Danio rerio

0 known processes

api5

apoptosis inhibitor 5

(Aliases: wu:fb26c03,zgc:66211,sr:nyz021,api5l1)

api5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of mrna splicing via spliceosome GO:0048024 3 0.956
regulation of mrna processing GO:0050684 3 0.809
alternative mrna splicing via spliceosome GO:0000380 1 0.726
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.722
mrna splicing via spliceosome GO:0000398 10 0.513
regulation of macromolecule metabolic process GO:0060255 317 0.492
rna splicing via transesterification reactions GO:0000375 10 0.430
cellular aromatic compound metabolic process GO:0006725 295 0.385
nucleobase containing compound metabolic process GO:0006139 274 0.374
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.367
rna metabolic process GO:0016070 219 0.313
larval development GO:0002164 2 0.285
gene expression GO:0010467 252 0.278
rna localization GO:0006403 4 0.265
heterocycle metabolic process GO:0046483 290 0.253
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.239
macromolecule biosynthetic process GO:0009059 227 0.237
rna splicing GO:0008380 16 0.234
regulation of rna metabolic process GO:0051252 224 0.229
regulation of nitrogen compound metabolic process GO:0051171 251 0.226
regionalization GO:0003002 274 0.224
organic cyclic compound metabolic process GO:1901360 301 0.213
3 utr mediated mrna stabilization GO:0070935 3 0.198
regulation of primary metabolic process GO:0080090 311 0.195
regulation of cellular biosynthetic process GO:0031326 245 0.192
nucleic acid metabolic process GO:0090304 244 0.190
cellular nitrogen compound metabolic process GO:0034641 290 0.187
nitrogen compound metabolic process GO:0006807 319 0.184
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.181
maternal determination of anterior posterior axis embryo GO:0008358 4 0.177
cellular macromolecule biosynthetic process GO:0034645 224 0.177
positive regulation of translation GO:0045727 1 0.174
cellular macromolecule metabolic process GO:0044260 391 0.172
cellular component morphogenesis GO:0032989 336 0.168
biosynthetic process GO:0009058 294 0.163
regulation of rna biosynthetic process GO:2001141 213 0.162
mrna metabolic process GO:0016071 20 0.153
regulation of transcription dna templated GO:0006355 213 0.149
positive regulation of biological process GO:0048518 253 0.147
regulation of cellular metabolic process GO:0031323 320 0.146
regulation of nucleic acid templated transcription GO:1903506 213 0.137
nucleobase containing compound biosynthetic process GO:0034654 205 0.135
positive regulation of cellular biosynthetic process GO:0031328 68 0.132
mrna processing GO:0006397 14 0.132
cellular biosynthetic process GO:0044249 286 0.132
spliceosomal snrnp assembly GO:0000387 2 0.130
segmentation GO:0035282 97 0.127
negative regulation of rna splicing GO:0033119 1 0.124
regulation of gene expression GO:0010468 265 0.119
regulation of stem cell differentiation GO:2000736 4 0.115
dorsal ventral pattern formation GO:0009953 125 0.115
stem cell maintenance GO:0019827 4 0.114
pole plasm assembly GO:0007315 4 0.113
organic substance biosynthetic process GO:1901576 289 0.111
regulation of biosynthetic process GO:0009889 250 0.108
regulation of protein complex assembly GO:0043254 3 0.108
regulation of mrna metabolic process GO:1903311 6 0.105
locomotion GO:0040011 313 0.104
cytoplasm organization GO:0007028 4 0.102
embryo development ending in birth or egg hatching GO:0009792 271 0.100
rna transport GO:0050658 2 0.097
aging GO:0007568 2 0.095
vasculature development GO:0001944 278 0.095
positive regulation of cellular process GO:0048522 201 0.094
positive regulation of gene expression GO:0010628 71 0.093
regulation of cell differentiation GO:0045595 142 0.091
regulation of multicellular organism growth GO:0040014 4 0.088
embryonic pattern specification GO:0009880 44 0.086
nuclear transcribed mrna catabolic process GO:0000956 4 0.085
cellular component biogenesis GO:0044085 178 0.084
regulation of macromolecule biosynthetic process GO:0010556 225 0.081
mrna catabolic process GO:0006402 6 0.080
nucleic acid templated transcription GO:0097659 181 0.079
regulation of rna splicing GO:0043484 8 0.078
negative regulation of biological process GO:0048519 304 0.078
Human
digestive tract morphogenesis GO:0048546 231 0.077
