Danio rerio

21 known processes

agr2

anterior gradient homolog 2 (Xenopus laevis)

(Aliases: MGC112187,zgc:112187,wu:fj29g05)

agr2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular sodium ion homeostasis GO:0006883 1 0.489
sensory organ development GO:0007423 393 0.368
single organism localization GO:1902578 225 0.283
Mouse
amide transport GO:0042886 12 0.282
regulation of sodium ion transport GO:0002028 2 0.279
regulation of metal ion transport GO:0010959 4 0.278
membrane repolarization GO:0086009 2 0.257
inorganic ion transmembrane transport GO:0098660 57 0.248
response to chemical GO:0042221 320 0.207
purine nucleoside monophosphate catabolic process GO:0009128 4 0.207
nucleoside monophosphate catabolic process GO:0009125 4 0.191
peptide transport GO:0015833 1 0.186
inorganic cation transmembrane transport GO:0098662 50 0.186
negative regulation of heart contraction GO:0045822 2 0.180
regulation of cellular metabolic process GO:0031323 320 0.176
larval development GO:0002164 2 0.173
response to abiotic stimulus GO:0009628 122 0.168
regulation of metabolic process GO:0019222 359 0.166
response to oxygen containing compound GO:1901700 55 0.160
aging GO:0007568 2 0.155
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.151
specification of organ axis polarity GO:0010084 2 0.148
brain development GO:0007420 293 0.141
positive regulation of cellular process GO:0048522 201 0.135
specification of axis polarity GO:0065001 4 0.134
positive regulation of blood circulation GO:1903524 2 0.131
organonitrogen compound metabolic process GO:1901564 74 0.129
positive regulation of transport GO:0051050 2 0.129
negative regulation of blood circulation GO:1903523 2 0.125
sodium ion transport GO:0006814 24 0.116
transmembrane transport GO:0055085 120 0.113
transport GO:0006810 220 0.108
Mouse
response to lipid GO:0033993 60 0.104
establishment of endothelial barrier GO:0061028 3 0.100
response to biotic stimulus GO:0009607 97 0.098
nitrogen compound transport GO:0071705 23 0.097
nucleobase containing compound metabolic process GO:0006139 274 0.094
ribonucleoside monophosphate catabolic process GO:0009158 4 0.091
tube morphogenesis GO:0035239 349 0.091
adult behavior GO:0030534 2 0.090
response to nutrient GO:0007584 3 0.088
regulation of cardiac muscle contraction GO:0055117 2 0.085
heterocycle metabolic process GO:0046483 290 0.084
membrane hyperpolarization GO:0060081 1 0.082
leukocyte proliferation GO:0070661 1 0.080
metal ion transport GO:0030001 58 0.080
atp catabolic process GO:0006200 4 0.078
negative regulation of metabolic process GO:0009892 86 0.078
cell migration GO:0016477 237 0.075
response to drug GO:0042493 3 0.073
embryonic organ development GO:0048568 381 0.072
single organism metabolic process GO:0044710 217 0.069
cell migration involved in heart formation GO:0060974 10 0.066
cellular response to external stimulus GO:0071496 2 0.065
regulation of primary metabolic process GO:0080090 311 0.064
morphogenesis of an epithelium GO:0002009 333 0.059
collagen biosynthetic process GO:0032964 2 0.059
cellular response to lipid GO:0071396 39 0.058
system process GO:0003008 185 0.058
homeostatic process GO:0042592 142 0.056
regulation of blood pressure GO:0008217 1 0.056
cation transmembrane transport GO:0098655 65 0.055
glucocorticoid metabolic process GO:0008211 2 0.054
positive regulation of heart contraction GO:0045823 2 0.053
cellular aromatic compound metabolic process GO:0006725 295 0.052
regulation of localization GO:0032879 104 0.051
positive regulation of biological process GO:0048518 253 0.050
monovalent inorganic cation transport GO:0015672 42 0.050
protein localization to nucleus GO:0034504 3 0.049
multi organism reproductive process GO:0044703 36 0.049
developmental growth GO:0048589 166 0.048
regulation of cytoplasmic transport GO:1903649 4 0.048
polyol transport GO:0015791 7 0.046
nitrogen compound metabolic process GO:0006807 319 0.046
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.045
phosphate containing compound metabolic process GO:0006796 108 0.045
regulation of striated muscle contraction GO:0006942 2 0.045
angiogenesis GO:0001525 158 0.043
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.042
negative regulation of multicellular organismal process GO:0051241 69 0.042
cellular response to chemical stimulus GO:0070887 157 0.042
multicellular organismal macromolecule metabolic process GO:0044259 2 0.042
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.041
regulation of establishment of protein localization GO:0070201 4 0.041
regulation of actin filament based movement GO:1903115 1 0.040
regulation of erk1 and erk2 cascade GO:0070372 4 0.040
ear development GO:0043583 127 0.040
establishment of localization GO:0051234 244 0.040
