Danio rerio

19 known processes

casrl

calcium-sensing receptor, like

casrl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic organ development GO:0048568 381 0.426
skeletal system development GO:0001501 181 0.369
embryonic organ morphogenesis GO:0048562 274 0.287
embryonic skeletal system morphogenesis GO:0048704 93 0.274
immune system development GO:0002520 191 0.232
cellular component morphogenesis GO:0032989 336 0.226
embryonic skeletal system development GO:0048706 97 0.223
chordate embryonic development GO:0043009 271 0.208
actomyosin structure organization GO:0031032 53 0.199
response to steroid hormone GO:0048545 35 0.170
androgen metabolic process GO:0008209 2 0.155
calcium ion import GO:0070509 4 0.149
striated muscle cell development GO:0055002 108 0.146
embryonic cranial skeleton morphogenesis GO:0048701 90 0.140
cellular biosynthetic process GO:0044249 286 0.126
response to other organism GO:0051707 97 0.125
response to abiotic stimulus GO:0009628 122 0.123
estrogen metabolic process GO:0008210 2 0.117
mesenchyme development GO:0060485 127 0.111
response to organic cyclic compound GO:0014070 51 0.105
system process GO:0003008 185 0.103
neural crest cell differentiation GO:0014033 72 0.101
heart contraction GO:0060047 71 0.101
hematopoietic or lymphoid organ development GO:0048534 191 0.101
androgen biosynthetic process GO:0006702 1 0.100
response to lipid GO:0033993 60 0.095
skeletal system morphogenesis GO:0048705 102 0.095
response to vitamin GO:0033273 3 0.093
heart process GO:0003015 71 0.092
response to stress GO:0006950 263 0.091
cellular response to organic cyclic compound GO:0071407 38 0.091
mechanosensory lateral line system development GO:0048881 49 0.087
very long chain fatty acid biosynthetic process GO:0042761 4 0.087
response to corticosteroid GO:0031960 1 0.083
mesenchymal cell differentiation GO:0048762 87 0.083
regulation of protein ubiquitination GO:0031396 3 0.081
skeletal muscle organ development GO:0060538 78 0.080
cellular response to extracellular stimulus GO:0031668 2 0.080
regulation of heart rate GO:0002027 5 0.079
immune system process GO:0002376 241 0.077
cellular response to starvation GO:0009267 1 0.075
cellular hormone metabolic process GO:0034754 19 0.073
cellular response to lipid GO:0071396 39 0.072
nitric oxide metabolic process GO:0046209 2 0.071
cellular response to nutrient levels GO:0031669 2 0.069
regulation of multicellular organism growth GO:0040014 4 0.068
sarcomere organization GO:0045214 26 0.067
neuron development GO:0048666 262 0.066
response to glucocorticoid GO:0051384 1 0.066
sensory perception of chemical stimulus GO:0007606 3 0.065
cellular response to external stimulus GO:0071496 2 0.064
hormone biosynthetic process GO:0042446 3 0.064
defense response GO:0006952 47 0.063
sensory system development GO:0048880 76 0.062
cardiac muscle cell development GO:0055013 20 0.061
response to organic substance GO:0010033 153 0.060
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.060
developmental growth GO:0048589 166 0.059
signal transduction GO:0007165 455 0.058
muscle cell development GO:0055001 115 0.058
regulation of blood circulation GO:1903522 32 0.058
regulation of biological quality GO:0065008 263 0.057
single organism biosynthetic process GO:0044711 71 0.057
regulation of tube size GO:0035150 2 0.055
positive regulation of biological process GO:0048518 253 0.055
organic cyclic compound biosynthetic process GO:1901362 223 0.054
regulation of programmed cell death GO:0043067 101 0.054
defense response to other organism GO:0098542 33 0.053
biosynthetic process GO:0009058 294 0.052
metal ion homeostasis GO:0055065 26 0.051
gastrulation GO:0007369 208 0.051
positive regulation of cellular metabolic process GO:0031325 94 0.051
compound eye development GO:0048749 2 0.050
sensory organ development GO:0007423 393 0.050
regulation of metabolic process GO:0019222 359 0.049
gtp metabolic process GO:0046039 4 0.048
guanosine containing compound catabolic process GO:1901069 2 0.048
