Danio rerio

54 known processes

cdx1a

caudal type homeo box transcription factor 1 a

(Aliases: cdx2)

cdx1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.669
brain development GO:0007420 293 0.659
head development GO:0060322 303 0.422
biosynthetic process GO:0009058 294 0.364
sensory organ development GO:0007423 393 0.353
regulation of cellular biosynthetic process GO:0031326 245 0.352
negative regulation of biological process GO:0048519 304 0.328
regulation of multicellular organismal development GO:2000026 223 0.299
hormone transport GO:0009914 2 0.299
transcription from rna polymerase ii promoter GO:0006366 80 0.290
regulation of nitrogen compound metabolic process GO:0051171 251 0.272
lipid storage GO:0019915 1 0.270
cellular biosynthetic process GO:0044249 286 0.268
heart development GO:0007507 313 0.260
localization of cell GO:0051674 244 0.254
generation of neurons GO:0048699 385 0.252
tube morphogenesis GO:0035239 349 0.239
positive regulation of cell fate commitment GO:0010455 1 0.237
regionalization GO:0003002 274 0.220
organic substance biosynthetic process GO:1901576 289 0.219
blood vessel development GO:0001568 246 0.211
negative regulation of cellular process GO:0048523 283 0.209
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.181
aromatic compound biosynthetic process GO:0019438 217 0.170
foregut morphogenesis GO:0007440 4 0.168
heart looping GO:0001947 94 0.155
hormone secretion GO:0046879 2 0.154
eye development GO:0001654 277 0.150
regulation of gene expression GO:0010468 265 0.144
embryonic foregut morphogenesis GO:0048617 1 0.144
vasculature development GO:0001944 278 0.143
response to stress GO:0006950 263 0.140
determination of left right symmetry GO:0007368 179 0.139
digestive system development GO:0055123 289 0.138
gene expression GO:0010467 252 0.135
neuron development GO:0048666 262 0.132
embryo development ending in birth or egg hatching GO:0009792 271 0.129
locomotion GO:0040011 313 0.127
cellular amine metabolic process GO:0044106 2 0.126
adult behavior GO:0030534 2 0.126
morphogenesis of an epithelium GO:0002009 333 0.126
cell differentiation in spinal cord GO:0021515 40 0.125
regulation of response to stimulus GO:0048583 269 0.120
signal transduction GO:0007165 455 0.120
cell motility GO:0048870 244 0.111
cellular aromatic compound metabolic process GO:0006725 295 0.108
cell surface receptor signaling pathway GO:0007166 325 0.107
nucleobase containing compound metabolic process GO:0006139 274 0.106
nucleic acid templated transcription GO:0097659 181 0.106
regulation of hormone secretion GO:0046883 2 0.103
regulation of biosynthetic process GO:0009889 250 0.099
regulation of rna biosynthetic process GO:2001141 213 0.099
retina development in camera type eye GO:0060041 146 0.098
appendage development GO:0048736 80 0.097
response to external stimulus GO:0009605 264 0.097
rna biosynthetic process GO:0032774 181 0.095
embryonic organ development GO:0048568 381 0.095
regulation of biological quality GO:0065008 263 0.094
maintenance of location GO:0051235 4 0.091
heterocycle biosynthetic process GO:0018130 215 0.091
regulation of rna metabolic process GO:0051252 224 0.091
regulation of macromolecule biosynthetic process GO:0010556 225 0.090
determination of bilateral symmetry GO:0009855 204 0.090
regulation of cellular metabolic process GO:0031323 320 0.089
nucleobase containing compound biosynthetic process GO:0034654 205 0.089
digestive tract development GO:0048565 265 0.088
aging GO:0007568 2 0.088
pancreas development GO:0031016 84 0.087
regulation of primary metabolic process GO:0080090 311 0.084
negative regulation of rna biosynthetic process GO:1902679 45 0.083
embryonic organ morphogenesis GO:0048562 274 0.083
cellular component biogenesis GO:0044085 178 0.081
cellular nitrogen compound biosynthetic process GO:0044271 218 0.080
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.079
sensory organ morphogenesis GO:0090596 200 0.078
regulation of macromolecule metabolic process GO:0060255 317 0.077
regulation of metabolic process GO:0019222 359 0.075
eye morphogenesis GO:0048592 144 0.074
regulation of neural precursor cell proliferation GO:2000177 3 0.073
embryonic heart tube development GO:0035050 133 0.070
lipid biosynthetic process GO:0008610 22 0.069
