Danio rerio

26 known processes

cacnb4b

calcium channel, voltage-dependent, beta 4b subunit

(Aliases: zgc:136550,cacnb4.1,MGC136550)

cacnb4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
voltage gated calcium channel complex assembly GO:0070978 1 0.977
Zebrafish
heart morphogenesis GO:0003007 156 0.777
regulation of ion transmembrane transport GO:0034765 18 0.557
Zebrafish Mouse
determination of heart left right asymmetry GO:0061371 117 0.502
embryonic heart tube morphogenesis GO:0003143 108 0.492
signal transduction GO:0007165 455 0.391
Mouse
regulation of gene expression GO:0010468 265 0.387
determination of bilateral symmetry GO:0009855 204 0.382
multicellular organismal signaling GO:0035637 22 0.381
Mouse
tube morphogenesis GO:0035239 349 0.366
morphogenesis of an epithelium GO:0002009 333 0.313
regulation of transmembrane transport GO:0034762 18 0.313
Zebrafish Mouse
cellular macromolecule metabolic process GO:0044260 391 0.312
ion transmembrane transport GO:0034220 91 0.308
Zebrafish Mouse
nitrogen compound metabolic process GO:0006807 319 0.299
Mouse
hindbrain morphogenesis GO:0021575 22 0.253
epiboly GO:0090504 41 0.236
epithelial tube morphogenesis GO:0060562 148 0.217
heterocycle metabolic process GO:0046483 290 0.215
Mouse
metal ion transport GO:0030001 58 0.214
Zebrafish Mouse Worm
embryonic heart tube development GO:0035050 133 0.208
convergent extension GO:0060026 118 0.207
determination of left right symmetry GO:0007368 179 0.200
specification of symmetry GO:0009799 204 0.194
negative regulation of cellular process GO:0048523 283 0.194
cation transmembrane transport GO:0098655 65 0.191
Zebrafish Mouse
cell death in response to oxidative stress GO:0036473 2 0.186
organic cyclic compound biosynthetic process GO:1901362 223 0.181
establishment of localization GO:0051234 244 0.172
Zebrafish Mouse Worm
gamma aminobutyric acid signaling pathway GO:0007214 1 0.168
Mouse
regulation of cellular metabolic process GO:0031323 320 0.167
cellular biosynthetic process GO:0044249 286 0.142
aromatic compound biosynthetic process GO:0019438 217 0.138
cellular nitrogen compound biosynthetic process GO:0044271 218 0.133
muscle contraction GO:0006936 18 0.131
Zebrafish Worm
macromolecule biosynthetic process GO:0009059 227 0.128
sensory perception GO:0007600 39 0.126
Mouse
regulation of calcium ion transport GO:0051924 2 0.126
Worm
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.125
head development GO:0060322 303 0.125
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.124
aging GO:0007568 2 0.123
response to vitamin b3 GO:0033552 2 0.123
maintenance of location GO:0051235 4 0.121
digestive system development GO:0055123 289 0.117
calcium ion transport GO:0006816 18 0.117
Zebrafish Mouse Worm
system process GO:0003008 185 0.117
Zebrafish Mouse Worm
embryonic organ development GO:0048568 381 0.113
heart looping GO:0001947 94 0.106
cellular macromolecule biosynthetic process GO:0034645 224 0.104
gastrulation GO:0007369 208 0.104
regulation of metal ion transport GO:0010959 4 0.103
Worm
regulation of macromolecule metabolic process GO:0060255 317 0.103
regulation of response to stimulus GO:0048583 269 0.102
Mouse
transcription dna templated GO:0006351 181 0.101
regulation of nitrogen compound metabolic process GO:0051171 251 0.098
generation of neurons GO:0048699 385 0.097
regulation of primary metabolic process GO:0080090 311 0.097
transmembrane transport GO:0055085 120 0.097
Zebrafish Mouse
cellular component assembly GO:0022607 170 0.095
Zebrafish
muscle system process GO:0003012 20 0.090
Zebrafish Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.089
negative regulation of biological process GO:0048519 304 0.086
bmp signaling pathway GO:0030509 52 0.086
chordate embryonic development GO:0043009 271 0.085
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.082
central nervous system development GO:0007417 387 0.080
cellular nitrogen compound metabolic process GO:0034641 290 0.078
Mouse
cation transport GO:0006812 81 0.077
Zebrafish Mouse Worm
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.076
regulation of signal transduction GO:0009966 225 0.073
divalent metal ion transport GO:0070838 20 0.072
