Danio rerio

37 known processes

btk

Bruton agammaglobulinemia tyrosine kinase

btk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune system process GO:0002376 241 0.421
definitive hemopoiesis GO:0060216 18 0.408
gene expression GO:0010467 252 0.384
positive regulation of protein complex assembly GO:0031334 2 0.379
response to chemical GO:0042221 320 0.355
hemopoiesis GO:0030097 183 0.346
regulation of protein complex assembly GO:0043254 3 0.320
Fly
regulation of gene expression GO:0010468 265 0.281
response to external stimulus GO:0009605 264 0.267
Zebrafish
syncytium formation GO:0006949 12 0.262
positive regulation of protein polymerization GO:0032273 2 0.252
synaptic growth at neuromuscular junction GO:0051124 2 0.232
organic cyclic compound biosynthetic process GO:1901362 223 0.219
regulation of macromolecule metabolic process GO:0060255 317 0.216
Zebrafish
regulation of protein polymerization GO:0032271 2 0.216
Fly
protein polymerization GO:0051258 4 0.199
Fly
positive regulation of cellular component biogenesis GO:0044089 3 0.192
endosomal transport GO:0016197 2 0.187
negative regulation of synapse assembly GO:0051964 2 0.178
regulation of synapse organization GO:0050807 3 0.168
regulation of synapse assembly GO:0051963 3 0.165
regulation of multicellular organismal development GO:2000026 223 0.164
hematopoietic progenitor cell differentiation GO:0002244 23 0.163
heterocycle biosynthetic process GO:0018130 215 0.163
actin polymerization or depolymerization GO:0008154 2 0.157
Fly
macromolecule biosynthetic process GO:0009059 227 0.152
Fly
nucleic acid templated transcription GO:0097659 181 0.151
organelle organization GO:0006996 227 0.150
Fly
regulation of cytokine production GO:0001817 3 0.149
cellular response to external stimulus GO:0071496 2 0.143
rna biosynthetic process GO:0032774 181 0.141
wnt signaling pathway GO:0016055 80 0.136
actin filament polymerization GO:0030041 2 0.136
Fly
neutrophil migration GO:1990266 10 0.129
positive regulation of cytokine production GO:0001819 2 0.127
biosynthetic process GO:0009058 294 0.125
Fly
epithelial cell morphogenesis GO:0003382 2 0.125
nucleic acid metabolic process GO:0090304 244 0.124
Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.121
myeloid leukocyte migration GO:0097529 12 0.119
neutrophil chemotaxis GO:0030593 10 0.118
spermatid development GO:0007286 2 0.118
heterocycle metabolic process GO:0046483 290 0.117
Fly
transcription dna templated GO:0006351 181 0.117
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.115
cellular nitrogen compound metabolic process GO:0034641 290 0.112
Fly
macrophage chemotaxis GO:0048246 3 0.111
granulocyte migration GO:0097530 11 0.111
leukocyte chemotaxis GO:0030595 12 0.109
cellular component movement GO:0006928 335 0.109
i kappab kinase nf kappab signaling GO:0007249 4 0.108
Mouse
actin filament based movement GO:0030048 1 0.107
leukocyte differentiation GO:0002521 25 0.107
generation of neurons GO:0048699 385 0.104
regionalization GO:0003002 274 0.103
signal transduction GO:0007165 455 0.103
larval development GO:0002164 2 0.102
spermatid differentiation GO:0048515 2 0.100
negative regulation of multicellular organismal process GO:0051241 69 0.097
nitrogen compound metabolic process GO:0006807 319 0.097
Fly
regulation of cellular metabolic process GO:0031323 320 0.096
Zebrafish
regulation of biological quality GO:0065008 263 0.093
Zebrafish Fly
neuron projection development GO:0031175 180 0.092
positive regulation of cytoskeleton organization GO:0051495 3 0.092
regulation of biosynthetic process GO:0009889 250 0.091
syncytium formation by plasma membrane fusion GO:0000768 12 0.091
embryonic organ development GO:0048568 381 0.086
organic substance biosynthetic process GO:1901576 289 0.085
Fly
cell projection organization GO:0030030 284 0.085
cellular response to molecule of bacterial origin GO:0071219 3 0.085
cell migration GO:0016477 237 0.083
regulation of nucleic acid templated transcription GO:1903506 213 0.083
cellular biosynthetic process GO:0044249 286 0.083
Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.081
regulation of metabolic process GO:0019222 359 0.080
Zebrafish
regulation of primary metabolic process GO:0080090 311 0.079
Zebrafish
myeloid cell differentiation GO:0030099 86 0.078
cell chemotaxis GO:0060326 17 0.077
