Danio rerio

63 known processes

cftr

cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)

(Aliases: si:dkey-270i2.2)

cftr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.803
embryonic organ development GO:0048568 381 0.517
response to other organism GO:0051707 97 0.414
regulation of rna metabolic process GO:0051252 224 0.373
regulation of response to stimulus GO:0048583 269 0.287
heart jogging GO:0003146 40 0.286
axoneme assembly GO:0035082 9 0.241
inner ear receptor cell development GO:0060119 20 0.232
muscle cell differentiation GO:0042692 139 0.219
embryo development ending in birth or egg hatching GO:0009792 271 0.211
regulation of metabolic process GO:0019222 359 0.201
nitrogen compound metabolic process GO:0006807 319 0.200
regulation of primary metabolic process GO:0080090 311 0.197
specification of symmetry GO:0009799 204 0.181
somitogenesis GO:0001756 87 0.179
somatic muscle development GO:0007525 4 0.161
regulation of heart contraction GO:0008016 32 0.153
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.151
smoothened signaling pathway GO:0007224 30 0.144
rna metabolic process GO:0016070 219 0.144
regulation of myotube differentiation GO:0010830 2 0.144
somite development GO:0061053 96 0.137
digestive tract development GO:0048565 265 0.133
organic cyclic compound biosynthetic process GO:1901362 223 0.132
Mouse
cellular component biogenesis GO:0044085 178 0.124
neuron development GO:0048666 262 0.122
maintenance of location GO:0051235 4 0.122
gene expression GO:0010467 252 0.120
locomotion GO:0040011 313 0.113
positive regulation of biological process GO:0048518 253 0.111
Human Rat
cellular component assembly involved in morphogenesis GO:0010927 107 0.110
determination of left right symmetry GO:0007368 179 0.109
embryonic organ morphogenesis GO:0048562 274 0.109
organic substance biosynthetic process GO:1901576 289 0.105
Mouse
cell morphogenesis GO:0000902 289 0.103
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.102
negative regulation of macromolecule metabolic process GO:0010605 76 0.100
chordate embryonic development GO:0043009 271 0.098
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.094
regulation of multicellular organism growth GO:0040014 4 0.093
positive regulation of cellular biosynthetic process GO:0031328 68 0.092
regulation of gene expression GO:0010468 265 0.089
cellular nitrogen compound biosynthetic process GO:0044271 218 0.089
macroautophagy GO:0016236 1 0.086
negative regulation of mitosis GO:0045839 3 0.086
neural tube patterning GO:0021532 33 0.086
multicellular organism growth GO:0035264 4 0.086
regulation of response to extracellular stimulus GO:0032104 1 0.085
embryonic heart tube morphogenesis GO:0003143 108 0.085
heart morphogenesis GO:0003007 156 0.085
heart development GO:0007507 313 0.085
diencephalon development GO:0021536 58 0.081
autophagy GO:0006914 4 0.080
nucleocytoplasmic transport GO:0006913 4 0.080
regulation of response to nutrient levels GO:0032107 1 0.080
lipid storage GO:0019915 1 0.080
defense response to fungus GO:0050832 2 0.079
nucleic acid templated transcription GO:0097659 181 0.078
negative regulation of nuclear division GO:0051784 3 0.077
segmentation GO:0035282 97 0.076
response to bacterium GO:0009617 58 0.076
regulation of response to stress GO:0080134 36 0.076
positive regulation of cellular process GO:0048522 201 0.076
Human
pronephros development GO:0048793 69 0.076
determination of bilateral symmetry GO:0009855 204 0.072
regulation of establishment of planar polarity GO:0090175 4 0.070
regulation of cell communication GO:0010646 232 0.070
cellular macromolecule metabolic process GO:0044260 391 0.070
positive regulation of cell cycle GO:0045787 3 0.068
dna templated transcription elongation GO:0006354 3 0.067
stem cell maintenance GO:0019827 4 0.067
regulation of cellular metabolic process GO:0031323 320 0.066
regulation of circadian rhythm GO:0042752 4 0.066
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.066
organic cyclic compound metabolic process GO:1901360 301 0.064
Mouse
regulation of transcription dna templated GO:0006355 213 0.063
microtubule bundle formation GO:0001578 9 0.063
heterocycle metabolic process GO:0046483 290 0.063
response to fluid shear stress GO:0034405 2 0.063
neural tube development GO:0021915 62 0.063
organelle assembly GO:0070925 110 0.062
