Danio rerio

0 known processes

actn3a

actinin alpha 3a

(Aliases: actn3,ACTN2,zgc:63559,actnl,MGC63559)

actn3a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
skeletal muscle tissue development GO:0007519 67 0.997
Zebrafish
skeletal muscle fiber development GO:0048741 35 0.995
Zebrafish
skeletal muscle organ development GO:0060538 78 0.994
Zebrafish
myotube cell development GO:0014904 35 0.984
Zebrafish
muscle cell development GO:0055001 115 0.966
Zebrafish Fly
voluntary skeletal muscle contraction GO:0003010 4 0.942
nucleobase containing compound metabolic process GO:0006139 274 0.921
myofibril assembly GO:0030239 48 0.920
Zebrafish Fly
muscle fiber development GO:0048747 52 0.917
Zebrafish
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.890
muscle organ development GO:0007517 101 0.868
Zebrafish
chordate embryonic development GO:0043009 271 0.859
striated muscle cell development GO:0055002 108 0.840
Zebrafish Fly
skeletal myofibril assembly GO:0014866 7 0.834
striated muscle tissue development GO:0014706 110 0.833
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.753
Worm
muscle structure development GO:0061061 196 0.698
Zebrafish Fly
locomotion GO:0040011 313 0.638
skeletal muscle thin filament assembly GO:0030240 4 0.620
muscle tissue development GO:0060537 110 0.598
Zebrafish
larval development GO:0002164 2 0.594
skeletal muscle myosin thick filament assembly GO:0030241 5 0.575
striated muscle cell differentiation GO:0051146 129 0.563
Zebrafish Fly
heterocycle biosynthetic process GO:0018130 215 0.555
cellular aromatic compound metabolic process GO:0006725 295 0.530
nucleic acid templated transcription GO:0097659 181 0.529
cell migration GO:0016477 237 0.525
regulation of sarcomere organization GO:0060297 2 0.522
regulation of biological quality GO:0065008 263 0.486
twitch skeletal muscle contraction GO:0014721 4 0.470
adult behavior GO:0030534 2 0.460
Fly
organic cyclic compound metabolic process GO:1901360 301 0.446
myotube differentiation GO:0014902 45 0.438
Zebrafish
nucleoside monophosphate catabolic process GO:0009125 4 0.425
aromatic compound biosynthetic process GO:0019438 217 0.417
nitrogen compound metabolic process GO:0006807 319 0.406
heart development GO:0007507 313 0.373
Zebrafish
ion transmembrane transport GO:0034220 91 0.336
heterocycle metabolic process GO:0046483 290 0.333
anterior posterior pattern specification GO:0009952 152 0.326
cellular component movement GO:0006928 335 0.326
actin filament based movement GO:0030048 1 0.324
blood circulation GO:0008015 87 0.318
muscle cell differentiation GO:0042692 139 0.318
Zebrafish Fly
skeletal muscle contraction GO:0003009 5 0.316
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.309
somitogenesis GO:0001756 87 0.299
cell motility GO:0048870 244 0.298
maintenance of location GO:0051235 4 0.297
cellular biosynthetic process GO:0044249 286 0.297
biosynthetic process GO:0009058 294 0.292
purine nucleoside monophosphate catabolic process GO:0009128 4 0.284
regulation of multicellular organismal development GO:2000026 223 0.280
signal transduction GO:0007165 455 0.273
embryonic organ morphogenesis GO:0048562 274 0.266
organic cyclic compound biosynthetic process GO:1901362 223 0.254
muscle system process GO:0003012 20 0.243
Mouse
somite development GO:0061053 96 0.242
heart contraction GO:0060047 71 0.228
cognition GO:0050890 1 0.227
transcription from rna polymerase ii promoter GO:0006366 80 0.227
actin filament based process GO:0030029 64 0.216
Zebrafish Fly
transmembrane transport GO:0055085 120 0.215
regulation of cellular metabolic process GO:0031323 320 0.202
embryonic organ development GO:0048568 381 0.201
behavior GO:0007610 74 0.199
Fly
regulation of rna metabolic process GO:0051252 224 0.183
regulation of developmental process GO:0050793 247 0.180
slow twitch skeletal muscle fiber contraction GO:0031444 3 0.174
localization of cell GO:0051674 244 0.174
cellular nitrogen compound metabolic process GO:0034641 290 0.169
synaptic transmission cholinergic GO:0007271 4 0.162
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.160
organic substance biosynthetic process GO:1901576 289 0.154
regulation of cellular biosynthetic process GO:0031326 245 0.151
regulation of multicellular organismal process GO:0051239 277 0.150
