Danio rerio

110 known processes

adra2da

adrenergic, alpha-2D-, receptor a

(Aliases: MGC158196)

adra2da biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of purine nucleotide biosynthetic process GO:1900372 7 0.976
negative regulation of camp biosynthetic process GO:0030818 7 0.957
negative regulation of camp metabolic process GO:0030815 7 0.857
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.801
negative regulation of cyclase activity GO:0031280 6 0.764
negative regulation of lyase activity GO:0051350 6 0.723
negative regulation of purine nucleotide metabolic process GO:1900543 7 0.712
negative regulation of nucleotide biosynthetic process GO:0030809 7 0.683
regulation of cyclase activity GO:0031279 12 0.656
negative regulation of nucleotide metabolic process GO:0045980 7 0.497
regulation of lyase activity GO:0051339 12 0.479
negative regulation of cyclic nucleotide biosynthetic process GO:0030803 7 0.479
signal transduction GO:0007165 455 0.418
biosynthetic process GO:0009058 294 0.324
regulation of cyclic nucleotide metabolic process GO:0030799 15 0.255
regulation of macromolecule metabolic process GO:0060255 317 0.210
regulation of multicellular organismal development GO:2000026 223 0.198
head development GO:0060322 303 0.195
regulation of circadian rhythm GO:0042752 4 0.193
regulation of response to stimulus GO:0048583 269 0.187
sensory organ development GO:0007423 393 0.184
regulation of multicellular organismal process GO:0051239 277 0.184
hormone transport GO:0009914 2 0.180
nucleotide biosynthetic process GO:0009165 21 0.175
eye development GO:0001654 277 0.166
regulation of adenylate cyclase activity GO:0045761 6 0.166
heart process GO:0003015 71 0.165
negative regulation of cellular process GO:0048523 283 0.161
negative regulation of innate immune response GO:0045824 2 0.151
ribose phosphate biosynthetic process GO:0046390 20 0.149
adrenergic receptor signaling pathway GO:0071875 5 0.141
organic cyclic compound biosynthetic process GO:1901362 223 0.140
regulation of primary metabolic process GO:0080090 311 0.139
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.129
nucleobase containing compound biosynthetic process GO:0034654 205 0.129
establishment of localization GO:0051234 244 0.124
entrainment of circadian clock GO:0009649 2 0.122
regulation of cellular metabolic process GO:0031323 320 0.116
regulation of biological quality GO:0065008 263 0.113
regulation of biosynthetic process GO:0009889 250 0.108
circulatory system process GO:0003013 87 0.107
cellular nitrogen compound biosynthetic process GO:0044271 218 0.107
regulation of cellular biosynthetic process GO:0031326 245 0.105
negative regulation of catalytic activity GO:0043086 21 0.102
system process GO:0003008 185 0.102
regulation of camp biosynthetic process GO:0030817 9 0.100
organophosphate biosynthetic process GO:0090407 23 0.099
neurological system process GO:0050877 62 0.099
ribonucleotide biosynthetic process GO:0009260 20 0.097
negative regulation of immune response GO:0050777 2 0.097
camp biosynthetic process GO:0006171 11 0.097
death GO:0016265 121 0.094
regulation of gene expression GO:0010468 265 0.094
response to chemical GO:0042221 320 0.093
cyclic nucleotide metabolic process GO:0009187 18 0.092
cellular biosynthetic process GO:0044249 286 0.092
neuron differentiation GO:0030182 353 0.092
embryonic organ development GO:0048568 381 0.090
cyclic purine nucleotide metabolic process GO:0052652 18 0.089
regulation of metabolic process GO:0019222 359 0.087
organic substance biosynthetic process GO:1901576 289 0.086
aging GO:0007568 2 0.084
g protein coupled receptor signaling pathway GO:0007186 74 0.081
muscle cell differentiation GO:0042692 139 0.080
gene expression GO:0010467 252 0.080
hormone secretion GO:0046879 2 0.078
sleep GO:0030431 1 0.077
regulation of camp metabolic process GO:0030814 9 0.074
response to radiation GO:0009314 51 0.073
response to external stimulus GO:0009605 264 0.073
negative regulation of biological process GO:0048519 304 0.071