positive regulation of jun kinase activity GO:0043507 2 0.062
positive regulation of muscle organ development GO:0048636 1 0.062
regulation of signal transduction GO:0009966 225 0.062
blood vessel morphogenesis GO:0048514 216 0.060
signal transduction GO:0007165 455 0.059
regulation of blood vessel size GO:0050880 2 0.059
Rat
cellular component assembly GO:0022607 170 0.059
aromatic compound biosynthetic process GO:0019438 217 0.058
embryonic heart tube development GO:0035050 133 0.058
regulation of developmental process GO:0050793 247 0.058
cellular macromolecule biosynthetic process GO:0034645 224 0.058
nucleobase containing compound metabolic process GO:0006139 274 0.058
positive regulation of catabolic process GO:0009896 4 0.057
regulation of collagen metabolic process GO:0010712 2 0.056
aging GO:0007568 2 0.056
regulation of macromolecule biosynthetic process GO:0010556 225 0.056
regulation of cellular biosynthetic process GO:0031326 245 0.056
cellular component morphogenesis GO:0032989 336 0.055
cell motility GO:0048870 244 0.055
glial cell proliferation GO:0014009 4 0.055
regulation of rna biosynthetic process GO:2001141 213 0.055
striated muscle cell differentiation GO:0051146 129 0.054
regulation of biological quality GO:0065008 263 0.054
Mouse Rat
regulation of multicellular organismal metabolic process GO:0044246 2 0.053
guanosine containing compound catabolic process GO:1901069 2 0.052
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.052
rna biosynthetic process GO:0032774 181 0.052
left right pattern formation GO:0060972 19 0.052
protein import into nucleus GO:0006606 3 0.052
regulation of biosynthetic process GO:0009889 250 0.052
cilium movement involved in cell motility GO:0060294 3 0.051
cilium movement GO:0003341 26 0.050
regulation of mrna processing GO:0050684 3 0.050
nucleic acid metabolic process GO:0090304 244 0.050
convergent extension GO:0060026 118 0.049
positive regulation of cellular catabolic process GO:0031331 3 0.049
dorsal ventral pattern formation GO:0009953 125 0.048
positive regulation of nucleoside metabolic process GO:0045979 1 0.048
regulation of protein transport GO:0051223 3 0.048
septum transversum development GO:0003343 4 0.048
response to biotic stimulus GO:0009607 97 0.047
cilium morphogenesis GO:0060271 85 0.047
cell projection organization GO:0030030 284 0.047
regulation of nitrogen compound metabolic process GO:0051171 251 0.046
multi organism process GO:0051704 134 0.046
negative regulation of metabolic process GO:0009892 86 0.046
regulation of production of molecular mediator of immune response GO:0002700 1 0.046
protein localization to nucleus GO:0034504 3 0.045
collagen metabolic process GO:0032963 2 0.045
heterocycle biosynthetic process GO:0018130 215 0.045
single organism nuclear import GO:1902593 3 0.045
response to external biotic stimulus GO:0043207 97 0.045
epithelial cilium movement involved in determination of left right asymmetry GO:0060287 8 0.045
macromolecule biosynthetic process GO:0009059 227 0.045
collagen biosynthetic process GO:0032964 2 0.045
cilium assembly GO:0042384 58 0.045
anterior posterior pattern specification GO:0009952 152 0.044
proepicardium development GO:0003342 4 0.044
cell proliferation involved in heart morphogenesis GO:0061323 2 0.044
protein targeting to nucleus GO:0044744 3 0.043
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.042
cellular nitrogen compound metabolic process GO:0034641 290 0.042
positive regulation of cell activation GO:0050867 1 0.042
nuclear transport GO:0051169 4 0.042
heart looping GO:0001947 94 0.042
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.041
determination of left right asymmetry in nervous system GO:0035545 4 0.041
cilium organization GO:0044782 71 0.041
positive regulation of striated muscle tissue development GO:0045844 1 0.040
mechanoreceptor differentiation GO:0042490 37 0.040
sarcomere organization GO:0045214 26 0.040
regulation of nucleotide catabolic process GO:0030811 2 0.040
regulation of skeletal muscle tissue development GO:0048641 4 0.040
heart process GO:0003015 71 0.039
regulation of nucleoside metabolic process GO:0009118 2 0.039
production of molecular mediator of immune response GO:0002440 2 0.039
enzyme linked receptor protein signaling pathway GO:0007167 106 0.038
axial mesoderm formation GO:0048320 4 0.038
