Danio rerio

110 known processes

adra2db

adrenergic, alpha-2D-, receptor b

(Aliases: zgc:194662)

adra2db biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
adrenergic receptor signaling pathway GO:0071875 5 0.992
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.807
negative regulation of lyase activity GO:0051350 6 0.786
negative regulation of innate immune response GO:0045824 2 0.713
Worm
negative regulation of camp metabolic process GO:0030815 7 0.678
negative regulation of camp biosynthetic process GO:0030818 7 0.648
negative regulation of purine nucleotide biosynthetic process GO:1900372 7 0.628
cyclic nucleotide metabolic process GO:0009187 18 0.624
regulation of adenylate cyclase activity GO:0045761 6 0.620
aromatic compound biosynthetic process GO:0019438 217 0.602
organophosphate biosynthetic process GO:0090407 23 0.585
camp biosynthetic process GO:0006171 11 0.533
negative regulation of purine nucleotide metabolic process GO:1900543 7 0.518
regulation of nitrogen compound metabolic process GO:0051171 251 0.514
negative regulation of nucleotide biosynthetic process GO:0030809 7 0.492
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.490
nucleobase containing compound biosynthetic process GO:0034654 205 0.489
response to stress GO:0006950 263 0.471
Worm
negative regulation of cyclase activity GO:0031280 6 0.469
purine nucleotide biosynthetic process GO:0006164 20 0.451
negative regulation of nucleotide metabolic process GO:0045980 7 0.413
regulation of camp biosynthetic process GO:0030817 9 0.411
cyclic purine nucleotide metabolic process GO:0052652 18 0.403
negative regulation of cyclic nucleotide biosynthetic process GO:0030803 7 0.392
embryonic organ morphogenesis GO:0048562 274 0.387
heterocycle biosynthetic process GO:0018130 215 0.385
organic substance biosynthetic process GO:1901576 289 0.347
camp metabolic process GO:0046058 11 0.341
negative regulation of biological process GO:0048519 304 0.338
organic cyclic compound biosynthetic process GO:1901362 223 0.334
digestive system development GO:0055123 289 0.327
cellular macromolecule metabolic process GO:0044260 391 0.302
ribonucleotide biosynthetic process GO:0009260 20 0.291
cellular nitrogen compound biosynthetic process GO:0044271 218 0.285
regulation of primary metabolic process GO:0080090 311 0.251
signal transduction GO:0007165 455 0.209
cellular biosynthetic process GO:0044249 286 0.205
nucleotide biosynthetic process GO:0009165 21 0.205
regulation of macromolecule metabolic process GO:0060255 317 0.204
g protein coupled receptor signaling pathway GO:0007186 74 0.204
regulation of cellular metabolic process GO:0031323 320 0.176
generation of neurons GO:0048699 385 0.174
cyclic nucleotide biosynthetic process GO:0009190 18 0.172
biosynthetic process GO:0009058 294 0.171
nitrogen compound metabolic process GO:0006807 319 0.166
regulation of biosynthetic process GO:0009889 250 0.164
single organism localization GO:1902578 225 0.147
nucleoside phosphate biosynthetic process GO:1901293 21 0.146
heterocycle metabolic process GO:0046483 290 0.142
negative regulation of catalytic activity GO:0043086 21 0.142
negative regulation of biosynthetic process GO:0009890 55 0.140
regulation of response to stimulus GO:0048583 269 0.139
Worm
cellular nitrogen compound metabolic process GO:0034641 290 0.137
immune system process GO:0002376 241 0.136
Worm
nucleobase containing compound metabolic process GO:0006139 274 0.134
regulation of metabolic process GO:0019222 359 0.133
negative regulation of cellular process GO:0048523 283 0.130
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.130
regulation of cyclase activity GO:0031279 12 0.129
cell surface receptor signaling pathway GO:0007166 325 0.129
ribose phosphate biosynthetic process GO:0046390 20 0.127
blood circulation GO:0008015 87 0.126
Zebrafish
negative regulation of metabolic process GO:0009892 86 0.123
positive regulation of transport GO:0051050 2 0.121
muscle cell development GO:0055001 115 0.120
gene expression GO:0010467 252 0.119
circadian sleep wake cycle process GO:0022410 2 0.118
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.114
response to abiotic stimulus GO:0009628 122 0.114
regulation of cellular biosynthetic process GO:0031326 245 0.108
regionalization GO:0003002 274 0.101