Zebrafish Mouse Worm
rna metabolic process GO:0016070 219 0.071
negative regulation of response to stimulus GO:0048585 104 0.068
embryonic cranial skeleton morphogenesis GO:0048701 90 0.068
regulation of cell communication GO:0010646 232 0.067
locomotion GO:0040011 313 0.065
Worm
gastrulation with mouth forming second GO:0001702 44 0.064
cellular aromatic compound metabolic process GO:0006725 295 0.064
Mouse
metal ion homeostasis GO:0055065 26 0.062
Mouse
calcium ion homeostasis GO:0055074 19 0.062
Mouse
neuron neuron synaptic transmission GO:0007270 1 0.062
Mouse
response to abiotic stimulus GO:0009628 122 0.061
Mouse
heart development GO:0007507 313 0.060
axonogenesis GO:0007409 152 0.059
response to chemical GO:0042221 320 0.059
morphogenesis of an epithelial sheet GO:0002011 49 0.058
response to nutrient GO:0007584 3 0.058
regulation of membrane potential GO:0042391 23 0.057
Mouse
negative regulation of developmental process GO:0051093 65 0.056
thymus development GO:0048538 10 0.055
Mouse
biosynthetic process GO:0009058 294 0.054
organic substance biosynthetic process GO:1901576 289 0.054
muscle cell development GO:0055001 115 0.054
Mouse
nucleic acid templated transcription GO:0097659 181 0.053
developmental growth involved in morphogenesis GO:0060560 86 0.053
embryonic organ morphogenesis GO:0048562 274 0.053
adult behavior GO:0030534 2 0.052
Mouse
striated muscle cell differentiation GO:0051146 129 0.051
Mouse
chemical homeostasis GO:0048878 49 0.051
Mouse
regulation of multicellular organismal process GO:0051239 277 0.050
detection of abiotic stimulus GO:0009582 24 0.050
Mouse
response to oxygen containing compound GO:1901700 55 0.050
divalent inorganic cation transport GO:0072511 21 0.049
Zebrafish Mouse Worm
regulation of rna metabolic process GO:0051252 224 0.048
transmission of nerve impulse GO:0019226 19 0.047
Mouse
cardiac muscle tissue development GO:0048738 48 0.047
positive regulation of secretion by cell GO:1903532 1 0.047
nucleic acid metabolic process GO:0090304 244 0.047
synaptic growth at neuromuscular junction GO:0051124 2 0.046
muscle fiber development GO:0048747 52 0.045
Mouse
circulatory system process GO:0003013 87 0.045
regulation of heart contraction GO:0008016 32 0.045
single organism metabolic process GO:0044710 217 0.044
Mouse
embryonic skeletal joint development GO:0072498 3 0.043
organic cyclic compound metabolic process GO:1901360 301 0.042
Mouse
digestive tract morphogenesis GO:0048546 231 0.042
regulation of locomotion GO:0040012 55 0.041
Worm
embryonic skeletal joint morphogenesis GO:0060272 3 0.040
neuron development GO:0048666 262 0.040
regulation of developmental process GO:0050793 247 0.040
inorganic cation transmembrane transport GO:0098662 50 0.039
Zebrafish Mouse
camera type eye photoreceptor cell differentiation GO:0060219 19 0.039
gland development GO:0048732 143 0.038
Mouse
regulation of cell differentiation GO:0045595 142 0.037
cellular component morphogenesis GO:0032989 336 0.037
central nervous system neuron axonogenesis GO:0021955 18 0.036
response to alkaloid GO:0043279 2 0.036
response to vitamin GO:0033273 3 0.036
amino acid transport GO:0006865 2 0.036
Mouse
cellular component movement GO:0006928 335 0.035
cellular component biogenesis GO:0044085 178 0.035
Zebrafish
cell morphogenesis GO:0000902 289 0.035
behavior GO:0007610 74 0.035
Mouse Worm
angiogenesis GO:0001525 158 0.035
growth GO:0040007 174 0.033
heart contraction GO:0060047 71 0.033
muscle cell differentiation GO:0042692 139 0.033
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.033
negative regulation of gene expression GO:0010629 65 0.032
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.032
organelle assembly GO:0070925 110 0.031
immune response GO:0006955 28 0.031
Mouse
negative regulation of multicellular organismal process GO:0051241 69 0.030
negative regulation of wnt signaling pathway GO:0030178 30 0.030
ion transport GO:0006811 114 0.030
Zebrafish Mouse Worm
body morphogenesis GO:0010171 16 0.030
Worm
cellular response to lipid GO:0071396 39 0.029
transcription from rna polymerase ii promoter GO:0006366 80 0.029
regulation of signaling GO:0023051 235 0.029
