Danio rerio

40 known processes

blm

Bloom syndrome

blm biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitotic recombination GO:0006312 2 0.461
response to arsenic containing substance GO:0046685 5 0.426
negative regulation of dna recombination GO:0045910 2 0.328
regulation of dna recombination GO:0000018 2 0.253
monoamine transport GO:0015844 1 0.195
sensory organ development GO:0007423 393 0.159
eye development GO:0001654 277 0.127
aging GO:0007568 2 0.115
synaptic transmission glycinergic GO:0060012 1 0.100
nucleic acid metabolic process GO:0090304 244 0.098
transmembrane transport GO:0055085 120 0.097
neuron neuron synaptic transmission GO:0007270 1 0.092
amino acid transport GO:0006865 2 0.089
regulation of biological quality GO:0065008 263 0.080
cellular macromolecule metabolic process GO:0044260 391 0.077
response to chemical GO:0042221 320 0.061
regulation of binding GO:0051098 3 0.059
negative regulation of dna metabolic process GO:0051053 4 0.059
hematopoietic or lymphoid organ development GO:0048534 191 0.056
regulation of macromolecule metabolic process GO:0060255 317 0.056
negative regulation of cellular process GO:0048523 283 0.055
modification dependent protein catabolic process GO:0019941 3 0.054
regulation of multicellular organismal process GO:0051239 277 0.053
regulation of cytokine production GO:0001817 3 0.052
multicellular organism growth GO:0035264 4 0.051
neutral amino acid transport GO:0015804 2 0.046
protein acetylation GO:0006473 2 0.046
cellular component morphogenesis GO:0032989 336 0.045
regulation of protein binding GO:0043393 3 0.044
negative regulation of biological process GO:0048519 304 0.044
single organism localization GO:1902578 225 0.044
nitrogen compound metabolic process GO:0006807 319 0.043
response to drug GO:0042493 3 0.042
digestive system development GO:0055123 289 0.042
positive regulation of cell cycle GO:0045787 3 0.040
nucleocytoplasmic transport GO:0006913 4 0.039
erythrocyte homeostasis GO:0034101 55 0.039
regulation of nitrogen compound metabolic process GO:0051171 251 0.039
protein localization to nucleus GO:0034504 3 0.039
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.036
system process GO:0003008 185 0.035
cellular component movement GO:0006928 335 0.035
g1 s transition of mitotic cell cycle GO:0000082 1 0.035
regulation of cellular metabolic process GO:0031323 320 0.035
regulation of cellular amine metabolic process GO:0033238 0 0.035
amine metabolic process GO:0009308 2 0.034
regulation of primary metabolic process GO:0080090 311 0.033
nuclear transport GO:0051169 4 0.033
ubiquitin dependent protein catabolic process GO:0006511 3 0.033
organic hydroxy compound transport GO:0015850 14 0.033
single organism transport GO:0044765 206 0.032
cellular aromatic compound metabolic process GO:0006725 295 0.032
adult behavior GO:0030534 2 0.032
regulation of nucleoside metabolic process GO:0009118 2 0.031
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.031
membrane hyperpolarization GO:0060081 1 0.031
regionalization GO:0003002 274 0.031
embryonic organ development GO:0048568 381 0.031
cell projection assembly GO:0030031 64 0.031
somatic muscle development GO:0007525 4 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.030
regulation of signaling GO:0023051 235 0.030
organic cyclic compound metabolic process GO:1901360 301 0.030
muscle hypertrophy GO:0014896 2 0.030
left right pattern formation GO:0060972 19 0.030
cell cycle g1 s phase transition GO:0044843 1 0.030
ion transmembrane transport GO:0034220 91 0.029
establishment of protein localization to organelle GO:0072594 4 0.029
localization of cell GO:0051674 244 0.028
camera type eye development GO:0043010 222 0.028
regulation of muscle hypertrophy GO:0014743 2 0.028
pore complex assembly GO:0046931 2 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.028
anion transmembrane transport GO:0098656 12 0.027
regulation of synaptic plasticity GO:0048167 1 0.027
regulation of protein transport GO:0051223 3 0.027
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.027
heterocycle metabolic process GO:0046483 290 0.027
regulation of dna metabolic process GO:0051052 11 0.026
regulation of membrane potential GO:0042391 23 0.026
leukocyte proliferation GO:0070661 1 0.026
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.026
proteasomal protein catabolic process GO:0010498 2 0.025
microtubule organizing center organization GO:0031023 1 0.025
protein secretion GO:0009306 1 0.025
neurotransmitter secretion GO:0007269 2 0.025
developmental programmed cell death GO:0010623 4 0.025
response to carbohydrate GO:0009743 3 0.025
regulation of nucleotide catabolic process GO:0030811 2 0.025
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
homeostasis of number of cells GO:0048872 62 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
establishment of localization GO:0051234 244 0.025
cellular amine metabolic process GO:0044106 2 0.024
