Danio rerio

19 known processes

bik

BCL2-interacting killer (apoptosis-inducing)

(Aliases: si:dkey-31f5.6)

bik biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.213
response to chemical GO:0042221 320 0.168
regulation of muscle contraction GO:0006937 3 0.156
response to organic substance GO:0010033 153 0.151
single organism transport GO:0044765 206 0.119
head development GO:0060322 303 0.100
regulation of nitrogen compound metabolic process GO:0051171 251 0.092
regulation of primary metabolic process GO:0080090 311 0.089
g protein coupled receptor signaling pathway GO:0007186 74 0.080
single organism membrane fusion GO:0044801 2 0.079
single organism metabolic process GO:0044710 217 0.078
brain development GO:0007420 293 0.076
nitrogen compound metabolic process GO:0006807 319 0.071
heterocycle metabolic process GO:0046483 290 0.067
guanosine containing compound catabolic process GO:1901069 2 0.066
gtp metabolic process GO:0046039 4 0.064
regulation of response to stimulus GO:0048583 269 0.063
signal transduction in absence of ligand GO:0038034 1 0.063
negative regulation of mitosis GO:0045839 3 0.063
central nervous system development GO:0007417 387 0.062
organic cyclic compound metabolic process GO:1901360 301 0.061
guanosine containing compound metabolic process GO:1901068 4 0.060
homeostatic process GO:0042592 142 0.059
larval development GO:0002164 2 0.059
cellular response to chemical stimulus GO:0070887 157 0.058
immune system process GO:0002376 241 0.058
chordate embryonic development GO:0043009 271 0.058
cellular response to endogenous stimulus GO:0071495 68 0.057
cellular response to organic substance GO:0071310 105 0.056
transport GO:0006810 220 0.056
regulation of metal ion transport GO:0010959 4 0.055
cellular nitrogen compound biosynthetic process GO:0044271 218 0.055
response to stress GO:0006950 263 0.055
regulation of signaling GO:0023051 235 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.054
organic cyclic compound biosynthetic process GO:1901362 223 0.053
regulation of system process GO:0044057 40 0.053
response to lipid GO:0033993 60 0.053
gtp catabolic process GO:0006184 2 0.053
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.052
nucleobase containing compound metabolic process GO:0006139 274 0.052
cellular aromatic compound metabolic process GO:0006725 295 0.051
programmed cell death GO:0012501 119 0.051
neurological system process GO:0050877 62 0.049
regulation of protein localization to nucleus GO:1900180 2 0.047
cellular macromolecule metabolic process GO:0044260 391 0.047
negative regulation of nuclear division GO:0051784 3 0.047
immune system development GO:0002520 191 0.046
regulation of rna metabolic process GO:0051252 224 0.045
regulation of sodium ion transport GO:0002028 2 0.045
response to endogenous stimulus GO:0009719 83 0.044
muscle structure development GO:0061061 196 0.044
cellular nitrogen compound metabolic process GO:0034641 290 0.044
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.044
regulation of signal transduction GO:0009966 225 0.044
cell surface receptor signaling pathway GO:0007166 325 0.043
transmembrane transport GO:0055085 120 0.043
response to transition metal nanoparticle GO:1990267 28 0.042
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.042
sensory organ development GO:0007423 393 0.042
heterocycle biosynthetic process GO:0018130 215 0.041
regulation of biological quality GO:0065008 263 0.041
small molecule metabolic process GO:0044281 77 0.041
regulation of cellular metabolic process GO:0031323 320 0.041
positive regulation of cellular catabolic process GO:0031331 3 0.040
gene expression GO:0010467 252 0.039
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.039
mitochondrion organization GO:0007005 4 0.039
positive regulation of gtp catabolic process GO:0033126 1 0.039
multicellular organismal homeostasis GO:0048871 29 0.038
regulation of multicellular organismal process GO:0051239 277 0.038
multicellular organism growth GO:0035264 4 0.038
regulation of gene expression GO:0010468 265 0.037
response to glucocorticoid GO:0051384 1 0.037
regulation of establishment of protein localization GO:0070201 4 0.036