organic cyclic compound metabolic process GO:1901360 301 0.101
negative regulation of gene expression GO:0010629 65 0.098
sleep GO:0030431 1 0.094
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.092
regulation of transcription dna templated GO:0006355 213 0.091
organonitrogen compound metabolic process GO:1901564 74 0.087
carbohydrate derivative biosynthetic process GO:1901137 43 0.087
regulation of developmental process GO:0050793 247 0.085
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.085
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 5 0.082
establishment of localization GO:0051234 244 0.081
purine containing compound biosynthetic process GO:0072522 20 0.081
regulation of systemic arterial blood pressure GO:0003073 1 0.078
regulation of circadian sleep wake cycle GO:0042749 1 0.077
regulation of multicellular organismal development GO:2000026 223 0.075
chemical homeostasis GO:0048878 49 0.075
single organism transport GO:0044765 206 0.074
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 5 0.074
sensory organ morphogenesis GO:0090596 200 0.073
regulation of protein catabolic process GO:0042176 1 0.068
defense response GO:0006952 47 0.068
Worm
regulation of camp metabolic process GO:0030814 9 0.067
regulation of rna biosynthetic process GO:2001141 213 0.066
pigmentation GO:0043473 85 0.066
phosphate containing compound metabolic process GO:0006796 108 0.065
transcription dna templated GO:0006351 181 0.063
organelle organization GO:0006996 227 0.063
signal transduction in absence of ligand GO:0038034 1 0.063
blood vessel development GO:0001568 246 0.062
appendage morphogenesis GO:0035107 56 0.061
muscle structure development GO:0061061 196 0.061
cellular aromatic compound metabolic process GO:0006725 295 0.060
rna biosynthetic process GO:0032774 181 0.060
response to chemical GO:0042221 320 0.059
Worm
regulation of rna metabolic process GO:0051252 224 0.059
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.058
single organism metabolic process GO:0044710 217 0.058
regulation of blood pressure GO:0008217 1 0.057
heart development GO:0007507 313 0.056
cellular protein catabolic process GO:0044257 4 0.056
negative regulation of molecular function GO:0044092 23 0.056
negative regulation of defense response GO:0031348 2 0.055
Worm
multicellular organism growth GO:0035264 4 0.054
regulation of signal transduction GO:0009966 225 0.053
Worm
regulation of multicellular organismal process GO:0051239 277 0.053
Zebrafish
regulation of tube size GO:0035150 2 0.053
striated muscle cell development GO:0055002 108 0.052
negative regulation of cellular metabolic process GO:0031324 77 0.052
negative regulation of response to stimulus GO:0048585 104 0.051
Worm
embryonic organ development GO:0048568 381 0.051
neuron differentiation GO:0030182 353 0.051
embryonic skeletal system morphogenesis GO:0048704 93 0.051
regulation of nucleic acid templated transcription GO:1903506 213 0.050
cellular ketone metabolic process GO:0042180 11 0.050
embryo development ending in birth or egg hatching GO:0009792 271 0.050
regulation of multicellular organism growth GO:0040014 4 0.050
negative regulation of cellular biosynthetic process GO:0031327 55 0.049
embryonic skeletal system development GO:0048706 97 0.048
regulation of macromolecule biosynthetic process GO:0010556 225 0.048
eye development GO:0001654 277 0.047
regulation of hormone secretion GO:0046883 2 0.047
circadian sleep wake cycle sleep GO:0050802 1 0.047
regulation of signaling GO:0023051 235 0.047
Worm
single organism biosynthetic process GO:0044711 71 0.047
nucleic acid metabolic process GO:0090304 244 0.047
transmembrane transport GO:0055085 120 0.046
purine containing compound metabolic process GO:0072521 29 0.046
multicellular organismal water homeostasis GO:0050891 1 0.045
cellular macromolecule biosynthetic process GO:0034645 224 0.044
cell projection organization GO:0030030 284 0.044
regulation of biological quality GO:0065008 263 0.043
Zebrafish
modification dependent macromolecule catabolic process GO:0043632 3 0.042
regulation of circadian rhythm GO:0042752 4 0.042
phosphorus metabolic process GO:0006793 109 0.042
vasculature development GO:0001944 278 0.042
head development GO:0060322 303 0.042
sensory organ development GO:0007423 393 0.042
