Danio rerio

31 known processes

brca2

breast cancer 2, early onset

(Aliases: fancd1)

brca2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
oocyte anterior posterior axis specification GO:0007314 4 0.669
oocyte differentiation GO:0009994 14 0.649
sexual reproduction GO:0019953 36 0.649
anterior posterior pattern specification GO:0009952 152 0.579
germ cell development GO:0007281 22 0.567
gamete generation GO:0007276 33 0.539
nucleic acid metabolic process GO:0090304 244 0.520
pole plasm assembly GO:0007315 4 0.512
segmentation GO:0035282 97 0.507
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.462
negative regulation of dna recombination GO:0045910 2 0.437
oocyte axis specification GO:0007309 5 0.411
meiotic chromosome segregation GO:0045132 3 0.404
oocyte development GO:0048599 14 0.368
chromosome organization GO:0051276 31 0.362
regionalization GO:0003002 274 0.334
cellular macromolecule metabolic process GO:0044260 391 0.326
single organism metabolic process GO:0044710 217 0.298
organic cyclic compound metabolic process GO:1901360 301 0.294
germ line stem cell division GO:0042078 1 0.284
cellular aromatic compound metabolic process GO:0006725 295 0.279
multicellular organism reproduction GO:0032504 35 0.278
oocyte construction GO:0007308 5 0.250
nucleobase containing compound metabolic process GO:0006139 274 0.250
meiosis i GO:0007127 1 0.245
developmental process involved in reproduction GO:0003006 27 0.241
spermatid development GO:0007286 2 0.237
multicellular organismal reproductive process GO:0048609 35 0.236
single organism organelle organization GO:1902589 199 0.231
regulation of dna recombination GO:0000018 2 0.226
maternal determination of anterior posterior axis embryo GO:0008358 4 0.219
macromolecule biosynthetic process GO:0009059 227 0.215
spermatid differentiation GO:0048515 2 0.207
cellular response to dna damage stimulus GO:0006974 24 0.203
meiotic cell cycle process GO:1903046 3 0.161
female gamete generation GO:0007292 14 0.158
anterior posterior axis specification GO:0009948 20 0.148
rna metabolic process GO:0016070 219 0.147
nucleoside monophosphate catabolic process GO:0009125 4 0.139
oocyte maturation GO:0001556 4 0.137
cellular biosynthetic process GO:0044249 286 0.137
nitrogen compound metabolic process GO:0006807 319 0.132
response to stress GO:0006950 263 0.131
single organism reproductive process GO:0044702 40 0.131
synapsis GO:0007129 1 0.130
cellular macromolecule biosynthetic process GO:0034645 224 0.129
dna biosynthetic process GO:0071897 3 0.125
regulation of metabolic process GO:0019222 359 0.123
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.123
spermatogenesis GO:0007283 7 0.120
sensory organ morphogenesis GO:0090596 200 0.120
cellular nitrogen compound metabolic process GO:0034641 290 0.119
multi organism process GO:0051704 134 0.119
centrosome organization GO:0051297 1 0.119
cytoplasm organization GO:0007028 4 0.117
chromosome organization involved in meiosis GO:0070192 1 0.117
biosynthetic process GO:0009058 294 0.114
reproduction GO:0000003 40 0.112
regulation of cellular biosynthetic process GO:0031326 245 0.108
regulation of cell maturation GO:1903429 1 0.107
cell cycle g2 m phase transition GO:0044839 4 0.102
nucleobase containing compound biosynthetic process GO:0034654 205 0.101
stem cell division GO:0017145 1 0.098
regulation of nitrogen compound metabolic process GO:0051171 251 0.097
regulation of cellular metabolic process GO:0031323 320 0.093
regulation of macromolecule metabolic process GO:0060255 317 0.091
positive regulation of mrna metabolic process GO:1903313 2 0.091
eye development GO:0001654 277 0.087
heterocycle metabolic process GO:0046483 290 0.087
regulation of mrna catabolic process GO:0061013 3 0.086
microtubule cytoskeleton organization GO:0000226 33 0.084
regulation of mrna processing GO:0050684 3 0.082
intracellular mrna localization GO:0008298 1 0.081
stem cell maintenance GO:0019827 4 0.081
dna metabolic process GO:0006259 27 0.080
female meiotic division GO:0007143 2 0.080
axis specification GO:0009798 43 0.079
cellular component assembly GO:0022607 170 0.078
multi organism reproductive process GO:0044703 36 0.077
anterior posterior axis specification embryo GO:0008595 5 0.077
