
heart morphogenesis GO:0003007 156 0.173
single organism transport GO:0044765 206 0.168
Human
nuclear division GO:0000280 23 0.168
Worm
nucleoside monophosphate catabolic process GO:0009125 4 0.167
wnt signaling pathway GO:0016055 80 0.160
sensory organ development GO:0007423 393 0.158
muscle cell cellular homeostasis GO:0046716 5 0.158
heterocycle metabolic process GO:0046483 290 0.157
Mouse
cell migration GO:0016477 237 0.156
somatic muscle development GO:0007525 4 0.139
tube morphogenesis GO:0035239 349 0.136
morphogenesis of an epithelium GO:0002009 333 0.136
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.132
protein metabolic process GO:0019538 183 0.131
Worm
regulation of macromolecule metabolic process GO:0060255 317 0.131
Mouse
maintenance of location GO:0051235 4 0.124
actin filament based movement GO:0030048 1 0.113
mitotic nuclear division GO:0007067 18 0.111
Worm
generation of neurons GO:0048699 385 0.110
mitochondrion organization GO:0007005 4 0.110
central nervous system development GO:0007417 387 0.109
cellular nitrogen compound biosynthetic process GO:0044271 218 0.108
Mouse
cell part morphogenesis GO:0032990 246 0.105
voluntary skeletal muscle contraction GO:0003010 4 0.103
gene expression GO:0010467 252 0.102
negative regulation of heart contraction GO:0045822 2 0.098
neuron differentiation GO:0030182 353 0.097
meiotic nuclear division GO:0007126 4 0.097
negative regulation of blood circulation GO:1903523 2 0.096
organonitrogen compound metabolic process GO:1901564 74 0.096
cardiac cell development GO:0055006 21 0.095
inorganic cation transmembrane transport GO:0098662 50 0.095
Human
negative regulation of cellular process GO:0048523 283 0.094
Human
purine nucleoside monophosphate catabolic process GO:0009128 4 0.094
heart contraction GO:0060047 71 0.093
system process GO:0003008 185 0.092
Mouse
single organism behavior GO:0044708 24 0.091
Fly
cardiac muscle tissue development GO:0048738 48 0.089
multi organism reproductive process GO:0044703 36 0.088
regulation of biological quality GO:0065008 263 0.083
Human
response to external stimulus GO:0009605 264 0.079
regulation of sodium ion transmembrane transporter activity GO:2000649 1 0.078
inorganic ion transmembrane transport GO:0098660 57 0.073
Human
cell substrate adhesion GO:0031589 4 0.072
Human
positive regulation of biological process GO:0048518 253 0.070
Human
macromolecule biosynthetic process GO:0009059 227 0.069
Mouse
neuron development GO:0048666 262 0.068
striated muscle contraction GO:0006941 12 0.068
sequestering of metal ion GO:0051238 3 0.067
regulation of nucleoside metabolic process GO:0009118 2 0.067
embryonic organ development GO:0048568 381 0.066
skeletal myofibril assembly GO:0014866 7 0.066
cell morphogenesis GO:0000902 289 0.065
biosynthetic process GO:0009058 294 0.065
Mouse
cardiac muscle cell differentiation GO:0055007 30 0.064
embryonic heart tube morphogenesis GO:0003143 108 0.063
regulation of cellular metabolic process GO:0031323 320 0.063
Mouse
regulation of multicellular organismal process GO:0051239 277 0.063
mitotic cell cycle process GO:1903047 48 0.062
Worm
neuron projection development GO:0031175 180 0.061
cell projection assembly GO:0030031 64 0.060
Human
nucleobase containing compound biosynthetic process GO:0034654 205 0.060
Mouse
ventricular cardiac muscle tissue development GO:0003229 3 0.058
skeletal muscle thin filament assembly GO:0030240 4 0.058
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.057
regulation of sodium ion transmembrane transport GO:1902305 1 0.057
cellular biosynthetic process GO:0044249 286 0.056
Mouse
smooth muscle contraction GO:0006939 2 0.056
regulation of blood circulation GO:1903522 32 0.055
epithelial tube morphogenesis GO:0060562 148 0.055
regulation of nucleotide metabolic process GO:0006140 17 0.054
intracellular signal transduction GO:0035556 85 0.053