positive regulation of rna metabolic process GO:0051254 59 0.042
negative regulation of nucleic acid templated transcription GO:1903507 45 0.041
retina development in camera type eye GO:0060041 146 0.040
immune system development GO:0002520 191 0.040
negative regulation of transcription dna templated GO:0045892 45 0.040
oxoacid metabolic process GO:0043436 31 0.040
chordate embryonic development GO:0043009 271 0.040
negative regulation of macromolecule metabolic process GO:0010605 76 0.039
circulatory system process GO:0003013 87 0.039
Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.039
response to biotic stimulus GO:0009607 97 0.038
cellular response to unfolded protein GO:0034620 2 0.038
Worm
positive regulation of cellular process GO:0048522 201 0.037
aging GO:0007568 2 0.037
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.037
regulation of gene expression GO:0010468 265 0.037
ion transport GO:0006811 114 0.036
inorganic cation transmembrane transport GO:0098662 50 0.036
medial fin morphogenesis GO:0035141 14 0.036
female gonad development GO:0008585 4 0.036
response to xenobiotic stimulus GO:0009410 45 0.035
cellular component assembly involved in morphogenesis GO:0010927 107 0.035
nucleic acid templated transcription GO:0097659 181 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.035
morphogenesis of an epithelium GO:0002009 333 0.035
muscle cell differentiation GO:0042692 139 0.034
small molecule metabolic process GO:0044281 77 0.034
negative regulation of phosphate metabolic process GO:0045936 13 0.034
regulation of lyase activity GO:0051339 12 0.034
embryonic heart tube development GO:0035050 133 0.034
locomotion GO:0040011 313 0.033
homeostatic process GO:0042592 142 0.033
single organism organelle organization GO:1902589 199 0.033
regulation of protein complex assembly GO:0043254 3 0.032
transcription from rna polymerase ii promoter GO:0006366 80 0.032
hormone secretion GO:0046879 2 0.032
ribose phosphate metabolic process GO:0019693 27 0.031
regulation of cell communication GO:0010646 232 0.031
Worm
regulation of programmed cell death GO:0043067 101 0.030
rna metabolic process GO:0016070 219 0.030
transport GO:0006810 220 0.030
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.030
amine metabolic process GO:0009308 2 0.030
growth GO:0040007 174 0.029
glucose homeostasis GO:0042593 1 0.029
ear development GO:0043583 127 0.029
circadian sleep wake cycle GO:0042745 2 0.029
response to radiation GO:0009314 51 0.029
appendage development GO:0048736 80 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.029
leukocyte proliferation GO:0070661 1 0.029
gastrulation GO:0007369 208 0.028
digestive tract morphogenesis GO:0048546 231 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.028
stem cell differentiation GO:0048863 117 0.028
system process GO:0003008 185 0.027
Zebrafish
embryonic skeletal joint development GO:0072498 3 0.027
purine nucleotide metabolic process GO:0006163 27 0.027
camera type eye development GO:0043010 222 0.027
stem cell fate commitment GO:0048865 1 0.027
cytokinesis GO:0000910 3 0.027
fin development GO:0033333 77 0.026
positive regulation of biological process GO:0048518 253 0.026
cellular carbohydrate metabolic process GO:0044262 4 0.026
ion transmembrane transport GO:0034220 91 0.026
negative regulation of signaling GO:0023057 96 0.026
cellular component movement GO:0006928 335 0.026
organelle assembly GO:0070925 110 0.026
purine ribonucleotide biosynthetic process GO:0009152 20 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.025
peptide transport GO:0015833 1 0.025
positive regulation of nucleic acid templated transcription GO:1903508 57 0.025
negative regulation of adenylate cyclase activity GO:0007194 6 0.025
organic acid metabolic process GO:0006082 31 0.025
wound healing GO:0042060 90 0.025
lymphocyte proliferation GO:0046651 1 0.025
regulation of anatomical structure morphogenesis GO:0022603 130 0.025
hindbrain development GO:0030902 91 0.025
regulation of establishment of protein localization GO:0070201 4 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
tube morphogenesis GO:0035239 349 0.024
positive regulation of macromolecule metabolic process GO:0010604 93 0.024
regulation of transporter activity GO:0032409 2 0.024