carboxylic acid metabolic process GO:0019752 22 0.048
cellular response to chemical stimulus GO:0070887 157 0.048
larval development GO:0002164 2 0.048
response to ketone GO:1901654 1 0.046
cell migration GO:0016477 237 0.046
response to bacterium GO:0009617 58 0.044
actin filament based process GO:0030029 64 0.044
embryo development ending in birth or egg hatching GO:0009792 271 0.042
growth GO:0040007 174 0.042
neural crest cell development GO:0014032 62 0.042
central nervous system development GO:0007417 387 0.042
positive regulation of cellular process GO:0048522 201 0.042
negative regulation of biological process GO:0048519 304 0.041
cellular response to steroid hormone stimulus GO:0071383 31 0.041
blood circulation GO:0008015 87 0.039
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.039
regulation of multicellular organismal process GO:0051239 277 0.039
neuron differentiation GO:0030182 353 0.039
myofibril assembly GO:0030239 48 0.038
response to biotic stimulus GO:0009607 97 0.038
cellular response to endogenous stimulus GO:0071495 68 0.038
cell substrate adhesion GO:0031589 4 0.037
mesenchymal cell development GO:0014031 78 0.037
axon development GO:0061564 166 0.037
developmental growth involved in morphogenesis GO:0060560 86 0.036
regulation of cell communication GO:0010646 232 0.036
multicellular organism growth GO:0035264 4 0.036
positive regulation of myeloid cell differentiation GO:0045639 2 0.036
calcium ion transport into cytosol GO:0060402 3 0.035
cytoskeleton organization GO:0007010 96 0.035
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.035
muscle cell differentiation GO:0042692 139 0.034
regulation of blood pressure GO:0008217 1 0.034
transmembrane transport GO:0055085 120 0.033
fluid transport GO:0042044 17 0.033
long chain fatty acid biosynthetic process GO:0042759 1 0.033
lateral line system development GO:0048925 76 0.033
regulation of autophagy GO:0010506 3 0.033
stem cell differentiation GO:0048863 117 0.033
steroid biosynthetic process GO:0006694 5 0.033
locomotion GO:0040011 313 0.032
aging GO:0007568 2 0.032
rrna catabolic process GO:0016075 1 0.032
negative regulation of cytokine production GO:0001818 1 0.032
positive regulation of immune effector process GO:0002699 3 0.031
organic substance biosynthetic process GO:1901576 289 0.031
response to chemical GO:0042221 320 0.031
single organism metabolic process GO:0044710 217 0.031
lateral line development GO:0048882 66 0.031
appendage morphogenesis GO:0035107 56 0.031
long chain fatty acid metabolic process GO:0001676 1 0.031
muscle tissue development GO:0060537 110 0.031
germ line stem cell maintenance GO:0030718 2 0.030
macromolecule modification GO:0043412 111 0.029
embryonic viscerocranium morphogenesis GO:0048703 52 0.029
sodium ion import GO:0097369 3 0.029
striated muscle tissue development GO:0014706 110 0.029
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.029
urea transport GO:0015840 11 0.028
ossification GO:0001503 23 0.028
pigmentation GO:0043473 85 0.028
cation homeostasis GO:0055080 33 0.028
regulation of dna templated transcription in response to stress GO:0043620 0 0.027
autophagy GO:0006914 4 0.027
regulation of signal transduction GO:0009966 225 0.027
response to hydrogen peroxide GO:0042542 3 0.027
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.027
myotube cell development GO:0014904 35 0.027
stem cell proliferation GO:0072089 4 0.027
cell morphogenesis GO:0000902 289 0.027
nitrogen compound metabolic process GO:0006807 319 0.027
response to molecule of bacterial origin GO:0002237 14 0.026
response to nutrient GO:0007584 3 0.026
positive regulation of metabolic process GO:0009893 108 0.026
cellular response to organic substance GO:0071310 105 0.026
posterior lateral line system development GO:0048915 46 0.026
positive regulation of neuron apoptotic process GO:0043525 1 0.026
eye development GO:0001654 277 0.025
response to endogenous stimulus GO:0009719 83 0.025
response to osmotic stress GO:0006970 11 0.025