cell projection morphogenesis GO:0048858 244 0.077
myotube differentiation GO:0014902 45 0.076
regulation of rna metabolic process GO:0051252 224 0.074
regulation of multicellular organismal process GO:0051239 277 0.072
regulation of nervous system development GO:0051960 90 0.071
cellular macromolecule biosynthetic process GO:0034645 224 0.069
Fly
hematopoietic stem cell differentiation GO:0060218 20 0.068
rna metabolic process GO:0016070 219 0.068
regulation of nitrogen compound metabolic process GO:0051171 251 0.068
negative regulation of cellular process GO:0048523 283 0.067
embryo development ending in birth or egg hatching GO:0009792 271 0.067
Fly
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.067
morphogenesis of an epithelium GO:0002009 333 0.066
Zebrafish
locomotion GO:0040011 313 0.066
response to stress GO:0006950 263 0.065
cellular response to chemical stimulus GO:0070887 157 0.064
cell motility GO:0048870 244 0.064
neuron differentiation GO:0030182 353 0.062
regulation of embryonic development GO:0045995 47 0.062
regulation of developmental process GO:0050793 247 0.061
transport GO:0006810 220 0.060
Fly
cellular component morphogenesis GO:0032989 336 0.060
localization of cell GO:0051674 244 0.060
protein secretion GO:0009306 1 0.059
multi organism process GO:0051704 134 0.058
Zebrafish Fly
skin development GO:0043588 54 0.058
stem cell differentiation GO:0048863 117 0.057
single organism reproductive process GO:0044702 40 0.057
Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.057
negative regulation of biological process GO:0048519 304 0.057
regulation of cellular biosynthetic process GO:0031326 245 0.056
hematopoietic or lymphoid organ development GO:0048534 191 0.056
positive regulation of biological process GO:0048518 253 0.054
growth GO:0040007 174 0.053
aromatic compound biosynthetic process GO:0019438 217 0.053
epithelium migration GO:0090132 25 0.052
skeletal muscle organ development GO:0060538 78 0.052
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.052
stem cell maintenance GO:0019827 4 0.050
epithelial cell differentiation GO:0030855 116 0.050
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.050
striated muscle cell differentiation GO:0051146 129 0.050
leukocyte proliferation GO:0070661 1 0.049
axon development GO:0061564 166 0.049
epithelial cell migration GO:0010631 25 0.049
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.048
positive regulation of cellular process GO:0048522 201 0.048
actin mediated cell contraction GO:0070252 1 0.047
regulation of organelle organization GO:0033043 29 0.046
Fly
regulation of cell motility GO:2000145 46 0.046
positive regulation of cell cycle GO:0045787 3 0.045
multi organism reproductive process GO:0044703 36 0.045
Fly
muscle structure development GO:0061061 196 0.044
single organism transport GO:0044765 206 0.044
Fly
positive regulation of stress activated mapk cascade GO:0032874 3 0.042
homeostasis of number of cells GO:0048872 62 0.041
regulation of cell communication GO:0010646 232 0.041
regulation of immune system process GO:0002682 34 0.041
regulation of neutrophil migration GO:1902622 6 0.040
establishment of localization GO:0051234 244 0.040
Fly
lipid storage GO:0019915 1 0.039
regulation of signaling GO:0023051 235 0.039
positive regulation of jnk cascade GO:0046330 3 0.039
autophagy GO:0006914 4 0.038
toll like receptor signaling pathway GO:0002224 4 0.038
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.038
response to bacterium GO:0009617 58 0.038
sensory organ development GO:0007423 393 0.038
regulation of cellular component organization GO:0051128 86 0.037
Fly
regulation of transcription dna templated GO:0006355 213 0.037
cellular response to stress GO:0033554 62 0.037
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.037
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.036
entrainment of circadian clock by photoperiod GO:0043153 1 0.036
regulation of autophagy GO:0010506 3 0.036
single organism localization GO:1902578 225 0.036
Fly
cellular aromatic compound metabolic process GO:0006725 295 0.035
Fly
organic substance transport GO:0071702 58 0.035
protein metabolic process GO:0019538 183 0.034
Zebrafish Mouse Fly
regulation of cytoskeleton organization GO:0051493 11 0.034
Fly
epithelial cell development GO:0002064 42 0.034