development of primary female sexual characteristics GO:0046545 4 0.076
multicellular organism growth GO:0035264 4 0.074
aging GO:0007568 2 0.073
muscle cell development GO:0055001 115 0.071
purine nucleoside monophosphate catabolic process GO:0009128 4 0.070
negative regulation of biological process GO:0048519 304 0.069
microtubule based process GO:0007017 60 0.069
signal transduction GO:0007165 455 0.068
regulation of nucleic acid templated transcription GO:1903506 213 0.068
aromatic compound biosynthetic process GO:0019438 217 0.067
positive regulation of mrna processing GO:0050685 1 0.067
dicarboxylic acid metabolic process GO:0043648 1 0.064
ribonucleoside monophosphate catabolic process GO:0009158 4 0.063
negative regulation of cellular process GO:0048523 283 0.063
organelle assembly GO:0070925 110 0.061
female sex differentiation GO:0046660 4 0.060
blastoderm segmentation GO:0007350 6 0.059
regulation of oocyte development GO:0060281 3 0.059
centrosome duplication GO:0051298 1 0.058
positive regulation of cell cycle GO:0045787 3 0.056
establishment of localization in cell GO:0051649 77 0.054
female germ line stem cell maintenance GO:0036099 1 0.053
germ line stem cell maintenance GO:0030718 2 0.052
female meiosis chromosome segregation GO:0016321 1 0.052
g2 m transition of mitotic cell cycle GO:0000086 4 0.052
reciprocal meiotic recombination GO:0007131 1 0.051
dorsal ventral pattern formation GO:0009953 125 0.051
negative regulation of protein metabolic process GO:0051248 16 0.050
macroautophagy GO:0016236 1 0.050
regulation of rna biosynthetic process GO:2001141 213 0.049
cellular response to estradiol stimulus GO:0071392 1 0.049
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.049
double strand break repair GO:0006302 3 0.049
apoptotic process GO:0006915 116 0.048
ovarian follicle development GO:0001541 2 0.048
rna localization GO:0006403 4 0.047
cell death GO:0008219 121 0.047
stem cell differentiation GO:0048863 117 0.046
regulation of cell death GO:0010941 103 0.046
reciprocal dna recombination GO:0035825 1 0.045
chromosome segregation GO:0007059 12 0.045
regulation of macromolecule biosynthetic process GO:0010556 225 0.045
negative regulation of gene expression GO:0010629 65 0.045
myotube cell development GO:0014904 35 0.045
organelle organization GO:0006996 227 0.044
regulation of primary metabolic process GO:0080090 311 0.044
reproductive process GO:0022414 40 0.044
regulation of multicellular organism growth GO:0040014 4 0.043
ovulation cycle GO:0042698 2 0.043
cell cycle process GO:0022402 53 0.043
organic cyclic compound biosynthetic process GO:1901362 223 0.043
microtubule organizing center organization GO:0031023 1 0.043
positive regulation of stem cell proliferation GO:2000648 1 0.043
blood vessel morphogenesis GO:0048514 216 0.042
cellular localization GO:0051641 97 0.042
morphogenesis of an epithelium GO:0002009 333 0.042
embryonic axis specification GO:0000578 12 0.042
anatomical structure homeostasis GO:0060249 36 0.042
negative regulation of biosynthetic process GO:0009890 55 0.041
cell cycle GO:0007049 93 0.041
regulation of apoptotic process GO:0042981 98 0.041
cardiac atrium morphogenesis GO:0003209 2 0.040
protein modification process GO:0036211 100 0.039
protein metabolic process GO:0019538 183 0.039
maintenance of location GO:0051235 4 0.039
positive regulation of catabolic process GO:0009896 4 0.038
muscle fiber development GO:0048747 52 0.037
organic substance biosynthetic process GO:1901576 289 0.037
pronuclear migration GO:0035046 1 0.036
response to abiotic stimulus GO:0009628 122 0.036
spindle assembly GO:0051225 2 0.036
male meiosis GO:0007140 2 0.035
mitochondrion organization GO:0007005 4 0.035
rna biosynthetic process GO:0032774 181 0.035
dna repair GO:0006281 6 0.035
negative regulation of cell death GO:0060548 60 0.035
gene expression GO:0010467 252 0.035
cellular component movement GO:0006928 335 0.034
regulation of multicellular organismal development GO:2000026 223 0.034
heterocycle biosynthetic process GO:0018130 215 0.034
rhythmic process GO:0048511 21 0.033
rna catabolic process GO:0006401 7 0.033
cell migration GO:0016477 237 0.033
ovulation cycle process GO:0022602 2 0.032
female gonad development GO:0008585 4 0.032
cytoskeleton organization GO:0007010 96 0.032
