Danio rerio

0 known processes

actn3b

actinin alpha 3b

(Aliases: zgc:77243,wu:fb95c03,fb95c03,wu:fc11d03)

actn3b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
muscle cell development GO:0055001 115 0.984
Zebrafish Fly
myofibril assembly GO:0030239 48 0.950
Zebrafish Fly
striated muscle cell development GO:0055002 108 0.937
Zebrafish Fly
single organism organelle organization GO:1902589 199 0.888
Zebrafish Worm Fly
striated muscle cell differentiation GO:0051146 129 0.886
Zebrafish Fly
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.867
actin cytoskeleton organization GO:0030036 63 0.845
Zebrafish Fly
purine nucleoside monophosphate catabolic process GO:0009128 4 0.822
heart development GO:0007507 313 0.821
Zebrafish
organelle assembly GO:0070925 110 0.810
Zebrafish Fly
embryo development ending in birth or egg hatching GO:0009792 271 0.801
Worm
organelle organization GO:0006996 227 0.760
Zebrafish Worm Fly
actin filament based process GO:0030029 64 0.699
Zebrafish Fly
muscle structure development GO:0061061 196 0.671
Zebrafish Fly
cellular component assembly GO:0022607 170 0.625
Zebrafish Fly
heart contraction GO:0060047 71 0.618
chordate embryonic development GO:0043009 271 0.597
blood circulation GO:0008015 87 0.591
muscle cell differentiation GO:0042692 139 0.568
Zebrafish Fly
anterior posterior pattern specification GO:0009952 152 0.558
larval development GO:0002164 2 0.558
cardiac muscle cell differentiation GO:0055007 30 0.553
cellular component morphogenesis GO:0032989 336 0.505
Zebrafish Fly
nitrogen compound metabolic process GO:0006807 319 0.478
skeletal muscle organ development GO:0060538 78 0.474
Zebrafish
skeletal muscle thin filament assembly GO:0030240 4 0.459
muscle system process GO:0003012 20 0.440
Mouse
ventricular cardiac myofibril assembly GO:0055005 4 0.429
atp catabolic process GO:0006200 4 0.422
heart morphogenesis GO:0003007 156 0.418
ventricular cardiac muscle tissue development GO:0003229 3 0.408
cellular component assembly involved in morphogenesis GO:0010927 107 0.408
Zebrafish Fly
skeletal myofibril assembly GO:0014866 7 0.396
muscle fiber development GO:0048747 52 0.348
Zebrafish
cytokinesis GO:0000910 3 0.342
cell projection organization GO:0030030 284 0.338
neuron development GO:0048666 262 0.324
somitogenesis GO:0001756 87 0.323
circulatory system process GO:0003013 87 0.321
neuron differentiation GO:0030182 353 0.314
lymphoid lineage cell migration GO:0097534 4 0.286
heart process GO:0003015 71 0.255
myotube cell development GO:0014904 35 0.253
Zebrafish
system process GO:0003008 185 0.250
Mouse
heterocycle biosynthetic process GO:0018130 215 0.246
skeletal muscle contraction GO:0003009 5 0.240
voluntary skeletal muscle contraction GO:0003010 4 0.236
cellular component biogenesis GO:0044085 178 0.231
Zebrafish Fly
aging GO:0007568 2 0.230
muscle organ development GO:0007517 101 0.220
Zebrafish
cardiac muscle cell development GO:0055013 20 0.216
cellular nitrogen compound metabolic process GO:0034641 290 0.196
nucleoside monophosphate catabolic process GO:0009125 4 0.195
sarcomere organization GO:0045214 26 0.187
Zebrafish Fly
aromatic compound biosynthetic process GO:0019438 217 0.181
cellular component movement GO:0006928 335 0.181
regulation of heart contraction GO:0008016 32 0.180
nucleic acid templated transcription GO:0097659 181 0.176
ribonucleoside monophosphate catabolic process GO:0009158 4 0.175
organic substance biosynthetic process GO:1901576 289 0.174
regulation of nucleoside metabolic process GO:0009118 2 0.173
maintenance of location GO:0051235 4 0.169
heart looping GO:0001947 94 0.168
rna biosynthetic process GO:0032774 181 0.163
adult behavior GO:0030534 2 0.144
Fly
regulation of purine nucleotide catabolic process GO:0033121 2 0.137
generation of neurons GO:0048699 385 0.136
cardiac cell development GO:0055006 21 0.132
lipid storage GO:0019915 1 0.130
heterocycle metabolic process GO:0046483 290 0.130
nucleobase containing compound biosynthetic process GO:0034654 205 0.125
muscle tissue development GO:0060537 110 0.123
Zebrafish