modification dependent macromolecule catabolic process GO:0043632 3 0.024
response to stress GO:0006950 263 0.024
negative regulation of cellular catabolic process GO:0031330 3 0.024
nuclear import GO:0051170 3 0.024
sensory organ morphogenesis GO:0090596 200 0.023
nucleobase containing compound metabolic process GO:0006139 274 0.023
transport GO:0006810 220 0.023
cellular response to oxygen levels GO:0071453 1 0.022
cellular protein catabolic process GO:0044257 4 0.022
oxoacid metabolic process GO:0043436 31 0.022
regulation of neurotransmitter secretion GO:0046928 1 0.022
neurotransmitter transport GO:0006836 2 0.022
positive regulation of map kinase activity GO:0043406 3 0.022
cellular ketone metabolic process GO:0042180 11 0.022
nitrogen compound transport GO:0071705 23 0.022
maintenance of location GO:0051235 4 0.022
developmental growth GO:0048589 166 0.022
liver development GO:0001889 96 0.022
peptide transport GO:0015833 1 0.022
nuclear export GO:0051168 1 0.021
cell motility GO:0048870 244 0.021
immune system process GO:0002376 241 0.021
protein acylation GO:0043543 3 0.021
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.021
cell morphogenesis GO:0000902 289 0.021
protein targeting to nucleus GO:0044744 3 0.021
cellular protein complex assembly GO:0043623 19 0.021
centrosome organization GO:0051297 1 0.021
regulation of gtp catabolic process GO:0033124 2 0.021
regulation of stem cell differentiation GO:2000736 4 0.021
i kappab kinase nf kappab signaling GO:0007249 4 0.020
response to heat GO:0009408 6 0.020
regulation of protein localization to nucleus GO:1900180 2 0.020
primitive erythrocyte differentiation GO:0060319 5 0.020
ion transport GO:0006811 114 0.020
peptidyl serine phosphorylation GO:0018105 1 0.020
negative regulation of protein kinase activity GO:0006469 4 0.020
digestive tract development GO:0048565 265 0.019
response to amino acid GO:0043200 2 0.019
regulation of transporter activity GO:0032409 2 0.019
regulation of rho protein signal transduction GO:0035023 2 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
positive regulation of myeloid cell differentiation GO:0045639 2 0.019
positive regulation of catabolic process GO:0009896 4 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
guanosine containing compound catabolic process GO:1901069 2 0.019
immune system development GO:0002520 191 0.019
protein polymerization GO:0051258 4 0.019
centrosome cycle GO:0007098 1 0.019
protein metabolic process GO:0019538 183 0.019
guanosine containing compound metabolic process GO:1901068 4 0.019
regulation of multicellular organism growth GO:0040014 4 0.019
positive regulation of transport GO:0051050 2 0.019
actin polymerization or depolymerization GO:0008154 2 0.018
negative regulation of hormone secretion GO:0046888 2 0.018
locomotor rhythm GO:0045475 3 0.018
positive regulation of cellular catabolic process GO:0031331 3 0.018
positive regulation of ras protein signal transduction GO:0046579 1 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
gtp metabolic process GO:0046039 4 0.018
regulation of protein complex assembly GO:0043254 3 0.018
muscle system process GO:0003012 20 0.018
lipid storage GO:0019915 1 0.018
homeostatic process GO:0042592 142 0.018
regulation of cell differentiation GO:0045595 142 0.018
gland development GO:0048732 143 0.018
regulation of protein catabolic process GO:0042176 1 0.017
negative regulation of catabolic process GO:0009895 3 0.017
gtp catabolic process GO:0006184 2 0.017
response to hexose GO:0009746 3 0.017
meiotic nuclear division GO:0007126 4 0.017
organic acid metabolic process GO:0006082 31 0.017
negative regulation of kinase activity GO:0033673 4 0.017
cellular component disassembly GO:0022411 1 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
stem cell maintenance GO:0019827 4 0.017
erythrocyte differentiation GO:0030218 54 0.017
myeloid cell differentiation GO:0030099 86 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
myeloid cell homeostasis GO:0002262 56 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
regulation of cell shape GO:0008360 1 0.017
hemopoiesis GO:0030097 183 0.017
protein import into nucleus GO:0006606 3 0.017
cellular biosynthetic process GO:0044249 286 0.017
locomotion GO:0040011 313 0.017
cellular transition metal ion homeostasis GO:0046916 3 0.017
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.017
meiotic chromosome segregation GO:0045132 3 0.017
organelle localization GO:0051640 49 0.017
gene expression GO:0010467 252 0.016
positive regulation of cell death GO:0010942 29 0.016
response to temperature stimulus GO:0009266 15 0.016
neuron remodeling GO:0016322 1 0.016
regulation of endocrine process GO:0044060 2 0.016
regulation of gtpase activity GO:0043087 2 0.016
hormone secretion GO:0046879 2 0.016
regulation of blood pressure GO:0008217 1 0.016
response to abiotic stimulus GO:0009628 122 0.016