proton transport GO:0015992 7 0.053
regulation of rna metabolic process GO:0051252 224 0.051
Mouse
regulation of purine nucleotide catabolic process GO:0033121 2 0.050
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.050
cardiocyte differentiation GO:0035051 44 0.050
heart process GO:0003015 71 0.049
cellular macromolecule metabolic process GO:0044260 391 0.049
Mouse
transmembrane transport GO:0055085 120 0.049
Human
cellular protein complex assembly GO:0043623 19 0.049
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.048
atp catabolic process GO:0006200 4 0.047
purine ribonucleotide metabolic process GO:0009150 27 0.047
cellular aromatic compound metabolic process GO:0006725 295 0.047
Mouse
eye development GO:0001654 277 0.046
reproduction GO:0000003 40 0.045
somitogenesis GO:0001756 87 0.045
multicellular organismal signaling GO:0035637 22 0.045
multi organism process GO:0051704 134 0.045
regulation of multicellular organism growth GO:0040014 4 0.044
cardiac muscle fiber development GO:0048739 3 0.044
regulation of reproductive process GO:2000241 4 0.043
embryonic organ morphogenesis GO:0048562 274 0.042
response to stress GO:0006950 263 0.042
macromolecular complex subunit organization GO:0043933 74 0.041
Human
regulation of nitrogen compound metabolic process GO:0051171 251 0.041
Mouse
digestive system development GO:0055123 289 0.040
regulation of sarcomere organization GO:0060297 2 0.039
cilium assembly GO:0042384 58 0.039
cell matrix adhesion GO:0007160 4 0.039
Human
multicellular organism growth GO:0035264 4 0.039
multicellular organism reproduction GO:0032504 35 0.039
regulation of cellular component movement GO:0051270 55 0.039
cardiac muscle cell contraction GO:0086003 1 0.038
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.038
small molecule metabolic process GO:0044281 77 0.038
cell projection morphogenesis GO:0048858 244 0.037
cation transport GO:0006812 81 0.037
Human
protein complex subunit organization GO:0071822 46 0.035
Human
cardiac muscle tissue morphogenesis GO:0055008 7 0.035
regulation of macromolecule biosynthetic process GO:0010556 225 0.035
Mouse
lipid storage GO:0019915 1 0.035
homeostatic process GO:0042592 142 0.034
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.034
Mouse
action potential GO:0001508 19 0.033
cell morphogenesis involved in differentiation GO:0000904 195 0.033
regionalization GO:0003002 274 0.033
positive regulation of transport GO:0051050 2 0.032
Human
regulation of cellular biosynthetic process GO:0031326 245 0.032
Mouse
regulation of localization GO:0032879 104 0.032
Human
cation homeostasis GO:0055080 33 0.031
twitch skeletal muscle contraction GO:0014721 4 0.031
cation transmembrane transport GO:0098655 65 0.031
Human
negative regulation of protein phosphorylation GO:0001933 4 0.031
meiotic cell cycle process GO:1903046 3 0.031
cardiac atrium development GO:0003230 4 0.030
oocyte maturation GO:0001556 4 0.030
rna metabolic process GO:0016070 219 0.030
Mouse
purine containing compound metabolic process GO:0072521 29 0.029
taxis GO:0042330 109 0.029
specification of symmetry GO:0009799 204 0.029
neuron projection guidance GO:0097485 86 0.028
axon development GO:0061564 166 0.028
stem cell differentiation GO:0048863 117 0.028
rna biosynthetic process GO:0032774 181 0.027
Mouse
developmental growth GO:0048589 166 0.027
apical junction assembly GO:0043297 1 0.027
reactive oxygen species biosynthetic process GO:1903409 1 0.027
phosphorus metabolic process GO:0006793 109 0.027
nucleic acid metabolic process GO:0090304 244 0.026
Mouse
macromolecule catabolic process GO:0009057 15 0.026
Worm
mitotic cell cycle GO:0000278 64 0.026
Worm
regulation of circadian rhythm GO:0042752 4 0.026
regulation of blood pressure GO:0008217 1 0.025
regulation of cardiac muscle contraction GO:0055117 2 0.025
locomotor rhythm GO:0045475 3 0.025
circulatory system process GO:0003013 87 0.024