programmed cell death GO:0012501 119 0.032
positive regulation of biological process GO:0048518 253 0.032
phosphorylation GO:0016310 69 0.032
positive regulation of striated muscle tissue development GO:0045844 1 0.032
cellular component biogenesis GO:0044085 178 0.032
striated muscle cell differentiation GO:0051146 129 0.031
atp catabolic process GO:0006200 4 0.031
embryonic organ development GO:0048568 381 0.031
cell substrate adhesion GO:0031589 4 0.031
positive regulation of signal transduction GO:0009967 56 0.031
transport GO:0006810 220 0.030
positive regulation of cell communication GO:0010647 56 0.030
specification of axis polarity GO:0065001 4 0.030
locomotion GO:0040011 313 0.030
regulation of dna catabolic process GO:1903624 1 0.030
regulation of autophagy GO:0010506 3 0.030
cellular macromolecule catabolic process GO:0044265 12 0.030
positive regulation of neuron death GO:1901216 1 0.029
regulation of smad protein complex assembly GO:0010990 1 0.029
developmental maturation GO:0021700 34 0.029
cellular protein modification process GO:0006464 100 0.029
response to vitamin GO:0033273 3 0.029
regulation of cell differentiation GO:0045595 142 0.029
macromolecule modification GO:0043412 111 0.028
cellular response to stress GO:0033554 62 0.028
cilium morphogenesis GO:0060271 85 0.028
meiotic nuclear division GO:0007126 4 0.028
somatic cell dna recombination GO:0016444 1 0.028
erythrocyte maturation GO:0043249 8 0.028
central nervous system development GO:0007417 387 0.027
rna 3 end processing GO:0031123 2 0.027
positive regulation of transport GO:0051050 2 0.027
skeletal muscle organ development GO:0060538 78 0.027
transcription from rna polymerase ii promoter GO:0006366 80 0.026
negative regulation of cellular metabolic process GO:0031324 77 0.026
regulation of dna replication GO:0006275 3 0.026
regulation of rna metabolic process GO:0051252 224 0.026
insulin like growth factor receptor signaling pathway GO:0048009 4 0.025
tripartite regional subdivision GO:0007351 5 0.025
regulation of transcription dna templated GO:0006355 213 0.025
cell aging GO:0007569 2 0.025
negative regulation of macromolecule metabolic process GO:0010605 76 0.025
catabolic process GO:0009056 32 0.025
sister chromatid cohesion GO:0007062 2 0.024
cellular response to superoxide GO:0071451 2 0.024
regulation of cell communication GO:0010646 232 0.024
one carbon compound transport GO:0019755 14 0.024
response to amphetamine GO:0001975 1 0.024
cellular nitrogen compound biosynthetic process GO:0044271 218 0.024
mitotic dna integrity checkpoint GO:0044774 4 0.024
meiosis ii GO:0007135 1 0.024
determination of heart left right asymmetry GO:0061371 117 0.024
b cell activation GO:0042113 2 0.023
nuclear migration GO:0007097 3 0.023
growth GO:0040007 174 0.023
cognition GO:0050890 1 0.023
autophagy GO:0006914 4 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
brain development GO:0007420 293 0.022
single organism cellular localization GO:1902580 46 0.022
rna processing GO:0006396 25 0.022
chromatin modification GO:0016568 21 0.022
head development GO:0060322 303 0.022
stem cell development GO:0048864 82 0.022
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.021
macromolecule localization GO:0033036 54 0.021
cellular response to oxygen radical GO:0071450 2 0.021
sensory organ development GO:0007423 393 0.021
carbon dioxide transport GO:0015670 3 0.021
regulation of skeletal muscle fiber development GO:0048742 2 0.021
regulation of cell development GO:0060284 100 0.021
mechanosensory behavior GO:0007638 2 0.021
regulation of synaptic plasticity GO:0048167 1 0.021
embryonic organ morphogenesis GO:0048562 274 0.021
mrna processing GO:0006397 14 0.021
single organism transport GO:0044765 206 0.021
cellular amine metabolic process GO:0044106 2 0.020
positive regulation of neural precursor cell proliferation GO:2000179 1 0.020
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.020
cellular protein metabolic process GO:0044267 129 0.020
mitotic cell cycle process GO:1903047 48 0.020
rna splicing GO:0008380 16 0.020
regulation of gene silencing by rna GO:0060966 1 0.020
transcription dna templated GO:0006351 181 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
