Danio rerio

0 known processes

brd2b

bromodomain containing 2b

brd2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of rna metabolic process GO:0051252 224 0.418
Human Worm Fly
regulation of cellular biosynthetic process GO:0031326 245 0.357
Human Worm Fly
regulation of transcription dna templated GO:0006355 213 0.310
Human Worm Fly
regulation of rna biosynthetic process GO:2001141 213 0.276
Human Worm Fly
embryonic limb morphogenesis GO:0030326 2 0.263
nucleic acid templated transcription GO:0097659 181 0.256
Human Worm Fly
striated muscle tissue development GO:0014706 110 0.248
nucleic acid metabolic process GO:0090304 244 0.243
Human Worm Fly
macromolecule biosynthetic process GO:0009059 227 0.236
Human Worm Fly
alpha amino acid metabolic process GO:1901605 3 0.232
cellular macromolecule metabolic process GO:0044260 391 0.214
Human Worm Fly
regulation of nitrogen compound metabolic process GO:0051171 251 0.211
Human Worm Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.208
Human Worm Fly
cell part morphogenesis GO:0032990 246 0.208
regulation of macromolecule metabolic process GO:0060255 317 0.202
Human Worm Fly
signal transduction GO:0007165 455 0.191
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.190
Human Worm
heterocycle metabolic process GO:0046483 290 0.178
Human Worm Fly
nucleobase containing compound metabolic process GO:0006139 274 0.174
Human Worm Fly
negative regulation of biological process GO:0048519 304 0.167
Fly
transcription dna templated GO:0006351 181 0.157
Human Worm Fly
rna biosynthetic process GO:0032774 181 0.154
Human Worm Fly
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.150
i kappab kinase nf kappab signaling GO:0007249 4 0.146
brain development GO:0007420 293 0.146
nitrogen compound metabolic process GO:0006807 319 0.145
Human Worm Fly
digestive tract development GO:0048565 265 0.142
organic cyclic compound biosynthetic process GO:1901362 223 0.136
Human Worm Fly
g2 dna damage checkpoint GO:0031572 3 0.136
response to vitamin GO:0033273 3 0.132
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.131
response to organic substance GO:0010033 153 0.131
cilium morphogenesis GO:0060271 85 0.126
organic cyclic compound metabolic process GO:1901360 301 0.125
Human Worm Fly
negative regulation of transcription dna templated GO:0045892 45 0.121
Fly
positive regulation of muscle organ development GO:0048636 1 0.120
negative regulation of cellular process GO:0048523 283 0.115
Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.110
regulation of metabolic process GO:0019222 359 0.109
Human Worm Fly
cellular aromatic compound metabolic process GO:0006725 295 0.105
Human Worm Fly
negative regulation of metabolic process GO:0009892 86 0.100
Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.099
Human Worm Fly
aging GO:0007568 2 0.099
amine metabolic process GO:0009308 2 0.099
negative regulation of rna metabolic process GO:0051253 48 0.098
Fly
oocyte maturation GO:0001556 4 0.098
regulation of gene expression GO:0010468 265 0.097
Human Worm Fly
organic acid metabolic process GO:0006082 31 0.097
regulation of cellular amine metabolic process GO:0033238 0 0.096
cellular macromolecular complex assembly GO:0034622 24 0.095
Human
muscle fiber development GO:0048747 52 0.092
regulation of cellular metabolic process GO:0031323 320 0.092
Human Worm Fly
skeletal muscle tissue development GO:0007519 67 0.091
muscle tissue development GO:0060537 110 0.087
positive regulation of rna metabolic process GO:0051254 59 0.087
meiotic cell cycle process GO:1903046 3 0.087
positive regulation of nucleic acid templated transcription GO:1903508 57 0.086
regulation of primary metabolic process GO:0080090 311 0.085
Human Worm Fly
neuroblast differentiation GO:0014016 1 0.083
Worm
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.082
Human Worm Fly
stem cell fate commitment GO:0048865 1 0.077
Worm
vasculature development GO:0001944 278 0.077
regulation of mrna processing GO:0050684 3 0.075
eye development GO:0001654 277 0.075
convergent extension GO:0060026 118 0.072
regulation of nucleic acid templated transcription GO:1903506 213 0.072
Human Worm Fly
skeletal muscle organ development GO:0060538 78 0.072
generation of neurons GO:0048699 385 0.071
Worm
cellular nitrogen compound metabolic process GO:0034641 290 0.071
Human Worm Fly
g2 m transition of mitotic cell cycle GO:0000086 4 0.070