response to wounding GO:0009611 116 0.024
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.024
maintenance of location GO:0051235 4 0.024
death GO:0016265 121 0.024
regulation of cellular ketone metabolic process GO:0010565 7 0.024
striated muscle cell differentiation GO:0051146 129 0.023
regulation of protein import into nucleus GO:0042306 2 0.023
positive regulation of secretion GO:0051047 1 0.023
negative regulation of protein transport GO:0051224 3 0.023
regulation of heart rate GO:0002027 5 0.023
Zebrafish
negative regulation of catabolic process GO:0009895 3 0.023
camera type eye morphogenesis GO:0048593 108 0.023
neuron development GO:0048666 262 0.023
startle response GO:0001964 4 0.023
pancreas development GO:0031016 84 0.023
apoptotic process GO:0006915 116 0.022
negative regulation of cell differentiation GO:0045596 46 0.022
segmentation GO:0035282 97 0.022
regulation of apoptotic process GO:0042981 98 0.022
regulation of blood vessel size GO:0050880 2 0.022
response to topologically incorrect protein GO:0035966 2 0.022
Worm
hemopoiesis GO:0030097 183 0.022
negative regulation of phosphorus metabolic process GO:0010563 13 0.022
forebrain cell migration GO:0021885 1 0.021
regulation of molecular function GO:0065009 70 0.021
eye morphogenesis GO:0048592 144 0.021
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.021
er nucleus signaling pathway GO:0006984 2 0.021
Worm
myofibril assembly GO:0030239 48 0.021
positive regulation of cellular metabolic process GO:0031325 94 0.021
carbohydrate derivative metabolic process GO:1901135 61 0.021
protein localization to nucleus GO:0034504 3 0.020
vasculogenesis GO:0001570 41 0.020
heart contraction GO:0060047 71 0.020
Zebrafish
positive regulation of catabolic process GO:0009896 4 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
sensory perception GO:0007600 39 0.020
regulation of response to stress GO:0080134 36 0.020
Worm
angiogenesis GO:0001525 158 0.019
negative regulation of immune response GO:0050777 2 0.019
Worm
cell motility GO:0048870 244 0.019
proteasomal protein catabolic process GO:0010498 2 0.019
stem cell division GO:0017145 1 0.019
regulation of phosphate metabolic process GO:0019220 43 0.019
cellular amine metabolic process GO:0044106 2 0.019
mesenchyme development GO:0060485 127 0.019
protein metabolic process GO:0019538 183 0.019
digestive tract development GO:0048565 265 0.018
inorganic ion transmembrane transport GO:0098660 57 0.018
positive regulation of metabolic process GO:0009893 108 0.018
carbohydrate homeostasis GO:0033500 1 0.018
cell part morphogenesis GO:0032990 246 0.018
intracellular estrogen receptor signaling pathway GO:0030520 3 0.018
response to nutrient GO:0007584 3 0.018
larval development GO:0002164 2 0.018
response to other organism GO:0051707 97 0.017
ribonucleotide metabolic process GO:0009259 27 0.017
developmental growth GO:0048589 166 0.017
mononuclear cell proliferation GO:0032943 1 0.017
somite development GO:0061053 96 0.017
positive regulation of cellular biosynthetic process GO:0031328 68 0.017
regulation of growth GO:0040008 42 0.017
response to vitamin GO:0033273 3 0.017
nucleotide metabolic process GO:0009117 28 0.017
regulation of cell differentiation GO:0045595 142 0.017
intracellular signal transduction GO:0035556 85 0.016
localization of cell GO:0051674 244 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
negative regulation of muscle tissue development GO:1901862 2 0.016
water homeostasis GO:0030104 4 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
regulation of inflammatory response GO:0050727 2 0.016
negative regulation of rna biosynthetic process GO:1902679 45 0.016
positive regulation of cellular component biogenesis GO:0044089 3 0.016
neural crest cell differentiation GO:0014033 72 0.016
cation homeostasis GO:0055080 33 0.016
response to monosaccharide GO:0034284 3 0.016
positive regulation of protein complex assembly GO:0031334 2 0.016
phototransduction GO:0007602 2 0.016
cellular component biogenesis GO:0044085 178 0.016
regulation of protein polymerization GO:0032271 2 0.015
negative regulation of protein phosphorylation GO:0001933 4 0.015
ubiquitin dependent protein catabolic process GO:0006511 3 0.015
gland development GO:0048732 143 0.015
sodium ion transport GO:0006814 24 0.015