establishment of localization GO:0051234 244 0.036
regulation of synaptic plasticity GO:0048167 1 0.036
negative regulation of cellular process GO:0048523 283 0.036
regulation of metabolic process GO:0019222 359 0.036
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.035
regulation of ion transport GO:0043269 22 0.035
rna biosynthetic process GO:0032774 181 0.035
aging GO:0007568 2 0.035
regulation of developmental process GO:0050793 247 0.035
regulation of biosynthetic process GO:0009889 250 0.034
positive regulation of neuron apoptotic process GO:0043525 1 0.033
protein import into nucleus GO:0006606 3 0.033
regulation of gtp catabolic process GO:0033124 2 0.033
system process GO:0003008 185 0.032
nucleic acid metabolic process GO:0090304 244 0.032
regulation of nucleoside metabolic process GO:0009118 2 0.032
regulation of tube size GO:0035150 2 0.031
response to drug GO:0042493 3 0.031
membrane fusion GO:0061025 2 0.030
positive regulation of cell cycle GO:0045787 3 0.030
protein localization to nucleus GO:0034504 3 0.030
organonitrogen compound metabolic process GO:1901564 74 0.030
regulation of cellular biosynthetic process GO:0031326 245 0.030
regulation of protein transport GO:0051223 3 0.030
extrinsic apoptotic signaling pathway GO:0097191 3 0.029
regulation of gtpase activity GO:0043087 2 0.029
mononuclear cell proliferation GO:0032943 1 0.029
positive regulation of blood circulation GO:1903524 2 0.029
embryo development ending in birth or egg hatching GO:0009792 271 0.028
negative regulation of biological process GO:0048519 304 0.028
establishment of protein localization to organelle GO:0072594 4 0.028
regulation of purine nucleotide catabolic process GO:0033121 2 0.028
positive regulation of catabolic process GO:0009896 4 0.028
apoptotic process GO:0006915 116 0.027
action potential GO:0001508 19 0.027
negative regulation of metabolic process GO:0009892 86 0.027
organic acid metabolic process GO:0006082 31 0.027
regulation of cytokine production GO:0001817 3 0.027
circulatory system process GO:0003013 87 0.027
positive regulation of macromolecule metabolic process GO:0010604 93 0.027
regulation of cytoplasmic transport GO:1903649 4 0.027
cell motility GO:0048870 244 0.027
response to organic cyclic compound GO:0014070 51 0.026
positive regulation of gtpase activity GO:0043547 1 0.026
metal ion transport GO:0030001 58 0.026
response to cadmium ion GO:0046686 14 0.026
positive regulation of biological process GO:0048518 253 0.026
death GO:0016265 121 0.026
aromatic compound biosynthetic process GO:0019438 217 0.026
nucleic acid templated transcription GO:0097659 181 0.025
cellular component morphogenesis GO:0032989 336 0.025
biosynthetic process GO:0009058 294 0.025
regulation of macromolecule metabolic process GO:0060255 317 0.025
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.025
positive regulation of epithelial cell differentiation GO:0030858 2 0.025
growth GO:0040007 174 0.025
striated muscle tissue development GO:0014706 110 0.024
embryonic hemopoiesis GO:0035162 53 0.024
establishment of endothelial barrier GO:0061028 3 0.024
positive regulation of neuron death GO:1901216 1 0.024
maintenance of location GO:0051235 4 0.024
regulation of inflammatory response GO:0050727 2 0.024
positive regulation of apoptotic signaling pathway GO:2001235 1 0.024
regulation of blood pressure GO:0008217 1 0.024
determination of bilateral symmetry GO:0009855 204 0.024
negative regulation of signaling GO:0023057 96 0.023
nuclear transport GO:0051169 4 0.023
muscle cell differentiation GO:0042692 139 0.023
response to hormone GO:0009725 48 0.023
response to external stimulus GO:0009605 264 0.023
regulation of blood vessel size GO:0050880 2 0.022
regulation of endothelial cell proliferation GO:0001936 1 0.022
tube morphogenesis GO:0035239 349 0.022
morphogenesis of an epithelium GO:0002009 333 0.022
phagocytosis GO:0006909 3 0.022
organelle fusion GO:0048284 3 0.022
response to corticosteroid GO:0031960 1 0.022
negative regulation of gene expression GO:0010629 65 0.022
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