centrosome organization GO:0051297 1 0.068
negative regulation of transcription dna templated GO:0045892 45 0.068
heterocycle metabolic process GO:0046483 290 0.068
carboxylic acid metabolic process GO:0019752 22 0.067
regulation of multicellular organismal process GO:0051239 277 0.066
chordate embryonic development GO:0043009 271 0.066
cell fate specification GO:0001708 68 0.065
organic cyclic compound biosynthetic process GO:1901362 223 0.064
peptide transport GO:0015833 1 0.062
larval development GO:0002164 2 0.062
cell fate commitment GO:0045165 99 0.061
positive regulation of cellular process GO:0048522 201 0.061
regulation of transcription dna templated GO:0006355 213 0.059
forebrain development GO:0030900 96 0.059
bmp signaling pathway GO:0030509 52 0.058
mesenchyme development GO:0060485 127 0.058
determination of heart left right asymmetry GO:0061371 117 0.058
negative regulation of mesodermal cell fate specification GO:0042662 3 0.058
positive regulation of cellular component biogenesis GO:0044089 3 0.056
specification of symmetry GO:0009799 204 0.056
epithelial cell differentiation GO:0030855 116 0.056
regulation of developmental process GO:0050793 247 0.056
regulation of nucleic acid templated transcription GO:1903506 213 0.055
organic cyclic compound metabolic process GO:1901360 301 0.055
cellular component movement GO:0006928 335 0.055
somitogenesis GO:0001756 87 0.053
blood vessel morphogenesis GO:0048514 216 0.053
regulation of cellular amine metabolic process GO:0033238 0 0.053
transcription dna templated GO:0006351 181 0.053
fin development GO:0033333 77 0.052
digestive tract morphogenesis GO:0048546 231 0.052
immune system process GO:0002376 241 0.051
cellular nitrogen compound metabolic process GO:0034641 290 0.051
neural retina development GO:0003407 49 0.051
pectoral fin development GO:0033339 50 0.050
amine metabolic process GO:0009308 2 0.050
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.049
embryonic heart tube morphogenesis GO:0003143 108 0.048
immune system development GO:0002520 191 0.047
retina layer formation GO:0010842 24 0.046
neuroblast proliferation GO:0007405 2 0.045
regulation of cell communication GO:0010646 232 0.045
negative regulation of nucleic acid templated transcription GO:1903507 45 0.044
somite development GO:0061053 96 0.044
regulation of gastrulation GO:0010470 24 0.044
regulation of signal transduction GO:0009966 225 0.044
renal system development GO:0072001 94 0.044
thioester metabolic process GO:0035383 1 0.043
post embryonic morphogenesis GO:0009886 4 0.043
endocrine system development GO:0035270 65 0.043
response to nutrient GO:0007584 3 0.042
ventral spinal cord development GO:0021517 35 0.042
regulation of stem cell differentiation GO:2000736 4 0.042
homeostatic process GO:0042592 142 0.040
macromolecule biosynthetic process GO:0009059 227 0.040
cell proliferation in hindbrain GO:0021534 4 0.040
axis specification GO:0009798 43 0.040
neural tube patterning GO:0021532 33 0.040
negative regulation of rna metabolic process GO:0051253 48 0.039
camera type eye development GO:0043010 222 0.039
retina morphogenesis in camera type eye GO:0060042 79 0.039
rna metabolic process GO:0016070 219 0.039
cell projection organization GO:0030030 284 0.038
protein localization to nucleus GO:0034504 3 0.038
gastrulation GO:0007369 208 0.038
regulation of localization GO:0032879 104 0.037
negative regulation of endodermal cell fate specification GO:0042664 8 0.036
kidney development GO:0001822 92 0.036
positive regulation of stem cell proliferation GO:2000648 1 0.036
cellular macromolecule biosynthetic process GO:0034645 224 0.035
positive regulation of neural precursor cell proliferation GO:2000179 1 0.034
regulation of cell activation GO:0050865 1 0.034
positive regulation of muscle tissue development GO:1901863 1 0.034
endodermal cell fate commitment GO:0001711 18 0.034
liver development GO:0001889 96 0.034
regulation of stem cell proliferation GO:0072091 2 0.034
oxoacid metabolic process GO:0043436 31 0.033
response to monosaccharide GO:0034284 3 0.033
protein metabolic process GO:0019538 183 0.033
growth GO:0040007 174 0.033
positive regulation of biological process GO:0048518 253 0.033
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.033