cellular macromolecular complex assembly GO:0034622 24 0.038
muscle cell fate commitment GO:0042693 9 0.038
cellular biosynthetic process GO:0044249 286 0.037
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.037
compound eye development GO:0048749 2 0.037
axis specification GO:0009798 43 0.036
myofibril assembly GO:0030239 48 0.036
vasculature development GO:0001944 278 0.036
regulation of wound healing GO:0061041 2 0.036
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.036
leukocyte proliferation GO:0070661 1 0.035
cardiac atrium morphogenesis GO:0003209 2 0.035
negative regulation of protein transport GO:0051224 3 0.035
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.035
calcium mediated signaling GO:0019722 2 0.035
regulation of dna templated transcription elongation GO:0032784 3 0.034
inner ear receptor cell differentiation GO:0060113 29 0.034
cell fate specification GO:0001708 68 0.034
gtp metabolic process GO:0046039 4 0.034
response to inorganic substance GO:0010035 38 0.034
actin mediated cell contraction GO:0070252 1 0.034
regulation of myelination GO:0031641 1 0.034
regulation of nucleocytoplasmic transport GO:0046822 2 0.033
notochord development GO:0030903 54 0.033
photoreceptor cell fate commitment GO:0046552 1 0.033
phagocytosis GO:0006909 3 0.033
cellular aromatic compound metabolic process GO:0006725 295 0.033
regulation of postsynaptic membrane potential GO:0060078 1 0.033
actin filament based process GO:0030029 64 0.033
protein metabolic process GO:0019538 183 0.033
pericardium morphogenesis GO:0003344 1 0.032
rna splicing GO:0008380 16 0.032
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.032
somite specification GO:0001757 12 0.032
cell migration involved in gastrulation GO:0042074 79 0.032
regulation of heart morphogenesis GO:2000826 17 0.032
cell part morphogenesis GO:0032990 246 0.032
invagination involved in gastrulation with mouth forming second GO:0055109 1 0.032
proximal tubule development GO:0072014 3 0.031
glial cell migration GO:0008347 3 0.031
regulation of macromolecule metabolic process GO:0060255 317 0.031
germ line stem cell maintenance GO:0030718 2 0.030
phosphatidylinositol mediated signaling GO:0048015 2 0.030
retinal rod cell development GO:0046548 4 0.030
cardiac atrium development GO:0003230 4 0.030
positive regulation of nucleotide catabolic process GO:0030813 1 0.030
regulation of gtpase activity GO:0043087 2 0.029
organelle organization GO:0006996 227 0.029
cellular component movement GO:0006928 335 0.029
adult behavior GO:0030534 2 0.029
anterior posterior axis specification GO:0009948 20 0.029
atrioventricular valve formation GO:0003190 3 0.029
b cell mediated immunity GO:0019724 3 0.029
pericardium development GO:0060039 1 0.029
hepaticobiliary system development GO:0061008 98 0.028
mononuclear cell proliferation GO:0032943 1 0.028
mesoderm development GO:0007498 88 0.028
axon development GO:0061564 166 0.028
regulation of organelle assembly GO:1902115 4 0.027
protein complex subunit organization GO:0071822 46 0.027
cytoskeleton dependent cytokinesis GO:0061640 3 0.027
carbohydrate derivative metabolic process GO:1901135 61 0.027
macromolecular complex subunit organization GO:0043933 74 0.027
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.027
nuclear export GO:0051168 1 0.027
morphogenesis of an epithelium GO:0002009 333 0.027
sensory perception of mechanical stimulus GO:0050954 16 0.027
cellular component disassembly GO:0022411 1 0.026
ras protein signal transduction GO:0007265 7 0.026
regulation of gtp catabolic process GO:0033124 2 0.026
developmental growth GO:0048589 166 0.026
cellular protein complex assembly GO:0043623 19 0.026
rostrocaudal neural tube patterning GO:0021903 29 0.026
regulation of signaling GO:0023051 235 0.026
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.026
epithelial cell differentiation GO:0030855 116 0.026
interspecies interaction between organisms GO:0044419 4 0.026
endocardial cell differentiation GO:0060956 5 0.026
protein import GO:0017038 3 0.025
phosphate containing compound metabolic process GO:0006796 108 0.025
nuclear import GO:0051170 3 0.025
heart valve formation GO:0003188 4 0.025
oxoacid metabolic process GO:0043436 31 0.025
myeloid leukocyte differentiation GO:0002573 15 0.025
transcription dna templated GO:0006351 181 0.025
embryonic skeletal joint development GO:0072498 3 0.025