heart development GO:0007507 313 0.024
regulation of cell death GO:0010941 103 0.024
response to oxygen containing compound GO:1901700 55 0.024
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.024
somatic muscle development GO:0007525 4 0.024
apoptotic process GO:0006915 116 0.024
cytosolic calcium ion transport GO:0060401 3 0.024
regulation of system process GO:0044057 40 0.024
response to salt stress GO:0009651 10 0.024
response to external biotic stimulus GO:0043207 97 0.024
regulation of cell activation GO:0050865 1 0.023
activation of immune response GO:0002253 9 0.023
cell morphogenesis involved in differentiation GO:0000904 195 0.023
fatty acid elongation GO:0030497 1 0.023
cardiac muscle cell differentiation GO:0055007 30 0.023
appendage development GO:0048736 80 0.023
fatty acid biosynthetic process GO:0006633 4 0.022
response to lipopolysaccharide GO:0032496 13 0.022
regulation of protein localization to nucleus GO:1900180 2 0.022
positive regulation of cellular catabolic process GO:0031331 3 0.022
nitric oxide biosynthetic process GO:0006809 2 0.022
establishment of localization GO:0051234 244 0.022
muscle organ development GO:0007517 101 0.021
organic cyclic compound metabolic process GO:1901360 301 0.021
b cell activation GO:0042113 2 0.021
macroautophagy GO:0016236 1 0.021
iron ion homeostasis GO:0055072 4 0.020
cellular response to hormone stimulus GO:0032870 39 0.020
actin cytoskeleton organization GO:0030036 63 0.020
striated muscle cell differentiation GO:0051146 129 0.020
regulation of locomotion GO:0040012 55 0.020
cellular component assembly GO:0022607 170 0.020
regulation of inflammatory response GO:0050727 2 0.020
positive regulation of cellular biosynthetic process GO:0031328 68 0.019
skeletal muscle tissue development GO:0007519 67 0.019
immunoglobulin production GO:0002377 1 0.019
defense response to bacterium GO:0042742 22 0.019
multi organism process GO:0051704 134 0.019
cellular response to topologically incorrect protein GO:0035967 2 0.019
response to external stimulus GO:0009605 264 0.019
complement activation GO:0006956 3 0.019
amine metabolic process GO:0009308 2 0.019
cell proliferation GO:0008283 80 0.019
homeostasis of number of cells GO:0048872 62 0.019
positive regulation of jnk cascade GO:0046330 3 0.018
positive regulation of rna biosynthetic process GO:1902680 57 0.018
nuclear import GO:0051170 3 0.018
immune response GO:0006955 28 0.018
response to uv GO:0009411 3 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
regulation of organ growth GO:0046620 3 0.018
directional locomotion GO:0033058 1 0.018
axonogenesis GO:0007409 152 0.018
muscle fiber development GO:0048747 52 0.018
tube morphogenesis GO:0035239 349 0.018
sphingolipid biosynthetic process GO:0030148 2 0.018
positive regulation of stem cell proliferation GO:2000648 1 0.018
ion transport GO:0006811 114 0.017
cellular amino acid metabolic process GO:0006520 7 0.017
epithelial cell morphogenesis GO:0003382 2 0.017
neuron projection development GO:0031175 180 0.017
positive regulation of cell substrate adhesion GO:0010811 1 0.017
golgi vesicle transport GO:0048193 3 0.017
b cell mediated immunity GO:0019724 3 0.017
regulation of transcription from rna polymerase ii promoter in response to oxidative stress GO:0043619 0 0.017
membrane invagination GO:0010324 1 0.017
ion homeostasis GO:0050801 41 0.017
membrane lipid biosynthetic process GO:0046467 2 0.017
gtp catabolic process GO:0006184 2 0.017
regulation of macromolecule metabolic process GO:0060255 317 0.017
aromatic compound biosynthetic process GO:0019438 217 0.017
cellular component movement GO:0006928 335 0.016
regulation of blood vessel size GO:0050880 2 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
muscle structure development GO:0061061 196 0.016
positive regulation of catabolic process GO:0009896 4 0.016
immunoglobulin mediated immune response GO:0016064 3 0.016
negative regulation of epithelial cell proliferation GO:0050680 1 0.016
regulation of response to nutrient levels GO:0032107 1 0.016
