Danio rerio

110 known processes

adra2a

adrenergic, alpha-2A-, receptor

adra2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.850
regulation of response to stimulus GO:0048583 269 0.841
Human Worm
cellular nitrogen compound biosynthetic process GO:0044271 218 0.727
cell surface receptor signaling pathway GO:0007166 325 0.702
negative regulation of nucleotide metabolic process GO:0045980 7 0.650
negative regulation of lyase activity GO:0051350 6 0.577
small molecule metabolic process GO:0044281 77 0.466
cellular aromatic compound metabolic process GO:0006725 295 0.455
negative regulation of camp biosynthetic process GO:0030818 7 0.452
organonitrogen compound metabolic process GO:1901564 74 0.421
aromatic compound biosynthetic process GO:0019438 217 0.419
defense response GO:0006952 47 0.416
Worm
organic substance biosynthetic process GO:1901576 289 0.411
organic cyclic compound metabolic process GO:1901360 301 0.390
negative regulation of purine nucleotide metabolic process GO:1900543 7 0.365
cognition GO:0050890 1 0.349
positive regulation of metabolic process GO:0009893 108 0.335
Human
negative regulation of biological process GO:0048519 304 0.321
aging GO:0007568 2 0.305
circadian sleep wake cycle sleep GO:0050802 1 0.301
positive regulation of biological process GO:0048518 253 0.295
Human
negative regulation of camp metabolic process GO:0030815 7 0.293
nucleobase containing compound biosynthetic process GO:0034654 205 0.290
nitrogen compound metabolic process GO:0006807 319 0.278
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.275
g protein coupled receptor signaling pathway GO:0007186 74 0.275
biosynthetic process GO:0009058 294 0.266
immune system process GO:0002376 241 0.265
Worm
positive regulation of macromolecule metabolic process GO:0010604 93 0.259
Human
regulation of metabolic process GO:0019222 359 0.251
regulation of multicellular organismal process GO:0051239 277 0.235
Human Zebrafish
nucleoside phosphate biosynthetic process GO:1901293 21 0.230
response to organic substance GO:0010033 153 0.224
Human Worm
cellular macromolecule metabolic process GO:0044260 391 0.223
Human
organophosphate biosynthetic process GO:0090407 23 0.218
regulation of signaling GO:0023051 235 0.207
Human Worm
cellular nitrogen compound metabolic process GO:0034641 290 0.207
negative regulation of purine nucleotide biosynthetic process GO:1900372 7 0.200
response to abiotic stimulus GO:0009628 122 0.198
single organism metabolic process GO:0044710 217 0.198
cellular response to chemical stimulus GO:0070887 157 0.198
Human Worm
purine nucleotide biosynthetic process GO:0006164 20 0.195
cellular response to organic substance GO:0071310 105 0.193
Human Worm
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.190
protein metabolic process GO:0019538 183 0.186
Human
positive regulation of cell communication GO:0010647 56 0.185
Human
cellular biosynthetic process GO:0044249 286 0.181
response to drug GO:0042493 3 0.171
regulation of nitrogen compound metabolic process GO:0051171 251 0.168
hemopoiesis GO:0030097 183 0.167
maintenance of location GO:0051235 4 0.166
positive regulation of cellular process GO:0048522 201 0.165
Human
circadian sleep wake cycle process GO:0022410 2 0.165
hematopoietic or lymphoid organ development GO:0048534 191 0.160
heterocycle metabolic process GO:0046483 290 0.158
negative regulation of nucleotide biosynthetic process GO:0030809 7 0.154
response to chemical GO:0042221 320 0.153
Human Worm
carbohydrate derivative metabolic process GO:1901135 61 0.151
single organism biosynthetic process GO:0044711 71 0.144
ribonucleotide metabolic process GO:0009259 27 0.142
embryo development ending in birth or egg hatching GO:0009792 271 0.137
phosphorus metabolic process GO:0006793 109 0.131
cyclic nucleotide metabolic process GO:0009187 18 0.126
protein n linked glycosylation GO:0006487 1 0.125
system process GO:0003008 185 0.123
Zebrafish
regulation of circadian sleep wake cycle GO:0042749 1 0.119
nucleobase containing compound metabolic process GO:0006139 274 0.116
purine containing compound metabolic process GO:0072521 29 0.112
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.112
Human
transport GO:0006810 220 0.111
Human
ribose phosphate metabolic process GO:0019693 27 0.110
homeostatic process GO:0042592 142 0.106
Human
erythrocyte differentiation GO:0030218 54 0.104
regulation of biological quality GO:0065008 263 0.104