striated muscle cell differentiation GO:0051146 129 0.069
rna metabolic process GO:0016070 219 0.068
Human Worm Fly
organic substance biosynthetic process GO:1901576 289 0.068
Human Worm Fly
digestive system development GO:0055123 289 0.068
positive regulation of transport GO:0051050 2 0.066
regulation of cell development GO:0060284 100 0.064
regulation of metal ion transport GO:0010959 4 0.064
reactive oxygen species biosynthetic process GO:1903409 1 0.063
mitotic g2 dna damage checkpoint GO:0007095 3 0.063
negative regulation of gene expression GO:0010629 65 0.062
Fly
muscle organ development GO:0007517 101 0.060
mitotic dna integrity checkpoint GO:0044774 4 0.060
cellular component assembly GO:0022607 170 0.060
Human
somitogenesis GO:0001756 87 0.060
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.058
Fly
negative regulation of response to stimulus GO:0048585 104 0.057
regulation of skeletal muscle fiber development GO:0048742 2 0.057
muscle structure development GO:0061061 196 0.057
regulation of cellular amino acid metabolic process GO:0006521 0 0.057
mitotic g2 m transition checkpoint GO:0044818 3 0.055
cellular amine metabolic process GO:0044106 2 0.055
growth GO:0040007 174 0.054
biosynthetic process GO:0009058 294 0.053
Human Worm Fly
oxoacid metabolic process GO:0043436 31 0.052
cell fate specification GO:0001708 68 0.051
Worm
cellular macromolecule biosynthetic process GO:0034645 224 0.050
Human Worm Fly
gastrulation GO:0007369 208 0.049
regulation of biosynthetic process GO:0009889 250 0.049
Human Worm Fly
protein homooligomerization GO:0051260 3 0.049
cellular biosynthetic process GO:0044249 286 0.048
Human Worm Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.048
negative regulation of cellular metabolic process GO:0031324 77 0.048
Fly
regulation of synapse organization GO:0050807 3 0.046
cell cycle g2 m phase transition GO:0044839 4 0.046
alternative mrna splicing via spliceosome GO:0000380 1 0.045
stem cell maintenance GO:0019827 4 0.045
meiotic nuclear division GO:0007126 4 0.045
camera type eye morphogenesis GO:0048593 108 0.045
digestive tract morphogenesis GO:0048546 231 0.044
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.044
cellular ketone metabolic process GO:0042180 11 0.044
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.044
Fly
retina morphogenesis in camera type eye GO:0060042 79 0.044
aromatic compound biosynthetic process GO:0019438 217 0.043
Human Worm Fly
neuroblast fate commitment GO:0014017 1 0.043
Worm
mitotic dna damage checkpoint GO:0044773 4 0.043
cell surface receptor signaling pathway GO:0007166 325 0.043
cellular component biogenesis GO:0044085 178 0.042
Human
developmental cell growth GO:0048588 52 0.042
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.042
transcription from rna polymerase ii promoter GO:0006366 80 0.042
Human Worm
positive regulation of cellular process GO:0048522 201 0.041
central nervous system development GO:0007417 387 0.041
regulation of protein transport GO:0051223 3 0.041
anterior posterior pattern specification GO:0009952 152 0.040
Fly
heart development GO:0007507 313 0.040
regulation of response to stimulus GO:0048583 269 0.040
chromatin organization GO:0006325 22 0.040
Human
macromolecular complex assembly GO:0065003 35 0.040
Human
regulation of cellular ketone metabolic process GO:0010565 7 0.039
epithelial cell morphogenesis GO:0003382 2 0.039
negative regulation of chemotaxis GO:0050922 4 0.038
nucleobase containing compound biosynthetic process GO:0034654 205 0.038
Human Worm Fly
macromolecular complex subunit organization GO:0043933 74 0.038
Human
phosphorylation GO:0016310 69 0.038
nephron morphogenesis GO:0072028 2 0.038
negative regulation of bmp signaling pathway GO:0030514 13 0.037
regulation of inflammatory response GO:0050727 2 0.037
gene expression GO:0010467 252 0.037
Human Worm Fly
skeletal muscle fiber development GO:0048741 35 0.036
organelle organization GO:0006996 227 0.036
Human
regulation of axonogenesis GO:0050770 32 0.035
extrinsic apoptotic signaling pathway GO:0097191 3 0.035
negative regulation of nucleic acid templated transcription GO:1903507 45 0.035
Fly
morphogenesis of an epithelium GO:0002009 333 0.035
nephron tubule morphogenesis GO:0072078 1 0.034
positive regulation of cell cycle GO:0045787 3 0.034
negative regulation of cell communication GO:0010648 96 0.033
regulation of mrna splicing via spliceosome GO:0048024 3 0.033