oxidation reduction process GO:0055114 41 0.016
response to unfolded protein GO:0006986 2 0.016
stem cell development GO:0048864 82 0.016
response to nitrogen compound GO:1901698 19 0.016
hormone metabolic process GO:0042445 19 0.016
humoral immune response mediated by circulating immunoglobulin GO:0002455 3 0.016
regulation of production of molecular mediator of immune response GO:0002700 1 0.016
transcription dna templated GO:0006351 181 0.016
homeostatic process GO:0042592 142 0.016
negative regulation of cell differentiation GO:0045596 46 0.016
protein targeting to nucleus GO:0044744 3 0.016
protein import into nucleus GO:0006606 3 0.015
cell surface receptor signaling pathway GO:0007166 325 0.015
er nucleus signaling pathway GO:0006984 2 0.015
fin morphogenesis GO:0033334 53 0.015
heart looping GO:0001947 94 0.015
female gonad development GO:0008585 4 0.015
cell motility GO:0048870 244 0.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.015
transport GO:0006810 220 0.015
notochord development GO:0030903 54 0.015
cellular macromolecule metabolic process GO:0044260 391 0.015
regulation of nucleic acid templated transcription GO:1903506 213 0.015
endochondral bone growth GO:0003416 2 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
myeloid cell differentiation GO:0030099 86 0.015
negative regulation of defense response GO:0031348 2 0.015
organelle organization GO:0006996 227 0.015
protein localization to nucleus GO:0034504 3 0.015
positive regulation of gene expression GO:0010628 71 0.015
single organism nuclear import GO:1902593 3 0.015
negative regulation of biosynthetic process GO:0009890 55 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
rna metabolic process GO:0016070 219 0.015
regulation of cell substrate adhesion GO:0010810 1 0.015
regulation of nitrogen compound metabolic process GO:0051171 251 0.015
fin development GO:0033333 77 0.015
smooth muscle contraction GO:0006939 2 0.015
cardiac cell development GO:0055006 21 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
immune effector process GO:0002252 23 0.014
positive regulation of rna metabolic process GO:0051254 59 0.014
lipid storage GO:0019915 1 0.014
regulation of response to stimulus GO:0048583 269 0.014
negative regulation of protein transport GO:0051224 3 0.014
circulatory system process GO:0003013 87 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
antimicrobial humoral response GO:0019730 2 0.014
positive regulation of stress activated mapk cascade GO:0032874 3 0.014
generation of neurons GO:0048699 385 0.014
regulation of heart contraction GO:0008016 32 0.014
regulation of protein transport GO:0051223 3 0.014
cell proliferation in forebrain GO:0021846 3 0.014
rna biosynthetic process GO:0032774 181 0.014
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.014
anterior lateral line system development GO:0048898 9 0.014
cell death in response to oxidative stress GO:0036473 2 0.014
regulation of immune system process GO:0002682 34 0.013
positive regulation of neuron death GO:1901216 1 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
cell part morphogenesis GO:0032990 246 0.013
gland development GO:0048732 143 0.013
nucleic acid templated transcription GO:0097659 181 0.013
regulation of transcription dna templated GO:0006355 213 0.013
cellular response to oxygen containing compound GO:1901701 20 0.013
antibacterial humoral response GO:0019731 2 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
positive regulation of cell activation GO:0050867 1 0.013
digestive tract morphogenesis GO:0048546 231 0.013
neural crest cell migration GO:0001755 42 0.013
cell killing GO:0001906 2 0.013
sensory perception GO:0007600 39 0.013
regulation of cytokine production GO:0001817 3 0.013
positive regulation of transcription dna templated GO:0045893 57 0.013
cell projection organization GO:0030030 284 0.012
cellular response to decreased oxygen levels GO:0036294 1 0.012
response to topologically incorrect protein GO:0035966 2 0.012