regulation of signal transduction GO:0009966 225 0.034
immune system development GO:0002520 191 0.034
muscle organ development GO:0007517 101 0.034
nucleobase containing compound metabolic process GO:0006139 274 0.034
Fly
negative regulation of myeloid leukocyte differentiation GO:0002762 1 0.033
cellular amide metabolic process GO:0043603 4 0.033
response to wounding GO:0009611 116 0.033
morphogenesis of embryonic epithelium GO:0016331 30 0.033
multicellular organism reproduction GO:0032504 35 0.032
Fly
regulation of synaptic plasticity GO:0048167 1 0.032
maintenance of location GO:0051235 4 0.032
monocyte differentiation GO:0030224 2 0.032
microtubule cytoskeleton organization GO:0000226 33 0.031
regulation of cellular component movement GO:0051270 55 0.030
cellular localization GO:0051641 97 0.030
multicellular organismal reproductive process GO:0048609 35 0.030
Fly
regulation of cell activation GO:0050865 1 0.030
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.030
granulocyte chemotaxis GO:0071621 11 0.030
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.030
protein complex assembly GO:0006461 30 0.030
Fly
positive regulation of multicellular organismal process GO:0051240 52 0.029
regulation of cell morphogenesis GO:0022604 42 0.029
negative regulation of developmental process GO:0051093 65 0.029
aging GO:0007568 2 0.029
Fly
myeloid cell homeostasis GO:0002262 56 0.029
cellular component assembly GO:0022607 170 0.029
Fly
microtubule based process GO:0007017 60 0.029
defense response GO:0006952 47 0.029
stem cell proliferation GO:0072089 4 0.028
antimicrobial humoral response GO:0019730 2 0.028
cellular macromolecule metabolic process GO:0044260 391 0.028
Zebrafish Mouse Fly
regulation of phosphorus metabolic process GO:0051174 43 0.028
Zebrafish
ameboidal type cell migration GO:0001667 143 0.028
leukocyte migration GO:0050900 15 0.028
response to organic substance GO:0010033 153 0.028
heart development GO:0007507 313 0.027
regulation of anatomical structure morphogenesis GO:0022603 130 0.027
leukocyte activation GO:0045321 12 0.027
macroautophagy GO:0016236 1 0.027
amine metabolic process GO:0009308 2 0.027
regulation of anatomical structure size GO:0090066 33 0.027
Fly
sexual reproduction GO:0019953 36 0.027
Fly
small molecule metabolic process GO:0044281 77 0.027
defense response to other organism GO:0098542 33 0.027
cellular response to organic substance GO:0071310 105 0.027
response to oxygen containing compound GO:1901700 55 0.027
production of molecular mediator of immune response GO:0002440 2 0.026
regulation of molecular function GO:0065009 70 0.026
Zebrafish
taxis GO:0042330 109 0.026
muscle attachment GO:0016203 9 0.026
epidermis development GO:0008544 48 0.026
cell part morphogenesis GO:0032990 246 0.025
granulocyte differentiation GO:0030851 8 0.025
developmental process involved in reproduction GO:0003006 27 0.025
Fly
regulation of leukocyte migration GO:0002685 8 0.025
regulation of binding GO:0051098 3 0.025
positive regulation of histone modification GO:0031058 1 0.025
cellular response to lipopolysaccharide GO:0071222 3 0.024
negative regulation of leukocyte differentiation GO:1902106 1 0.024
regulation of rna biosynthetic process GO:2001141 213 0.024
positive regulation of metabolic process GO:0009893 108 0.023
regulation of response to stress GO:0080134 36 0.023
female sex differentiation GO:0046660 4 0.023
homeostatic process GO:0042592 142 0.023
Zebrafish
positive regulation of molecular function GO:0044093 33 0.023
positive regulation of map kinase activity GO:0043406 3 0.023
muscle cell differentiation GO:0042692 139 0.023
peptide metabolic process GO:0006518 1 0.023
single organism metabolic process GO:0044710 217 0.023
Fly
regulation of cell shape GO:0008360 1 0.023
neuron projection morphogenesis GO:0048812 161 0.023
actin cytoskeleton organization GO:0030036 63 0.022
Fly
regulation of cellular amine metabolic process GO:0033238 0 0.022
microtubule bundle formation GO:0001578 9 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
female gonad development GO:0008585 4 0.022
somatic stem cell maintenance GO:0035019 1 0.022
angiogenesis GO:0001525 158 0.021
synapse organization GO:0050808 21 0.021
cell morphogenesis involved in differentiation GO:0000904 195 0.021
