Danio rerio

0 known processes

cfl1

cofilin 1 (non-muscle)

(Aliases: wu:fb18a04,cb86,wu:fk77b03,sb:cb86,zgc:56501)

cfl1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
actin filament polymerization GO:0030041 2 0.347
actin polymerization or depolymerization GO:0008154 2 0.213
Mouse
multicellular organismal water homeostasis GO:0050891 1 0.200
morphogenesis of an epithelium GO:0002009 333 0.200
organelle organization GO:0006996 227 0.165
Mouse
cellular component biogenesis GO:0044085 178 0.153
regulation of water loss via skin GO:0033561 1 0.149
positive regulation of cellular component biogenesis GO:0044089 3 0.143
phagocytosis GO:0006909 3 0.141
aging GO:0007568 2 0.136
cellular component assembly GO:0022607 170 0.130
regulation of cell matrix adhesion GO:0001952 1 0.117
vasculature development GO:0001944 278 0.106
positive regulation of transport GO:0051050 2 0.101
stem cell maintenance GO:0019827 4 0.099
single organism localization GO:1902578 225 0.081
transport GO:0006810 220 0.081
negative regulation of protein transport GO:0051224 3 0.081
establishment of localization GO:0051234 244 0.075
response to external biotic stimulus GO:0043207 97 0.073
regulation of defense response to virus by host GO:0050691 1 0.069
positive regulation of defense response to virus by host GO:0002230 0 0.069
positive regulation of protein complex assembly GO:0031334 2 0.067
keratinocyte differentiation GO:0030216 0 0.067
glomerulus development GO:0032835 27 0.064
single organism transport GO:0044765 206 0.064
alpha amino acid metabolic process GO:1901605 3 0.062
cognition GO:0050890 1 0.058
single organism membrane organization GO:0044802 20 0.058
determination of bilateral symmetry GO:0009855 204 0.058
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.057
single organism organelle organization GO:1902589 199 0.057
Mouse
establishment of skin barrier GO:0061436 1 0.055
membrane fusion GO:0061025 2 0.052
water homeostasis GO:0030104 4 0.051
positive regulation of protein polymerization GO:0032273 2 0.051
single organism membrane fusion GO:0044801 2 0.051
extrinsic apoptotic signaling pathway GO:0097191 3 0.051
tube morphogenesis GO:0035239 349 0.051
maintenance of location GO:0051235 4 0.048
regulation of establishment of protein localization GO:0070201 4 0.046
intestinal absorption GO:0050892 2 0.046
actin cytoskeleton organization GO:0030036 63 0.045
Mouse
sensory organ development GO:0007423 393 0.044
membrane invagination GO:0010324 1 0.044
muscle structure development GO:0061061 196 0.043
urea transmembrane transport GO:0071918 9 0.042
cellular protein metabolic process GO:0044267 129 0.041
s adenosylmethionine metabolic process GO:0046500 1 0.040
negative regulation of defense response GO:0031348 2 0.040
oxoacid metabolic process GO:0043436 31 0.040
organic hydroxy compound transport GO:0015850 14 0.040
digestive tract development GO:0048565 265 0.039
protein polymerization GO:0051258 4 0.038
ion transport GO:0006811 114 0.038
cellular component assembly involved in morphogenesis GO:0010927 107 0.037
regulation of ion transmembrane transporter activity GO:0032412 2 0.037
organic substance biosynthetic process GO:1901576 289 0.036
regulation of protein import into nucleus GO:0042306 2 0.035
single organism metabolic process GO:0044710 217 0.034
protein secretion GO:0009306 1 0.034
establishment of protein localization to organelle GO:0072594 4 0.033
cytoplasm organization GO:0007028 4 0.033
actin filament based process GO:0030029 64 0.033
Mouse
adherens junction organization GO:0034332 4 0.033
lipid digestion GO:0044241 3 0.032
regulation of protein complex assembly GO:0043254 3 0.032
positive regulation of cytoskeleton organization GO:0051495 3 0.031
Mouse
response to organic substance GO:0010033 153 0.031