negative regulation of cellular process GO:0048523 283 0.077
Human
rna biosynthetic process GO:0032774 181 0.075
response to stress GO:0006950 263 0.075
organic cyclic compound biosynthetic process GO:1901362 223 0.074
muscle structure development GO:0061061 196 0.074
oocyte development GO:0048599 14 0.068
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.068
regulation of protein transport GO:0051223 3 0.067
nucleocytoplasmic transport GO:0006913 4 0.066
multicellular organism growth GO:0035264 4 0.064
transcription from rna polymerase ii promoter GO:0006366 80 0.063
establishment of rna localization GO:0051236 3 0.063
growth GO:0040007 174 0.062
positive regulation of macromolecule metabolic process GO:0010604 93 0.060
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.059
regulation of establishment of protein localization GO:0070201 4 0.057
positive regulation of cellular component biogenesis GO:0044089 3 0.056
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.056
regulation of metabolic process GO:0019222 359 0.054
dna templated transcription elongation GO:0006354 3 0.054
rna stabilization GO:0043489 4 0.053
negative regulation of cellular biosynthetic process GO:0031327 55 0.053
transcription dna templated GO:0006351 181 0.052
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.051
oocyte anterior posterior axis specification GO:0007314 4 0.051
protein localization to nucleus GO:0034504 3 0.051
cellular component assembly GO:0022607 170 0.051
cell morphogenesis GO:0000902 289 0.051
ribosomal small subunit biogenesis GO:0042274 2 0.050
single organism metabolic process GO:0044710 217 0.049
nuclear transport GO:0051169 4 0.047
meiotic nuclear division GO:0007126 4 0.046
cellular component disassembly GO:0022411 1 0.046
nucleic acid transport GO:0050657 2 0.045
programmed cell death GO:0012501 119 0.045
Human
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.045
anterior posterior pattern specification GO:0009952 152 0.045
establishment of protein localization to organelle GO:0072594 4 0.044
positive regulation of metabolic process GO:0009893 108 0.043
regulation of tube size GO:0035150 2 0.042
signal transduction GO:0007165 455 0.042
nuclear import GO:0051170 3 0.041
negative regulation of cellular metabolic process GO:0031324 77 0.041
protein complex disassembly GO:0043241 1 0.041
nuclear export GO:0051168 1 0.041
embryonic digestive tract morphogenesis GO:0048557 3 0.041
rna export from nucleus GO:0006405 1 0.040
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.040
regulation of nucleocytoplasmic transport GO:0046822 2 0.039
multi organism process GO:0051704 134 0.039
spermatid differentiation GO:0048515 2 0.038
oocyte construction GO:0007308 5 0.038
heterocycle biosynthetic process GO:0018130 215 0.038
regulation of developmental process GO:0050793 247 0.038
macromolecular complex disassembly GO:0032984 1 0.038
regulation of cell development GO:0060284 100 0.038
positive regulation of cell cycle GO:0045787 3 0.037
tube morphogenesis GO:0035239 349 0.037
oogenesis GO:0048477 14 0.037
spermatid development GO:0007286 2 0.036
mrna stabilization GO:0048255 4 0.036
rna processing GO:0006396 25 0.036
actin filament polymerization GO:0030041 2 0.036
organelle organization GO:0006996 227 0.036
regulation of biological quality GO:0065008 263 0.035
rna catabolic process GO:0006401 7 0.035
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.035
apoptotic process GO:0006915 116 0.035
Human
aromatic compound catabolic process GO:0019439 15 0.034
protein import into nucleus GO:0006606 3 0.032
central nervous system development GO:0007417 387 0.032
negative regulation of rna biosynthetic process GO:1902679 45 0.031
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.031
regulation of multicellular organismal process GO:0051239 277 0.030
negative regulation of signal transduction GO:0009968 94 0.030
regulation of oocyte development GO:0060281 3 0.030
head development GO:0060322 303 0.030
germ line stem cell maintenance GO:0030718 2 0.030
positive regulation of cellular metabolic process GO:0031325 94 0.030
protein complex localization GO:0031503 1 0.030
stem cell development GO:0048864 82 0.029
positive regulation of biosynthetic process GO:0009891 68 0.029
mrna transport GO:0051028 2 0.029
generation of neurons GO:0048699 385 0.029