heart development GO:0007507 313 0.071
regulation of circadian sleep wake cycle GO:0042749 1 0.071
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.070
phototransduction GO:0007602 2 0.068
blood circulation GO:0008015 87 0.066
cellular component movement GO:0006928 335 0.065
nucleobase containing compound metabolic process GO:0006139 274 0.065
inner ear development GO:0048839 126 0.063
regulation of system process GO:0044057 40 0.061
generation of neurons GO:0048699 385 0.060
eye morphogenesis GO:0048592 144 0.060
lipid catabolic process GO:0016042 4 0.059
regulation of nitrogen compound metabolic process GO:0051171 251 0.059
regulation of ion transmembrane transporter activity GO:0032412 2 0.058
response to light stimulus GO:0009416 46 0.058
regulation of hormone secretion GO:0046883 2 0.057
sensory organ morphogenesis GO:0090596 200 0.056
cyclic nucleotide biosynthetic process GO:0009190 18 0.054
cellular aromatic compound metabolic process GO:0006725 295 0.054
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.054
single organism transport GO:0044765 206 0.052
circadian sleep wake cycle process GO:0022410 2 0.052
regulation of localization GO:0032879 104 0.051
transport GO:0006810 220 0.051
response to stress GO:0006950 263 0.050
regulation of developmental process GO:0050793 247 0.050
response to unfolded protein GO:0006986 2 0.050
single organism localization GO:1902578 225 0.049
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.048
apoptotic process GO:0006915 116 0.047
heart contraction GO:0060047 71 0.047
cellular protein catabolic process GO:0044257 4 0.046
nitrogen compound metabolic process GO:0006807 319 0.046
purine nucleotide biosynthetic process GO:0006164 20 0.046
cellular response to organic substance GO:0071310 105 0.045
regulation of protein catabolic process GO:0042176 1 0.043
cellular macromolecule metabolic process GO:0044260 391 0.043
embryonic organ morphogenesis GO:0048562 274 0.043
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.043
response to topologically incorrect protein GO:0035966 2 0.043
circadian sleep wake cycle sleep GO:0050802 1 0.043
regulation of heart contraction GO:0008016 32 0.041
brain development GO:0007420 293 0.041
organonitrogen compound metabolic process GO:1901564 74 0.041
myeloid cell homeostasis GO:0002262 56 0.040
stem cell fate commitment GO:0048865 1 0.040
regulation of signaling GO:0023051 235 0.040
homeostatic process GO:0042592 142 0.039
peptide transport GO:0015833 1 0.039
positive regulation of cellular catabolic process GO:0031331 3 0.039
regulation of rna metabolic process GO:0051252 224 0.037
cell surface receptor signaling pathway GO:0007166 325 0.037
regulation of signal transduction GO:0009966 225 0.036
cellular response to radiation GO:0071478 4 0.036
central nervous system development GO:0007417 387 0.036
regulation of anatomical structure morphogenesis GO:0022603 130 0.035
embryonic skeletal system morphogenesis GO:0048704 93 0.035
regulation of blood circulation GO:1903522 32 0.035
macromolecule biosynthetic process GO:0009059 227 0.035
organic cyclic compound metabolic process GO:1901360 301 0.035
adult behavior GO:0030534 2 0.035
negative regulation of kinase activity GO:0033673 4 0.034
glucose homeostasis GO:0042593 1 0.034
growth GO:0040007 174 0.034
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.034
single organism biosynthetic process GO:0044711 71 0.034
muscle structure development GO:0061061 196 0.034
positive regulation of catabolic process GO:0009896 4 0.034
female gonad development GO:0008585 4 0.033
regulation of systemic arterial blood pressure GO:0003073 1 0.032
camp metabolic process GO:0046058 11 0.032
neuronal action potential GO:0019228 18 0.032
cellular macromolecule biosynthetic process GO:0034645 224 0.032
determination of left right symmetry GO:0007368 179 0.032
oxoacid metabolic process GO:0043436 31 0.032
neuron development GO:0048666 262 0.032
cranial nerve development GO:0021545 42 0.031