regulation of nucleic acid templated transcription GO:1903506 213 0.025
gtp catabolic process GO:0006184 2 0.024
guanosine containing compound metabolic process GO:1901068 4 0.024
bone morphogenesis GO:0060349 11 0.024
establishment of protein localization to organelle GO:0072594 4 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
endosomal transport GO:0016197 2 0.024
actomyosin structure organization GO:0031032 53 0.024
negative regulation of biological process GO:0048519 304 0.024
striated muscle cell development GO:0055002 108 0.024
urogenital system development GO:0001655 97 0.023
regulation of intracellular protein transport GO:0033157 3 0.023
neural crest cell migration GO:0001755 42 0.023
positive regulation of gliogenesis GO:0014015 2 0.023
regulation of protein targeting GO:1903533 2 0.023
neuron neuron synaptic transmission GO:0007270 1 0.023
localization of cell GO:0051674 244 0.023
antimicrobial humoral response GO:0019730 2 0.023
pigment cell differentiation GO:0050931 38 0.023
negative regulation of cytoplasmic transport GO:1903650 2 0.023
endoderm formation GO:0001706 29 0.023
positive regulation of gtp catabolic process GO:0033126 1 0.022
regulation of protein import into nucleus GO:0042306 2 0.022
determination of pancreatic left right asymmetry GO:0035469 11 0.022
ventricular cardiac muscle tissue development GO:0003229 3 0.022
apoptotic process involved in development GO:1902742 2 0.022
response to wounding GO:0009611 116 0.022
nitric oxide biosynthetic process GO:0006809 2 0.022
positive regulation of translation GO:0045727 1 0.022
receptor recycling GO:0001881 4 0.022
cell proliferation GO:0008283 80 0.022
muscle structure development GO:0061061 196 0.022
homeostasis of number of cells GO:0048872 62 0.022
muscle tissue development GO:0060537 110 0.022
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.022
single organism organelle organization GO:1902589 199 0.021
epithelial cilium movement GO:0003351 15 0.021
protein polyubiquitination GO:0000209 4 0.021
monocyte differentiation GO:0030224 2 0.021
regulation of protein ubiquitination GO:0031396 3 0.021
cytokinesis GO:0000910 3 0.021
negative regulation of cysteine type endopeptidase activity GO:2000117 8 0.021
regulation of smoothened signaling pathway GO:0008589 18 0.021
inner ear development GO:0048839 126 0.021
b cell activation GO:0042113 2 0.021
determination of left right asymmetry in diencephalon GO:0035462 4 0.021
heart formation GO:0060914 13 0.021
regulation of anatomical structure morphogenesis GO:0022603 130 0.021
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.021
vasculogenesis GO:0001570 41 0.021
single organism metabolic process GO:0044710 217 0.021
blood vessel development GO:0001568 246 0.021
regulation of glial cell differentiation GO:0045685 4 0.020
distal tubule development GO:0072017 1 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
circulatory system process GO:0003013 87 0.020
Rat
stem cell proliferation GO:0072089 4 0.020
carboxylic acid metabolic process GO:0019752 22 0.020
endocardium morphogenesis GO:0003160 4 0.020
transcription from rna polymerase ii promoter GO:0006366 80 0.020
negative regulation of cellular metabolic process GO:0031324 77 0.020
stem cell development GO:0048864 82 0.020
immune system process GO:0002376 241 0.020
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.020
notochord morphogenesis GO:0048570 17 0.020
establishment of localization GO:0051234 244 0.020
Human Mouse Rat
stem cell division GO:0017145 1 0.020
positive regulation of muscle tissue development GO:1901863 1 0.020
reactive nitrogen species metabolic process GO:2001057 0 0.020
stem cell differentiation GO:0048863 117 0.020
response to virus GO:0009615 21 0.019
positive regulation of striated muscle cell differentiation GO:0051155 1 0.019
regulation of ion transmembrane transporter activity GO:0032412 2 0.019
Human
positive regulation of gene expression GO:0010628 71 0.019
neuron differentiation GO:0030182 353 0.019
negative regulation of signal transduction GO:0009968 94 0.019
transmembrane transport GO:0055085 120 0.019
Human Mouse
regulation of cell substrate adhesion GO:0010810 1 0.019
positive regulation of nervous system development GO:0051962 25 0.019
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.019
transport GO:0006810 220 0.019
Human Mouse Rat