energy reserve metabolic process GO:0006112 2 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.012
death GO:0016265 121 0.012
interspecies interaction between organisms GO:0044419 4 0.012
neuron neuron synaptic transmission GO:0007270 1 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
digestive system development GO:0055123 289 0.012
hatching GO:0035188 4 0.012
response to alkaloid GO:0043279 2 0.012
multicellular organismal response to stress GO:0033555 2 0.012
erythrocyte homeostasis GO:0034101 55 0.012
nuclear transport GO:0051169 4 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
regulation of signaling GO:0023051 235 0.012
macromolecular complex subunit organization GO:0043933 74 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
growth plate cartilage development GO:0003417 2 0.011
female sex differentiation GO:0046660 4 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
apoptotic process involved in morphogenesis GO:0060561 2 0.011
regulation of apoptotic process GO:0042981 98 0.011
negative regulation of cytokine mediated signaling pathway GO:0001960 2 0.011
positive regulation of neural precursor cell proliferation GO:2000179 1 0.011
regulation of gtp catabolic process GO:0033124 2 0.011
glutamate receptor signaling pathway GO:0007215 1 0.011
negative regulation of reproductive process GO:2000242 3 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
epithelial cell differentiation GO:0030855 116 0.011
cell matrix adhesion GO:0007160 4 0.011
positive regulation of epithelial cell proliferation GO:0050679 1 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
negative regulation of multi organism process GO:0043901 3 0.011
response to inorganic substance GO:0010035 38 0.011
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
innate immune response GO:0045087 13 0.011
protein complex biogenesis GO:0070271 30 0.011
localization of cell GO:0051674 244 0.011
regulation of primary metabolic process GO:0080090 311 0.011
cell migration involved in gastrulation GO:0042074 79 0.011
fat soluble vitamin metabolic process GO:0006775 4 0.011
single organism localization GO:1902578 225 0.011
cognition GO:0050890 1 0.011
behavior GO:0007610 74 0.011
cardiocyte differentiation GO:0035051 44 0.010
protein import GO:0017038 3 0.010
protein secretion GO:0009306 1 0.010
regulation of response to extracellular stimulus GO:0032104 1 0.010
programmed cell death GO:0012501 119 0.010
single organism organelle organization GO:1902589 199 0.010
organic acid metabolic process GO:0006082 31 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
mitotic metaphase plate congression GO:0007080 1 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.010
zymogen activation GO:0031638 3 0.010
regulation of skeletal muscle tissue development GO:0048641 4 0.010
positive regulation of nucleic acid templated transcription GO:1903508 57 0.010
regulation of cysteine type endopeptidase activity GO:2000116 21 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010
small molecule metabolic process GO:0044281 77 0.010
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.010
positive regulation of cell adhesion GO:0045785 1 0.010
cellular amine metabolic process GO:0044106 2 0.010
ear development GO:0043583 127 0.010
positive regulation of defense response to virus by host GO:0002230 0 0.010

casrl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.020
inherited metabolic disorder DOID:655 0 0.020
motor neuron disease DOID:231 0 0.019
central nervous system disease DOID:331 0 0.019
amyotrophic lateral sclerosis DOID:332 0 0.019
disease of anatomical entity DOID:7 0 0.019
neurodegenerative disease DOID:1289 0 0.019
nervous system disease DOID:863 0 0.019
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
heart disease DOID:114 0 0.011
cardiomyopathy DOID:0050700 0 0.011
intrinsic cardiomyopathy DOID:0060036 0 0.011
cardiovascular system disease DOID:1287 0 0.011
musculoskeletal system disease DOID:17 0 0.011
muscle tissue disease DOID:66 0 0.011