regulation of neural precursor cell proliferation GO:2000177 3 0.021
lymphocyte activation GO:0046649 10 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
regulation of cellular component size GO:0032535 30 0.021
Fly
sequestering of calcium ion GO:0051208 3 0.021
response to drug GO:0042493 3 0.021
cognition GO:0050890 1 0.021
Fly
cellular response to hypoxia GO:0071456 1 0.021
regulation of erythrocyte differentiation GO:0045646 2 0.021
positive regulation of catabolic process GO:0009896 4 0.020
neuron development GO:0048666 262 0.020
regulation of cell migration GO:0030334 40 0.020
cellular macromolecular complex assembly GO:0034622 24 0.020
Fly
regulation of inflammatory response GO:0050727 2 0.020
regulation of response to stimulus GO:0048583 269 0.020
vasculature development GO:0001944 278 0.020
cell activation GO:0001775 16 0.020
regulation of cytokine biosynthetic process GO:0042035 1 0.020
proteolysis GO:0006508 38 0.020
cellular response to starvation GO:0009267 1 0.020
germ cell development GO:0007281 22 0.020
Fly
regulation of jun kinase activity GO:0043506 3 0.020
development of primary female sexual characteristics GO:0046545 4 0.019
reproduction GO:0000003 40 0.019
Fly
positive regulation of biosynthetic process GO:0009891 68 0.019
intracellular signal transduction GO:0035556 85 0.019
Mouse
neuron neuron synaptic transmission GO:0007270 1 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
proteasomal protein catabolic process GO:0010498 2 0.019
innate immune response GO:0045087 13 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
phagocytosis GO:0006909 3 0.019
posttranscriptional regulation of gene expression GO:0010608 14 0.019
response to carbohydrate GO:0009743 3 0.019
embryonic hemopoiesis GO:0035162 53 0.019
negative regulation of metabolic process GO:0009892 86 0.018
protein complex subunit organization GO:0071822 46 0.018
Fly
tissue migration GO:0090130 37 0.018
epidermal cell fate specification GO:0009957 4 0.018
regulation of translational initiation GO:0006446 1 0.018
regulation of locomotion GO:0040012 55 0.018
rna localization GO:0006403 4 0.018
positive regulation of blood circulation GO:1903524 2 0.018
response to endogenous stimulus GO:0009719 83 0.018
negative regulation of kinase activity GO:0033673 4 0.018
nuclear migration GO:0007097 3 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
cellular response to reactive oxygen species GO:0034614 2 0.018
behavior GO:0007610 74 0.017
Fly
multicellular organism growth GO:0035264 4 0.017
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
cellular component biogenesis GO:0044085 178 0.017
Fly
positive regulation of cellular catabolic process GO:0031331 3 0.017
negative regulation of rna metabolic process GO:0051253 48 0.017
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.017
actin filament based process GO:0030029 64 0.017
Fly
hepaticobiliary system development GO:0061008 98 0.017
exocytosis GO:0006887 1 0.017
regulation of multicellular organism growth GO:0040014 4 0.017
regulation of reactive oxygen species metabolic process GO:2000377 2 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
cellular modified amino acid metabolic process GO:0006575 3 0.017
regulation of reproductive process GO:2000241 4 0.017
regulation of organ growth GO:0046620 3 0.017
sequestering of metal ion GO:0051238 3 0.017
establishment of protein localization to organelle GO:0072594 4 0.017
b cell differentiation GO:0030183 1 0.016
regulation of response to biotic stimulus GO:0002831 2 0.016
interspecies interaction between organisms GO:0044419 4 0.016
regulation of response to external stimulus GO:0032101 31 0.016
response to other organism GO:0051707 97 0.016
Zebrafish
erythrocyte development GO:0048821 24 0.016
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.016
guanosine containing compound metabolic process GO:1901068 4 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
defense response to bacterium GO:0042742 22 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
guanosine containing compound catabolic process GO:1901069 2 0.016
neurotransmitter transport GO:0006836 2 0.016
oxoacid metabolic process GO:0043436 31 0.016
developmental growth GO:0048589 166 0.016
cytokine metabolic process GO:0042107 1 0.016
regulation of protein metabolic process GO:0051246 56 0.015