heterocycle biosynthetic process GO:0018130 215 0.033
Human Worm Fly
regulation of organelle assembly GO:1902115 4 0.033
nephron epithelium morphogenesis GO:0072088 1 0.033
cardiac atrium development GO:0003230 4 0.033
b cell activation GO:0042113 2 0.032
striated muscle cell development GO:0055002 108 0.032
positive regulation of muscle tissue development GO:1901863 1 0.032
ribonucleoprotein complex biogenesis GO:0022613 13 0.031
retinal cone cell development GO:0046549 8 0.031
head development GO:0060322 303 0.031
carboxylic acid metabolic process GO:0019752 22 0.031
response to chemical GO:0042221 320 0.030
cellular amino acid biosynthetic process GO:0008652 2 0.030
tube morphogenesis GO:0035239 349 0.030
bmp signaling pathway GO:0030509 52 0.030
cellular protein metabolic process GO:0044267 129 0.030
regionalization GO:0003002 274 0.029
Fly
cerebellar granular layer formation GO:0021684 3 0.029
positive regulation of translation GO:0045727 1 0.028
negative regulation of catalytic activity GO:0043086 21 0.028
enzyme linked receptor protein signaling pathway GO:0007167 106 0.027
otolith development GO:0048840 32 0.027
eye morphogenesis GO:0048592 144 0.027
cellular component assembly involved in morphogenesis GO:0010927 107 0.027
multi organism process GO:0051704 134 0.027
negative regulation of protein kinase activity GO:0006469 4 0.027
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.027
Fly
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.027
negative regulation of signaling GO:0023057 96 0.027
outflow tract morphogenesis GO:0003151 1 0.026
neuron differentiation GO:0030182 353 0.026
regulation of multicellular organismal process GO:0051239 277 0.026
Worm
cellular response to nutrient levels GO:0031669 2 0.026
negative regulation of biosynthetic process GO:0009890 55 0.026
Fly
heart looping GO:0001947 94 0.026
single organism metabolic process GO:0044710 217 0.026
regulation of developmental process GO:0050793 247 0.026
Worm
cellular amino acid metabolic process GO:0006520 7 0.025
blood vessel development GO:0001568 246 0.025
negative regulation of signal transduction GO:0009968 94 0.025
positive regulation of cellular biosynthetic process GO:0031328 68 0.025
axonogenesis GO:0007409 152 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.025
Fly
neuromuscular synaptic transmission GO:0007274 2 0.025
nucleoside monophosphate catabolic process GO:0009125 4 0.025
specification of axis polarity GO:0065001 4 0.025
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.025
negative regulation of rna biosynthetic process GO:1902679 45 0.024
Fly
organonitrogen compound metabolic process GO:1901564 74 0.024
macromolecule modification GO:0043412 111 0.024
neuron development GO:0048666 262 0.024
positive regulation of embryonic development GO:0040019 3 0.024
dna biosynthetic process GO:0071897 3 0.024
protein metabolic process GO:0019538 183 0.024
regulation of postsynaptic membrane potential GO:0060078 1 0.023
cell death GO:0008219 121 0.023
positive regulation of cellular amine metabolic process GO:0033240 0 0.023
negative regulation of macromolecule metabolic process GO:0010605 76 0.023
Fly
cellular carbohydrate metabolic process GO:0044262 4 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.023
ribonucleoside monophosphate catabolic process GO:0009158 4 0.023
muscle cell development GO:0055001 115 0.023
purine nucleoside monophosphate catabolic process GO:0009128 4 0.022
negative regulation of mapk cascade GO:0043409 4 0.022
connective tissue development GO:0061448 99 0.022
chordate embryonic development GO:0043009 271 0.022
somite development GO:0061053 96 0.022
regulation of cell communication GO:0010646 232 0.022
histone phosphorylation GO:0016572 2 0.022
camera type eye photoreceptor cell differentiation GO:0060219 19 0.022
telomere organization GO:0032200 1 0.022
protein localization to nucleus GO:0034504 3 0.022
intracellular signal transduction GO:0035556 85 0.022
positive regulation of gastrulation GO:2000543 2 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.021
cellular response to steroid hormone stimulus GO:0071383 31 0.021
rna splicing GO:0008380 16 0.021
cell projection organization GO:0030030 284 0.021
muscle cell differentiation GO:0042692 139 0.021
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.021
convergent extension involved in gastrulation GO:0060027 71 0.021