cellular nitrogen compound biosynthetic process GO:0044271 218 0.029
regulation of reproductive process GO:2000241 4 0.029
aromatic compound biosynthetic process GO:0019438 217 0.028
regulation of protein localization to nucleus GO:1900180 2 0.028
meiotic chromosome segregation GO:0045132 3 0.028
transcription from rna polymerase iii promoter GO:0006383 1 0.028
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.028
dna catabolic process GO:0006308 1 0.028
intracellular steroid hormone receptor signaling pathway GO:0030518 5 0.028
negative regulation of cell differentiation GO:0045596 46 0.028
regulation of intracellular protein transport GO:0033157 3 0.027
positive regulation of chromatin modification GO:1903310 1 0.027
stem cell differentiation GO:0048863 117 0.027
regeneration GO:0031099 91 0.027
response to abiotic stimulus GO:0009628 122 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.027
adherens junction organization GO:0034332 4 0.027
chromosome organization involved in meiosis GO:0070192 1 0.027
nucleoside monophosphate catabolic process GO:0009125 4 0.027
actin polymerization or depolymerization GO:0008154 2 0.027
cell death GO:0008219 121 0.027
Human
germ cell development GO:0007281 22 0.027
positive regulation of dna metabolic process GO:0051054 1 0.026
macromolecule localization GO:0033036 54 0.026
regulation of cellular component organization GO:0051128 86 0.026
negative regulation of developmental process GO:0051093 65 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.026
regulation of glial cell differentiation GO:0045685 4 0.025
transport GO:0006810 220 0.025
nucleobase containing compound transport GO:0015931 2 0.025
chemosensory behavior GO:0007635 1 0.025
single organism nuclear import GO:1902593 3 0.025
regulation of cytokine production GO:0001817 3 0.025
gamete generation GO:0007276 33 0.025
positive regulation of transport GO:0051050 2 0.025
response to chemical GO:0042221 320 0.025
intracellular transport GO:0046907 32 0.024
phosphorus metabolic process GO:0006793 109 0.024
determination of bilateral symmetry GO:0009855 204 0.024
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.024
regulation of mrna stability GO:0043488 4 0.024
protein import GO:0017038 3 0.024
lateral inhibition GO:0046331 1 0.024
regulation of cellular protein metabolic process GO:0032268 52 0.024
single organism localization GO:1902578 225 0.024
digestive tract development GO:0048565 265 0.023
neuromuscular synaptic transmission GO:0007274 2 0.023
organic cyclic compound catabolic process GO:1901361 15 0.023
regulation of meiotic cell cycle GO:0051445 1 0.023
positive regulation of rna biosynthetic process GO:1902680 57 0.023
muscle organ development GO:0007517 101 0.023
negative regulation of signaling GO:0023057 96 0.023
amine metabolic process GO:0009308 2 0.023
dna templated transcription initiation GO:0006352 1 0.023
positive regulation of multicellular organismal process GO:0051240 52 0.023
axis specification GO:0009798 43 0.022
muscle cell differentiation GO:0042692 139 0.022
peptidyl lysine acetylation GO:0018394 2 0.022
regulation of circadian rhythm GO:0042752 4 0.022
cellular protein metabolic process GO:0044267 129 0.022
nucleic acid phosphodiester bond hydrolysis GO:0090305 6 0.021
neuron differentiation GO:0030182 353 0.021
positive regulation of nucleic acid templated transcription GO:1903508 57 0.021
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
regulation of embryonic development GO:0045995 47 0.021
double strand break repair GO:0006302 3 0.021
negative regulation of programmed cell death GO:0043069 58 0.021
Human
regulation of epithelial cell proliferation GO:0050678 3 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.020
striated muscle cell development GO:0055002 108 0.020
development of primary female sexual characteristics GO:0046545 4 0.020
mechanosensory behavior GO:0007638 2 0.020
positive regulation of glial cell differentiation GO:0045687 1 0.020
regulation of signaling GO:0023051 235 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
phagocytosis engulfment GO:0006911 1 0.020
positive regulation of rna metabolic process GO:0051254 59 0.020
anterior posterior axis specification GO:0009948 20 0.020
meiotic cell cycle process GO:1903046 3 0.020
regulation of cell shape GO:0008360 1 0.020
convergent extension GO:0060026 118 0.020
