Danio rerio

34 known processes

ap1m2

adaptor-related protein complex 1, mu 2 subunit

(Aliases: Ap1m1,MGC103537,zgc:103537)

ap1m2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular process GO:0048522 201 0.352
regulation of biological quality GO:0065008 263 0.225
response to drug GO:0042493 3 0.169
hormone transport GO:0009914 2 0.154
aging GO:0007568 2 0.143
hormone secretion GO:0046879 2 0.109
regulation of hormone secretion GO:0046883 2 0.108
negative regulation of biological process GO:0048519 304 0.103
positive regulation of cellular component biogenesis GO:0044089 3 0.102
regulation of metabolic process GO:0019222 359 0.100
response to external stimulus GO:0009605 264 0.100
locomotion GO:0040011 313 0.095
Worm
positive regulation of cellular catabolic process GO:0031331 3 0.085
regulation of cell communication GO:0010646 232 0.083
multicellular organismal homeostasis GO:0048871 29 0.082
transport GO:0006810 220 0.078
regulation of autophagy GO:0010506 3 0.078
establishment of localization GO:0051234 244 0.077
regulation of response to stimulus GO:0048583 269 0.077
cellular macromolecule metabolic process GO:0044260 391 0.074
regulation of multicellular organism growth GO:0040014 4 0.073
regulation of response to nutrient levels GO:0032107 1 0.072
organonitrogen compound metabolic process GO:1901564 74 0.069
cellular response to nutrient levels GO:0031669 2 0.069
guanosine containing compound metabolic process GO:1901068 4 0.068
small molecule metabolic process GO:0044281 77 0.064
nucleoside monophosphate catabolic process GO:0009125 4 0.064
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.063
regulation of developmental process GO:0050793 247 0.063
regulation of carbohydrate metabolic process GO:0006109 4 0.062
type b pancreatic cell development GO:0003323 4 0.062
regulation of primary metabolic process GO:0080090 311 0.062
organic acid metabolic process GO:0006082 31 0.062
guanosine containing compound catabolic process GO:1901069 2 0.062
carbohydrate derivative metabolic process GO:1901135 61 0.060
cellular aromatic compound metabolic process GO:0006725 295 0.058
positive regulation of transport GO:0051050 2 0.057
cellular nitrogen compound metabolic process GO:0034641 290 0.057
autophagy GO:0006914 4 0.057
peptide transport GO:0015833 1 0.057
monovalent inorganic cation transport GO:0015672 42 0.056
single organism transport GO:0044765 206 0.054
cell motility GO:0048870 244 0.053
organic cyclic compound biosynthetic process GO:1901362 223 0.053
atp catabolic process GO:0006200 4 0.053
phagocytosis GO:0006909 3 0.053
single organism metabolic process GO:0044710 217 0.052
cellular carbohydrate metabolic process GO:0044262 4 0.052
negative regulation of cellular process GO:0048523 283 0.052
oxoacid metabolic process GO:0043436 31 0.051
nucleoside phosphate metabolic process GO:0006753 28 0.051
killing of cells in other organism involved in symbiotic interaction GO:0051883 1 0.050
nitrogen compound metabolic process GO:0006807 319 0.050
nucleobase containing compound metabolic process GO:0006139 274 0.049
xenobiotic metabolic process GO:0006805 4 0.049
regulation of purine nucleotide catabolic process GO:0033121 2 0.049
nucleic acid templated transcription GO:0097659 181 0.049
macroautophagy GO:0016236 1 0.047
gtp metabolic process GO:0046039 4 0.047
regulation of multicellular organismal development GO:2000026 223 0.047
regulation of biosynthetic process GO:0009889 250 0.047
response to chemical GO:0042221 320 0.046
single organism localization GO:1902578 225 0.046
regulation of metal ion transport GO:0010959 4 0.046
signal transduction GO:0007165 455 0.045
homeostatic process GO:0042592 142 0.044
chordate embryonic development GO:0043009 271 0.044
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.043
cellular component morphogenesis GO:0032989 336 0.042
Worm
regulation of molecular function GO:0065009 70 0.042
aromatic compound biosynthetic process GO:0019438 217 0.041
transmembrane transport GO:0055085 120 0.041
response to nutrient GO:0007584 3 0.041
cellular biosynthetic process GO:0044249 286 0.041
regulation of gtp catabolic process GO:0033124 2 0.041
larval development GO:0002164 2 0.041
Worm
organic cyclic compound metabolic process GO:1901360 301 0.040