peripheral nervous system neuron differentiation GO:0048934 28 0.033
embryonic camera type eye development GO:0031076 29 0.032
regulation of neuron migration GO:2001222 2 0.032
negative regulation of gastrulation GO:2000542 11 0.032
muscle tissue development GO:0060537 110 0.032
compound eye development GO:0048749 2 0.032
cardiac muscle cell differentiation GO:0055007 30 0.031
skeletal system development GO:0001501 181 0.031
aorta morphogenesis GO:0035909 3 0.031
negative regulation of developmental process GO:0051093 65 0.031
response to vitamin GO:0033273 3 0.031
blood circulation GO:0008015 87 0.031
dorsal ventral pattern formation GO:0009953 125 0.031
ameboidal type cell migration GO:0001667 143 0.030
skeletal muscle organ development GO:0060538 78 0.030
regulation of reproductive process GO:2000241 4 0.030
neuron differentiation GO:0030182 353 0.030
multicellular organism growth GO:0035264 4 0.030
response to drug GO:0042493 3 0.030
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.030
positive regulation of response to stimulus GO:0048584 80 0.029
small molecule metabolic process GO:0044281 77 0.029
embryonic appendage morphogenesis GO:0035113 30 0.029
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.029
floor plate morphogenesis GO:0033505 12 0.028
positive regulation of protein complex assembly GO:0031334 2 0.028
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.028
mechanoreceptor differentiation GO:0042490 37 0.028
macromolecule modification GO:0043412 111 0.028
regulation of multicellular organism growth GO:0040014 4 0.028
organic acid metabolic process GO:0006082 31 0.027
transcription from rna polymerase iii promoter GO:0006383 1 0.027
negative regulation of wnt signaling pathway involved in heart development GO:0003308 2 0.027
endoderm development GO:0007492 49 0.027
anterior posterior pattern specification GO:0009952 152 0.026
fin morphogenesis GO:0033334 53 0.026
epidermis development GO:0008544 48 0.026
hematopoietic or lymphoid organ development GO:0048534 191 0.025
endodermal digestive tract morphogenesis GO:0061031 2 0.025
negative regulation of gene expression GO:0010629 65 0.025
nucleic acid metabolic process GO:0090304 244 0.025
regulation of transcription involved in cell fate commitment GO:0060850 1 0.025
cardiac muscle tissue development GO:0048738 48 0.025
kupffer s vesicle development GO:0070121 50 0.025
response to vitamin b3 GO:0033552 2 0.025
appendage morphogenesis GO:0035107 56 0.025
angiogenesis GO:0001525 158 0.024
system process GO:0003008 185 0.024
epithelial tube morphogenesis GO:0060562 148 0.024
transport GO:0006810 220 0.024
regulation of wnt signaling pathway GO:0030111 53 0.024
epidermal cell fate specification GO:0009957 4 0.024
cell projection morphogenesis GO:0048858 244 0.024
regulation of cardiac muscle cell differentiation GO:2000725 1 0.024
positive regulation of gene expression GO:0010628 71 0.024
lipid metabolic process GO:0006629 52 0.023
regulation of embryonic development GO:0045995 47 0.023
ear development GO:0043583 127 0.023
multi organism process GO:0051704 134 0.023
regulation of cell development GO:0060284 100 0.023
cellular lipid metabolic process GO:0044255 36 0.023
gland development GO:0048732 143 0.022
heart morphogenesis GO:0003007 156 0.022
positive regulation of biosynthetic process GO:0009891 68 0.022
regulation of endodermal cell fate specification GO:0042663 15 0.022
hindbrain development GO:0030902 91 0.022
developmental growth involved in morphogenesis GO:0060560 86 0.022
skeletal muscle tissue development GO:0007519 67 0.022
cardiocyte differentiation GO:0035051 44 0.022
negative regulation of endodermal cell differentiation GO:1903225 8 0.022
hepaticobiliary system development GO:0061008 98 0.021
positive regulation of striated muscle tissue development GO:0045844 1 0.021
positive regulation of cellular metabolic process GO:0031325 94 0.021
forebrain regionalization GO:0021871 4 0.021
oligodendrocyte cell fate specification GO:0021778 4 0.021
cellular macromolecule metabolic process GO:0044260 391 0.021
regulation of locomotion GO:0040012 55 0.021
muscle fiber development GO:0048747 52 0.021
cell migration GO:0016477 237 0.021
epidermal cell differentiation GO:0009913 36 0.021