brain development GO:0007420 293 0.020
negative regulation of ras protein signal transduction GO:0046580 1 0.020
dna metabolic process GO:0006259 27 0.019
cellular macromolecular complex assembly GO:0034622 24 0.019
cell motility GO:0048870 244 0.019
single organism reproductive process GO:0044702 40 0.019
single organism organelle organization GO:1902589 199 0.019
macromolecule catabolic process GO:0009057 15 0.019
maintenance of location GO:0051235 4 0.019
striated muscle cell differentiation GO:0051146 129 0.019
cell migration GO:0016477 237 0.019
regulation of multicellular organismal development GO:2000026 223 0.019
organic acid metabolic process GO:0006082 31 0.019
system process GO:0003008 185 0.019
protein k63 linked ubiquitination GO:0070534 2 0.018
female gonad development GO:0008585 4 0.018
protein metabolic process GO:0019538 183 0.018
cellular component movement GO:0006928 335 0.018
maturation of ssu rrna GO:0030490 1 0.018
negative regulation of gene expression GO:0010629 65 0.018
adherens junction assembly GO:0034333 1 0.018
establishment of localization in cell GO:0051649 77 0.018
cell aging GO:0007569 2 0.018
atp catabolic process GO:0006200 4 0.018
regulation of organ growth GO:0046620 3 0.018
cellular ketone metabolic process GO:0042180 11 0.018
negative regulation of biosynthetic process GO:0009890 55 0.018
posttranscriptional gene silencing GO:0016441 3 0.018
sensory organ development GO:0007423 393 0.018
methylation GO:0032259 22 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
intracellular signal transduction GO:0035556 85 0.017
embryonic axis specification GO:0000578 12 0.017
inner ear development GO:0048839 126 0.017
negative regulation of transcription dna templated GO:0045892 45 0.017
cytoskeleton organization GO:0007010 96 0.017
cellular localization GO:0051641 97 0.017
neuron projection development GO:0031175 180 0.017
rna 3 end processing GO:0031123 2 0.017
negative regulation of metabolic process GO:0009892 86 0.017
intracellular mrna localization GO:0008298 1 0.017
regulation of growth GO:0040008 42 0.017
cellular amine metabolic process GO:0044106 2 0.017
regulation of growth rate GO:0040009 1 0.017
positive regulation of chromosome organization GO:2001252 1 0.016
protein complex assembly GO:0006461 30 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
negative regulation of intracellular signal transduction GO:1902532 22 0.016
negative regulation of response to stimulus GO:0048585 104 0.016
immune system process GO:0002376 241 0.016
bmp signaling pathway GO:0030509 52 0.016
regulation of protein targeting GO:1903533 2 0.016
protein localization GO:0008104 40 0.016
developmental maturation GO:0021700 34 0.016
regulation of apoptotic process GO:0042981 98 0.016
Human
membrane invagination GO:0010324 1 0.016
response to biotic stimulus GO:0009607 97 0.015
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.015
enzyme linked receptor protein signaling pathway GO:0007167 106 0.015
small gtpase mediated signal transduction GO:0007264 8 0.015
negative regulation of cell communication GO:0010648 96 0.015
protein targeting to nucleus GO:0044744 3 0.015
astrocyte differentiation GO:0048708 1 0.015
phagocytosis GO:0006909 3 0.015
ear development GO:0043583 127 0.015
hemopoiesis GO:0030097 183 0.015
negative regulation of nucleic acid templated transcription GO:1903507 45 0.015
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.015
positive regulation of gliogenesis GO:0014015 2 0.015
negative regulation of rna metabolic process GO:0051253 48 0.015
cell projection organization GO:0030030 284 0.015
protein polymerization GO:0051258 4 0.015
macromolecular complex subunit organization GO:0043933 74 0.014
stem cell proliferation GO:0072089 4 0.014
heart development GO:0007507 313 0.014
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
response to external biotic stimulus GO:0043207 97 0.014
regulation of signal transduction GO:0009966 225 0.014
female gamete generation GO:0007292 14 0.014
gene silencing by rna GO:0031047 4 0.014
pharyngeal muscle development GO:0043282 4 0.014
determination of heart left right asymmetry GO:0061371 117 0.014
nucleobase containing compound catabolic process GO:0034655 15 0.014
ribonucleoprotein complex biogenesis GO:0022613 13 0.014
mrna export from nucleus GO:0006406 1 0.014