lipid storage GO:0019915 1 0.040
negative regulation of kinase activity GO:0033673 4 0.040
regulation of nucleotide catabolic process GO:0030811 2 0.039
mitochondrion organization GO:0007005 4 0.039
gene expression GO:0010467 252 0.038
cellular macromolecule biosynthetic process GO:0034645 224 0.038
response to other organism GO:0051707 97 0.038
positive regulation of gtpase activity GO:0043547 1 0.037
regulation of protein localization to nucleus GO:1900180 2 0.037
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.036
regulation of cellular metabolic process GO:0031323 320 0.036
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.036
positive regulation of nucleoside metabolic process GO:0045979 1 0.036
regulation of nucleoside metabolic process GO:0009118 2 0.035
response to external biotic stimulus GO:0043207 97 0.035
cellular protein metabolic process GO:0044267 129 0.035
regulation of catalytic activity GO:0050790 55 0.035
cell morphogenesis GO:0000902 289 0.035
Worm
regulation of response to oxidative stress GO:1902882 2 0.035
programmed cell death GO:0012501 119 0.034
macromolecule modification GO:0043412 111 0.034
regulation of multicellular organismal process GO:0051239 277 0.034
phosphorus metabolic process GO:0006793 109 0.034
carboxylic acid metabolic process GO:0019752 22 0.034
water homeostasis GO:0030104 4 0.034
macromolecule biosynthetic process GO:0009059 227 0.032
positive regulation of developmental process GO:0051094 50 0.032
regulation of nitrogen compound metabolic process GO:0051171 251 0.032
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.031
intracellular signal transduction GO:0035556 85 0.031
regulation of phosphate metabolic process GO:0019220 43 0.031
negative regulation of protein kinase activity GO:0006469 4 0.031
cellular amino acid metabolic process GO:0006520 7 0.031
regulation of rna biosynthetic process GO:2001141 213 0.031
cellular ketone metabolic process GO:0042180 11 0.031
glucose homeostasis GO:0042593 1 0.031
nucleobase containing compound biosynthetic process GO:0034654 205 0.031
positive regulation of nucleotide catabolic process GO:0030813 1 0.031
cell matrix adhesion GO:0007160 4 0.031
response to biotic stimulus GO:0009607 97 0.031
regulation of response to extracellular stimulus GO:0032104 1 0.030
organic substance biosynthetic process GO:1901576 289 0.030
cellular response to starvation GO:0009267 1 0.030
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.030
purine nucleoside monophosphate catabolic process GO:0009128 4 0.030
negative regulation of programmed cell death GO:0043069 58 0.030
regulation of membrane potential GO:0042391 23 0.029
regulation of synapse assembly GO:0051963 3 0.029
protein modification process GO:0036211 100 0.029
digestive tract development GO:0048565 265 0.029
cellular response to extracellular stimulus GO:0031668 2 0.029
negative regulation of hormone secretion GO:0046888 2 0.028
hematopoietic or lymphoid organ development GO:0048534 191 0.028
cell substrate adhesion GO:0031589 4 0.028
regulation of organ growth GO:0046620 3 0.027
negative regulation of protein phosphorylation GO:0001933 4 0.027
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.027
purine ribonucleoside metabolic process GO:0046128 10 0.027
cellular response to chemical stimulus GO:0070887 157 0.027
cellular nitrogen compound biosynthetic process GO:0044271 218 0.026
hemopoiesis GO:0030097 183 0.026
regulation of signal transduction GO:0009966 225 0.026
neurological system process GO:0050877 62 0.026
ribonucleoside monophosphate catabolic process GO:0009158 4 0.026
phosphorylation GO:0016310 69 0.026
oxidation reduction process GO:0055114 41 0.026
cellular localization GO:0051641 97 0.026
brain development GO:0007420 293 0.026
regulation of transport GO:0051049 45 0.026
heterocycle biosynthetic process GO:0018130 215 0.025
protein polyubiquitination GO:0000209 4 0.025
heterocycle metabolic process GO:0046483 290 0.025
gastrulation GO:0007369 208 0.025
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.025
cell migration GO:0016477 237 0.024
cation transmembrane transport GO:0098655 65 0.024
regulation of cytokine production GO:0001817 3 0.024
biosynthetic process GO:0009058 294 0.024
protein metabolic process GO:0019538 183 0.024