organic cyclic compound biosynthetic process GO:1901362 223 0.123
locomotion GO:0040011 313 0.120
muscle contraction GO:0006936 18 0.119
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.118
cellular aromatic compound metabolic process GO:0006725 295 0.118
striated muscle tissue development GO:0014706 110 0.112
Zebrafish
twitch skeletal muscle contraction GO:0014721 4 0.111
positive regulation of biological process GO:0048518 253 0.111
cell motility GO:0048870 244 0.110
cardiac ventricle morphogenesis GO:0003208 7 0.109
skeletal muscle fiber development GO:0048741 35 0.109
Zebrafish
regulation of muscle contraction GO:0006937 3 0.109
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.108
macromolecule biosynthetic process GO:0009059 227 0.105
regionalization GO:0003002 274 0.103
skeletal muscle tissue development GO:0007519 67 0.099
Zebrafish
cardiocyte differentiation GO:0035051 44 0.099
protein stabilization GO:0050821 2 0.098
regulation of developmental process GO:0050793 247 0.098
negative regulation of biological process GO:0048519 304 0.097
establishment of localization GO:0051234 244 0.097
somatic muscle development GO:0007525 4 0.096
blood vessel development GO:0001568 246 0.095
specification of symmetry GO:0009799 204 0.092
cytoskeleton dependent cytokinesis GO:0061640 3 0.090
response to activity GO:0014823 14 0.090
multicellular organismal movement GO:0050879 8 0.088
single organism localization GO:1902578 225 0.088
musculoskeletal movement GO:0050881 8 0.087
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.085
skeletal system development GO:0001501 181 0.085
regulation of biosynthetic process GO:0009889 250 0.084
organonitrogen compound metabolic process GO:1901564 74 0.084
cellular biosynthetic process GO:0044249 286 0.082
regulation of rna metabolic process GO:0051252 224 0.082
regulation of macromolecule biosynthetic process GO:0010556 225 0.080
response to chemical GO:0042221 320 0.080
positive regulation of blood circulation GO:1903524 2 0.079
sensory organ development GO:0007423 393 0.079
Zebrafish
cell migration GO:0016477 237 0.075
cell morphogenesis GO:0000902 289 0.075
cardiac myofibril assembly GO:0055003 9 0.074
regulation of gene expression GO:0010468 265 0.074
transport GO:0006810 220 0.074
somite development GO:0061053 96 0.073
regulation of cellular metabolic process GO:0031323 320 0.072
cell projection morphogenesis GO:0048858 244 0.070
regulation of biological quality GO:0065008 263 0.064
epidermal cell fate specification GO:0009957 4 0.064
embryonic heart tube development GO:0035050 133 0.063
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.063
cell morphogenesis involved in differentiation GO:0000904 195 0.063
actomyosin structure organization GO:0031032 53 0.062
Zebrafish Fly
biosynthetic process GO:0009058 294 0.062
regulation of macromolecule metabolic process GO:0060255 317 0.061
immune system process GO:0002376 241 0.060
cardiac muscle fiber development GO:0048739 3 0.058
cardiac ventricle development GO:0003231 9 0.058
ion transmembrane transport GO:0034220 91 0.058
cardiac muscle tissue development GO:0048738 48 0.058
regulation of blood pressure GO:0008217 1 0.057
regulation of ion transmembrane transporter activity GO:0032412 2 0.057
water homeostasis GO:0030104 4 0.056
localization of cell GO:0051674 244 0.056
growth GO:0040007 174 0.056
neuron projection morphogenesis GO:0048812 161 0.055
cardiac chamber development GO:0003205 19 0.055
connective tissue development GO:0061448 99 0.053
cardiac muscle tissue morphogenesis GO:0055008 7 0.053
positive regulation of transcription dna templated GO:0045893 57 0.051
vasculature development GO:0001944 278 0.050
macromolecule catabolic process GO:0009057 15 0.050
Worm
post embryonic morphogenesis GO:0009886 4 0.050
regulation of multicellular organismal process GO:0051239 277 0.049
pharyngeal muscle development GO:0043282 4 0.049
cell part morphogenesis GO:0032990 246 0.048
rna metabolic process GO:0016070 219 0.048
cell maturation GO:0048469 23 0.047
regulation of protein polymerization GO:0032271 2 0.044