regulation of bone mineralization GO:0030500 2 0.028
regulation of skeletal muscle fiber development GO:0048742 2 0.028
rna biosynthetic process GO:0032774 181 0.028
retina morphogenesis in camera type eye GO:0060042 79 0.028
neuron differentiation GO:0030182 353 0.027
mesenchymal cell proliferation GO:0010463 1 0.027
larval development GO:0002164 2 0.027
regulation of binding GO:0051098 3 0.027
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902176 2 0.027
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.026
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.026
blood vessel development GO:0001568 246 0.026
localization of cell GO:0051674 244 0.026
heterocycle biosynthetic process GO:0018130 215 0.025
response to glucocorticoid GO:0051384 1 0.025
glomerulus vasculature development GO:0072012 2 0.025
cell motility GO:0048870 244 0.025
negative regulation of bmp signaling pathway GO:0030514 13 0.024
notochord development GO:0030903 54 0.024
cyclic nucleotide metabolic process GO:0009187 18 0.024
Mouse
negative regulation of cell differentiation GO:0045596 46 0.023
single organism localization GO:1902578 225 0.023
Zebrafish Mouse Worm
negative regulation of macromolecule metabolic process GO:0010605 76 0.023
brain development GO:0007420 293 0.022
enzyme linked receptor protein signaling pathway GO:0007167 106 0.022
calcium ion transmembrane transport GO:0070588 13 0.022
Zebrafish Mouse
cellular calcium ion homeostasis GO:0006874 13 0.022
Mouse
positive regulation of transport GO:0051050 2 0.022
response to external stimulus GO:0009605 264 0.022
Mouse
cell projection organization GO:0030030 284 0.021
carbohydrate derivative metabolic process GO:1901135 61 0.021
Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.021
phagocytosis GO:0006909 3 0.021
regionalization GO:0003002 274 0.021
cellular response to organic substance GO:0071310 105 0.021
regulation of dna replication GO:0006275 3 0.021
multi organism process GO:0051704 134 0.020
Worm
kidney vasculature development GO:0061440 2 0.020
positive regulation of immune system process GO:0002684 17 0.020
Mouse
regulation of response to oxidative stress GO:1902882 2 0.020
regulation of macromolecule biosynthetic process GO:0010556 225 0.020
regulation of biosynthetic process GO:0009889 250 0.019
cell cell signaling GO:0007267 52 0.019
Mouse
embryo development ending in birth or egg hatching GO:0009792 271 0.019
regulation of protein catabolic process GO:0042176 1 0.019
regulation of cellular biosynthetic process GO:0031326 245 0.019
eye photoreceptor cell differentiation GO:0001754 45 0.018
lymphocyte proliferation GO:0046651 1 0.018
heart process GO:0003015 71 0.018
reactive oxygen species biosynthetic process GO:1903409 1 0.018
gene expression GO:0010467 252 0.018
small molecule metabolic process GO:0044281 77 0.018
Mouse
alpha amino acid metabolic process GO:1901605 3 0.018
detection of stimulus involved in sensory perception GO:0050906 21 0.018
Mouse
cellular response to reactive oxygen species GO:0034614 2 0.018
nitric oxide biosynthetic process GO:0006809 2 0.017
nucleobase containing compound metabolic process GO:0006139 274 0.017
Mouse
morphogenesis of an epithelial fold GO:0060571 1 0.017
cellular protein complex assembly GO:0043623 19 0.017
Zebrafish
female gonad development GO:0008585 4 0.017
response to organic substance GO:0010033 153 0.017
response to light stimulus GO:0009416 46 0.017
Mouse
germ line stem cell maintenance GO:0030718 2 0.017
positive regulation of muscle tissue development GO:1901863 1 0.017
negative regulation of signaling GO:0023057 96 0.017
ameboidal type cell migration GO:0001667 143 0.017
cell part morphogenesis GO:0032990 246 0.016
regulation of metabolic process GO:0019222 359 0.016
cellular response to retinoic acid GO:0071300 1 0.016
negative regulation of metabolic process GO:0009892 86 0.016
regulation of bmp signaling pathway GO:0030510 39 0.016
carboxylic acid transport GO:0046942 8 0.016
Mouse
digestive tract development GO:0048565 265 0.016
retinoic acid receptor signaling pathway GO:0048384 16 0.016
cell projection morphogenesis GO:0048858 244 0.016
lipid storage GO:0019915 1 0.016