ribonucleoside monophosphate catabolic process GO:0009158 4 0.149
rna metabolic process GO:0016070 219 0.147
regulation of wound healing GO:0061041 2 0.147
protein stabilization GO:0050821 2 0.145
multicellular organismal reproductive process GO:0048609 35 0.145
regulation of primary metabolic process GO:0080090 311 0.139
organonitrogen compound metabolic process GO:1901564 74 0.138
muscle contraction GO:0006936 18 0.137
Mouse
response to activity GO:0014823 14 0.137
regulation of macromolecule metabolic process GO:0060255 317 0.132
rna biosynthetic process GO:0032774 181 0.128
cell projection morphogenesis GO:0048858 244 0.127
regulation of organelle assembly GO:1902115 4 0.122
oocyte development GO:0048599 14 0.118
regulation of nitrogen compound metabolic process GO:0051171 251 0.108
muscle cell cellular homeostasis GO:0046716 5 0.108
system process GO:0003008 185 0.108
Mouse
cell projection organization GO:0030030 284 0.106
digestive system development GO:0055123 289 0.105
regulation of muscle contraction GO:0006937 3 0.105
somite specification GO:0001757 12 0.097
regulation of macromolecule biosynthetic process GO:0010556 225 0.097
cellular nitrogen compound biosynthetic process GO:0044271 218 0.094
establishment of localization GO:0051234 244 0.094
positive regulation of wound healing GO:0090303 1 0.093
multi organism reproductive process GO:0044703 36 0.093
inorganic cation transmembrane transport GO:0098662 50 0.093
segmentation GO:0035282 97 0.093
atp catabolic process GO:0006200 4 0.092
nucleic acid metabolic process GO:0090304 244 0.089
cellular ion homeostasis GO:0006873 17 0.088
transcription dna templated GO:0006351 181 0.087
mesenchyme development GO:0060485 127 0.087
regulation of metabolic process GO:0019222 359 0.085
cardiac muscle fiber development GO:0048739 3 0.081
regulation of cell development GO:0060284 100 0.081
cell morphogenesis involved in differentiation GO:0000904 195 0.080
vasculature development GO:0001944 278 0.079
regulation of biosynthetic process GO:0009889 250 0.079
macromolecule biosynthetic process GO:0009059 227 0.079
cardiac muscle myosin thick filament assembly GO:0071690 1 0.077
regulation of gene expression GO:0010468 265 0.076
multicellular organism growth GO:0035264 4 0.076
nucleobase containing compound biosynthetic process GO:0034654 205 0.075
catabolic process GO:0009056 32 0.075
Worm
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.074
sarcomere organization GO:0045214 26 0.074
Zebrafish Fly
multicellular organism reproduction GO:0032504 35 0.072
embryonic cranial skeleton morphogenesis GO:0048701 90 0.071
sequestering of metal ion GO:0051238 3 0.071
neuroblast differentiation GO:0014016 1 0.071
embryonic pattern specification GO:0009880 44 0.070
regulation of nucleic acid templated transcription GO:1903506 213 0.069
cellular component morphogenesis GO:0032989 336 0.067
Zebrafish Fly
axonogenesis GO:0007409 152 0.064
organic cyclic compound catabolic process GO:1901361 15 0.064
sensory organ development GO:0007423 393 0.062
Zebrafish
organelle assembly GO:0070925 110 0.061
Zebrafish Fly
cellular macromolecule metabolic process GO:0044260 391 0.060
gene expression GO:0010467 252 0.059
intracellular signal transduction GO:0035556 85 0.058
single organism reproductive process GO:0044702 40 0.058
brain development GO:0007420 293 0.058
ventricular cardiac muscle tissue development GO:0003229 3 0.057
organelle organization GO:0006996 227 0.056
Zebrafish Worm Fly
heart looping GO:0001947 94 0.055
digestive tract development GO:0048565 265 0.054
neuron differentiation GO:0030182 353 0.054
organophosphate metabolic process GO:0019637 37 0.054
cell migration involved in gastrulation GO:0042074 79 0.053
negative regulation of biological process GO:0048519 304 0.052
multi organism process GO:0051704 134 0.051
neuron development GO:0048666 262 0.051
cellular homeostasis GO:0019725 26 0.051
striated muscle myosin thick filament assembly GO:0071688 6 0.051
generation of neurons GO:0048699 385 0.051
musculoskeletal movement GO:0050881 8 0.050
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.050
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.049
small molecule metabolic process GO:0044281 77 0.049
regulation of transcription dna templated GO:0006355 213 0.049
regulation of cell differentiation GO:0045595 142 0.048