behavior GO:0007610 74 0.044
Fly
regulation of primary metabolic process GO:0080090 311 0.044
positive regulation of rna biosynthetic process GO:1902680 57 0.042
endocardial cushion formation GO:0003272 2 0.041
embryonic organ development GO:0048568 381 0.041
carboxylic acid metabolic process GO:0019752 22 0.041
sequestering of metal ion GO:0051238 3 0.041
positive regulation of gene expression GO:0010628 71 0.040
organic cyclic compound metabolic process GO:1901360 301 0.040
small molecule metabolic process GO:0044281 77 0.040
positive regulation of metabolic process GO:0009893 108 0.039
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.038
segmentation GO:0035282 97 0.038
skeletal muscle myosin thick filament assembly GO:0030241 5 0.038
nucleobase containing compound metabolic process GO:0006139 274 0.038
regulation of membrane potential GO:0042391 23 0.037
axon development GO:0061564 166 0.037
cellular nitrogen compound biosynthetic process GO:0044271 218 0.037
regulation of nucleic acid templated transcription GO:1903506 213 0.037
regulation of system process GO:0044057 40 0.037
regulation of protein complex assembly GO:0043254 3 0.036
regulation of nitric oxide mediated signal transduction GO:0010749 1 0.036
nucleic acid metabolic process GO:0090304 244 0.036
eye development GO:0001654 277 0.035
Zebrafish
slow twitch skeletal muscle fiber contraction GO:0031444 3 0.035
purine ribonucleotide metabolic process GO:0009150 27 0.035
transcription dna templated GO:0006351 181 0.034
brain development GO:0007420 293 0.034
regulation of organ growth GO:0046620 3 0.034
chondrocyte intercalation involved in growth plate cartilage morphogenesis GO:0003428 1 0.034
positive regulation of rna metabolic process GO:0051254 59 0.033
cytoskeleton organization GO:0007010 96 0.033
Zebrafish Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.033
mitochondrion organization GO:0007005 4 0.033
positive regulation of cellular process GO:0048522 201 0.033
digestive tract development GO:0048565 265 0.032
regulation of sarcomere organization GO:0060297 2 0.032
regulation of response to stimulus GO:0048583 269 0.032
regulation of cellular biosynthetic process GO:0031326 245 0.032
nitric oxide mediated signal transduction GO:0007263 2 0.032
apoptotic process involved in development GO:1902742 2 0.031
multicellular organism growth GO:0035264 4 0.031
regulation of nucleotide catabolic process GO:0030811 2 0.030
regulation of heart growth GO:0060420 2 0.030
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.030
tube morphogenesis GO:0035239 349 0.030
meiotic nuclear division GO:0007126 4 0.029
multi organism reproductive process GO:0044703 36 0.029
positive regulation of cellular metabolic process GO:0031325 94 0.029
regulation of rna biosynthetic process GO:2001141 213 0.029
neuron projection development GO:0031175 180 0.029
oocyte anterior posterior axis specification GO:0007314 4 0.029
embryonic cranial skeleton morphogenesis GO:0048701 90 0.029
wound healing GO:0042060 90 0.029
angiogenesis GO:0001525 158 0.028
lymphoid lineage cell migration into thymus GO:0097535 4 0.028
homeostatic process GO:0042592 142 0.028
directional locomotion GO:0033058 1 0.028
ventricular cardiac muscle cell differentiation GO:0055012 6 0.028
digestive system development GO:0055123 289 0.028
cognition GO:0050890 1 0.027
macromolecular complex subunit organization GO:0043933 74 0.027
endocardial cushion morphogenesis GO:0003203 3 0.027
centrosome organization GO:0051297 1 0.027
regulation of cell communication GO:0010646 232 0.027
sequestering of calcium ion GO:0051208 3 0.027
response to stress GO:0006950 263 0.026
regulation of metal ion transport GO:0010959 4 0.026
regulation of metabolic process GO:0019222 359 0.025
transcription from rna polymerase ii promoter GO:0006366 80 0.025
cellular response to nutrient levels GO:0031669 2 0.024
central nervous system myelination GO:0022010 2 0.024
muscle organ morphogenesis GO:0048644 8 0.024
cellular component disassembly GO:0022411 1 0.024
chemotaxis GO:0006935 104 0.024