cellular macromolecule biosynthetic process GO:0034645 224 0.022
dorsal ventral pattern formation GO:0009953 125 0.022
regulation of response to oxidative stress GO:1902882 2 0.021
macromolecule biosynthetic process GO:0009059 227 0.021
transmission of nerve impulse GO:0019226 19 0.021
single organism localization GO:1902578 225 0.021
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.021
rna metabolic process GO:0016070 219 0.021
positive regulation of transport GO:0051050 2 0.021
sensory perception of pain GO:0019233 1 0.021
regulation of circadian rhythm GO:0042752 4 0.021
heart development GO:0007507 313 0.020
single organism nuclear import GO:1902593 3 0.020
erythrocyte differentiation GO:0030218 54 0.020
neuron neuron synaptic transmission GO:0007270 1 0.020
regulation of cell communication GO:0010646 232 0.020
generation of neurons GO:0048699 385 0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.019
regulation of reactive oxygen species metabolic process GO:2000377 2 0.019
regulation of membrane potential GO:0042391 23 0.019
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
organic substance biosynthetic process GO:1901576 289 0.019
amine metabolic process GO:0009308 2 0.019
cellular component biogenesis GO:0044085 178 0.019
mesenchyme development GO:0060485 127 0.019
smooth muscle contraction GO:0006939 2 0.019
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.019
regulation of heart contraction GO:0008016 32 0.019
positive regulation of cellular component biogenesis GO:0044089 3 0.019
hematopoietic or lymphoid organ development GO:0048534 191 0.019
regulation of cardiac muscle contraction GO:0055117 2 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
positive regulation of signal transduction GO:0009967 56 0.019
anatomical structure homeostasis GO:0060249 36 0.019
cellular response to oxygen levels GO:0071453 1 0.019
positive regulation of cellular process GO:0048522 201 0.018
regulation of mitochondrion organization GO:0010821 1 0.018
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
cell cycle arrest GO:0007050 1 0.018
embryonic organ morphogenesis GO:0048562 274 0.018
phosphate containing compound metabolic process GO:0006796 108 0.018
positive regulation of muscle cell differentiation GO:0051149 1 0.018
ion transmembrane transport GO:0034220 91 0.018
response to nutrient GO:0007584 3 0.018
regulation of striated muscle contraction GO:0006942 2 0.018
ventricular cardiac muscle tissue development GO:0003229 3 0.018
oxoacid metabolic process GO:0043436 31 0.018
regulation of multicellular organism growth GO:0040014 4 0.017
mesenchymal cell differentiation GO:0048762 87 0.017
regulation of jak stat cascade GO:0046425 3 0.017
embryonic organ development GO:0048568 381 0.017
regulation of reproductive process GO:2000241 4 0.017
sleep GO:0030431 1 0.017
single organism biosynthetic process GO:0044711 71 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.017
nuclear import GO:0051170 3 0.017
superoxide metabolic process GO:0006801 2 0.017
regulation of cellular component organization GO:0051128 86 0.017
protein import GO:0017038 3 0.017
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.017
liver development GO:0001889 96 0.017
positive regulation of nucleoside metabolic process GO:0045979 1 0.016
lipid metabolic process GO:0006629 52 0.016
positive regulation of cytokine production GO:0001819 2 0.016
peptide transport GO:0015833 1 0.016
protein acetylation GO:0006473 2 0.016
somite development GO:0061053 96 0.016
positive regulation of response to stimulus GO:0048584 80 0.016
tyrosine phosphorylation of stat protein GO:0007260 1 0.016
tissue homeostasis GO:0001894 25 0.016
pigmentation GO:0043473 85 0.016
cellular amine metabolic process GO:0044106 2 0.016
regulation of macromolecule biosynthetic process GO:0010556 225 0.016
cellular response to hypoxia GO:0071456 1 0.016
response to methylmercury GO:0051597 11 0.016
negative regulation of kinase activity GO:0033673 4 0.016
cognition GO:0050890 1 0.016
myeloid cell homeostasis GO:0002262 56 0.016
cell proliferation GO:0008283 80 0.016
regulation of rna biosynthetic process GO:2001141 213 0.016