cell motility GO:0048870 244 0.031
locomotion GO:0040011 313 0.031
determination of bilateral symmetry GO:0009855 204 0.031
nucleic acid metabolic process GO:0090304 244 0.030
axon development GO:0061564 166 0.030
nerve development GO:0021675 45 0.030
regulation of ion transmembrane transport GO:0034765 18 0.030
vasculature development GO:0001944 278 0.029
regulation of transmembrane transporter activity GO:0022898 2 0.029
retina morphogenesis in camera type eye GO:0060042 79 0.029
regulation of programmed cell death GO:0043067 101 0.029
regulation of rna biosynthetic process GO:2001141 213 0.028
camera type eye morphogenesis GO:0048593 108 0.028
heterocycle biosynthetic process GO:0018130 215 0.028
carbohydrate derivative metabolic process GO:1901135 61 0.027
er nucleus signaling pathway GO:0006984 2 0.027
circadian regulation of gene expression GO:0032922 8 0.027
retina development in camera type eye GO:0060041 146 0.027
regulation of nucleotide biosynthetic process GO:0030808 15 0.027
regulation of nucleic acid templated transcription GO:1903506 213 0.027
sensory perception GO:0007600 39 0.027
negative regulation of secretion GO:0051048 2 0.027
regulation of transcription dna templated GO:0006355 213 0.027
cell part morphogenesis GO:0032990 246 0.027
chemical homeostasis GO:0048878 49 0.027
aromatic compound biosynthetic process GO:0019438 217 0.026
endoplasmic reticulum unfolded protein response GO:0030968 2 0.026
cell cell signaling GO:0007267 52 0.025
glial cell migration GO:0008347 3 0.025
programmed cell death GO:0012501 119 0.025
larval development GO:0002164 2 0.025
olfactory lobe development GO:0021988 4 0.025
carboxylic acid metabolic process GO:0019752 22 0.025
ion transport GO:0006811 114 0.024
regionalization GO:0003002 274 0.024
blood vessel morphogenesis GO:0048514 216 0.024
circadian sleep wake cycle GO:0042745 2 0.024
cellular response to chemical stimulus GO:0070887 157 0.024
cellular response to light stimulus GO:0071482 4 0.024
negative regulation of cell differentiation GO:0045596 46 0.024
regulation of cell communication GO:0010646 232 0.023
regulation of nervous system development GO:0051960 90 0.023
nucleoside phosphate biosynthetic process GO:1901293 21 0.023
axonogenesis GO:0007409 152 0.023
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.023
skeletal system development GO:0001501 181 0.023
carbohydrate homeostasis GO:0033500 1 0.023
regulation of sequestering of calcium ion GO:0051282 4 0.023
regulation of apoptotic process GO:0042981 98 0.023
tube morphogenesis GO:0035239 349 0.023
morphogenesis of an epithelium GO:0002009 333 0.022
regulation of cell death GO:0010941 103 0.022
rna biosynthetic process GO:0032774 181 0.022
cognition GO:0050890 1 0.022
cell death GO:0008219 121 0.022
hindbrain morphogenesis GO:0021575 22 0.022
negative regulation of secretion by cell GO:1903531 2 0.022
circadian rhythm GO:0007623 19 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.021
hematopoietic or lymphoid organ development GO:0048534 191 0.021
response to organic substance GO:0010033 153 0.021
response to abiotic stimulus GO:0009628 122 0.021
organic substance transport GO:0071702 58 0.020
negative regulation of cellular biosynthetic process GO:0031327 55 0.020
cellular response to unfolded protein GO:0034620 2 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
single organism organelle organization GO:1902589 199 0.020
specification of symmetry GO:0009799 204 0.020
regulation of metal ion transport GO:0010959 4 0.020
camera type eye development GO:0043010 222 0.020
positive regulation of gene expression GO:0010628 71 0.020
negative regulation of molecular function GO:0044092 23 0.020
localization of cell GO:0051674 244 0.019
response to endogenous stimulus GO:0009719 83 0.019
cell projection organization GO:0030030 284 0.019
ion transmembrane transport GO:0034220 91 0.019
organic acid metabolic process GO:0006082 31 0.019
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.019