oocyte development GO:0048599 14 0.023
intracellular signal transduction GO:0035556 85 0.023
embryonic organ morphogenesis GO:0048562 274 0.023
cell cycle process GO:0022402 53 0.023
Worm
purine ribonucleoside triphosphate biosynthetic process GO:0009206 2 0.023
muscle cell cellular homeostasis GO:0046716 5 0.023
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.022
protein depolymerization GO:0051261 1 0.022
growth plate cartilage morphogenesis GO:0003422 1 0.022
axonogenesis GO:0007409 152 0.022
regulation of cell projection assembly GO:0060491 4 0.021
epithelial tube morphogenesis GO:0060562 148 0.021
regulation of growth GO:0040008 42 0.021
developmental programmed cell death GO:0010623 4 0.021
immune system development GO:0002520 191 0.021
organic acid metabolic process GO:0006082 31 0.021
positive regulation of muscle organ development GO:0048636 1 0.020
mesenchyme development GO:0060485 127 0.020
cytoplasm organization GO:0007028 4 0.020
carbohydrate derivative metabolic process GO:1901135 61 0.020
striated muscle myosin thick filament assembly GO:0071688 6 0.020
reproduction GO:0000003 40 0.020
head development GO:0060322 303 0.020
cardiac chamber morphogenesis GO:0003206 12 0.020
gene expression GO:0010467 252 0.019
positive regulation of nucleic acid templated transcription GO:1903508 57 0.019
regulation of transmembrane transporter activity GO:0022898 2 0.019
cell death GO:0008219 121 0.019
cell substrate adhesion GO:0031589 4 0.019
positive regulation of transport GO:0051050 2 0.019
cellular macromolecule biosynthetic process GO:0034645 224 0.019
regulation of establishment of planar polarity GO:0090175 4 0.018
mitotic nuclear division GO:0007067 18 0.018
Worm
protein polymerization GO:0051258 4 0.018
actin filament polymerization GO:0030041 2 0.018
feeding behavior GO:0007631 5 0.018
regulation of heart rate GO:0002027 5 0.018
cellular modified amino acid metabolic process GO:0006575 3 0.018
protein metabolic process GO:0019538 183 0.018
Worm
cell growth GO:0016049 57 0.018
developmental maturation GO:0021700 34 0.018
cell surface receptor signaling pathway GO:0007166 325 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.018
skeletal system morphogenesis GO:0048705 102 0.018
protein complex disassembly GO:0043241 1 0.018
developmental growth GO:0048589 166 0.017
amine metabolic process GO:0009308 2 0.017
morphogenesis of an epithelium GO:0002009 333 0.017
pole plasm assembly GO:0007315 4 0.017
cell cycle GO:0007049 93 0.017
Worm
actin filament based movement GO:0030048 1 0.017
regulation of mrna processing GO:0050684 3 0.017
response to organic substance GO:0010033 153 0.017
cytosolic calcium ion transport GO:0060401 3 0.017
purine containing compound metabolic process GO:0072521 29 0.017
regulation of developmental growth GO:0048638 38 0.016
maternal determination of anterior posterior axis embryo GO:0008358 4 0.016
macromolecular complex disassembly GO:0032984 1 0.016
striated muscle contraction GO:0006941 12 0.016
patterning of blood vessels GO:0001569 15 0.016
single organism transport GO:0044765 206 0.016
myotome development GO:0061055 1 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.016
regulation of organelle organization GO:0033043 29 0.016
cartilage development GO:0051216 96 0.016
regulation of hydrolase activity GO:0051336 28 0.015
ventricular cardiac muscle cell development GO:0055015 5 0.015
hatching GO:0035188 4 0.015
nucleoside triphosphate biosynthetic process GO:0009142 2 0.015
cell matrix adhesion GO:0007160 4 0.015
death GO:0016265 121 0.015
sister chromatid cohesion GO:0007062 2 0.015
kidney development GO:0001822 92 0.015
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.015
internal peptidyl lysine acetylation GO:0018393 2 0.015
muscle tissue morphogenesis GO:0060415 7 0.015
organelle fission GO:0048285 23 0.014
Worm
cellular amino acid metabolic process GO:0006520 7 0.014
oxoacid metabolic process GO:0043436 31 0.014
mitotic cell cycle process GO:1903047 48 0.014
Worm
atrial cardiac myofibril assembly GO:0055004 2 0.014