negative regulation of cellular metabolic process GO:0031324 77 0.016
regulation of epithelial cell proliferation GO:0050678 3 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
cellular response to hormone stimulus GO:0032870 39 0.016
reactive nitrogen species metabolic process GO:2001057 0 0.016
cell migration GO:0016477 237 0.016
locomotion GO:0040011 313 0.015
cellular response to decreased oxygen levels GO:0036294 1 0.015
digestive tract development GO:0048565 265 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
renal system development GO:0072001 94 0.015
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.015
stem cell maintenance GO:0019827 4 0.015
circadian sleep wake cycle sleep GO:0050802 1 0.015
digestive system development GO:0055123 289 0.015
regulation of calcium ion transport GO:0051924 2 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.015
carbohydrate derivative metabolic process GO:1901135 61 0.015
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.015
regulation of autophagy GO:0010506 3 0.015
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.015
bmp signaling pathway GO:0030509 52 0.015
cellular ketone metabolic process GO:0042180 11 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
cellular response to radiation GO:0071478 4 0.015
cell morphogenesis GO:0000902 289 0.015
retina morphogenesis in camera type eye GO:0060042 79 0.015
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.014
multicellular organismal signaling GO:0035637 22 0.014
negative regulation of protein phosphorylation GO:0001933 4 0.014
response to steroid hormone GO:0048545 35 0.014
regionalization GO:0003002 274 0.014
positive regulation of jak stat cascade GO:0046427 2 0.014
cellular response to nutrient levels GO:0031669 2 0.014
ear development GO:0043583 127 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
negative regulation of signal transduction GO:0009968 94 0.014
regulation of cell activation GO:0050865 1 0.014
catabolic process GO:0009056 32 0.014
kidney development GO:0001822 92 0.014
regulation of programmed cell death GO:0043067 101 0.014
regulation of nucleic acid templated transcription GO:1903506 213 0.014
regulation of myotube differentiation GO:0010830 2 0.014
hormone biosynthetic process GO:0042446 3 0.014
cellular response to external stimulus GO:0071496 2 0.014
fluid transport GO:0042044 17 0.014
regulation of organ growth GO:0046620 3 0.014
hepaticobiliary system development GO:0061008 98 0.014
regulation of anatomical structure morphogenesis GO:0022603 130 0.014
epithelial cell differentiation GO:0030855 116 0.014
positive regulation of cell division GO:0051781 2 0.013
epidermal cell fate specification GO:0009957 4 0.013
skeletal system morphogenesis GO:0048705 102 0.013
fatty acid transport GO:0015908 1 0.013
cation transport GO:0006812 81 0.013
regulation of cellular component movement GO:0051270 55 0.013
negative regulation of defense response GO:0031348 2 0.013
neuronal action potential GO:0019228 18 0.013
somatic muscle development GO:0007525 4 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.013
endocrine process GO:0050886 2 0.013
response to estrogen GO:0043627 27 0.013
response to abiotic stimulus GO:0009628 122 0.013
positive regulation of metabolic process GO:0009893 108 0.013
water homeostasis GO:0030104 4 0.013
gland development GO:0048732 143 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
regulation of molecular function GO:0065009 70 0.013
peptidyl lysine acetylation GO:0018394 2 0.013
membrane hyperpolarization GO:0060081 1 0.013
regulation of binding GO:0051098 3 0.013
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.013
erythrocyte homeostasis GO:0034101 55 0.013
regulation of cellular response to oxidative stress GO:1900407 2 0.013
ion transport GO:0006811 114 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
p38mapk cascade GO:0038066 1 0.012
female sex differentiation GO:0046660 4 0.012
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.012
muscle tissue development GO:0060537 110 0.012
lipid storage GO:0019915 1 0.012
leukocyte proliferation GO:0070661 1 0.012
epiboly GO:0090504 41 0.012