regulation of gastrulation GO:0010470 24 0.019
ubiquitin dependent protein catabolic process GO:0006511 3 0.019
regulation of hormone levels GO:0010817 21 0.019
inorganic cation transmembrane transport GO:0098662 50 0.019
rna metabolic process GO:0016070 219 0.019
appendage development GO:0048736 80 0.018
cellular homeostasis GO:0019725 26 0.018
cell projection morphogenesis GO:0048858 244 0.018
embryonic camera type eye development GO:0031076 29 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
negative regulation of cellular metabolic process GO:0031324 77 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
ear development GO:0043583 127 0.018
regulation of cell differentiation GO:0045595 142 0.018
regulation of ion transport GO:0043269 22 0.018
mesoderm development GO:0007498 88 0.017
epithelial tube morphogenesis GO:0060562 148 0.017
cation homeostasis GO:0055080 33 0.017
endocrine process GO:0050886 2 0.017
regeneration GO:0031099 91 0.017
cellular response to stress GO:0033554 62 0.017
response to hexose GO:0009746 3 0.017
regulation of transport GO:0051049 45 0.017
nucleic acid templated transcription GO:0097659 181 0.017
embryonic skeletal system development GO:0048706 97 0.017
neuron projection development GO:0031175 180 0.016
erythrocyte homeostasis GO:0034101 55 0.016
peptide metabolic process GO:0006518 1 0.016
neuron projection guidance GO:0097485 86 0.016
negative regulation of defense response GO:0031348 2 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
negative regulation of biosynthetic process GO:0009890 55 0.016
single organism metabolic process GO:0044710 217 0.016
purine containing compound metabolic process GO:0072521 29 0.016
negative regulation of multicellular organismal process GO:0051241 69 0.016
regulation of transporter activity GO:0032409 2 0.016
response to hormone GO:0009725 48 0.016
behavior GO:0007610 74 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
fin development GO:0033333 77 0.015
regulation of calcium ion transport GO:0051924 2 0.015
myofibril assembly GO:0030239 48 0.015
regulation of multicellular organism growth GO:0040014 4 0.015
synaptic transmission GO:0007268 35 0.015
maintenance of location GO:0051235 4 0.015
cellular chemical homeostasis GO:0055082 17 0.015
chemotaxis GO:0006935 104 0.015
cell morphogenesis GO:0000902 289 0.015
epithelial cell differentiation GO:0030855 116 0.015
cellular response to external stimulus GO:0071496 2 0.015
positive regulation of transport GO:0051050 2 0.015
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 5 0.015
response to oxygen containing compound GO:1901700 55 0.015
angiogenesis GO:0001525 158 0.015
skeletal system morphogenesis GO:0048705 102 0.015
positive regulation of multicellular organismal process GO:0051240 52 0.015
gastrulation GO:0007369 208 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
transmembrane transport GO:0055085 120 0.014
negative regulation of apoptotic process GO:0043066 55 0.014
embryonic heart tube development GO:0035050 133 0.014
regulation of protein complex assembly GO:0043254 3 0.014
cytoskeleton organization GO:0007010 96 0.014
heart morphogenesis GO:0003007 156 0.014
neuron projection morphogenesis GO:0048812 161 0.014
digestive tract development GO:0048565 265 0.014
single organism behavior GO:0044708 24 0.014
negative regulation of adenylate cyclase activity GO:0007194 6 0.014
positive regulation of cellular process GO:0048522 201 0.014
action potential GO:0001508 19 0.014
regulation of blood pressure GO:0008217 1 0.014
mechanosensory behavior GO:0007638 2 0.014
heterocycle metabolic process GO:0046483 290 0.013
cellular component morphogenesis GO:0032989 336 0.013
establishment of localization in cell GO:0051649 77 0.013
chordate embryonic development GO:0043009 271 0.013
erythrocyte development GO:0048821 24 0.013
abducens nerve development GO:0021560 1 0.013
response to drug GO:0042493 3 0.013
negative regulation of signaling GO:0023057 96 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