single organism metabolic process GO:0044710 217 0.014
organic substance catabolic process GO:1901575 28 0.014
Worm
regulation of multicellular organism growth GO:0040014 4 0.014
inositol lipid mediated signaling GO:0048017 2 0.014
hemopoiesis GO:0030097 183 0.014
tissue remodeling GO:0048771 4 0.014
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.014
growth plate cartilage development GO:0003417 2 0.014
protein homooligomerization GO:0051260 3 0.013
oogenesis GO:0048477 14 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
protein complex subunit organization GO:0071822 46 0.013
dna catabolic process GO:0006308 1 0.013
nuclear division GO:0000280 23 0.013
Worm
regulation of transporter activity GO:0032409 2 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
regulation of protein complex disassembly GO:0043244 1 0.013
regulation of cellular component size GO:0032535 30 0.013
nucleobase containing small molecule metabolic process GO:0055086 32 0.013
small molecule catabolic process GO:0044282 3 0.013
protein acetylation GO:0006473 2 0.013
membrane organization GO:0061024 21 0.013
single organism reproductive process GO:0044702 40 0.013
intracellular mrna localization GO:0008298 1 0.013
protein catabolic process GO:0030163 7 0.012
Worm
central nervous system neuron development GO:0021954 29 0.012
positive regulation of cellular biosynthetic process GO:0031328 68 0.012
ras protein signal transduction GO:0007265 7 0.012
phosphorus metabolic process GO:0006793 109 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
granulocyte chemotaxis GO:0071621 11 0.012
cellular protein complex disassembly GO:0043624 1 0.012
anatomical structure homeostasis GO:0060249 36 0.012
regulation of cytoskeleton organization GO:0051493 11 0.012
catabolic process GO:0009056 32 0.012
Worm
regulation of behavior GO:0050795 24 0.012
limb bud formation GO:0060174 2 0.012
nucleoside phosphate metabolic process GO:0006753 28 0.012
negative regulation of cellular process GO:0048523 283 0.012
immune response GO:0006955 28 0.011
regulation of sequestering of calcium ion GO:0051282 4 0.011
positive regulation of cellular catabolic process GO:0031331 3 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
signal transduction GO:0007165 455 0.011
cellular catabolic process GO:0044248 27 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
heart growth GO:0060419 7 0.011
circadian sleep wake cycle GO:0042745 2 0.011
er nucleus signaling pathway GO:0006984 2 0.011
regulation of cell shape GO:0008360 1 0.011
notochord development GO:0030903 54 0.011
positive regulation of biosynthetic process GO:0009891 68 0.011
regulation of anatomical structure size GO:0090066 33 0.011
response to wounding GO:0009611 116 0.011
leukocyte chemotaxis GO:0030595 12 0.011
lipid homeostasis GO:0055088 3 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
cardiac muscle contraction GO:0060048 6 0.010
regulation of myotube differentiation GO:0010830 2 0.010
centrosome duplication GO:0051298 1 0.010
membrane repolarization GO:0086009 2 0.010
regulation of signal transduction GO:0009966 225 0.010
basement membrane assembly GO:0070831 3 0.010
response to nutrient GO:0007584 3 0.010
taxis GO:0042330 109 0.010
actin polymerization or depolymerization GO:0008154 2 0.010
protein complex biogenesis GO:0070271 30 0.010
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.010
positive regulation of molecular function GO:0044093 33 0.010

actn3b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.504
muscular disease DOID:0080000 0 0.504
heart disease DOID:114 0 0.504
cardiomyopathy DOID:0050700 0 0.504
disease of anatomical entity DOID:7 0 0.504
intrinsic cardiomyopathy DOID:0060036 0 0.504
cardiovascular system disease DOID:1287 0 0.504
musculoskeletal system disease DOID:17 0 0.504
muscle tissue disease DOID:66 0 0.504
hypertrophic cardiomyopathy DOID:11984 0 0.201
leigh disease DOID:3652 0 0.048
disease of metabolism DOID:0014667 0 0.048
mitochondrial metabolism disease DOID:700 0 0.048
inherited metabolic disorder DOID:655 0 0.048
dilated cardiomyopathy DOID:12930 0 0.024