lymphocyte proliferation GO:0046651 1 0.012
heart process GO:0003015 71 0.012
regulation of cell differentiation GO:0045595 142 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
developmental growth GO:0048589 166 0.012
regulation of protein targeting GO:1903533 2 0.012
developmental pigmentation GO:0048066 48 0.012
cellular biosynthetic process GO:0044249 286 0.012
transcription dna templated GO:0006351 181 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
regulation of cell shape GO:0008360 1 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
developmental programmed cell death GO:0010623 4 0.012
regulation of nucleocytoplasmic transport GO:0046822 2 0.012
regulation of transporter activity GO:0032409 2 0.012
female gonad development GO:0008585 4 0.012
ameboidal type cell migration GO:0001667 143 0.012
ribonucleoside monophosphate catabolic process GO:0009158 4 0.012
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
embryonic heart tube development GO:0035050 133 0.012
positive regulation of secretion GO:0051047 1 0.012
actin filament based movement GO:0030048 1 0.012
localization of cell GO:0051674 244 0.012
positive regulation of endothelial cell proliferation GO:0001938 1 0.012
autophagy GO:0006914 4 0.012
meiotic nuclear division GO:0007126 4 0.011
lateral line system development GO:0048925 76 0.011
regulation of protein complex assembly GO:0043254 3 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
protein acylation GO:0043543 3 0.011
protein metabolic process GO:0019538 183 0.011
oxidation reduction process GO:0055114 41 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
positive regulation of striated muscle cell differentiation GO:0051155 1 0.011
protein targeting to nucleus GO:0044744 3 0.011
gastrulation GO:0007369 208 0.011
response to topologically incorrect protein GO:0035966 2 0.011
negative regulation of nucleic acid templated transcription GO:1903507 45 0.011
retina development in camera type eye GO:0060041 146 0.011
neural retina development GO:0003407 49 0.011
angiogenesis GO:0001525 158 0.011
positive regulation of cell communication GO:0010647 56 0.011
monocyte differentiation GO:0030224 2 0.011
adult behavior GO:0030534 2 0.011
tissue remodeling GO:0048771 4 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
negative regulation of cell communication GO:0010648 96 0.011
defense response GO:0006952 47 0.011
intracellular signal transduction GO:0035556 85 0.011
aromatic compound catabolic process GO:0019439 15 0.011
neural crest cell migration GO:0001755 42 0.011
regulation of circadian sleep wake cycle GO:0042749 1 0.011
positive regulation of developmental process GO:0051094 50 0.011
monovalent inorganic cation transport GO:0015672 42 0.011
response to cold GO:0009409 4 0.011
positive regulation of leukocyte differentiation GO:1902107 1 0.011
reactive oxygen species biosynthetic process GO:1903409 1 0.011
neuromast development GO:0048884 46 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.010
positive regulation of epithelial cell migration GO:0010634 2 0.010
segmentation GO:0035282 97 0.010
positive regulation of secretion by cell GO:1903532 1 0.010
endocrine system development GO:0035270 65 0.010
regulation of cell cycle GO:0051726 52 0.010
membrane repolarization GO:0086009 2 0.010
locomotory behavior GO:0007626 34 0.010
i kappab kinase nf kappab signaling GO:0007249 4 0.010
cellular response to light stimulus GO:0071482 4 0.010
nitric oxide metabolic process GO:0046209 2 0.010
positive regulation of signaling GO:0023056 56 0.010
hemopoiesis GO:0030097 183 0.010
negative regulation of protein import into nucleus GO:0042308 2 0.010
germ line stem cell maintenance GO:0030718 2 0.010
ribosomal small subunit biogenesis GO:0042274 2 0.010
blood circulation GO:0008015 87 0.010
regulation of oocyte development GO:0060281 3 0.010

bik disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.045
musculoskeletal system disease DOID:17 0 0.016
disease of cellular proliferation DOID:14566 0 0.015
connective tissue disease DOID:65 0 0.013
cardiovascular system disease DOID:1287 0 0.012
nervous system disease DOID:863 0 0.011