cytosolic calcium ion transport GO:0060401 3 0.047
regulation of heart growth GO:0060420 2 0.046
cell aging GO:0007569 2 0.046
lipid storage GO:0019915 1 0.046
regulation of response to stimulus GO:0048583 269 0.046
regionalization GO:0003002 274 0.045
extrinsic apoptotic signaling pathway GO:0097191 3 0.045
regulation of nucleoside metabolic process GO:0009118 2 0.045
somatic muscle development GO:0007525 4 0.044
homeostatic process GO:0042592 142 0.044
morphogenesis of an epithelium GO:0002009 333 0.043
epithelial cell differentiation GO:0030855 116 0.043
phosphorus metabolic process GO:0006793 109 0.043
axon development GO:0061564 166 0.043
response to chemical GO:0042221 320 0.043
protein metabolic process GO:0019538 183 0.042
Worm
hemopoiesis GO:0030097 183 0.041
regulation of metal ion transport GO:0010959 4 0.041
positive regulation of nucleic acid templated transcription GO:1903508 57 0.041
chemotaxis GO:0006935 104 0.040
striated muscle contraction GO:0006941 12 0.040
inositol lipid mediated signaling GO:0048017 2 0.040
embryonic viscerocranium morphogenesis GO:0048703 52 0.039
cellular calcium ion homeostasis GO:0006874 13 0.039
locomotory behavior GO:0007626 34 0.039
Fly
single organism transport GO:0044765 206 0.038
regulation of mrna splicing via spliceosome GO:0048024 3 0.038
taxis GO:0042330 109 0.038
regulation of rna biosynthetic process GO:2001141 213 0.038
response to external stimulus GO:0009605 264 0.038
cell substrate adherens junction assembly GO:0007045 1 0.037
carbohydrate derivative metabolic process GO:1901135 61 0.036
positive regulation of macromolecule metabolic process GO:0010604 93 0.036
ameboidal type cell migration GO:0001667 143 0.035
positive regulation of gene expression GO:0010628 71 0.035
central nervous system development GO:0007417 387 0.035
positive regulation of biological process GO:0048518 253 0.034
blood vessel morphogenesis GO:0048514 216 0.034
cation homeostasis GO:0055080 33 0.034
multicellular organismal movement GO:0050879 8 0.034
metal ion transport GO:0030001 58 0.034
regulation of ion transmembrane transporter activity GO:0032412 2 0.033
cytoskeleton dependent cytokinesis GO:0061640 3 0.033
convergent extension involved in gastrulation GO:0060027 71 0.032
adherens junction assembly GO:0034333 1 0.031
cation transport GO:0006812 81 0.031
ribonucleotide metabolic process GO:0009259 27 0.031
regulation of nucleotide catabolic process GO:0030811 2 0.031
positive regulation of multicellular organismal process GO:0051240 52 0.031
growth GO:0040007 174 0.030
developmental process involved in reproduction GO:0003006 27 0.030
mitochondrion organization GO:0007005 4 0.030
regulation of multicellular organism growth GO:0040014 4 0.030
cardiac muscle cell differentiation GO:0055007 30 0.030
ion transport GO:0006811 114 0.030
peptidyl lysine methylation GO:0018022 3 0.030
microtubule organizing center organization GO:0031023 1 0.030
single organism biosynthetic process GO:0044711 71 0.029
organelle fission GO:0048285 23 0.029
Worm
regulation of phosphorus metabolic process GO:0051174 43 0.029
cellular component assembly involved in morphogenesis GO:0010927 107 0.029
Zebrafish Fly
cell part morphogenesis GO:0032990 246 0.028
histone h3 k4 methylation GO:0051568 2 0.028
cellular metal ion homeostasis GO:0006875 16 0.028
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.028
ras protein signal transduction GO:0007265 7 0.027
rna modification GO:0009451 2 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.026
organic substance catabolic process GO:1901575 28 0.026
Worm
growth plate cartilage development GO:0003417 2 0.026
anatomical structure homeostasis GO:0060249 36 0.025
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.025
regulation of calcium ion transport GO:0051924 2 0.025
metal ion homeostasis GO:0055065 26 0.025
cell fate commitment GO:0045165 99 0.025
reproduction GO:0000003 40 0.025
growth plate cartilage morphogenesis GO:0003422 1 0.025
carboxylic acid metabolic process GO:0019752 22 0.025
single organism behavior GO:0044708 24 0.024
Fly
cardiac muscle cell development GO:0055013 20 0.024
purine ribonucleotide metabolic process GO:0009150 27 0.024
nucleoside phosphate metabolic process GO:0006753 28 0.024
cytokinetic process GO:0032506 2 0.024
cardiac muscle tissue development GO:0048738 48 0.024