organic acid metabolic process GO:0006082 31 0.019
striated muscle cell development GO:0055002 108 0.019
negative regulation of metabolic process GO:0009892 86 0.019
negative regulation of programmed cell death GO:0043069 58 0.019
removal of superoxide radicals GO:0019430 2 0.019
mrna metabolic process GO:0016071 20 0.019
alpha amino acid metabolic process GO:1901605 3 0.019
centrosome cycle GO:0007098 1 0.018
larval development GO:0002164 2 0.018
defense response to other organism GO:0098542 33 0.018
dna catabolic process GO:0006308 1 0.018
organism emergence from protective structure GO:0071684 4 0.018
regulation of cell size GO:0008361 29 0.018
striated muscle tissue development GO:0014706 110 0.018
microtubule depolymerization GO:0007019 1 0.017
fertilization GO:0009566 3 0.017
nucleic acid templated transcription GO:0097659 181 0.017
death GO:0016265 121 0.017
b cell differentiation GO:0030183 1 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.017
establishment of organelle localization GO:0051656 45 0.017
regulation of localization GO:0032879 104 0.017
response to nitrogen compound GO:1901698 19 0.017
skeletal muscle fiber development GO:0048741 35 0.017
bmp signaling pathway GO:0030509 52 0.017
negative regulation of translation GO:0017148 1 0.017
regulation of translational initiation GO:0006446 1 0.017
response to superoxide GO:0000303 2 0.017
somitogenesis GO:0001756 87 0.016
mrna 3 end processing GO:0031124 2 0.016
mitotic cell cycle embryonic GO:0045448 2 0.016
cellular response to starvation GO:0009267 1 0.016
oocyte growth GO:0001555 1 0.016
non recombinational repair GO:0000726 2 0.016
notochord development GO:0030903 54 0.016
endosomal transport GO:0016197 2 0.016
organelle localization GO:0051640 49 0.016
immune system process GO:0002376 241 0.016
oogenesis GO:0048477 14 0.016
smad protein complex assembly GO:0007183 1 0.016
regulation of mrna metabolic process GO:1903311 6 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.015
chromatin organization GO:0006325 22 0.015
neuroblast fate commitment GO:0014017 1 0.015
heart valve formation GO:0003188 4 0.015
behavior GO:0007610 74 0.015
mitotic dna damage checkpoint GO:0044773 4 0.015
positive regulation of cellular process GO:0048522 201 0.015
negative regulation of cell differentiation GO:0045596 46 0.015
regulation of signaling GO:0023051 235 0.015
cellular response to organic cyclic compound GO:0071407 38 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
single organism localization GO:1902578 225 0.015
mrna polyadenylation GO:0006378 2 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
regulation of protein transport GO:0051223 3 0.015
dna templated transcription initiation GO:0006352 1 0.015
translational initiation GO:0006413 3 0.014
urogenital system development GO:0001655 97 0.014
cell migration involved in gastrulation GO:0042074 79 0.014
cellular response to hypoxia GO:0071456 1 0.014
organelle fission GO:0048285 23 0.014
enzyme linked receptor protein signaling pathway GO:0007167 106 0.014
regulation of binding GO:0051098 3 0.014
mitotic sister chromatid segregation GO:0000070 6 0.014
production of small rna involved in gene silencing by rna GO:0070918 1 0.014
glycoprotein metabolic process GO:0009100 23 0.014
gas transport GO:0015669 3 0.014
single organism biosynthetic process GO:0044711 71 0.014
regulation of biosynthetic process GO:0009889 250 0.014
regulation of myotube differentiation GO:0010830 2 0.014
carbohydrate derivative biosynthetic process GO:1901137 43 0.013
myotube differentiation GO:0014902 45 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
developmental growth GO:0048589 166 0.013
embryonic digestive tract development GO:0048566 4 0.013
response to corticosteroid GO:0031960 1 0.013
histone phosphorylation GO:0016572 2 0.013
regulation of nuclease activity GO:0032069 1 0.013
nuclear transport GO:0051169 4 0.013
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.013
cell maturation GO:0048469 23 0.013
regulation of wound healing GO:0061041 2 0.013
reactive oxygen species biosynthetic process GO:1903409 1 0.013
nuclear transcribed mrna catabolic process GO:0000956 4 0.013
regulation of cellular protein metabolic process GO:0032268 52 0.013
cellular component maintenance GO:0043954 3 0.013