Mouse
response to temperature stimulus GO:0009266 15 0.040
regulation of multicellular organism growth GO:0040014 4 0.040
locomotion GO:0040011 313 0.039
hormone metabolic process GO:0042445 19 0.039
blood vessel development GO:0001568 246 0.039
fluid transport GO:0042044 17 0.039
lipid digestion GO:0044241 3 0.039
neural tube patterning GO:0021532 33 0.039
negative regulation of map kinase activity GO:0043407 2 0.039
embryo development ending in birth or egg hatching GO:0009792 271 0.038
direct ossification GO:0036072 3 0.038
response to radiation GO:0009314 51 0.037
mononuclear cell proliferation GO:0032943 1 0.037
synaptic growth at neuromuscular junction GO:0051124 2 0.037
response to organic substance GO:0010033 153 0.037
lateral line development GO:0048882 66 0.037
lateral line system development GO:0048925 76 0.037
small molecule metabolic process GO:0044281 77 0.037
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.037
cell cell signaling GO:0007267 52 0.036
cellular component biogenesis GO:0044085 178 0.036
regulation of ion transport GO:0043269 22 0.035
osteoclast development GO:0036035 1 0.035
regulation of hormone levels GO:0010817 21 0.035
response to endogenous stimulus GO:0009719 83 0.035
positive regulation of protein polymerization GO:0032273 2 0.035
response to corticosteroid GO:0031960 1 0.034
cardiac muscle cell contraction GO:0086003 1 0.034
cellular response to organic cyclic compound GO:0071407 38 0.034
ion transport GO:0006811 114 0.034
intramembranous ossification GO:0001957 3 0.034
hormone transport GO:0009914 2 0.033
water transport GO:0006833 15 0.033
cell morphogenesis GO:0000902 289 0.033
regulation of reproductive process GO:2000241 4 0.033
response to external stimulus GO:0009605 264 0.033
otolith development GO:0048840 32 0.032
renal absorption GO:0070293 1 0.031
regulation of intracellular protein transport GO:0033157 3 0.031
cell motility GO:0048870 244 0.031
skeletal muscle organ development GO:0060538 78 0.030
reproductive process GO:0022414 40 0.030
vasculature development GO:0001944 278 0.030
signal transduction GO:0007165 455 0.030
organic cyclic compound metabolic process GO:1901360 301 0.030
eye development GO:0001654 277 0.030
development of primary female sexual characteristics GO:0046545 4 0.030
response to oxygen levels GO:0070482 25 0.030
regulation of gene expression GO:0010468 265 0.029
multi organism process GO:0051704 134 0.029
respiratory system development GO:0060541 5 0.029
Mouse
sexual reproduction GO:0019953 36 0.029
determination of bilateral symmetry GO:0009855 204 0.029
pancreas development GO:0031016 84 0.029
inorganic anion transport GO:0015698 25 0.029
regulation of nucleic acid templated transcription GO:1903506 213 0.028
sensory system development GO:0048880 76 0.028
embryonic heart tube morphogenesis GO:0003143 108 0.028
response to vitamin GO:0033273 3 0.028
regulation of cardiac muscle cell contraction GO:0086004 1 0.028
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.028
blood vessel morphogenesis GO:0048514 216 0.027
response to steroid hormone GO:0048545 35 0.027
cell death GO:0008219 121 0.027
regulation of muscle contraction GO:0006937 3 0.027
ion transmembrane transport GO:0034220 91 0.026
cellular nitrogen compound metabolic process GO:0034641 290 0.026
central nervous system development GO:0007417 387 0.025
reflex GO:0060004 2 0.025
otic vesicle morphogenesis GO:0071600 34 0.024
cation homeostasis GO:0055080 33 0.024
neuromuscular synaptic transmission GO:0007274 2 0.024
cellular response to biotic stimulus GO:0071216 3 0.024
regulation of protein transport GO:0051223 3 0.024
dorsal ventral pattern formation GO:0009953 125 0.023
ventricular system development GO:0021591 12 0.023
hydrogen peroxide metabolic process GO:0042743 2 0.023
biosynthetic process GO:0009058 294 0.023
epithelial tube morphogenesis GO:0060562 148 0.023
response to glucose GO:0009749 3 0.023
cellular component assembly GO:0022607 170 0.023
regulation of cellular biosynthetic process GO:0031326 245 0.023
regulation of calcium ion transport GO:0051924 2 0.023
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.022
heart looping GO:0001947 94 0.022
regionalization GO:0003002 274 0.022
phagocytosis GO:0006909 3 0.022
localization of cell GO:0051674 244 0.022
response to monosaccharide GO:0034284 3 0.022
regulation of biosynthetic process GO:0009889 250 0.022
regulation of oocyte development GO:0060281 3 0.022
organelle fusion GO:0048284 3 0.021
specification of symmetry GO:0009799 204 0.021
cellular component movement GO:0006928 335 0.021
rna metabolic process GO:0016070 219 0.021
camera type eye development GO:0043010 222 0.021
protein secretion GO:0009306 1 0.021