cell projection organization GO:0030030 284 0.023
Worm
gtp catabolic process GO:0006184 2 0.023
positive regulation of cytoskeleton organization GO:0051495 3 0.023
negative regulation of catalytic activity GO:0043086 21 0.023
cellular component movement GO:0006928 335 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
protein localization to nucleus GO:0034504 3 0.022
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.022
positive regulation of secretion GO:0051047 1 0.022
regulation of protein complex assembly GO:0043254 3 0.022
regulation of cell death GO:0010941 103 0.022
regulation of cell substrate adhesion GO:0010810 1 0.022
regulation of transcription dna templated GO:0006355 213 0.022
nucleic acid metabolic process GO:0090304 244 0.022
ion transmembrane transport GO:0034220 91 0.022
response to temperature stimulus GO:0009266 15 0.022
negative regulation of macromolecule metabolic process GO:0010605 76 0.022
positive regulation of catabolic process GO:0009896 4 0.022
lipid oxidation GO:0034440 1 0.022
regulation of cell development GO:0060284 100 0.021
response to uv GO:0009411 3 0.021
cell projection morphogenesis GO:0048858 244 0.021
Worm
regulation of anatomical structure morphogenesis GO:0022603 130 0.021
regulation of hormone levels GO:0010817 21 0.020
liver development GO:0001889 96 0.020
cellular modified amino acid metabolic process GO:0006575 3 0.020
negative regulation of multicellular organismal process GO:0051241 69 0.020
cell death GO:0008219 121 0.020
regulation of oxidative stress induced cell death GO:1903201 2 0.020
fat soluble vitamin metabolic process GO:0006775 4 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.019
embryo development ending in birth or egg hatching GO:0009792 271 0.019
Worm
death GO:0016265 121 0.019
cellular protein modification process GO:0006464 100 0.019
endoplasmic reticulum unfolded protein response GO:0030968 2 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
negative regulation of cell death GO:0060548 60 0.019
regulation of dendrite development GO:0050773 3 0.019
morphogenesis of an epithelium GO:0002009 333 0.019
system process GO:0003008 185 0.019
rna metabolic process GO:0016070 219 0.018
positive regulation of multicellular organismal process GO:0051240 52 0.018
membrane fusion GO:0061025 2 0.018
lipid homeostasis GO:0055088 3 0.018
glucocorticoid metabolic process GO:0008211 2 0.018
immune system process GO:0002376 241 0.018
Worm
regulation of blood pressure GO:0008217 1 0.018
regulation of localization GO:0032879 104 0.018
growth GO:0040007 174 0.018
negative regulation of protein import into nucleus GO:0042308 2 0.018
cellular response to hypoxia GO:0071456 1 0.018
peptidyl serine phosphorylation GO:0018105 1 0.018
regulation of cellular response to oxidative stress GO:1900407 2 0.018
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.018
ion transport GO:0006811 114 0.018
negative regulation of secretion by cell GO:1903531 2 0.018
regulation of signaling GO:0023051 235 0.018
swimming behavior GO:0036269 8 0.017
maintenance of location GO:0051235 4 0.017
disruption of cells of other organism GO:0044364 1 0.017
regulation of protein catabolic process GO:0042176 1 0.017
cellular response to external stimulus GO:0071496 2 0.017
actin filament based process GO:0030029 64 0.017
regulation of cell matrix adhesion GO:0001952 1 0.017
sensory organ development GO:0007423 393 0.017
peptide metabolic process GO:0006518 1 0.017
positive regulation of protein complex assembly GO:0031334 2 0.017
immune system development GO:0002520 191 0.017
regulation of sodium ion transport GO:0002028 2 0.017
nucleobase containing small molecule metabolic process GO:0055086 32 0.016
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.016
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.016
positive regulation of catalytic activity GO:0043085 25 0.016
multicellular organism growth GO:0035264 4 0.016
hydrogen peroxide metabolic process GO:0042743 2 0.016
positive regulation of biological process GO:0048518 253 0.016
negative regulation of cellular metabolic process GO:0031324 77 0.016
cell killing GO:0001906 2 0.016
regulation of cellular component organization GO:0051128 86 0.016
regulation of gene expression GO:0010468 265 0.016
negative regulation of dna replication GO:0008156 2 0.016