cellular component assembly involved in morphogenesis GO:0010927 107 0.014
gastrulation GO:0007369 208 0.014
cytokinesis GO:0000910 3 0.014
cellular response to dsrna GO:0071359 1 0.013
heterocycle catabolic process GO:0046700 15 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
regulation of gene expression epigenetic GO:0040029 11 0.013
regulation of binding GO:0051098 3 0.013
regulation of protein polymerization GO:0032271 2 0.013
regulation of anatomical structure morphogenesis GO:0022603 130 0.013
somite development GO:0061053 96 0.013
homeostatic process GO:0042592 142 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.013
positive regulation of transcription dna templated GO:0045893 57 0.013
cell surface receptor signaling pathway GO:0007166 325 0.013
single fertilization GO:0007338 3 0.013
myeloid cell differentiation GO:0030099 86 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
regulation of neurogenesis GO:0050767 87 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
negative regulation of mrna metabolic process GO:1903312 3 0.013
regulation of vasculature development GO:1901342 33 0.012
establishment of localization GO:0051234 244 0.012
interspecies interaction between organisms GO:0044419 4 0.012
pathway restricted smad protein phosphorylation GO:0060389 1 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
embryonic digestive tract development GO:0048566 4 0.012
regulation of intracellular signal transduction GO:1902531 57 0.012
cellular protein complex localization GO:0034629 1 0.012
regulation of organelle organization GO:0033043 29 0.012
regulation of cell communication GO:0010646 232 0.012
translational initiation GO:0006413 3 0.012
positive regulation of dna templated transcription elongation GO:0032786 1 0.012
specification of symmetry GO:0009799 204 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
response to uv GO:0009411 3 0.012
gene silencing GO:0016458 4 0.012
positive regulation of epithelial cell proliferation GO:0050679 1 0.012
neuroblast proliferation GO:0007405 2 0.012
cell substrate junction assembly GO:0007044 2 0.012
liver development GO:0001889 96 0.012
cell matrix adhesion GO:0007160 4 0.012
response to bacterium GO:0009617 58 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.012
regulation of dna damage response signal transduction by p53 class mediator GO:0043516 4 0.012
spliceosomal complex assembly GO:0000245 1 0.012
regulation of protein import into nucleus GO:0042306 2 0.011
cellular macromolecule localization GO:0070727 21 0.011
cell projection assembly GO:0030031 64 0.011
organonitrogen compound metabolic process GO:1901564 74 0.011
negative regulation of translation GO:0017148 1 0.011
digestive system development GO:0055123 289 0.011
angiogenesis GO:0001525 158 0.011
morphogenesis of an epithelium GO:0002009 333 0.011
protein homooligomerization GO:0051260 3 0.011
retina development in camera type eye GO:0060041 146 0.011
response to axon injury GO:0048678 14 0.011
fat soluble vitamin metabolic process GO:0006775 4 0.011
electron transport chain GO:0022900 2 0.011
cellular component maintenance GO:0043954 3 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
regulation of transporter activity GO:0032409 2 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
embryonic organ morphogenesis GO:0048562 274 0.011
oxoacid metabolic process GO:0043436 31 0.011
negative regulation of chromatin modification GO:1903309 1 0.011
ras protein signal transduction GO:0007265 7 0.011
sexual reproduction GO:0019953 36 0.011
regulation of protein metabolic process GO:0051246 56 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
heart morphogenesis GO:0003007 156 0.010
regulation of synapse assembly GO:0051963 3 0.010
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.010
oocyte axis specification GO:0007309 5 0.010
hepaticobiliary system development GO:0061008 98 0.010
regulation of response to stimulus GO:0048583 269 0.010
negative regulation of axon regeneration GO:0048681 4 0.010
muscle cell development GO:0055001 115 0.010

api5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.087
motor neuron disease DOID:231 0 0.043
central nervous system disease DOID:331 0 0.043
amyotrophic lateral sclerosis DOID:332 0 0.043
neurodegenerative disease DOID:1289 0 0.043
nervous system disease DOID:863 0 0.043