reproduction GO:0000003 40 0.021
female sex differentiation GO:0046660 4 0.020
chemical homeostasis GO:0048878 49 0.020
positive regulation of striated muscle tissue development GO:0045844 1 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
multicellular organismal metabolic process GO:0044236 2 0.020
endodermal cell fate commitment GO:0001711 18 0.020
camera type eye morphogenesis GO:0048593 108 0.020
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.020
death GO:0016265 121 0.020
regulation of cell shape GO:0008360 1 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
amine metabolic process GO:0009308 2 0.019
regulation of rna biosynthetic process GO:2001141 213 0.019
growth GO:0040007 174 0.019
membrane raft organization GO:0031579 1 0.019
cellular response to steroid hormone stimulus GO:0071383 31 0.019
cellular component morphogenesis GO:0032989 336 0.019
regulation of multicellular organismal process GO:0051239 277 0.019
negative regulation of kinase activity GO:0033673 4 0.019
germ cell development GO:0007281 22 0.019
gene expression GO:0010467 252 0.019
endothelial cell differentiation GO:0045446 20 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
regulation of ion transmembrane transporter activity GO:0032412 2 0.018
response to virus GO:0009615 21 0.018
regulation of protein localization to nucleus GO:1900180 2 0.018
osteoclast differentiation GO:0030316 1 0.018
oligopeptide transport GO:0006857 1 0.018
semicircular canal morphogenesis GO:0048752 18 0.018
chloride transmembrane transport GO:1902476 4 0.018
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
collagen metabolic process GO:0032963 2 0.018
cellular response to molecule of bacterial origin GO:0071219 3 0.018
lymphocyte proliferation GO:0046651 1 0.018
carbohydrate derivative metabolic process GO:1901135 61 0.018
intracellular signal transduction GO:0035556 85 0.018
erk1 and erk2 cascade GO:0070371 4 0.018
central nervous system myelination GO:0022010 2 0.018
actin filament based movement GO:0030048 1 0.017
renal system development GO:0072001 94 0.017
plasma membrane repair GO:0001778 2 0.017
regulation of epithelial cell proliferation GO:0050678 3 0.017
rostrocaudal neural tube patterning GO:0021903 29 0.017
response to arsenic containing substance GO:0046685 5 0.017
central nervous system myelin formation GO:0032289 1 0.017
intestinal absorption GO:0050892 2 0.017
gamete generation GO:0007276 33 0.017
positive regulation of catabolic process GO:0009896 4 0.017
regulation of hormone secretion GO:0046883 2 0.017
behavior GO:0007610 74 0.017
single organism transport GO:0044765 206 0.017
Mouse
response to external biotic stimulus GO:0043207 97 0.016
regulation of biological quality GO:0065008 263 0.016
Mouse
one carbon compound transport GO:0019755 14 0.016
inner ear development GO:0048839 126 0.016
negative regulation of biological process GO:0048519 304 0.016
limb bud formation GO:0060174 2 0.016
anatomical structure homeostasis GO:0060249 36 0.016
ear morphogenesis GO:0042471 64 0.016
neurotransmitter transport GO:0006836 2 0.016
p38mapk cascade GO:0038066 1 0.016
regulation of protein targeting GO:1903533 2 0.015
retinoic acid metabolic process GO:0042573 9 0.015
regulation of neuronal synaptic plasticity GO:0048168 1 0.015
response to other organism GO:0051707 97 0.015
multicellular organism reproduction GO:0032504 35 0.015
cellular biosynthetic process GO:0044249 286 0.015
response to hexose GO:0009746 3 0.015
negative regulation of cellular process GO:0048523 283 0.015
cardiocyte differentiation GO:0035051 44 0.015
striated muscle cell development GO:0055002 108 0.015
response to stress GO:0006950 263 0.015
regulation of developmental process GO:0050793 247 0.015
cellular amine metabolic process GO:0044106 2 0.015
protein heterooligomerization GO:0051291 1 0.015
cellular response to nutrient levels GO:0031669 2 0.015
embryonic heart tube development GO:0035050 133 0.015
multicellular organism growth GO:0035264 4 0.015
glucose homeostasis GO:0042593 1 0.014
regulation of gtpase activity GO:0043087 2 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.014
regulation of cell communication GO:0010646 232 0.014
semicircular canal development GO:0060872 24 0.014
transcription dna templated GO:0006351 181 0.014
regulation of cell motility GO:2000145 46 0.014
positive regulation of molecular function GO:0044093 33 0.014
intracellular receptor signaling pathway GO:0030522 30 0.014
apoptotic process GO:0006915 116 0.014
hepatocyte differentiation GO:0070365 1 0.014
water homeostasis GO:0030104 4 0.014
smooth muscle contraction GO:0006939 2 0.014
actin mediated cell contraction GO:0070252 1 0.014
actin filament based process GO:0030029 64 0.014
negative regulation of cytoplasmic transport GO:1903650 2 0.014