cell substrate junction assembly GO:0007044 2 0.023
ribonucleoside monophosphate metabolic process GO:0009161 5 0.023
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.023
digestive tract morphogenesis GO:0048546 231 0.023
purine ribonucleoside monophosphate metabolic process GO:0009167 5 0.023
blood vessel development GO:0001568 246 0.022
single organism organelle organization GO:1902589 199 0.022
Zebrafish Worm Fly
regulation of transmembrane transporter activity GO:0022898 2 0.022
gastrulation GO:0007369 208 0.022
single organism localization GO:1902578 225 0.022
renal tubule morphogenesis GO:0061333 1 0.022
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.022
regulation of reproductive process GO:2000241 4 0.021
germ cell development GO:0007281 22 0.021
cellular cation homeostasis GO:0030003 17 0.021
oocyte differentiation GO:0009994 14 0.021
negative regulation of cell death GO:0060548 60 0.021
iron ion homeostasis GO:0055072 4 0.021
regulation of signal transduction GO:0009966 225 0.020
cellular component biogenesis GO:0044085 178 0.020
Zebrafish Fly
regulation of neurogenesis GO:0050767 87 0.020
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.020
cytokinesis GO:0000910 3 0.020
regulation of mrna processing GO:0050684 3 0.020
regulation of endothelial cell proliferation GO:0001936 1 0.020
cell death in response to oxidative stress GO:0036473 2 0.020
nucleobase containing small molecule metabolic process GO:0055086 32 0.020
tube morphogenesis GO:0035239 349 0.020
sarcomerogenesis GO:0048769 4 0.020
skeletal system development GO:0001501 181 0.020
macromolecule catabolic process GO:0009057 15 0.019
Worm
neuroblast fate commitment GO:0014017 1 0.019
cellular respiration GO:0045333 3 0.019
regulation of behavior GO:0050795 24 0.019
calcium ion transport into cytosol GO:0060402 3 0.019
epithelial tube morphogenesis GO:0060562 148 0.019
response to stress GO:0006950 263 0.019
transport GO:0006810 220 0.019
immune system development GO:0002520 191 0.018
angiogenesis GO:0001525 158 0.018
skeletal system morphogenesis GO:0048705 102 0.018
regulation of circadian rhythm GO:0042752 4 0.018
purine containing compound metabolic process GO:0072521 29 0.018
regulation of molecular function GO:0065009 70 0.018
macromolecular complex subunit organization GO:0043933 74 0.018
immune system process GO:0002376 241 0.018
actin cytoskeleton organization GO:0030036 63 0.018
Zebrafish Fly
regulation of membrane potential GO:0042391 23 0.017
developmental growth GO:0048589 166 0.017
endothelial cell proliferation GO:0001935 11 0.017
regulation of cellular response to oxidative stress GO:1900407 2 0.017
regulation of establishment of planar polarity GO:0090175 4 0.016
regulation of organ growth GO:0046620 3 0.016
negative regulation of apoptotic process GO:0043066 55 0.016
regulation of skeletal muscle fiber development GO:0048742 2 0.016
mitotic cell cycle GO:0000278 64 0.016
Worm
aging GO:0007568 2 0.016
response to oxidative stress GO:0006979 11 0.016
positive regulation of transport GO:0051050 2 0.016
regulation of transporter activity GO:0032409 2 0.016
regulation of transmembrane transport GO:0034762 18 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
negative regulation of programmed cell death GO:0043069 58 0.016
positive regulation of rna biosynthetic process GO:1902680 57 0.016
potassium ion transmembrane transport GO:0071805 10 0.016
mitotic g2 m transition checkpoint GO:0044818 3 0.016
regulation of filopodium assembly GO:0051489 2 0.016
determination of left right symmetry GO:0007368 179 0.016
stem cell differentiation GO:0048863 117 0.016
regulation of photoreceptor cell differentiation GO:0046532 2 0.016
cardiac atrium morphogenesis GO:0003209 2 0.015
positive regulation of metabolic process GO:0009893 108 0.015
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.015
embryonic skeletal system development GO:0048706 97 0.015
appendage development GO:0048736 80 0.015
regulation of cell communication GO:0010646 232 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.015
lipid homeostasis GO:0055088 3 0.015
ear development GO:0043583 127 0.015
cell surface receptor signaling pathway GO:0007166 325 0.014
dna catabolic process GO:0006308 1 0.014
regulation of skeletal muscle tissue development GO:0048641 4 0.014