multicellular organism growth GO:0035264 4 0.013
mechanoreceptor differentiation GO:0042490 37 0.013
homeostasis of number of cells GO:0048872 62 0.013
response to wounding GO:0009611 116 0.013
cardiac cell development GO:0055006 21 0.013
immune system process GO:0002376 241 0.013
erythrocyte differentiation GO:0030218 54 0.013
peripheral nervous system neuron differentiation GO:0048934 28 0.013
response to carbohydrate GO:0009743 3 0.013
cellular response to oxygen containing compound GO:1901701 20 0.013
cellular component assembly GO:0022607 170 0.013
wound healing GO:0042060 90 0.012
pigmentation GO:0043473 85 0.012
positive regulation of biological process GO:0048518 253 0.012
negative regulation of protein transport GO:0051224 3 0.012
sequestering of calcium ion GO:0051208 3 0.012
negative regulation of metabolic process GO:0009892 86 0.012
endodermal cell fate specification GO:0001714 17 0.012
regulation of heart rate GO:0002027 5 0.012
proteasomal protein catabolic process GO:0010498 2 0.012
striated muscle tissue development GO:0014706 110 0.012
water homeostasis GO:0030104 4 0.012
response to organic cyclic compound GO:0014070 51 0.012
cellular response to nutrient levels GO:0031669 2 0.012
tissue regeneration GO:0042246 74 0.012
cation transmembrane transport GO:0098655 65 0.012
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
cellular ketone metabolic process GO:0042180 11 0.011
sensory perception of pain GO:0019233 1 0.011
pancreas development GO:0031016 84 0.011
response to glucose GO:0009749 3 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
small molecule metabolic process GO:0044281 77 0.011
specification of organ identity GO:0010092 2 0.011
negative regulation of protein phosphorylation GO:0001933 4 0.011
rhythmic process GO:0048511 21 0.011
central nervous system neuron differentiation GO:0021953 74 0.011
muscle organ development GO:0007517 101 0.011
transcription dna templated GO:0006351 181 0.011
meiotic nuclear division GO:0007126 4 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
amine metabolic process GO:0009308 2 0.011
actin filament based process GO:0030029 64 0.011
keratinocyte differentiation GO:0030216 0 0.011
trigeminal motor nucleus development GO:0021731 2 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
regulation of reproductive process GO:2000241 4 0.011
negative regulation of hormone secretion GO:0046888 2 0.011
regulation of sodium ion transmembrane transport GO:1902305 1 0.011
response to temperature stimulus GO:0009266 15 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.010
endodermal cell differentiation GO:0035987 19 0.010
detection of abiotic stimulus GO:0009582 24 0.010
actin cytoskeleton organization GO:0030036 63 0.010
phagocytosis GO:0006909 3 0.010
phototransduction visible light GO:0007603 2 0.010
negative regulation of programmed cell death GO:0043069 58 0.010
regulation of organ growth GO:0046620 3 0.010
lipid storage GO:0019915 1 0.010
negative regulation of cell death GO:0060548 60 0.010
negative regulation of protein kinase b signaling GO:0051898 2 0.010
regulation of response to nutrient levels GO:0032107 1 0.010
regulation of cytoplasmic transport GO:1903649 4 0.010
intrinsic apoptotic signaling pathway GO:0097193 20 0.010
negative regulation of cell communication GO:0010648 96 0.010
embryonic skeletal joint development GO:0072498 3 0.010
locomotor rhythm GO:0045475 3 0.010
post embryonic organ morphogenesis GO:0048563 1 0.010
embryonic skeletal joint morphogenesis GO:0060272 3 0.010
cell migration GO:0016477 237 0.010
regulation of transmembrane transport GO:0034762 18 0.010
positive regulation of protein complex assembly GO:0031334 2 0.010

adra2da disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.013
bone disease DOID:0080001 0 0.013
disease of anatomical entity DOID:7 0 0.013
acrocephalosyndactylia DOID:12960 0 0.013
dysostosis DOID:1934 0 0.013
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.013
synostosis DOID:11971 0 0.013