muscle structure development GO:0061061 196 0.014
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.014
establishment of protein localization to organelle GO:0072594 4 0.014
sensory perception GO:0007600 39 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
tube formation GO:0035148 25 0.013
single organism reproductive process GO:0044702 40 0.013
cranial suture morphogenesis GO:0060363 1 0.013
phosphorus metabolic process GO:0006793 109 0.013
gtp catabolic process GO:0006184 2 0.013
mesenchymal cell proliferation GO:0010463 1 0.013
digestive tract development GO:0048565 265 0.013
multicellular organismal reproductive process GO:0048609 35 0.013
positive regulation of cell cycle GO:0045787 3 0.013
reactive oxygen species biosynthetic process GO:1903409 1 0.013
heart development GO:0007507 313 0.013
germ line stem cell division GO:0042078 1 0.013
regulation of wound healing GO:0061041 2 0.013
regulation of cell activation GO:0050865 1 0.013
regulation of endothelial cell proliferation GO:0001936 1 0.013
cell surface receptor signaling pathway GO:0007166 325 0.013
lipid storage GO:0019915 1 0.013
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
head development GO:0060322 303 0.012
carbohydrate homeostasis GO:0033500 1 0.012
endodermal cell fate specification GO:0001714 17 0.012
response to carbohydrate GO:0009743 3 0.012
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.012
response to organic cyclic compound GO:0014070 51 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.012
glucocorticoid biosynthetic process GO:0006704 1 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
positive regulation of metabolic process GO:0009893 108 0.012
embryonic digestive tract morphogenesis GO:0048557 3 0.012
multicellular organismal homeostasis GO:0048871 29 0.012
antimicrobial humoral response GO:0019730 2 0.012
cellular response to organic substance GO:0071310 105 0.012
chordate embryonic development GO:0043009 271 0.012
positive regulation of epithelial cell proliferation GO:0050679 1 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.012
establishment of localization in cell GO:0051649 77 0.012
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.012
stem cell proliferation GO:0072089 4 0.012
response to inorganic substance GO:0010035 38 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
positive regulation of translation GO:0045727 1 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
morphogenesis of an epithelial fold GO:0060571 1 0.011
protein stabilization GO:0050821 2 0.011
tissue remodeling GO:0048771 4 0.011
regulation of signal transduction GO:0009966 225 0.011
axon ensheathment in central nervous system GO:0032291 2 0.011
sensory organ morphogenesis GO:0090596 200 0.011
protein complex assembly GO:0006461 30 0.011
response to alcohol GO:0097305 14 0.011
regulation of molecular function GO:0065009 70 0.011
cellular response to reactive oxygen species GO:0034614 2 0.011
female gamete generation GO:0007292 14 0.011
regulation of programmed cell death GO:0043067 101 0.011
response to mechanical stimulus GO:0009612 24 0.011
regulation of cellular component movement GO:0051270 55 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
regulation of membrane potential GO:0042391 23 0.011
cellular response to extracellular stimulus GO:0031668 2 0.011
regulation of response to external stimulus GO:0032101 31 0.011
stem cell differentiation GO:0048863 117 0.011
positive regulation of cell activation GO:0050867 1 0.011
regulation of signaling GO:0023051 235 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
neurotransmitter secretion GO:0007269 2 0.011
nuclear transport GO:0051169 4 0.010
glomerulus vasculature development GO:0072012 2 0.010
hormone secretion GO:0046879 2 0.010
small molecule catabolic process GO:0044282 3 0.010
heart morphogenesis GO:0003007 156 0.010
cellular homeostasis GO:0019725 26 0.010
negative regulation of multi organism process GO:0043901 3 0.010
positive regulation of locomotion GO:0040017 14 0.010
myelin assembly GO:0032288 1 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
regulation of hydrolase activity GO:0051336 28 0.010
detection of mechanical stimulus involved in sensory perception of sound GO:0050910 3 0.010
actin filament polymerization GO:0030041 2 0.010
oocyte anterior posterior axis specification GO:0007314 4 0.010

agr2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.073
cardiovascular system disease DOID:1287 0 0.049
musculoskeletal system disease DOID:17 0 0.027
artery disease DOID:0050828 0 0.015
vascular disease DOID:178 0 0.015
bone remodeling disease DOID:0080005 0 0.011
bone disease DOID:0080001 0 0.011
connective tissue disease DOID:65 0 0.011