negative regulation of myeloid leukocyte differentiation GO:0002762 1 0.013
cytoskeleton dependent intracellular transport GO:0030705 10 0.013
positive regulation of response to stimulus GO:0048584 80 0.013
cell projection organization GO:0030030 284 0.013
cardiac atrium development GO:0003230 4 0.013
cellular response to chemical stimulus GO:0070887 157 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
regulation of cardiac muscle tissue development GO:0055024 1 0.012
protein localization to nucleus GO:0034504 3 0.012
digestive tract development GO:0048565 265 0.012
response to radiation GO:0009314 51 0.012
blood vessel development GO:0001568 246 0.012
embryonic digestive tract morphogenesis GO:0048557 3 0.012
negative regulation of mitosis GO:0045839 3 0.012
immune response GO:0006955 28 0.012
protein localization to microtubule cytoskeleton GO:0072698 1 0.012
regulation of cell cycle process GO:0010564 20 0.012
response to drug GO:0042493 3 0.012
proximal distal pattern formation GO:0009954 1 0.012
regulation of deoxyribonuclease activity GO:0032070 1 0.012
actin cytoskeleton organization GO:0030036 63 0.012
regulation of cell cycle GO:0051726 52 0.012
determination of left right symmetry GO:0007368 179 0.012
homeostasis of number of cells within a tissue GO:0048873 4 0.012
stem cell proliferation GO:0072089 4 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
cellular amino acid metabolic process GO:0006520 7 0.012
positive regulation of chromosome segregation GO:0051984 1 0.012
establishment of localization GO:0051234 244 0.011
negative regulation of cell growth GO:0030308 7 0.011
response to external biotic stimulus GO:0043207 97 0.011
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.011
response to amine GO:0014075 1 0.011
regulation of dna metabolic process GO:0051052 11 0.011
germ cell migration GO:0008354 8 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
response to nutrient GO:0007584 3 0.011
embryonic pattern specification GO:0009880 44 0.011
regulation of neural precursor cell proliferation GO:2000177 3 0.011
response to organic cyclic compound GO:0014070 51 0.011
regulation of intracellular signal transduction GO:1902531 57 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
regulation of signal transduction GO:0009966 225 0.011
cellular response to dsrna GO:0071359 1 0.011
vasculature development GO:0001944 278 0.011
postsynaptic membrane organization GO:0001941 3 0.011
response to chemical GO:0042221 320 0.011
regulation of response to stimulus GO:0048583 269 0.011
positive regulation of signaling GO:0023056 56 0.011
immunoglobulin production GO:0002377 1 0.011
g2 dna damage checkpoint GO:0031572 3 0.011
negative regulation of leukocyte differentiation GO:1902106 1 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
monovalent inorganic cation transport GO:0015672 42 0.010
cell motility GO:0048870 244 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
regulation of nervous system development GO:0051960 90 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.010
cellular protein catabolic process GO:0044257 4 0.010
positive regulation of protein metabolic process GO:0051247 23 0.010
cellular response to nutrient levels GO:0031669 2 0.010
regulation of cellular component organization GO:0051128 86 0.010
response to endogenous stimulus GO:0009719 83 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.010
regulation of gene expression GO:0010468 265 0.010
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.010
cellular response to organic substance GO:0071310 105 0.010
cellular nitrogen compound catabolic process GO:0044270 15 0.010
regulation of protein targeting GO:1903533 2 0.010
stem cell fate commitment GO:0048865 1 0.010

brca2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 0 0.648
disease of anatomical entity DOID:7 0 0.648
anemia DOID:2355 0 0.648
hematopoietic system disease DOID:74 0 0.648
bone marrow disease DOID:4961 0 0.619
congenital hypoplastic anemia DOID:1342 0 0.465
aplastic anemia DOID:12449 0 0.465
fanconi s anemia DOID:13636 0 0.465
disease of metabolism DOID:0014667 0 0.016
inherited metabolic disorder DOID:655 0 0.016
musculoskeletal system disease DOID:17 0 0.015
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011