regulation of cell communication GO:0010646 232 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
autophagy GO:0006914 4 0.016
regulation of neurotransmitter transport GO:0051588 1 0.016
growth GO:0040007 174 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
determination of left right symmetry GO:0007368 179 0.016
positive regulation of secretion GO:0051047 1 0.016
response to hydrogen peroxide GO:0042542 3 0.015
action potential GO:0001508 19 0.015
small molecule metabolic process GO:0044281 77 0.015
negative regulation of cellular metabolic process GO:0031324 77 0.015
signal transduction in absence of ligand GO:0038034 1 0.015
cell substrate adhesion GO:0031589 4 0.015
eye morphogenesis GO:0048592 144 0.015
embryonic hemopoiesis GO:0035162 53 0.015
cellular response to external stimulus GO:0071496 2 0.015
fertilization GO:0009566 3 0.015
rna localization GO:0006403 4 0.015
response to glucose GO:0009749 3 0.015
regulation of autophagy GO:0010506 3 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.015
cell migration GO:0016477 237 0.015
regulation of dendrite development GO:0050773 3 0.015
l amino acid transport GO:0015807 1 0.015
blood vessel development GO:0001568 246 0.014
atp catabolic process GO:0006200 4 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
regulation of hormone secretion GO:0046883 2 0.014
hepaticobiliary system development GO:0061008 98 0.014
cell part morphogenesis GO:0032990 246 0.014
cardiac atrium development GO:0003230 4 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
larval development GO:0002164 2 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
generation of neurons GO:0048699 385 0.014
regulation of mrna splicing via spliceosome GO:0048024 3 0.014
organic substance biosynthetic process GO:1901576 289 0.014
eye photoreceptor cell differentiation GO:0001754 45 0.014
regulation of anatomical structure size GO:0090066 33 0.014
cellular response to nutrient levels GO:0031669 2 0.014
positive regulation of cell adhesion GO:0045785 1 0.014
single organism organelle organization GO:1902589 199 0.014
positive regulation of protein complex assembly GO:0031334 2 0.014
negative regulation of metabolic process GO:0009892 86 0.014
muscle structure development GO:0061061 196 0.014
positive regulation of nucleoside metabolic process GO:0045979 1 0.014
production of molecular mediator of immune response GO:0002440 2 0.013
single fertilization GO:0007338 3 0.013
carbohydrate homeostasis GO:0033500 1 0.013
morphogenesis of an epithelium GO:0002009 333 0.013
b cell activation GO:0042113 2 0.013
transcription dna templated GO:0006351 181 0.013
cell projection organization GO:0030030 284 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
peptidyl serine modification GO:0018209 2 0.013
cellular component assembly GO:0022607 170 0.013
phagocytosis GO:0006909 3 0.013
positive regulation of biological process GO:0048518 253 0.013
mitochondrion organization GO:0007005 4 0.013
single organism nuclear import GO:1902593 3 0.013
regulation of reactive oxygen species metabolic process GO:2000377 2 0.013
regulation of synaptic transmission glycinergic GO:0060092 1 0.013
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
head development GO:0060322 303 0.013
response to nutrient GO:0007584 3 0.013
retina development in camera type eye GO:0060041 146 0.013
endocrine process GO:0050886 2 0.013
meiotic cell cycle process GO:1903046 3 0.013
dopamine metabolic process GO:0042417 2 0.013
regulation of reproductive process GO:2000241 4 0.013
cell cycle arrest GO:0007050 1 0.013
b cell mediated immunity GO:0019724 3 0.013
protein complex disassembly GO:0043241 1 0.013
regulation of signal transduction GO:0009966 225 0.013
reflex GO:0060004 2 0.013
cell surface receptor signaling pathway GO:0007166 325 0.013
regulation of calcium ion transport GO:0051924 2 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
dna templated transcription elongation GO:0006354 3 0.012
protein localization to plasma membrane GO:0072659 1 0.012
protein import GO:0017038 3 0.012
heterocycle biosynthetic process GO:0018130 215 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
positive regulation of gtpase activity GO:0043547 1 0.012
synaptic growth at neuromuscular junction GO:0051124 2 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
chemosensory behavior GO:0007635 1 0.012
regulation of transcription dna templated GO:0006355 213 0.012
cell projection morphogenesis GO:0048858 244 0.012
small gtpase mediated signal transduction GO:0007264 8 0.012
posterior lateral line system development GO:0048915 46 0.012
neuron differentiation GO:0030182 353 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
macromolecular complex disassembly GO:0032984 1 0.012
stem cell proliferation GO:0072089 4 0.012
regulation of developmental process GO:0050793 247 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
sequestering of metal ion GO:0051238 3 0.012