Human Zebrafish
positive regulation of transport GO:0051050 2 0.101
response to stress GO:0006950 263 0.101
Human Mouse Worm
positive regulation of cellular metabolic process GO:0031325 94 0.097
Human
central nervous system development GO:0007417 387 0.096
cellular macromolecule biosynthetic process GO:0034645 224 0.096
regulation of cell communication GO:0010646 232 0.094
Human Worm
camp metabolic process GO:0046058 11 0.091
circadian sleep wake cycle GO:0042745 2 0.089
organophosphate metabolic process GO:0019637 37 0.087
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.087
negative regulation of cellular process GO:0048523 283 0.086
immune response GO:0006955 28 0.084
Worm
positive regulation of signaling GO:0023056 56 0.083
Human
gene expression GO:0010467 252 0.083
negative regulation of cyclic nucleotide biosynthetic process GO:0030803 7 0.082
multicellular organism growth GO:0035264 4 0.082
regulation of transport GO:0051049 45 0.081
Human
hormone transport GO:0009914 2 0.079
Human
positive regulation of gene expression GO:0010628 71 0.079
single organism transport GO:0044765 206 0.079
Human
carbohydrate metabolic process GO:0005975 12 0.078
peptide transport GO:0015833 1 0.078
Human
response to external stimulus GO:0009605 264 0.077
heterocycle biosynthetic process GO:0018130 215 0.077
oxoacid metabolic process GO:0043436 31 0.076
response to corticosteroid GO:0031960 1 0.075
regulation of adenylate cyclase activity GO:0045761 6 0.073
cell morphogenesis GO:0000902 289 0.073
regulation of biosynthetic process GO:0009889 250 0.072
nucleoside phosphate metabolic process GO:0006753 28 0.072
regulation of cyclase activity GO:0031279 12 0.072
regulation of phosphate metabolic process GO:0019220 43 0.072
regulation of localization GO:0032879 104 0.071
Human
camp biosynthetic process GO:0006171 11 0.071
regulation of molecular function GO:0065009 70 0.071
glucose homeostasis GO:0042593 1 0.068
Human
generation of neurons GO:0048699 385 0.066
regulation of circadian rhythm GO:0042752 4 0.065
regulation of camp metabolic process GO:0030814 9 0.064
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.064
locomotion GO:0040011 313 0.063
Human
carbohydrate derivative biosynthetic process GO:1901137 43 0.062
response to wounding GO:0009611 116 0.061
Human
purine nucleotide metabolic process GO:0006163 27 0.061
brain development GO:0007420 293 0.060
cyclic purine nucleotide metabolic process GO:0052652 18 0.059
organonitrogen compound biosynthetic process GO:1901566 47 0.058
regulation of cellular biosynthetic process GO:0031326 245 0.057
negative regulation of defense response GO:0031348 2 0.056
Worm
lipid storage GO:0019915 1 0.056
transcription dna templated GO:0006351 181 0.055
positive regulation of signal transduction GO:0009967 56 0.055
Human
enzyme linked receptor protein signaling pathway GO:0007167 106 0.054
Human
rna biosynthetic process GO:0032774 181 0.054
protein modification process GO:0036211 100 0.054
Human
negative regulation of innate immune response GO:0045824 2 0.053
Worm
organic substance transport GO:0071702 58 0.052
Human
regulation of rna metabolic process GO:0051252 224 0.051
regulation of inflammatory response GO:0050727 2 0.051
sleep GO:0030431 1 0.051
regulation of signal transduction GO:0009966 225 0.050
Human Worm
phosphate containing compound metabolic process GO:0006796 108 0.050
cell projection morphogenesis GO:0048858 244 0.049
single organism localization GO:1902578 225 0.049
Human
innate immune response GO:0045087 13 0.048
Worm
regulation of multicellular organismal development GO:2000026 223 0.047
response to radiation GO:0009314 51 0.047
cellular protein metabolic process GO:0044267 129 0.047
Human
digestive system development GO:0055123 289 0.046
regulation of multicellular organism growth GO:0040014 4 0.045
negative regulation of cyclase activity GO:0031280 6 0.045
purine ribonucleotide biosynthetic process GO:0009152 20 0.045
regulation of response to stress GO:0080134 36 0.045
Human Worm
intracellular signal transduction GO:0035556 85 0.044
Human
regulation of neurogenesis GO:0050767 87 0.044
regulation of macromolecule metabolic process GO:0060255 317 0.044
Human
positive regulation of non canonical wnt signaling pathway GO:2000052 3 0.043
regulation of immune system process GO:0002682 34 0.043
Worm
negative regulation of biosynthetic process GO:0009890 55 0.043
positive regulation of transcription dna templated GO:0045893 57 0.043