regulation of gtpase activity GO:0043087 2 0.016
cellular respiration GO:0045333 3 0.016
nucleotide metabolic process GO:0009117 28 0.015
protein import into nucleus GO:0006606 3 0.015
regulation of endocrine process GO:0044060 2 0.015
cell projection assembly GO:0030031 64 0.015
Worm
monocyte differentiation GO:0030224 2 0.015
cellular response to radiation GO:0071478 4 0.015
amide transport GO:0042886 12 0.015
organic substance transport GO:0071702 58 0.015
Worm
regulation of apoptotic process GO:0042981 98 0.015
nuclear export GO:0051168 1 0.015
adult behavior GO:0030534 2 0.015
killing of cells of other organism GO:0031640 1 0.015
negative regulation of cellular biosynthetic process GO:0031327 55 0.015
cellular response to oxygen levels GO:0071453 1 0.015
regulation of rna metabolic process GO:0051252 224 0.015
zymogen activation GO:0031638 3 0.015
regulation of response to external stimulus GO:0032101 31 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
negative regulation of rna metabolic process GO:0051253 48 0.015
adherens junction organization GO:0034332 4 0.015
long chain fatty acid metabolic process GO:0001676 1 0.015
negative regulation of protein localization to nucleus GO:1900181 2 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.014
negative regulation of cytoplasmic transport GO:1903650 2 0.014
embryonic hemopoiesis GO:0035162 53 0.014
protein localization to plasma membrane GO:0072659 1 0.014
negative regulation of molecular function GO:0044092 23 0.014
gland development GO:0048732 143 0.014
cellular response to stress GO:0033554 62 0.014
regulation of heart growth GO:0060420 2 0.014
nitrogen compound transport GO:0071705 23 0.014
positive regulation of gtp catabolic process GO:0033126 1 0.014
positive regulation of epithelial cell differentiation GO:0030858 2 0.014
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.014
regulation of dendrite morphogenesis GO:0048814 3 0.014
heart contraction GO:0060047 71 0.014
positive regulation of macromolecule metabolic process GO:0010604 93 0.014
cellular protein catabolic process GO:0044257 4 0.014
regulation of striated muscle contraction GO:0006942 2 0.014
energy reserve metabolic process GO:0006112 2 0.014
regulation of cytoplasmic transport GO:1903649 4 0.014
cellular amine metabolic process GO:0044106 2 0.014
regulation of neurogenesis GO:0050767 87 0.014
positive regulation of signaling GO:0023056 56 0.014
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.014
negative regulation of stem cell differentiation GO:2000737 2 0.013
cell cell signaling GO:0007267 52 0.013
regulation of transporter activity GO:0032409 2 0.013
regulation of synapse organization GO:0050807 3 0.013
response to glucose GO:0009749 3 0.013
regulation of cellular biosynthetic process GO:0031326 245 0.013
myeloid cell differentiation GO:0030099 86 0.013
apoptotic process involved in development GO:1902742 2 0.013
response to ketone GO:1901654 1 0.013
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.013
vitamin biosynthetic process GO:0009110 2 0.013
regulation of phosphorus metabolic process GO:0051174 43 0.013
regulation of neuron differentiation GO:0045664 56 0.013
steroid hormone secretion GO:0035929 1 0.013
negative regulation of signaling GO:0023057 96 0.013
response to inorganic substance GO:0010035 38 0.013
enteroendocrine cell differentiation GO:0035883 9 0.013
cellular catabolic process GO:0044248 27 0.013
regulation of circadian rhythm GO:0042752 4 0.013
amine metabolic process GO:0009308 2 0.013
cellular response to unfolded protein GO:0034620 2 0.013
positive regulation of cell development GO:0010720 25 0.013
transcription dna templated GO:0006351 181 0.013
response to stress GO:0006950 263 0.013
Worm
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.013
regulation of steroid hormone secretion GO:2000831 1 0.013
negative regulation of rna biosynthetic process GO:1902679 45 0.013
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.012
generation of neurons GO:0048699 385 0.012
regulation of protein binding GO:0043393 3 0.012
endosome organization GO:0007032 2 0.012
developmental growth involved in morphogenesis GO:0060560 86 0.012
multicellular organismal signaling GO:0035637 22 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