fatty acid catabolic process GO:0009062 1 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
phagocytosis engulfment GO:0006911 1 0.012
anion transport GO:0006820 38 0.011
female sex differentiation GO:0046660 4 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
chloride transmembrane transport GO:1902476 4 0.011
membrane invagination GO:0010324 1 0.011
b cell differentiation GO:0030183 1 0.011
cognition GO:0050890 1 0.011
biosynthetic process GO:0009058 294 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
glucose homeostasis GO:0042593 1 0.011
regulation of response to stimulus GO:0048583 269 0.011
regulation of protein polymerization GO:0032271 2 0.011
positive regulation of camp biosynthetic process GO:0030819 2 0.011
nuclear pore organization GO:0006999 2 0.011
spermatid development GO:0007286 2 0.011
cellular response to reactive oxygen species GO:0034614 2 0.011
endocrine hormone secretion GO:0060986 2 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
heart development GO:0007507 313 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
establishment of localization in cell GO:0051649 77 0.011
small molecule catabolic process GO:0044282 3 0.011
cellular component biogenesis GO:0044085 178 0.011
regulation of protein targeting GO:1903533 2 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
regulation of metal ion transport GO:0010959 4 0.011
apoptotic process involved in development GO:1902742 2 0.011
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
determination of bilateral symmetry GO:0009855 204 0.011
cellular lipid catabolic process GO:0044242 3 0.011
response to corticosteroid GO:0031960 1 0.011
regulation of metabolic process GO:0019222 359 0.011
lipid oxidation GO:0034440 1 0.011
synaptic vesicle localization GO:0097479 1 0.011
neuromuscular synaptic transmission GO:0007274 2 0.011
response to xenobiotic stimulus GO:0009410 45 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
response to external stimulus GO:0009605 264 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
regulation of apoptotic process GO:0042981 98 0.011
vasculature development GO:0001944 278 0.011
multicellular organismal signaling GO:0035637 22 0.011
axon development GO:0061564 166 0.011
sensory system development GO:0048880 76 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
cellular response to starvation GO:0009267 1 0.011
mitotic cell cycle GO:0000278 64 0.011
mitotic dna integrity checkpoint GO:0044774 4 0.011
organic substance transport GO:0071702 58 0.011
lymphangiogenesis GO:0001946 25 0.011
skeletal muscle tissue development GO:0007519 67 0.011
multicellular organismal metabolic process GO:0044236 2 0.011
intracellular mrna localization GO:0008298 1 0.011
calcium ion transport into cytosol GO:0060402 3 0.011
specification of symmetry GO:0009799 204 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
regulation of skeletal muscle tissue development GO:0048641 4 0.010
phosphate containing compound metabolic process GO:0006796 108 0.010
negative regulation of reproductive process GO:2000242 3 0.010
mononuclear cell proliferation GO:0032943 1 0.010
regulation of catalytic activity GO:0050790 55 0.010
negative regulation of cytokine production GO:0001818 1 0.010
fatty acid transport GO:0015908 1 0.010
cytokinesis GO:0000910 3 0.010
lateral line development GO:0048882 66 0.010
sensory perception of chemical stimulus GO:0007606 3 0.010
regulation of myotube differentiation GO:0010830 2 0.010
cell proliferation involved in heart morphogenesis GO:0061323 2 0.010
regulation of cellular component size GO:0032535 30 0.010
ribonucleoside monophosphate catabolic process GO:0009158 4 0.010
mitotic dna damage checkpoint GO:0044773 4 0.010
response to ketone GO:1901654 1 0.010
actin filament polymerization GO:0030041 2 0.010
negative regulation of cytoplasmic transport GO:1903650 2 0.010
regulation of organ morphogenesis GO:2000027 35 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
cation transport GO:0006812 81 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
regulation of mrna processing GO:0050684 3 0.010
organic anion transport GO:0015711 15 0.010
cellular protein metabolic process GO:0044267 129 0.010
zinc ion homeostasis GO:0055069 1 0.010
synaptic vesicle recycling GO:0036465 1 0.010
regulation of dna templated transcription elongation GO:0032784 3 0.010
regulation of protein import into nucleus GO:0042306 2 0.010

blm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.040
nervous system disease DOID:863 0 0.018
immune system disease DOID:2914 0 0.016
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
musculoskeletal system disease DOID:17 0 0.014
muscular disease DOID:0080000 0 0.013
muscle tissue disease DOID:66 0 0.013
sensory system disease DOID:0050155 0 0.011
retinal disease DOID:5679 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011
retinal degeneration DOID:8466 0 0.010