multicellular organismal metabolic process GO:0044236 2 0.019
regulation of tube size GO:0035150 2 0.019
Rat
positive regulation of cellular metabolic process GO:0031325 94 0.019
cellular response to fluid shear stress GO:0071498 1 0.019
negative regulation of bmp signaling pathway GO:0030514 13 0.019
regulation of cytoplasmic transport GO:1903649 4 0.018
negative regulation of gene expression GO:0010629 65 0.018
regulation of ras gtpase activity GO:0032318 2 0.018
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.018
regulation of cell proliferation GO:0042127 37 0.018
developmental process involved in reproduction GO:0003006 27 0.018
Mouse
extracellular matrix assembly GO:0085029 1 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.018
cellular response to chemical stimulus GO:0070887 157 0.018
sodium ion transmembrane transport GO:0035725 21 0.018
mesoderm formation GO:0001707 43 0.018
posttranscriptional regulation of gene expression GO:0010608 14 0.018
regulation of calcium ion dependent exocytosis GO:0017158 1 0.018
blastoderm segmentation GO:0007350 6 0.018
sequestering of metal ion GO:0051238 3 0.018
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.018
regulation of cell shape GO:0008360 1 0.017
centrosome duplication GO:0051298 1 0.017
intracellular signal transduction GO:0035556 85 0.017
regulation of cell activation GO:0050865 1 0.017
macromolecular complex disassembly GO:0032984 1 0.017
growth GO:0040007 174 0.017
rhombomere 5 morphogenesis GO:0021664 1 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
regulation of establishment of protein localization GO:0070201 4 0.017
cellular ketone metabolic process GO:0042180 11 0.017
biosynthetic process GO:0009058 294 0.017
Mouse
reactive oxygen species biosynthetic process GO:1903409 1 0.017
tube morphogenesis GO:0035239 349 0.017
positive regulation of cytoskeleton organization GO:0051495 3 0.017
midbrain hindbrain boundary development GO:0030917 23 0.017
epithelial tube morphogenesis GO:0060562 148 0.017
ventral spinal cord development GO:0021517 35 0.017
protein secretion GO:0009306 1 0.017
cell projection assembly GO:0030031 64 0.017
behavior GO:0007610 74 0.017
system process GO:0003008 185 0.016
Rat
immunoglobulin mediated immune response GO:0016064 3 0.016
response to abiotic stimulus GO:0009628 122 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.016
regulation of cellular protein metabolic process GO:0032268 52 0.016
regulation of synapse assembly GO:0051963 3 0.016
hypothalamus cell differentiation GO:0021979 4 0.016
aromatic compound catabolic process GO:0019439 15 0.016
nitric oxide metabolic process GO:0046209 2 0.016
inorganic ion transmembrane transport GO:0098660 57 0.016
Human Mouse
positive regulation of jak stat cascade GO:0046427 2 0.016
regulation of cell death GO:0010941 103 0.016
regulation of catalytic activity GO:0050790 55 0.016
lymphocyte proliferation GO:0046651 1 0.016
protein complex disassembly GO:0043241 1 0.016
muscle organ development GO:0007517 101 0.016
microtubule organizing center organization GO:0031023 1 0.016
positive regulation of cellular component biogenesis GO:0044089 3 0.016
forebrain development GO:0030900 96 0.016
formation of primary germ layer GO:0001704 62 0.016
positive regulation of metabolic process GO:0009893 108 0.016
cellular amine metabolic process GO:0044106 2 0.016
aorta development GO:0035904 4 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.015
protein stabilization GO:0050821 2 0.015
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.015
negative regulation of defense response GO:0031348 2 0.015
cell fate commitment GO:0045165 99 0.015
hemopoiesis GO:0030097 183 0.015
regulation of membrane potential GO:0042391 23 0.015
Mouse
cell migration involved in heart development GO:0060973 22 0.015
specification of organ position GO:0010159 3 0.015
3 utr mediated mrna stabilization GO:0070935 3 0.015
small molecule metabolic process GO:0044281 77 0.015
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.015
protein complex assembly GO:0006461 30 0.015
negative regulation of secretion by cell GO:1903531 2 0.015
spinal cord development GO:0021510 46 0.015
cell migration GO:0016477 237 0.015
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.015
cellular protein metabolic process GO:0044267 129 0.015
chemotaxis GO:0006935 104 0.015