carbohydrate homeostasis GO:0033500 1 0.012
regulation of protein transport GO:0051223 3 0.012
organophosphate metabolic process GO:0019637 37 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
regulation of tube size GO:0035150 2 0.012
regulation of postsynaptic membrane potential GO:0060078 1 0.012
negative regulation of intracellular protein transport GO:0090317 3 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
cell death in response to oxidative stress GO:0036473 2 0.012
inorganic ion transmembrane transport GO:0098660 57 0.012
purine nucleotide metabolic process GO:0006163 27 0.012
apoptotic process involved in morphogenesis GO:0060561 2 0.012
neuron differentiation GO:0030182 353 0.012
membrane invagination GO:0010324 1 0.012
cell part morphogenesis GO:0032990 246 0.012
Worm
positive regulation of secretion by cell GO:1903532 1 0.012
triglyceride homeostasis GO:0070328 2 0.012
response to carbohydrate GO:0009743 3 0.012
regulation of cellular component movement GO:0051270 55 0.012
cell surface receptor signaling pathway GO:0007166 325 0.012
sensory system development GO:0048880 76 0.012
hepaticobiliary system development GO:0061008 98 0.011
negative regulation of cell communication GO:0010648 96 0.011
cellular response to topologically incorrect protein GO:0035967 2 0.011
regulation of growth rate GO:0040009 1 0.011
regulation of dna replication GO:0006275 3 0.011
positive regulation of carbohydrate metabolic process GO:0045913 1 0.011
er nucleus signaling pathway GO:0006984 2 0.011
ribose phosphate metabolic process GO:0019693 27 0.011
organelle assembly GO:0070925 110 0.011
Worm
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
inorganic cation transmembrane transport GO:0098662 50 0.011
protein dephosphorylation GO:0006470 3 0.011
transmission of nerve impulse GO:0019226 19 0.011
endocrine hormone secretion GO:0060986 2 0.011
purine ribonucleotide metabolic process GO:0009150 27 0.011
nuclear import GO:0051170 3 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
regulation of cardiac muscle contraction GO:0055117 2 0.011
positive regulation of cell adhesion GO:0045785 1 0.011
myelin assembly GO:0032288 1 0.011
fat soluble vitamin biosynthetic process GO:0042362 2 0.011
protein acetylation GO:0006473 2 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
cellular amide metabolic process GO:0043603 4 0.011
apoptotic process GO:0006915 116 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
regulation of cell killing GO:0031341 2 0.011
regulation of response to biotic stimulus GO:0002831 2 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
regulation of binding GO:0051098 3 0.010
neural tube patterning GO:0021532 33 0.010
multi organism process GO:0051704 134 0.010
establishment of protein localization to plasma membrane GO:0090002 1 0.010
negative regulation of metabolic process GO:0009892 86 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.010
regulation of ion transmembrane transporter activity GO:0032412 2 0.010
nuclear transport GO:0051169 4 0.010
cellular component biogenesis GO:0044085 178 0.010
Worm
peptidyl lysine dimethylation GO:0018027 1 0.010
phototransduction GO:0007602 2 0.010
muscle fiber development GO:0048747 52 0.010
positive regulation of cell activation GO:0050867 1 0.010
type b pancreatic cell differentiation GO:0003309 8 0.010
negative regulation of intracellular transport GO:0032387 3 0.010
positive regulation of cellular metabolic process GO:0031325 94 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010

ap1m2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
musculoskeletal system disease DOID:17 0 0.046
disease of metabolism DOID:0014667 0 0.045
cardiovascular system disease DOID:1287 0 0.017
myopathy DOID:423 0 0.016
muscle tissue disease DOID:66 0 0.016
muscular disease DOID:0080000 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
cardiomyopathy DOID:0050700 0 0.015
heart disease DOID:114 0 0.015
acquired metabolic disease DOID:0060158 0 0.011
diabetes mellitus DOID:9351 0 0.011
type 2 diabetes mellitus DOID:9352 0 0.011
glucose metabolism disease DOID:4194 0 0.011
carbohydrate metabolism disease DOID:0050013 0 0.011
intrinsic cardiomyopathy DOID:0060036 0 0.010
inherited metabolic disorder DOID:655 0 0.010