monoamine transport GO:0015844 1 0.021
protein complex biogenesis GO:0070271 30 0.021
Human
protein acetylation GO:0006473 2 0.020
autophagy GO:0006914 4 0.020
regulation of tube size GO:0035150 2 0.020
blood vessel morphogenesis GO:0048514 216 0.020
small molecule catabolic process GO:0044282 3 0.020
regulation of anatomical structure morphogenesis GO:0022603 130 0.020
nuclear import GO:0051170 3 0.020
cell projection morphogenesis GO:0048858 244 0.020
positive regulation of gene expression GO:0010628 71 0.020
renal system vasculature development GO:0061437 2 0.020
myotube cell development GO:0014904 35 0.020
somatic cell dna recombination GO:0016444 1 0.020
protein oligomerization GO:0051259 7 0.020
hemopoiesis GO:0030097 183 0.019
anatomical structure arrangement GO:0048532 2 0.019
embryo development ending in birth or egg hatching GO:0009792 271 0.019
Worm
morphogenesis of an epithelial fold GO:0060571 1 0.019
regulation of intracellular signal transduction GO:1902531 57 0.019
cellular protein modification process GO:0006464 100 0.019
cellular response to organic substance GO:0071310 105 0.018
positive regulation of striated muscle tissue development GO:0045844 1 0.018
regulation of signal transduction GO:0009966 225 0.018
larval development GO:0002164 2 0.018
Worm
positive regulation of rna biosynthetic process GO:1902680 57 0.018
cellular response to external stimulus GO:0071496 2 0.018
ribosomal small subunit biogenesis GO:0042274 2 0.018
negative regulation of jnk cascade GO:0046329 1 0.018
response to bacterium GO:0009617 58 0.018
lipid digestion GO:0044241 3 0.018
negative regulation of kinase activity GO:0033673 4 0.017
ectodermal cell differentiation GO:0010668 2 0.017
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.017
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.017
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.017
response to fluid shear stress GO:0034405 2 0.017
atp catabolic process GO:0006200 4 0.017
protein import GO:0017038 3 0.017
regulation of glial cell differentiation GO:0045685 4 0.017
branchiomotor neuron axon guidance GO:0021785 1 0.017
organic acid catabolic process GO:0016054 3 0.017
b cell differentiation GO:0030183 1 0.017
response to external biotic stimulus GO:0043207 97 0.016
branching morphogenesis of an epithelial tube GO:0048754 15 0.016
positive regulation of synapse assembly GO:0051965 1 0.016
kidney vasculature development GO:0061440 2 0.016
vitamin metabolic process GO:0006766 11 0.016
protein complex localization GO:0031503 1 0.016
response to uv GO:0009411 3 0.016
camera type eye development GO:0043010 222 0.016
regulation of multicellular organismal development GO:2000026 223 0.016
Worm
positive regulation of transcription dna templated GO:0045893 57 0.016
regulation of signaling GO:0023051 235 0.016
regulation of myotube differentiation GO:0010830 2 0.016
reactive nitrogen species metabolic process GO:2001057 0 0.016
regulation of protein metabolic process GO:0051246 56 0.016
sensory organ morphogenesis GO:0090596 200 0.016
cell cell signaling GO:0007267 52 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.015
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.015
regulation of histone methylation GO:0031060 3 0.015
renal tubule morphogenesis GO:0061333 1 0.015
eye photoreceptor cell differentiation GO:0001754 45 0.015
positive regulation of biosynthetic process GO:0009891 68 0.015
negative regulation of multicellular organismal process GO:0051241 69 0.015
spinal cord development GO:0021510 46 0.015
regulation of cell differentiation GO:0045595 142 0.015
negative regulation of defense response GO:0031348 2 0.014
macromolecular complex disassembly GO:0032984 1 0.014
otic placode formation GO:0043049 23 0.014
phagocytosis GO:0006909 3 0.014
programmed cell death GO:0012501 119 0.014
catecholamine metabolic process GO:0006584 2 0.014
negative regulation of immune response GO:0050777 2 0.014
regulation of nervous system development GO:0051960 90 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
Human Worm Fly
membrane hyperpolarization GO:0060081 1 0.014
negative regulation of cell cycle GO:0045786 14 0.014
angiogenesis GO:0001525 158 0.014
negative regulation of axon guidance GO:1902668 1 0.013
cell substrate junction assembly GO:0007044 2 0.013
negative chemotaxis GO:0050919 1 0.013
cell aging GO:0007569 2 0.013