cranial nerve development GO:0021545 42 0.021
regulation of cell differentiation GO:0045595 142 0.021
acyl coa metabolic process GO:0006637 1 0.020
neuron projection development GO:0031175 180 0.020
wnt signaling pathway GO:0016055 80 0.020
striated muscle tissue development GO:0014706 110 0.020
ear morphogenesis GO:0042471 64 0.020
cellular response to decreased oxygen levels GO:0036294 1 0.020
negative regulation of biosynthetic process GO:0009890 55 0.020
inner ear development GO:0048839 126 0.019
nitrogen compound metabolic process GO:0006807 319 0.019
positive regulation of cell activation GO:0050867 1 0.019
central nervous system neuron differentiation GO:0021953 74 0.019
developmental pigmentation GO:0048066 48 0.019
negative regulation of signal transduction GO:0009968 94 0.019
neuron fate specification GO:0048665 20 0.019
mesenchymal cell differentiation GO:0048762 87 0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.019
water homeostasis GO:0030104 4 0.018
stem cell differentiation GO:0048863 117 0.018
formation of primary germ layer GO:0001704 62 0.018
macromolecule localization GO:0033036 54 0.018
positive regulation of cell communication GO:0010647 56 0.018
protein targeting to nucleus GO:0044744 3 0.018
ectodermal placode development GO:0071696 37 0.018
skin development GO:0043588 54 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.018
adenohypophysis development GO:0021984 15 0.018
post anal tail morphogenesis GO:0036342 19 0.017
nucleocytoplasmic transport GO:0006913 4 0.017
floor plate formation GO:0021508 12 0.017
endoderm formation GO:0001706 29 0.017
convergent extension GO:0060026 118 0.017
regulation of ion transmembrane transporter activity GO:0032412 2 0.017
stem cell proliferation GO:0072089 4 0.017
type b pancreatic cell development GO:0003323 4 0.017
centrosome cycle GO:0007098 1 0.016
notochord development GO:0030903 54 0.016
regulation of nodal signaling pathway GO:1900107 4 0.016
cell part morphogenesis GO:0032990 246 0.016
spindle assembly GO:0051225 2 0.016
spinal cord motor neuron cell fate specification GO:0021520 8 0.016
negative regulation of cellular biosynthetic process GO:0031327 55 0.016
neural crest cell development GO:0014032 62 0.016
negative regulation of muscle tissue development GO:1901862 2 0.016
neural tube development GO:0021915 62 0.016
negative regulation of stem cell differentiation GO:2000737 2 0.016
chemotaxis GO:0006935 104 0.016
positive regulation of transport GO:0051050 2 0.016
cell morphogenesis GO:0000902 289 0.016
embryonic digestive tract morphogenesis GO:0048557 3 0.016
negative regulation of oocyte development GO:0060283 2 0.015
photoreceptor cell fate commitment GO:0046552 1 0.015
negative regulation of protein complex assembly GO:0031333 1 0.015
eye photoreceptor cell differentiation GO:0001754 45 0.015
ectodermal placode morphogenesis GO:0071697 32 0.015
positive regulation of metabolic process GO:0009893 108 0.015
positive regulation of cellular amine metabolic process GO:0033240 0 0.015
somite specification GO:0001757 12 0.015
positive regulation of embryonic development GO:0040019 3 0.015
mesenchymal cell development GO:0014031 78 0.015
single organism organelle organization GO:1902589 199 0.015
response to organic substance GO:0010033 153 0.015
organonitrogen compound metabolic process GO:1901564 74 0.015
cellular ketone metabolic process GO:0042180 11 0.015
amide biosynthetic process GO:0043604 1 0.015
exocrine pancreas development GO:0031017 28 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
response to glucose GO:0009749 3 0.015
endodermal cell differentiation GO:0035987 19 0.014
positive regulation of cellular biosynthetic process GO:0031328 68 0.014
establishment of localization GO:0051234 244 0.014
inner ear receptor cell fate commitment GO:0060120 4 0.014
negative regulation of protein phosphorylation GO:0001933 4 0.014
response to chemical GO:0042221 320 0.014
non canonical wnt signaling pathway involved in heart development GO:0061341 2 0.014
protein complex biogenesis GO:0070271 30 0.014
organic substance transport GO:0071702 58 0.014
cellular component assembly GO:0022607 170 0.014
alcohol biosynthetic process GO:0046165 2 0.014
positive regulation of secretion GO:0051047 1 0.014
periodic partitioning GO:0007365 1 0.014