mesenchyme development GO:0060485 127 0.015
determination of liver left right asymmetry GO:0071910 11 0.015
regulation of binding GO:0051098 3 0.015
determination of heart left right asymmetry GO:0061371 117 0.015
regulation of oligodendrocyte differentiation GO:0048713 1 0.015
regulation of autophagy GO:0010506 3 0.015
endodermal cell fate determination GO:0007493 2 0.015
positive regulation of synapse assembly GO:0051965 1 0.015
regulation of system process GO:0044057 40 0.015
Rat
negative regulation of intracellular protein transport GO:0090317 3 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
positive regulation of macromolecule metabolic process GO:0010604 93 0.014
negative regulation of cell communication GO:0010648 96 0.014
vesicle mediated transport GO:0016192 22 0.014
cellular response to starvation GO:0009267 1 0.014
floor plate morphogenesis GO:0033505 12 0.014
skeletal muscle fiber development GO:0048741 35 0.014
negative regulation of protein localization to nucleus GO:1900181 2 0.014
macromolecule localization GO:0033036 54 0.014
Mouse
multicellular organismal macromolecule metabolic process GO:0044259 2 0.014
periodic partitioning GO:0007365 1 0.014
regulation of protein localization to nucleus GO:1900180 2 0.014
heart contraction GO:0060047 71 0.014
regulation of protein metabolic process GO:0051246 56 0.014
embryonic hemopoiesis GO:0035162 53 0.014
morphogenesis of an epithelial fold GO:0060571 1 0.014
cell surface receptor signaling pathway GO:0007166 325 0.014
developmental growth involved in morphogenesis GO:0060560 86 0.014
single organism localization GO:1902578 225 0.013
Human Mouse Rat
negative regulation of secretion GO:0051048 2 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
positive regulation of transport GO:0051050 2 0.013
Human
positive regulation of response to stimulus GO:0048584 80 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.013
multicellular organismal response to stress GO:0033555 2 0.013
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.013
response to antibiotic GO:0046677 1 0.013
lateral mesoderm development GO:0048368 23 0.013
mitotic cytokinesis GO:0000281 3 0.013
regulation of transporter activity GO:0032409 2 0.013
Human
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
motor neuron axon guidance GO:0008045 23 0.013
cell projection morphogenesis GO:0048858 244 0.013
kupffer s vesicle development GO:0070121 50 0.013
forebrain regionalization GO:0021871 4 0.013
developmental programmed cell death GO:0010623 4 0.013
positive regulation of gtpase activity GO:0043547 1 0.013
neuron projection development GO:0031175 180 0.013
heart rudiment morphogenesis GO:0003314 6 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
neurotransmitter transport GO:0006836 2 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
regulation of positive chemotaxis GO:0050926 4 0.013
body morphogenesis GO:0010171 16 0.013
hormone transport GO:0009914 2 0.013
response to organic substance GO:0010033 153 0.013
Mouse Rat
bmp signaling pathway involved in heart development GO:0061312 15 0.013
regulation of synaptic plasticity GO:0048167 1 0.012
mrna stabilization GO:0048255 4 0.012
cartilage morphogenesis GO:0060536 13 0.012
multi organism cellular process GO:0044764 2 0.012
regulation of mrna splicing via spliceosome GO:0048024 3 0.012
single organism reproductive process GO:0044702 40 0.012
Mouse
sensory perception of smell GO:0007608 2 0.012
response to nutrient GO:0007584 3 0.012
protein homooligomerization GO:0051260 3 0.012
kidney vasculature development GO:0061440 2 0.012
embryonic foregut morphogenesis GO:0048617 1 0.012
response to hydrogen peroxide GO:0042542 3 0.012
receptor internalization GO:0031623 2 0.012
hypochord development GO:0055016 3 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.012
rna localization GO:0006403 4 0.012
photoreceptor cell fate specification GO:0043704 1 0.012
circadian rhythm GO:0007623 19 0.012
macromolecular complex assembly GO:0065003 35 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.012

cftr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
sensory system disease DOID:0050155 0 0.014
disease of anatomical entity DOID:7 0 0.014
Human
eye and adnexa disease DOID:1492 0 0.014
nervous system disease DOID:863 0 0.014
eye disease DOID:5614 0 0.014
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012