positive regulation of catabolic process GO:0009896 4 0.013
neural retina development GO:0003407 49 0.013
stem cell division GO:0017145 1 0.013
regulation of blood vessel size GO:0050880 2 0.013
myotube differentiation GO:0014902 45 0.013
regulation of meiotic cell cycle GO:0051445 1 0.013
protein complex disassembly GO:0043241 1 0.013
forebrain development GO:0030900 96 0.013
meiotic chromosome segregation GO:0045132 3 0.012
negative regulation of phosphate metabolic process GO:0045936 13 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
proteasomal protein catabolic process GO:0010498 2 0.012
regulation of cardiac muscle tissue development GO:0055024 1 0.012
regeneration GO:0031099 91 0.012
optic placode formation GO:0001743 4 0.012
hormone biosynthetic process GO:0042446 3 0.012
female meiotic division GO:0007143 2 0.012
dorsal ventral pattern formation GO:0009953 125 0.012
interspecies interaction between organisms GO:0044419 4 0.012
cellular component movement GO:0006928 335 0.012
pronephric nephron tubule development GO:0039020 2 0.012
notochord development GO:0030903 54 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
collagen fibril organization GO:0030199 1 0.012
cellular pigmentation GO:0033059 30 0.012
regulation of embryonic development GO:0045995 47 0.012
protein modification process GO:0036211 100 0.012
axis specification GO:0009798 43 0.012
Fly
smooth muscle tissue development GO:0048745 1 0.012
regulation of cytokine production GO:0001817 3 0.012
cell fate commitment GO:0045165 99 0.012
Worm
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
determination of dorsal ventral asymmetry GO:0048262 34 0.012
g protein coupled receptor signaling pathway GO:0007186 74 0.012
transport GO:0006810 220 0.012
hematopoietic or lymphoid organ development GO:0048534 191 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
bone mineralization GO:0030282 9 0.011
viral process GO:0016032 1 0.011
segmentation GO:0035282 97 0.011
Fly
glomerulus vasculature development GO:0072012 2 0.011
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.011
erk1 and erk2 cascade GO:0070371 4 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
cerebellar granular layer morphogenesis GO:0021683 3 0.011
immune system development GO:0002520 191 0.011
death GO:0016265 121 0.011
microtubule depolymerization GO:0007019 1 0.011
negative regulation of oocyte development GO:0060283 2 0.011
maintenance of dna repeat elements GO:0043570 2 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
neurotransmitter transport GO:0006836 2 0.011
kupffer s vesicle development GO:0070121 50 0.011
glial cell differentiation GO:0010001 42 0.011
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.011
protein acylation GO:0043543 3 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 5 0.011
ubiquitin dependent protein catabolic process GO:0006511 3 0.011
regulation of cell matrix adhesion GO:0001952 1 0.011
endocardial cushion formation GO:0003272 2 0.011
membrane repolarization GO:0086009 2 0.011
cellular response to oxygen levels GO:0071453 1 0.011
positive regulation of neurogenesis GO:0050769 24 0.011
regulation of oocyte development GO:0060281 3 0.011
regulation of apoptotic process GO:0042981 98 0.011
regulation of cell aging GO:0090342 1 0.010
positive regulation of multicellular organismal process GO:0051240 52 0.010
cellular response to starvation GO:0009267 1 0.010
nitric oxide metabolic process GO:0046209 2 0.010
ectodermal cell fate specification GO:0001715 2 0.010
telomere maintenance GO:0000723 1 0.010
response to organic cyclic compound GO:0014070 51 0.010
homeostasis of number of cells GO:0048872 62 0.010
establishment of localization GO:0051234 244 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.010
neuron projection extension GO:1990138 45 0.010
regulation of cysteine type endopeptidase activity GO:2000116 21 0.010
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.010
ncrna metabolic process GO:0034660 12 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010
regulation of biomineral tissue development GO:0070167 2 0.010
ncrna catabolic process GO:0034661 1 0.010

brd2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.033
lysosomal storage disease DOID:3211 0 0.033
inherited metabolic disorder DOID:655 0 0.033
immune system disease DOID:2914 0 0.031
disease of anatomical entity DOID:7 0 0.031
hematopoietic system disease DOID:74 0 0.022