response to organic cyclic compound GO:0014070 51 0.043
immune system development GO:0002520 191 0.042
neuron projection morphogenesis GO:0048812 161 0.042
regulation of camp biosynthetic process GO:0030817 9 0.041
regulation of primary metabolic process GO:0080090 311 0.041
nucleobase containing small molecule metabolic process GO:0055086 32 0.040
single organism nuclear import GO:1902593 3 0.040
positive regulation of multicellular organismal process GO:0051240 52 0.040
Human
cellular response to topologically incorrect protein GO:0035967 2 0.040
Worm
regulation of innate immune response GO:0045088 11 0.040
Worm
eye development GO:0001654 277 0.039
pigmentation GO:0043473 85 0.039
positive regulation of cytokine production GO:0001819 2 0.039
Human
regulation of phosphorus metabolic process GO:0051174 43 0.039
positive regulation of striated muscle tissue development GO:0045844 1 0.038
rna metabolic process GO:0016070 219 0.037
negative regulation of signaling GO:0023057 96 0.036
Human
regulation of cell differentiation GO:0045595 142 0.036
establishment of localization GO:0051234 244 0.035
Human
organic cyclic compound biosynthetic process GO:1901362 223 0.035
nucleocytoplasmic transport GO:0006913 4 0.035
sensory organ development GO:0007423 393 0.034
larval development GO:0002164 2 0.034
response to light stimulus GO:0009416 46 0.034
angiogenesis GO:0001525 158 0.033
regulation of cyclic nucleotide metabolic process GO:0030799 15 0.033
er nucleus signaling pathway GO:0006984 2 0.033
Worm
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.033
multicellular organismal response to stress GO:0033555 2 0.033
Mouse
response to ketone GO:1901654 1 0.033
cell migration GO:0016477 237 0.032
Human
purine ribonucleotide metabolic process GO:0009150 27 0.032
ovulation cycle GO:0042698 2 0.032
organic acid metabolic process GO:0006082 31 0.031
multicellular organismal water homeostasis GO:0050891 1 0.031
gland development GO:0048732 143 0.031
response to nicotine GO:0035094 2 0.031
carboxylic acid metabolic process GO:0019752 22 0.030
opioid receptor signaling pathway GO:0038003 3 0.030
embryonic organ development GO:0048568 381 0.030
blood vessel development GO:0001568 246 0.029
cellular response to unfolded protein GO:0034620 2 0.029
Worm
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.028
cellular component assembly GO:0022607 170 0.028
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.028
transcription from rna polymerase ii promoter GO:0006366 80 0.028
response to alkaloid GO:0043279 2 0.028
regulation of inner ear receptor cell differentiation GO:2000980 1 0.028
chemical homeostasis GO:0048878 49 0.028
Human
transmembrane transport GO:0055085 120 0.028
purine containing compound biosynthetic process GO:0072522 20 0.027
response to oxygen containing compound GO:1901700 55 0.027
Human
negative regulation of signal transduction GO:0009968 94 0.027
positive regulation of nucleic acid templated transcription GO:1903508 57 0.027
behavior GO:0007610 74 0.026
nitrogen compound transport GO:0071705 23 0.026
Human
ribonucleotide biosynthetic process GO:0009260 20 0.025
positive regulation of developmental process GO:0051094 50 0.025
neurological system process GO:0050877 62 0.025
cellular homeostasis GO:0019725 26 0.025
Human
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.025
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 5 0.025
Human
positive regulation of cellular biosynthetic process GO:0031328 68 0.025
regulation of cellular metabolic process GO:0031323 320 0.025
cellular component morphogenesis GO:0032989 336 0.025
i kappab kinase nf kappab signaling GO:0007249 4 0.024
regionalization GO:0003002 274 0.024
camera type eye development GO:0043010 222 0.024
regulation of macromolecule biosynthetic process GO:0010556 225 0.024
cellular protein modification process GO:0006464 100 0.024
Human
nucleic acid metabolic process GO:0090304 244 0.023
macromolecule biosynthetic process GO:0009059 227 0.023
monoamine transport GO:0015844 1 0.023
regulation of catalytic activity GO:0050790 55 0.023
cellular component biogenesis GO:0044085 178 0.023
regulation of dna templated transcription in response to stress GO:0043620 0 0.023
lipid metabolic process GO:0006629 52 0.023
Human
chordate embryonic development GO:0043009 271 0.023
adrenergic receptor signaling pathway GO:0071875 5 0.023
head development GO:0060322 303 0.022