water homeostasis GO:0030104 4 0.024
negative regulation of biological process GO:0048519 304 0.024
Human
nucleobase containing small molecule metabolic process GO:0055086 32 0.024
nucleic acid templated transcription GO:0097659 181 0.024
Mouse
negative regulation of gene expression GO:0010629 65 0.024
regulation of transcription dna templated GO:0006355 213 0.024
cytokinesis GO:0000910 3 0.023
organelle fission GO:0048285 23 0.023
Worm
growth GO:0040007 174 0.023
regulation of system process GO:0044057 40 0.023
myosin filament organization GO:0031033 6 0.022
nitrogen compound metabolic process GO:0006807 319 0.022
Mouse
determination of heart left right asymmetry GO:0061371 117 0.022
modification dependent macromolecule catabolic process GO:0043632 3 0.022
regulation of transmembrane transporter activity GO:0022898 2 0.021
Human
regulation of nucleotide catabolic process GO:0030811 2 0.021
skeletal muscle myosin thick filament assembly GO:0030241 5 0.021
digestive tract development GO:0048565 265 0.021
immune system process GO:0002376 241 0.021
cellular catabolic process GO:0044248 27 0.021
organic cyclic compound biosynthetic process GO:1901362 223 0.020
Mouse
carboxylic acid metabolic process GO:0019752 22 0.020
digestive tract morphogenesis GO:0048546 231 0.020
heterocycle biosynthetic process GO:0018130 215 0.020
Mouse
head development GO:0060322 303 0.020
brain development GO:0007420 293 0.020
vasculature development GO:0001944 278 0.020
axonogenesis GO:0007409 152 0.020
ameboidal type cell migration GO:0001667 143 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.020
regulation of locomotion GO:0040012 55 0.019
cell motility GO:0048870 244 0.019
response to activity GO:0014823 14 0.019
single organism cellular localization GO:1902580 46 0.019
cell cycle process GO:0022402 53 0.019
Worm
ventricular cardiac myofibril assembly GO:0055005 4 0.018
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
Mouse
regulation of gene expression GO:0010468 265 0.018
lipid homeostasis GO:0055088 3 0.018
regulation of heart growth GO:0060420 2 0.018
sexual reproduction GO:0019953 36 0.018
nuclear transport GO:0051169 4 0.018
regulation of sequestering of calcium ion GO:0051282 4 0.018
sensory organ morphogenesis GO:0090596 200 0.018
segmentation GO:0035282 97 0.018
negative regulation of cellular metabolic process GO:0031324 77 0.017
regulation of muscle system process GO:0090257 5 0.017
metal ion transport GO:0030001 58 0.017
Human
actin filament organization GO:0007015 15 0.017
organic substance catabolic process GO:1901575 28 0.017
Worm
regulation of signal transduction GO:0009966 225 0.017
Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.017
Mouse
organelle localization GO:0051640 49 0.017
carbohydrate derivative metabolic process GO:1901135 61 0.017
cardiac atrium morphogenesis GO:0003209 2 0.017
myosin filament assembly GO:0031034 6 0.017
oxoacid metabolic process GO:0043436 31 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
cell death GO:0008219 121 0.016
negative regulation of metabolic process GO:0009892 86 0.016
regulation of metal ion transport GO:0010959 4 0.016
Human
regulation of cardiac muscle cell contraction GO:0086004 1 0.016
lipid digestion GO:0044241 3 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.016
Mouse
cardiac muscle contraction GO:0060048 6 0.016
regulation of myotube differentiation GO:0010830 2 0.016
regulation of striated muscle contraction GO:0006942 2 0.015
cognition GO:0050890 1 0.015
ribose phosphate metabolic process GO:0019693 27 0.015
purine ribonucleoside metabolic process GO:0046128 10 0.015
organophosphate metabolic process GO:0019637 37 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
macromolecular complex assembly GO:0065003 35 0.014
Human
endocytosis GO:0006897 16 0.014
regulation of dna templated transcription in response to stress GO:0043620 0 0.014