Zebrafish
response to nutrient GO:0007584 3 0.015
regulation of sequestering of calcium ion GO:0051282 4 0.015
positive regulation of secretion by cell GO:1903532 1 0.015
vesicle mediated transport GO:0016192 22 0.015
mrna stabilization GO:0048255 4 0.015
positive regulation of response to stimulus GO:0048584 80 0.015
macromolecular complex subunit organization GO:0043933 74 0.015
Fly
myeloid leukocyte differentiation GO:0002573 15 0.015
cellular protein complex assembly GO:0043623 19 0.015
Fly
translational initiation GO:0006413 3 0.015
regulation of dendrite development GO:0050773 3 0.015
cell morphogenesis GO:0000902 289 0.015
positive regulation of apoptotic signaling pathway GO:2001235 1 0.015
regulation of protein catabolic process GO:0042176 1 0.015
microtubule organizing center organization GO:0031023 1 0.015
modification dependent macromolecule catabolic process GO:0043632 3 0.015
positive regulation of cellular biosynthetic process GO:0031328 68 0.015
ventricular cardiac muscle tissue development GO:0003229 3 0.014
neutrophil differentiation GO:0030223 6 0.014
establishment of endothelial barrier GO:0061028 3 0.014
cellular response to nutrient levels GO:0031669 2 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
response to amino acid GO:0043200 2 0.014
circadian sleep wake cycle GO:0042745 2 0.014
adherens junction organization GO:0034332 4 0.014
dna methylation on cytosine GO:0032776 3 0.014
positive regulation of neuron projection regeneration GO:0070572 3 0.014
axon regeneration GO:0031103 14 0.014
system process GO:0003008 185 0.014
Fly
positive regulation of cytokine biosynthetic process GO:0042108 1 0.014
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
lymphocyte proliferation GO:0046651 1 0.014
erythrocyte differentiation GO:0030218 54 0.014
liver development GO:0001889 96 0.014
positive regulation of developmental process GO:0051094 50 0.014
cell surface receptor signaling pathway GO:0007166 325 0.014
response to corticosteroid GO:0031960 1 0.014
regulation of protein transport GO:0051223 3 0.014
positive regulation of macromolecule metabolic process GO:0010604 93 0.014
defense response to gram positive bacterium GO:0050830 6 0.014
sleep GO:0030431 1 0.013
negative regulation of chromosome organization GO:2001251 1 0.013
negative regulation of developmental growth GO:0048640 9 0.013
negative regulation of catabolic process GO:0009895 3 0.013
axonogenesis GO:0007409 152 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.013
locomotor rhythm GO:0045475 3 0.013
protein localization to nucleus GO:0034504 3 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
synapse assembly GO:0007416 9 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
nuclear transport GO:0051169 4 0.013
response to glucocorticoid GO:0051384 1 0.013
carbohydrate homeostasis GO:0033500 1 0.013
single fertilization GO:0007338 3 0.013
multicellular organismal metabolic process GO:0044236 2 0.013
negative regulation of biosynthetic process GO:0009890 55 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
regulation of catalytic activity GO:0050790 55 0.013
Zebrafish
centrosome organization GO:0051297 1 0.013
regulation of growth GO:0040008 42 0.013
protein modification process GO:0036211 100 0.013
Zebrafish Mouse Fly
regulation of muscle contraction GO:0006937 3 0.013
axon ensheathment in central nervous system GO:0032291 2 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
Fly
cellular response to biotic stimulus GO:0071216 3 0.013
cytokinesis GO:0000910 3 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
negative regulation of cytokine production GO:0001818 1 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
protein complex disassembly GO:0043241 1 0.012
cellular response to oxygen levels GO:0071453 1 0.012
b cell activation GO:0042113 2 0.012
neuroblast proliferation GO:0007405 2 0.012
regulation of tube size GO:0035150 2 0.012
carbohydrate biosynthetic process GO:0016051 1 0.012
negative regulation of cell communication GO:0010648 96 0.012
regulation of mrna processing GO:0050684 3 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
phagocytosis engulfment GO:0006911 1 0.012
phosphorylation GO:0016310 69 0.012
Zebrafish Mouse Fly
positive regulation of transport GO:0051050 2 0.012
positive regulation of epithelial cell migration GO:0010634 2 0.012