somitogenesis GO:0001756 87 0.015
embryonic hemopoiesis GO:0035162 53 0.015
muscle organ development GO:0007517 101 0.015
cell death GO:0008219 121 0.015
regulation of response to nutrient levels GO:0032107 1 0.014
muscle tissue development GO:0060537 110 0.014
single organism nuclear import GO:1902593 3 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
regulation of blood circulation GO:1903522 32 0.014
Zebrafish
response to salt stress GO:0009651 10 0.014
abducens nerve development GO:0021560 1 0.014
response to external stimulus GO:0009605 264 0.014
cellular response to radiation GO:0071478 4 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
phagocytosis GO:0006909 3 0.013
protein import GO:0017038 3 0.013
myotube cell development GO:0014904 35 0.013
macromolecule modification GO:0043412 111 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
Worm
gastrulation with mouth forming second GO:0001702 44 0.013
axon development GO:0061564 166 0.013
embryonic skeletal joint morphogenesis GO:0060272 3 0.013
protein modification process GO:0036211 100 0.013
cellular component morphogenesis GO:0032989 336 0.013
cardiac cell development GO:0055006 21 0.013
regulation of cell motility GO:2000145 46 0.013
negative regulation of multicellular organismal process GO:0051241 69 0.013
regulation of catalytic activity GO:0050790 55 0.013
positive regulation of cell cycle GO:0045787 3 0.012
regulation of cell activation GO:0050865 1 0.012
response to light stimulus GO:0009416 46 0.012
cell migration GO:0016477 237 0.012
positive regulation of transcription dna templated GO:0045893 57 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
response to glucose GO:0009749 3 0.012
positive regulation of cell differentiation GO:0045597 30 0.012
negative regulation of kinase activity GO:0033673 4 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
cardiac muscle cell development GO:0055013 20 0.012
regulation of cell death GO:0010941 103 0.012
lipid storage GO:0019915 1 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
regeneration GO:0031099 91 0.012
cellular component assembly GO:0022607 170 0.012
positive regulation of biosynthetic process GO:0009891 68 0.012
response to oxygen levels GO:0070482 25 0.012
immune response GO:0006955 28 0.012
Worm
neuron projection development GO:0031175 180 0.012
cardiac cell fate commitment GO:0060911 1 0.012
determination of bilateral symmetry GO:0009855 204 0.012
trigeminal motor nucleus development GO:0021731 2 0.012
cellular response to nutrient levels GO:0031669 2 0.012
positive regulation of gene expression GO:0010628 71 0.012
regulation of growth rate GO:0040009 1 0.012
negative regulation of rna metabolic process GO:0051253 48 0.011
skeletal muscle organ development GO:0060538 78 0.011
cell proliferation GO:0008283 80 0.011
regulation of transmembrane transporter activity GO:0022898 2 0.011
regulation of nucleotide biosynthetic process GO:0030808 15 0.011
morphogenesis of an epithelial sheet GO:0002011 49 0.011
epithelial cell differentiation GO:0030855 116 0.011
cellular response to light stimulus GO:0071482 4 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
proteolysis GO:0006508 38 0.011
cell projection morphogenesis GO:0048858 244 0.011
female sex differentiation GO:0046660 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
negative regulation of feeding behavior GO:2000252 2 0.010
regulation of water loss via skin GO:0033561 1 0.010
negative regulation of secretion GO:0051048 2 0.010
regulation of cellular protein catabolic process GO:1903362 1 0.010
retinal ganglion cell axon guidance GO:0031290 35 0.010
organophosphate metabolic process GO:0019637 37 0.010
regulation of skeletal muscle tissue development GO:0048641 4 0.010

adra2db disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
sensory system disease DOID:0050155 0 0.017
eye and adnexa disease DOID:1492 0 0.017
nervous system disease DOID:863 0 0.017
pfeiffer syndrome DOID:14705 0 0.013
bone development disease DOID:0080006 0 0.013
bone disease DOID:0080001 0 0.013
acrocephalosyndactylia DOID:12960 0 0.013
dysostosis DOID:1934 0 0.013
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.013
synostosis DOID:11971 0 0.013
orofacial cleft DOID:0050567 0 0.010
physical disorder DOID:0080015 0 0.010