regulation of gene expression GO:0010468 265 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.022
cellular response to endogenous stimulus GO:0071495 68 0.022
Human
inner ear development GO:0048839 126 0.022
sensory system development GO:0048880 76 0.022
ovulation cycle process GO:0022602 2 0.022
hormone metabolic process GO:0042445 19 0.021
regulation of ion transport GO:0043269 22 0.021
negative regulation of protein kinase b signaling GO:0051898 2 0.021
negative regulation of response to stimulus GO:0048585 104 0.021
Human Worm
negative regulation of cellular biosynthetic process GO:0031327 55 0.021
single organism behavior GO:0044708 24 0.021
growth GO:0040007 174 0.021
cell death GO:0008219 121 0.020
cell projection organization GO:0030030 284 0.020
negative regulation of catalytic activity GO:0043086 21 0.020
cation homeostasis GO:0055080 33 0.020
cyclic nucleotide biosynthetic process GO:0009190 18 0.020
response to unfolded protein GO:0006986 2 0.020
Worm
ion transmembrane transport GO:0034220 91 0.020
nucleic acid templated transcription GO:0097659 181 0.020
cellular amide metabolic process GO:0043603 4 0.020
taxis GO:0042330 109 0.020
positive regulation of muscle tissue development GO:1901863 1 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.019
Human
startle response GO:0001964 4 0.019
sensory perception GO:0007600 39 0.019
positive regulation of secretion by cell GO:1903532 1 0.019
cellular amine metabolic process GO:0044106 2 0.019
positive regulation of rna metabolic process GO:0051254 59 0.019
response to lipid GO:0033993 60 0.019
neuron migration GO:0001764 22 0.019
amine metabolic process GO:0009308 2 0.019
regulation of defense response GO:0031347 14 0.019
Worm
positive regulation of response to stimulus GO:0048584 80 0.019
Human
positive regulation of biosynthetic process GO:0009891 68 0.018
cellular response to drug GO:0035690 1 0.018
positive regulation of rna biosynthetic process GO:1902680 57 0.018
response to endogenous stimulus GO:0009719 83 0.018
Human
response to uv GO:0009411 3 0.018
toxin metabolic process GO:0009404 1 0.018
thermosensory behavior GO:0040040 1 0.018
blood vessel morphogenesis GO:0048514 216 0.018
embryonic organ morphogenesis GO:0048562 274 0.018
catecholamine metabolic process GO:0006584 2 0.018
regulation of metal ion transport GO:0010959 4 0.017
death GO:0016265 121 0.017
regulation of response to nutrient levels GO:0032107 1 0.017
response to dexamethasone GO:0071548 1 0.017
regulation of ion transmembrane transporter activity GO:0032412 2 0.017
cell morphogenesis involved in differentiation GO:0000904 195 0.017
cell part morphogenesis GO:0032990 246 0.017
neuron differentiation GO:0030182 353 0.017
response to steroid hormone GO:0048545 35 0.017
apoptotic process GO:0006915 116 0.017
cellular protein catabolic process GO:0044257 4 0.016
regulation of behavior GO:0050795 24 0.016
cellular ketone metabolic process GO:0042180 11 0.016
regulation of nucleic acid templated transcription GO:1903506 213 0.016
negative regulation of cytokine production GO:0001818 1 0.016
cellular biogenic amine metabolic process GO:0006576 2 0.016
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.016
cytoskeleton organization GO:0007010 96 0.016
cellular component movement GO:0006928 335 0.016
Human
regulation of hormone levels GO:0010817 21 0.016
Human
cation transport GO:0006812 81 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.015
Human
localization of cell GO:0051674 244 0.015
Human
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
divalent inorganic cation homeostasis GO:0072507 22 0.015
mitochondrion organization GO:0007005 4 0.015
regulation of intracellular signal transduction GO:1902531 57 0.014
Human
regulation of programmed cell death GO:0043067 101 0.014
neuron projection development GO:0031175 180 0.014
hormone secretion GO:0046879 2 0.014
Human
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 2 0.014
internal peptidyl lysine acetylation GO:0018393 2 0.014
negative regulation of multicellular organismal process GO:0051241 69 0.014
reciprocal dna recombination GO:0035825 1 0.014
regulation of fatty acid metabolic process GO:0019217 1 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.014
response to glucose GO:0009749 3 0.014
Human
erythrocyte homeostasis GO:0034101 55 0.014
locomotory behavior GO:0007626 34 0.014
nuclear import GO:0051170 3 0.014
nucleotide metabolic process GO:0009117 28 0.014