renal system vasculature development GO:0061437 2 0.016
central nervous system projection neuron axonogenesis GO:0021952 15 0.016
activation of immune response GO:0002253 9 0.016
Mouse
regulation of synapse assembly GO:0051963 3 0.016
immune system development GO:0002520 191 0.015
Mouse
detection of external stimulus GO:0009581 24 0.015
Mouse
immune system process GO:0002376 241 0.015
Mouse
embryonic body morphogenesis GO:0010172 6 0.015
Worm
eye development GO:0001654 277 0.015
eye morphogenesis GO:0048592 144 0.015
response to lipid GO:0033993 60 0.015
regulation of cell activation GO:0050865 1 0.015
regulation of skeletal muscle tissue development GO:0048641 4 0.015
neuron projection development GO:0031175 180 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
regulation of multicellular organismal development GO:2000026 223 0.015
sensory organ development GO:0007423 393 0.014
inorganic ion transmembrane transport GO:0098660 57 0.014
Zebrafish Mouse
response to radiation GO:0009314 51 0.014
Mouse
somatic muscle development GO:0007525 4 0.014
negative regulation of signal transduction GO:0009968 94 0.014
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.013
forebrain development GO:0030900 96 0.013
stem cell maintenance GO:0019827 4 0.013
regulation of immune system process GO:0002682 34 0.013
Mouse
mitotic sister chromatid cohesion GO:0007064 2 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
ion homeostasis GO:0050801 41 0.013
Mouse
positive regulation of cell cycle GO:0045787 3 0.013
protein complex biogenesis GO:0070271 30 0.013
Zebrafish
organic acid metabolic process GO:0006082 31 0.013
alternative mrna splicing via spliceosome GO:0000380 1 0.013
regulation of blood circulation GO:1903522 32 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
regulation of mrna splicing via spliceosome GO:0048024 3 0.012
energy reserve metabolic process GO:0006112 2 0.012
regulation of myotube differentiation GO:0010830 2 0.012
mesenchyme development GO:0060485 127 0.012
negative regulation of muscle tissue development GO:1901862 2 0.012
cellular metal ion homeostasis GO:0006875 16 0.012
Mouse
response to prostaglandin GO:0034694 5 0.012
blood circulation GO:0008015 87 0.012
intracellular receptor signaling pathway GO:0030522 30 0.012
g protein coupled receptor signaling pathway GO:0007186 74 0.012
Mouse
mesoderm development GO:0007498 88 0.012
organic anion transport GO:0015711 15 0.012
Mouse
regulation of reproductive process GO:2000241 4 0.012
blood vessel morphogenesis GO:0048514 216 0.012
mesenchymal cell differentiation GO:0048762 87 0.012
dna catabolic process GO:0006308 1 0.011
camera type eye development GO:0043010 222 0.011
cell migration GO:0016477 237 0.011
nucleobase containing compound biosynthetic process GO:0034654 205 0.011
negative regulation of cytokine production GO:0001818 1 0.011
hormone transport GO:0009914 2 0.011
regulation of biomineral tissue development GO:0070167 2 0.011
regulation of heart growth GO:0060420 2 0.011
response to estrogen GO:0043627 27 0.011
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 2 0.011
regulation of cellular response to oxidative stress GO:1900407 2 0.011
negative regulation of dna replication GO:0008156 2 0.011
regulation of cytokine production GO:0001817 3 0.011
small molecule catabolic process GO:0044282 3 0.010
regulation of meiotic cell cycle GO:0051445 1 0.010
response to carbohydrate GO:0009743 3 0.010
stem cell proliferation GO:0072089 4 0.010
lipid catabolic process GO:0016042 4 0.010
stem cell division GO:0017145 1 0.010
sensory perception of pain GO:0019233 1 0.010
protein metabolic process GO:0019538 183 0.010
regulation of tube size GO:0035150 2 0.010
regulation of oxidative stress induced cell death GO:1903201 2 0.010
response to endogenous stimulus GO:0009719 83 0.010
determination of ventral identity GO:0048264 21 0.010
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.010

cacnb4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
nervous system disease DOID:863 0 0.013
bone disease DOID:0080001 0 0.011
bone remodeling disease DOID:0080005 0 0.011
musculoskeletal system disease DOID:17 0 0.011
connective tissue disease DOID:65 0 0.011