regulation of protein localization to nucleus GO:1900180 2 0.031
regulation of protein transport GO:0051223 3 0.029
localization of cell GO:0051674 244 0.029
regulation of protein polymerization GO:0032271 2 0.029
cellular modified amino acid metabolic process GO:0006575 3 0.029
protein heterooligomerization GO:0051291 1 0.029
positive regulation of cell adhesion GO:0045785 1 0.028
activation of immune response GO:0002253 9 0.028
gastrulation GO:0007369 208 0.028
immune system process GO:0002376 241 0.027
protein complex subunit organization GO:0071822 46 0.026
Mouse
convergent extension GO:0060026 118 0.026
regulation of cytoplasmic transport GO:1903649 4 0.026
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.026
protein import GO:0017038 3 0.025
regulation of cytokine production GO:0001817 3 0.025
cellular component morphogenesis GO:0032989 336 0.025
regulation of epidermis development GO:0045682 2 0.024
skin development GO:0043588 54 0.024
actomyosin structure organization GO:0031032 53 0.024
regulation of response to stimulus GO:0048583 269 0.024
blood vessel morphogenesis GO:0048514 216 0.024
cellular protein modification process GO:0006464 100 0.024
cellular localization GO:0051641 97 0.023
kidney development GO:0001822 92 0.023
regulation of molecular function GO:0065009 70 0.023
death GO:0016265 121 0.023
response to acid chemical GO:0001101 17 0.023
wound healing GO:0042060 90 0.023
response to chemical GO:0042221 320 0.023
regulation of inflammatory response GO:0050727 2 0.023
negative regulation of nuclear division GO:0051784 3 0.023
regulation of biological quality GO:0065008 263 0.022
Mouse
regulation of epithelial cell proliferation GO:0050678 3 0.022
protein localization to plasma membrane GO:0072659 1 0.022
epithelial cell differentiation GO:0030855 116 0.022
extracellular structure organization GO:0043062 27 0.022
response to other organism GO:0051707 97 0.022
negative regulation of cytokine production GO:0001818 1 0.022
single organism biosynthetic process GO:0044711 71 0.021
organic acid metabolic process GO:0006082 31 0.021
protein import into nucleus GO:0006606 3 0.021
protein metabolic process GO:0019538 183 0.021
autophagy GO:0006914 4 0.021
signal transduction GO:0007165 455 0.021
synaptic vesicle transport GO:0048489 1 0.021
stem cell development GO:0048864 82 0.021
cellular response to chemical stimulus GO:0070887 157 0.020
urogenital system development GO:0001655 97 0.020
phagocytosis engulfment GO:0006911 1 0.020
regulation of cellular component organization GO:0051128 86 0.020
Mouse
regulation of cell differentiation GO:0045595 142 0.020
negative regulation of mitosis GO:0045839 3 0.019
response to stress GO:0006950 263 0.019
fatty acid biosynthetic process GO:0006633 4 0.019
organonitrogen compound metabolic process GO:1901564 74 0.019
guanosine containing compound catabolic process GO:1901069 2 0.019
negative regulation of biological process GO:0048519 304 0.019
metal ion transport GO:0030001 58 0.019
regeneration GO:0031099 91 0.019
cell substrate junction assembly GO:0007044 2 0.019
regulation of metabolic process GO:0019222 359 0.018
regulation of cell activation GO:0050865 1 0.018
macromolecular complex assembly GO:0065003 35 0.018
negative regulation of stem cell differentiation GO:2000737 2 0.018
vesicle organization GO:0016050 6 0.018
establishment of protein localization to plasma membrane GO:0090002 1 0.018
regulation of organelle organization GO:0033043 29 0.018
Mouse
cell junction organization GO:0034330 11 0.018
cellular macromolecule metabolic process GO:0044260 391 0.018
multi organism process GO:0051704 134 0.018
zymogen activation GO:0031638 3 0.018
lipid storage GO:0019915 1 0.018
apoptotic process GO:0006915 116 0.017
neuron neuron synaptic transmission GO:0007270 1 0.017