positive regulation of wound healing GO:0090303 1 0.014
blood vessel development GO:0001568 246 0.014
regulation of organ growth GO:0046620 3 0.014
inositol lipid mediated signaling GO:0048017 2 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
single organism reproductive process GO:0044702 40 0.013
regulation of transporter activity GO:0032409 2 0.013
Human
cell migration involved in gastrulation GO:0042074 79 0.013
regulation of skeletal muscle fiber development GO:0048742 2 0.013
amine metabolic process GO:0009308 2 0.013
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.013
receptor mediated endocytosis GO:0006898 6 0.013
peptidyl serine modification GO:0018209 2 0.013
ion transport GO:0006811 114 0.013
Human
somite development GO:0061053 96 0.013
regulation of wound healing GO:0061041 2 0.012
wound healing GO:0042060 90 0.012
ribonucleotide metabolic process GO:0009259 27 0.012
regulation of cell projection assembly GO:0060491 4 0.012
protein complex biogenesis GO:0070271 30 0.012
Human
immune system development GO:0002520 191 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.012
response to abiotic stimulus GO:0009628 122 0.012
positive regulation of metabolic process GO:0009893 108 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
organic cyclic compound metabolic process GO:1901360 301 0.012
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
angiogenesis GO:0001525 158 0.012
protein stabilization GO:0050821 2 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
positive regulation of cellular process GO:0048522 201 0.012
Human
negative regulation of signal transduction GO:0009968 94 0.012
striated muscle myosin thick filament assembly GO:0071688 6 0.011
regulation of bone mineralization GO:0030500 2 0.011
nucleoside metabolic process GO:0009116 11 0.011
cell aging GO:0007569 2 0.011
cellular component disassembly GO:0022411 1 0.011
axon guidance GO:0007411 86 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
regulation of primary metabolic process GO:0080090 311 0.011
Mouse
hydrogen transport GO:0006818 7 0.011
regulation of transmembrane transport GO:0034762 18 0.011
Human
regulation of cellular amine metabolic process GO:0033238 0 0.011
ras protein signal transduction GO:0007265 7 0.011
regulation of membrane potential GO:0042391 23 0.011
Human
regulation of lipid catabolic process GO:0050994 2 0.011
muscle tissue morphogenesis GO:0060415 7 0.011
cell substrate adherens junction assembly GO:0007045 1 0.011
Human
response to wounding GO:0009611 116 0.011
protein catabolic process GO:0030163 7 0.010
Worm
death GO:0016265 121 0.010
regulation of skeletal muscle cell differentiation GO:2001014 1 0.010
gamete generation GO:0007276 33 0.010
cellular ion homeostasis GO:0006873 17 0.010
transcription dna templated GO:0006351 181 0.010
regulation of filopodium assembly GO:0051489 2 0.010
neuroblast differentiation GO:0014016 1 0.010
central nervous system neuron differentiation GO:0021953 74 0.010
establishment of protein localization to organelle GO:0072594 4 0.010
regulation of cellular ph GO:0030641 1 0.010

actn2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.610
muscular disease DOID:0080000 0 0.610
heart disease DOID:114 0 0.610
cardiomyopathy DOID:0050700 0 0.610
disease of anatomical entity DOID:7 0 0.610
intrinsic cardiomyopathy DOID:0060036 0 0.610
cardiovascular system disease DOID:1287 0 0.610
musculoskeletal system disease DOID:17 0 0.610
muscle tissue disease DOID:66 0 0.610
dilated cardiomyopathy DOID:12930 0 0.046
immune system disease DOID:2914 0 0.019
neuromuscular disease DOID:440 0 0.014
charcot marie tooth disease type 2 DOID:0050539 0 0.014
charcot marie tooth disease DOID:10595 0 0.014
nervous system disease DOID:863 0 0.014
neuropathy DOID:870 0 0.014
muscular dystrophy DOID:9884 0 0.010
limb girdle muscular dystrophy DOID:11724 0 0.010