canonical wnt signaling pathway GO:0060070 48 0.012
response to biotic stimulus GO:0009607 97 0.012
Zebrafish
cytoskeleton organization GO:0007010 96 0.012
Fly
phosphate containing compound metabolic process GO:0006796 108 0.012
Zebrafish Mouse Fly
monoamine transport GO:0015844 1 0.012
single organism organelle organization GO:1902589 199 0.012
Fly
myeloid cell development GO:0061515 32 0.012
dna methylation or demethylation GO:0044728 8 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
protein targeting to nucleus GO:0044744 3 0.012
establishment of localization in cell GO:0051649 77 0.012
immunoglobulin mediated immune response GO:0016064 3 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
modification dependent protein catabolic process GO:0019941 3 0.012
chemotaxis GO:0006935 104 0.012
mononuclear cell proliferation GO:0032943 1 0.012
cortical actin cytoskeleton organization GO:0030866 1 0.011
response to external biotic stimulus GO:0043207 97 0.011
Zebrafish
regeneration GO:0031099 91 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
protein import into nucleus GO:0006606 3 0.011
protein localization to plasma membrane GO:0072659 1 0.011
negative regulation of map kinase activity GO:0043407 2 0.011
centrosome cycle GO:0007098 1 0.011
cell proliferation GO:0008283 80 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
positive regulation of jun kinase activity GO:0043507 2 0.011
protein import GO:0017038 3 0.011
axonal fasciculation GO:0007413 11 0.011
regulation of carbohydrate biosynthetic process GO:0043255 1 0.011
cellular protein metabolic process GO:0044267 129 0.011
Zebrafish Mouse Fly
cellular amine metabolic process GO:0044106 2 0.011
regulation of establishment of protein localization GO:0070201 4 0.011
regulation of erk1 and erk2 cascade GO:0070372 4 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
membrane invagination GO:0010324 1 0.011
fin development GO:0033333 77 0.011
humoral immune response GO:0006959 5 0.011
mapk cascade GO:0000165 18 0.011
regulation of cellular response to stress GO:0080135 20 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
positive regulation of secretion GO:0051047 1 0.011
blood vessel development GO:0001568 246 0.011
regulation of metal ion transport GO:0010959 4 0.011
gtp metabolic process GO:0046039 4 0.011
primitive erythrocyte differentiation GO:0060319 5 0.011
ion transmembrane transport GO:0034220 91 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.011
superoxide metabolic process GO:0006801 2 0.011
regulation of circadian rhythm GO:0042752 4 0.011
notochord development GO:0030903 54 0.011
lipid metabolic process GO:0006629 52 0.011
negative regulation of stem cell differentiation GO:2000737 2 0.011
macromolecular complex disassembly GO:0032984 1 0.011
protein complex biogenesis GO:0070271 30 0.011
Fly
regulation of blood vessel size GO:0050880 2 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.011
somatic muscle development GO:0007525 4 0.011
nuclear import GO:0051170 3 0.011
negative regulation of growth GO:0045926 10 0.011
erythrocyte maturation GO:0043249 8 0.011
oocyte anterior posterior axis specification GO:0007314 4 0.011
regulation of mapk cascade GO:0043408 14 0.010
negative regulation of cellular catabolic process GO:0031330 3 0.010
protein heterooligomerization GO:0051291 1 0.010
regulation of cell cycle process GO:0010564 20 0.010
positive regulation of chromosome organization GO:2001252 1 0.010
response to lipid GO:0033993 60 0.010
cell recognition GO:0008037 19 0.010
nucleotide biosynthetic process GO:0009165 21 0.010
sensory perception of chemical stimulus GO:0007606 3 0.010
cell death GO:0008219 121 0.010
regulation of developmental growth GO:0048638 38 0.010
cytoplasm organization GO:0007028 4 0.010
protein complex localization GO:0031503 1 0.010
response to uv GO:0009411 3 0.010
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.010
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.010

btk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.062
disease of cellular proliferation DOID:14566 0 0.062
organ system cancer DOID:0050686 0 0.028
disease of anatomical entity DOID:7 0 0.023
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
nervous system disease DOID:863 0 0.015
eye disease DOID:5614 0 0.015