nephron development GO:0072006 31 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
muscle cell differentiation GO:0042692 139 0.017
blood vessel development GO:0001568 246 0.017
regulation of actin cytoskeleton organization GO:0032956 8 0.017
Mouse
kidney epithelium development GO:0072073 23 0.017
negative regulation of epithelial cell proliferation GO:0050680 1 0.017
response to oxygen containing compound GO:1901700 55 0.017
digestive system development GO:0055123 289 0.017
plasma membrane repair GO:0001778 2 0.017
membrane raft organization GO:0031579 1 0.016
negative regulation of cellular process GO:0048523 283 0.016
regulation of metal ion transport GO:0010959 4 0.016
membrane organization GO:0061024 21 0.016
cell substrate adhesion GO:0031589 4 0.016
negative regulation of wound healing GO:0061045 1 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
regulation of protein targeting GO:1903533 2 0.016
protein modification process GO:0036211 100 0.016
regulation of cytoskeleton organization GO:0051493 11 0.016
Mouse
regulation of wound healing GO:0061041 2 0.016
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.016
protein complex assembly GO:0006461 30 0.016
regulation of binding GO:0051098 3 0.016
energy reserve metabolic process GO:0006112 2 0.016
neuroblast fate commitment GO:0014017 1 0.016
small molecule metabolic process GO:0044281 77 0.016
cell morphogenesis GO:0000902 289 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
cytosolic calcium ion transport GO:0060401 3 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
synaptic vesicle localization GO:0097479 1 0.015
regulation of locomotion GO:0040012 55 0.015
heart field specification GO:0003128 1 0.015
negative regulation of secretion GO:0051048 2 0.015
cellular nitrogen compound metabolic process GO:0034641 290 0.015
regulation of gtpase activity GO:0043087 2 0.015
cell death GO:0008219 121 0.015
vesicle mediated transport GO:0016192 22 0.015
cellular amine metabolic process GO:0044106 2 0.015
nuclear transport GO:0051169 4 0.015
positive regulation of gtp catabolic process GO:0033126 1 0.014
response to amino acid GO:0043200 2 0.014
positive regulation of catabolic process GO:0009896 4 0.014
extracellular matrix organization GO:0030198 27 0.014
nitrogen compound metabolic process GO:0006807 319 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
renal system development GO:0072001 94 0.014
macromolecular complex subunit organization GO:0043933 74 0.014
Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.014
proximal distal pattern formation GO:0009954 1 0.014
amine metabolic process GO:0009308 2 0.014
sensory system development GO:0048880 76 0.014
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.014
developmental growth GO:0048589 166 0.013
positive regulation of biological process GO:0048518 253 0.013
Mouse
positive regulation of cell substrate adhesion GO:0010811 1 0.013
hatching GO:0035188 4 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
positive regulation of cell cycle GO:0045787 3 0.013
axis elongation involved in somitogenesis GO:0090245 2 0.013
dorsal ventral pattern formation GO:0009953 125 0.013
protein processing GO:0016485 12 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
positive regulation of molecular function GO:0044093 33 0.013
regulation of localization GO:0032879 104 0.013
defense response to fungus GO:0050832 2 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
cell motility GO:0048870 244 0.013
programmed cell death GO:0012501 119 0.013
nuclear import GO:0051170 3 0.012
regulation of immune response GO:0050776 14 0.012
lateral line system development GO:0048925 76 0.012
striated muscle cell differentiation GO:0051146 129 0.012
defense response GO:0006952 47 0.012