regulation of tube size GO:0035150 2 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
centrosome organization GO:0051297 1 0.014
nucleoside monophosphate metabolic process GO:0009123 6 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
regulation of cell activation GO:0050865 1 0.014
superoxide metabolic process GO:0006801 2 0.014
larval behavior GO:0030537 5 0.014
meiotic cell cycle process GO:1903046 3 0.014
regulation of striated muscle contraction GO:0006942 2 0.014
cardiac atrium development GO:0003230 4 0.014
myosin filament assembly GO:0031034 6 0.014
regulation of blood vessel size GO:0050880 2 0.013
cellular amine metabolic process GO:0044106 2 0.013
regulation of catalytic activity GO:0050790 55 0.013
convergent extension GO:0060026 118 0.013
ribosomal small subunit biogenesis GO:0042274 2 0.013
cell cycle g2 m phase transition GO:0044839 4 0.013
cellular component assembly GO:0022607 170 0.013
Zebrafish Fly
posttranscriptional regulation of gene expression GO:0010608 14 0.013
myosin filament organization GO:0031033 6 0.013
cell morphogenesis GO:0000902 289 0.013
nephron epithelium morphogenesis GO:0072088 1 0.013
response to nutrient GO:0007584 3 0.013
cellular amino acid biosynthetic process GO:0008652 2 0.013
cellular divalent inorganic cation homeostasis GO:0072503 13 0.013
organ formation GO:0048645 17 0.013
sleep GO:0030431 1 0.013
response to extracellular stimulus GO:0009991 10 0.013
purine nucleoside monophosphate metabolic process GO:0009126 5 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
g2 m transition of mitotic cell cycle GO:0000086 4 0.012
reactive oxygen species biosynthetic process GO:1903409 1 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
embryonic skeletal system morphogenesis GO:0048704 93 0.012
positive regulation of cellular biosynthetic process GO:0031328 68 0.012
regulation of nervous system development GO:0051960 90 0.012
connective tissue development GO:0061448 99 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.012
gamete generation GO:0007276 33 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
developmental programmed cell death GO:0010623 4 0.012
cell maturation GO:0048469 23 0.012
regulation of purine nucleotide metabolic process GO:1900542 17 0.012
potassium ion transport GO:0006813 10 0.012
cell cycle GO:0007049 93 0.012
Worm
positive regulation of rna metabolic process GO:0051254 59 0.012
removal of superoxide radicals GO:0019430 2 0.011
positive regulation of developmental process GO:0051094 50 0.011
regulation of alcohol biosynthetic process GO:1902930 1 0.011
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.011
regulation of response to oxidative stress GO:1902882 2 0.011
heart morphogenesis GO:0003007 156 0.011
membrane repolarization GO:0086009 2 0.011
head development GO:0060322 303 0.011
autophagy GO:0006914 4 0.011
regulation of binding GO:0051098 3 0.011
developmental maturation GO:0021700 34 0.011
oogenesis GO:0048477 14 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
notochord development GO:0030903 54 0.011
mitotic cell cycle process GO:1903047 48 0.011
Worm
anterior commissure morphogenesis GO:0021960 3 0.011
regulation of protein binding GO:0043393 3 0.011
organic acid metabolic process GO:0006082 31 0.011
negative regulation of developmental process GO:0051093 65 0.011
death GO:0016265 121 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
skin development GO:0043588 54 0.010
stem cell fate commitment GO:0048865 1 0.010
negative regulation of gene expression GO:0010629 65 0.010
regulation of blood circulation GO:1903522 32 0.010
reproductive process GO:0022414 40 0.010
amine metabolic process GO:0009308 2 0.010

actn3a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.182
mitochondrial metabolism disease DOID:700 0 0.182
inherited metabolic disorder DOID:655 0 0.182
myopathy DOID:423 0 0.075
muscular disease DOID:0080000 0 0.075
heart disease DOID:114 0 0.075
cardiomyopathy DOID:0050700 0 0.075
disease of anatomical entity DOID:7 0 0.075
intrinsic cardiomyopathy DOID:0060036 0 0.075
cardiovascular system disease DOID:1287 0 0.075
musculoskeletal system disease DOID:17 0 0.075
muscle tissue disease DOID:66 0 0.075
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
endocrine gland cancer DOID:170 0 0.012
organ system cancer DOID:0050686 0 0.012