otic vesicle development GO:0071599 42 0.014
negative regulation of metabolic process GO:0009892 86 0.013
regulation of mesodermal cell fate specification GO:0042661 9 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
embryonic digestive tract development GO:0048566 4 0.013
heart process GO:0003015 71 0.013
peripheral nervous system development GO:0007422 55 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
endocrine process GO:0050886 2 0.013
common bile duct development GO:0061009 13 0.013
single organism metabolic process GO:0044710 217 0.013
cell proliferation GO:0008283 80 0.013
eye photoreceptor cell development GO:0042462 30 0.013
negative regulation of wnt signaling pathway GO:0030178 30 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
protein import GO:0017038 3 0.013
response to hexose GO:0009746 3 0.013
negative regulation of gliogenesis GO:0014014 1 0.013
cardiac conduction system development GO:0003161 1 0.013
stem cell development GO:0048864 82 0.013
positive regulation of striated muscle cell differentiation GO:0051155 1 0.013
photoreceptor cell fate specification GO:0043704 1 0.013
regulation of signaling GO:0023051 235 0.013
regulation of angiogenesis GO:0045765 26 0.012
glial cell differentiation GO:0010001 42 0.012
lateral line development GO:0048882 66 0.012
mesoderm morphogenesis GO:0048332 51 0.012
muscle structure development GO:0061061 196 0.012
pigmentation GO:0043473 85 0.012
striated muscle cell differentiation GO:0051146 129 0.012
cell proliferation in forebrain GO:0021846 3 0.012
cellular component morphogenesis GO:0032989 336 0.012
single organism nuclear import GO:1902593 3 0.012
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.012
neural crest cell differentiation GO:0014033 72 0.012
positive regulation of neuron migration GO:2001224 2 0.012
skeletal muscle fiber development GO:0048741 35 0.012
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.012
cellular protein modification process GO:0006464 100 0.012
axon development GO:0061564 166 0.011
regulation of apoptotic process GO:0042981 98 0.011
oocyte maturation GO:0001556 4 0.011
muscle cell differentiation GO:0042692 139 0.011
regulation of smoothened signaling pathway GO:0008589 18 0.011
regulation of cell motility GO:2000145 46 0.011
behavior GO:0007610 74 0.011
regulation of canonical wnt signaling pathway GO:0060828 34 0.011
regulation of epithelial cell proliferation GO:0050678 3 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
negative regulation of signaling GO:0023057 96 0.011
cardiac cell fate commitment GO:0060911 1 0.011
spinal cord development GO:0021510 46 0.011
locomotory behavior GO:0007626 34 0.011
positive regulation of signaling GO:0023056 56 0.011
cell death GO:0008219 121 0.011
positive regulation of multicellular organismal process GO:0051240 52 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
regulation of mesoderm development GO:2000380 11 0.011
microtubule organizing center organization GO:0031023 1 0.011
endocrine pancreas development GO:0031018 27 0.010
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.010
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.010
gall bladder development GO:0061010 1 0.010
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
forebrain morphogenesis GO:0048853 6 0.010
rostrocaudal neural tube patterning GO:0021903 29 0.010
signal transduction downstream of smoothened GO:0007227 1 0.010

cdx1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.195
musculoskeletal system disease DOID:17 0 0.034
nervous system disease DOID:863 0 0.019
disease of metabolism DOID:0014667 0 0.019
cardiovascular system disease DOID:1287 0 0.018
diabetes mellitus DOID:9351 0 0.015
glucose metabolism disease DOID:4194 0 0.015
acquired metabolic disease DOID:0060158 0 0.015
carbohydrate metabolism disease DOID:0050013 0 0.015
type 2 diabetes mellitus DOID:9352 0 0.015
connective tissue disease DOID:65 0 0.015
inherited metabolic disorder DOID:655 0 0.014
electroclinical syndrome DOID:0050701 0 0.013
brain disease DOID:936 0 0.013
central nervous system disease DOID:331 0 0.013
epilepsy syndrome DOID:1826 0 0.013
dysostosis DOID:1934 0 0.011
bone development disease DOID:0080006 0 0.011
bone disease DOID:0080001 0 0.011