regulation of circadian rhythm GO:0042752 4 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
intestinal cholesterol absorption GO:0030299 2 0.012
regulation of epithelial to mesenchymal transition GO:0010717 3 0.012
epithelial cell morphogenesis GO:0003382 2 0.012
organic acid transport GO:0015849 9 0.012
tissue regeneration GO:0042246 74 0.012
lipid catabolic process GO:0016042 4 0.012
specification of organ identity GO:0010092 2 0.012
cellular protein complex assembly GO:0043623 19 0.012
organelle assembly GO:0070925 110 0.012
release of sequestered calcium ion into cytosol GO:0051209 3 0.012
epidermal cell differentiation GO:0009913 36 0.012
covalent chromatin modification GO:0016569 20 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
epidermis development GO:0008544 48 0.012
system process GO:0003008 185 0.012
negative regulation of kinase activity GO:0033673 4 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
chromosome organization GO:0051276 31 0.011
positive regulation of cellular process GO:0048522 201 0.011
Mouse
negative regulation of response to stimulus GO:0048585 104 0.011
fin regeneration GO:0031101 51 0.011
t cell differentiation GO:0030217 6 0.011
negative regulation of sequestering of calcium ion GO:0051283 4 0.011
regulation of developmental process GO:0050793 247 0.011
cation transport GO:0006812 81 0.011
muscle cell development GO:0055001 115 0.011
positive regulation of ras protein signal transduction GO:0046579 1 0.011
gtp catabolic process GO:0006184 2 0.011
immune system development GO:0002520 191 0.011
long chain fatty acid biosynthetic process GO:0042759 1 0.011
ion transmembrane transport GO:0034220 91 0.011
positive regulation of cell matrix adhesion GO:0001954 1 0.011
meiotic nuclear division GO:0007126 4 0.011
single organism cellular localization GO:1902580 46 0.011
nucleocytoplasmic transport GO:0006913 4 0.011
regulation of immune system process GO:0002682 34 0.011
protein targeting to nucleus GO:0044744 3 0.011
rho protein signal transduction GO:0007266 5 0.011
desmosome assembly GO:0002159 2 0.011
innate immune response GO:0045087 13 0.011
macromolecule modification GO:0043412 111 0.011
digestive tract morphogenesis GO:0048546 231 0.011
regulation of programmed cell death GO:0043067 101 0.011
epithelial cell development GO:0002064 42 0.011
positive regulation of metabolic process GO:0009893 108 0.011
regulation of filopodium assembly GO:0051489 2 0.011
cellular response to external stimulus GO:0071496 2 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
monoamine transport GO:0015844 1 0.010
cytoskeleton organization GO:0007010 96 0.010
Mouse
regulation of cell substrate adhesion GO:0010810 1 0.010
protein localization to nucleus GO:0034504 3 0.010
atrioventricular valve development GO:0003171 11 0.010
regulation of biosynthetic process GO:0009889 250 0.010
cortical cytoskeleton organization GO:0030865 1 0.010
regulation of cellular metabolic process GO:0031323 320 0.010
defense response to other organism GO:0098542 33 0.010
cardiac cell fate commitment GO:0060911 1 0.010
regulation of eye photoreceptor cell development GO:0042478 2 0.010
regulation of mesenchymal cell proliferation GO:0010464 1 0.010
kidney vasculature morphogenesis GO:0061439 1 0.010

cfl1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
integumentary system disease DOID:16 0 0.064
disease of anatomical entity DOID:7 0 0.064
amyloidosis DOID:9120 0 0.016
acquired metabolic disease DOID:0060158 0 0.016
disease of metabolism DOID:0014667 0 0.016
myopathy DOID:423 0 0.012
heart disease DOID:114 0 0.012
cardiomyopathy DOID:0050700 0 0.012
muscle tissue disease DOID:66 0 0.012
cardiovascular system disease DOID:1287 0 0.012
muscular disease DOID:0080000 0 0.012
musculoskeletal system disease DOID:17 0 0.012