regulation of transporter activity GO:0032409 2 0.014
myeloid cell differentiation GO:0030099 86 0.014
neuron development GO:0048666 262 0.014
cellular ion homeostasis GO:0006873 17 0.013
protein complex assembly GO:0006461 30 0.013
cellular localization GO:0051641 97 0.013
Human
homeostasis of number of cells GO:0048872 62 0.013
response to external biotic stimulus GO:0043207 97 0.013
positive regulation of phosphate metabolic process GO:0045937 21 0.013
Human
protein localization to nucleus GO:0034504 3 0.013
apoptotic process involved in development GO:1902742 2 0.013
regulation of nervous system development GO:0051960 90 0.013
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 5 0.013
Human
response to oxygen levels GO:0070482 25 0.013
blood circulation GO:0008015 87 0.013
Zebrafish
regulation of carbohydrate metabolic process GO:0006109 4 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
regulation of blood pressure GO:0008217 1 0.013
negative regulation of apoptotic process GO:0043066 55 0.012
regulation of cell activation GO:0050865 1 0.012
developmental programmed cell death GO:0010623 4 0.012
cellular response to estradiol stimulus GO:0071392 1 0.012
ion transport GO:0006811 114 0.012
negative regulation of feeding behavior GO:2000252 2 0.012
sensory perception of pain GO:0019233 1 0.012
response to metal ion GO:0010038 34 0.012
regulation of dna templated transcription elongation GO:0032784 3 0.012
negative regulation of metabolic process GO:0009892 86 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
nucleotide biosynthetic process GO:0009165 21 0.012
retinal pigment epithelium development GO:0003406 8 0.012
regulation of ph GO:0006885 3 0.012
dna templated transcription elongation GO:0006354 3 0.012
cellular response to stress GO:0033554 62 0.012
Worm
monocarboxylic acid metabolic process GO:0032787 17 0.012
macromolecule modification GO:0043412 111 0.012
Human
female gonad development GO:0008585 4 0.011
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.011
positive regulation of cellular protein metabolic process GO:0032270 22 0.011
Human
protein complex biogenesis GO:0070271 30 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
metal ion homeostasis GO:0055065 26 0.011
regulation of purine nucleotide metabolic process GO:1900542 17 0.011
myeloid cell homeostasis GO:0002262 56 0.011
lymphocyte proliferation GO:0046651 1 0.011
regulation of rna biosynthetic process GO:2001141 213 0.011
dicarboxylic acid metabolic process GO:0043648 1 0.011
positive regulation of secretion GO:0051047 1 0.011
calcium ion homeostasis GO:0055074 19 0.011
response to other organism GO:0051707 97 0.011
sensory perception of touch GO:0050975 2 0.011
protein phosphorylation GO:0006468 47 0.011
Human
regulation of developmental process GO:0050793 247 0.011
positive regulation of dna templated transcription elongation GO:0032786 1 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
response to glucocorticoid GO:0051384 1 0.011
digestive tract morphogenesis GO:0048546 231 0.011
positive regulation of neurogenesis GO:0050769 24 0.011
regulation of protein metabolic process GO:0051246 56 0.011
Human
sequestering of calcium ion GO:0051208 3 0.011
negative regulation of cell differentiation GO:0045596 46 0.011
hindbrain development GO:0030902 91 0.011
phosphorylation GO:0016310 69 0.011
Human
response to biotic stimulus GO:0009607 97 0.011
response to xenobiotic stimulus GO:0009410 45 0.011
regulation of sequestering of calcium ion GO:0051282 4 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.011
intrinsic apoptotic signaling pathway GO:0097193 20 0.010
negative regulation of immune response GO:0050777 2 0.010
Worm
negative regulation of cellular metabolic process GO:0031324 77 0.010
regulation of cellular protein metabolic process GO:0032268 52 0.010
Human
regulation of nucleotide biosynthetic process GO:0030808 15 0.010
regulation of neuron differentiation GO:0045664 56 0.010
regulation of protein complex assembly GO:0043254 3 0.010
indole containing compound metabolic process GO:0042430 2 0.010
cellular carbohydrate metabolic process GO:0044262 4 0.010
regulation of nucleotide catabolic process GO:0030811 2 0.010
negative regulation of secretion GO:0051048 2 0.010
Human
muscle structure development GO:0061061 196 0.010
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.010

adra2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024