Danio rerio

0 known processes

cldn5b

claudin 5b

(Aliases: zgc:103419)

cldn5b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.402
blood vessel development GO:0001568 246 0.388
vasculature development GO:0001944 278 0.364
embryonic organ development GO:0048568 381 0.247
angiogenesis GO:0001525 158 0.211
morphogenesis of an epithelium GO:0002009 333 0.182
Zebrafish
regulation of cell activation GO:0050865 1 0.160
regulation of signal transduction GO:0009966 225 0.154
sensory organ development GO:0007423 393 0.153
Zebrafish
regulation of signaling GO:0023051 235 0.134
positive regulation of cellular process GO:0048522 201 0.128
regulation of metal ion transport GO:0010959 4 0.127
Zebrafish
immune system process GO:0002376 241 0.126
cell surface receptor signaling pathway GO:0007166 325 0.125
regulation of dna replication GO:0006275 3 0.124
hormone transport GO:0009914 2 0.113
tube morphogenesis GO:0035239 349 0.107
Zebrafish
single organism transport GO:0044765 206 0.106
Zebrafish
regulation of cell communication GO:0010646 232 0.104
stem cell maintenance GO:0019827 4 0.098
cell substrate adhesion GO:0031589 4 0.097
regulation of response to stimulus GO:0048583 269 0.093
positive regulation of cell activation GO:0050867 1 0.092
muscle structure development GO:0061061 196 0.089
hormone secretion GO:0046879 2 0.088
meiotic nuclear division GO:0007126 4 0.087
organic cyclic compound biosynthetic process GO:1901362 223 0.085
blood vessel morphogenesis GO:0048514 216 0.080
sensory organ morphogenesis GO:0090596 200 0.079
pericardium development GO:0060039 1 0.074
establishment of localization GO:0051234 244 0.071
Zebrafish
organelle organization GO:0006996 227 0.069
water homeostasis GO:0030104 4 0.067
cellular nitrogen compound metabolic process GO:0034641 290 0.064
response to glucose GO:0009749 3 0.063
negative regulation of cellular process GO:0048523 283 0.062
nucleobase containing compound metabolic process GO:0006139 274 0.061
response to carbohydrate GO:0009743 3 0.060
trabecula morphogenesis GO:0061383 2 0.059
nucleic acid metabolic process GO:0090304 244 0.058
lymph vessel development GO:0001945 27 0.057
cation transport GO:0006812 81 0.054
Zebrafish
organic substance biosynthetic process GO:1901576 289 0.054
cellular component morphogenesis GO:0032989 336 0.054
cell morphogenesis GO:0000902 289 0.053
negative regulation of response to stimulus GO:0048585 104 0.053
immune system development GO:0002520 191 0.052
transcription from rna polymerase ii promoter GO:0006366 80 0.051
g protein coupled receptor signaling pathway GO:0007186 74 0.051
positive regulation of transport GO:0051050 2 0.050
ion transport GO:0006811 114 0.049
Zebrafish
muscle organ development GO:0007517 101 0.047
negative regulation of biological process GO:0048519 304 0.047
organic cyclic compound metabolic process GO:1901360 301 0.047
regulation of cytokine production GO:0001817 3 0.046
regulation of organ growth GO:0046620 3 0.044
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.044
negative regulation of cell communication GO:0010648 96 0.044
transport GO:0006810 220 0.043
Zebrafish
negative regulation of signal transduction GO:0009968 94 0.043
negative regulation of signaling GO:0023057 96 0.043
peptide transport GO:0015833 1 0.043
regulation of nucleic acid templated transcription GO:1903506 213 0.043
regulation of rna biosynthetic process GO:2001141 213 0.043
regulation of bmp signaling pathway GO:0030510 39 0.042
metal ion transport GO:0030001 58 0.041
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.041
regulation of inflammatory response GO:0050727 2 0.041
endosomal transport GO:0016197 2 0.041
carbon dioxide transmembrane transport GO:0035378 1 0.041
myeloid leukocyte migration GO:0097529 12 0.041
positive regulation of biological process GO:0048518 253 0.041
endothelial cell differentiation GO:0045446 20 0.040
Zebrafish
regulation of localization GO:0032879 104 0.040
Zebrafish
pancreas development GO:0031016 84 0.040
myotube differentiation GO:0014902 45 0.039
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.039
rna biosynthetic process GO:0032774 181 0.039
generation of neurons GO:0048699 385 0.039
vasculogenesis GO:0001570 41 0.039
protein localization to nucleus GO:0034504 3 0.039
cilium organization GO:0044782 71 0.039
amine metabolic process GO:0009308 2 0.038
connective tissue development GO:0061448 99 0.038
aging GO:0007568 2 0.037
positive regulation of cell cycle GO:0045787 3 0.037
aromatic compound biosynthetic process GO:0019438 217 0.037
heart development GO:0007507 313 0.037
regulation of multicellular organismal process GO:0051239 277 0.036
neuron development GO:0048666 262 0.036
response to monosaccharide GO:0034284 3 0.036
cellular macromolecule metabolic process GO:0044260 391 0.036
regulation of cell shape GO:0008360 1 0.036
cellular aromatic compound metabolic process GO:0006725 295 0.035
cell matrix adhesion GO:0007160 4 0.035
regulation of gene expression GO:0010468 265 0.034
nitrogen compound metabolic process GO:0006807 319 0.034
heterocycle biosynthetic process GO:0018130 215 0.034
lateral inhibition GO:0046331 1 0.034
positive regulation of cell adhesion GO:0045785 1 0.033
germ line stem cell maintenance GO:0030718 2 0.033
heterocycle metabolic process GO:0046483 290 0.033
hemopoiesis GO:0030097 183 0.033
eye development GO:0001654 277 0.033
nucleic acid templated transcription GO:0097659 181 0.032
embryonic heart tube development GO:0035050 133 0.032
rna metabolic process GO:0016070 219 0.032
b cell differentiation GO:0030183 1 0.032
response to hexose GO:0009746 3 0.032
striated muscle cell development GO:0055002 108 0.031
lymphangiogenesis GO:0001946 25 0.031
lateral line system development GO:0048925 76 0.031
Zebrafish
regulation of biological quality GO:0065008 263 0.031
positive regulation of inflammatory response GO:0050729 1 0.031
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.031
dorsal ventral pattern formation GO:0009953 125 0.031
regulation of cellular metabolic process GO:0031323 320 0.031
cardiac atrium morphogenesis GO:0003209 2 0.030
guanosine containing compound metabolic process GO:1901068 4 0.030
transmission of nerve impulse GO:0019226 19 0.029
peptidyl serine modification GO:0018209 2 0.029
positive regulation of cytokine production GO:0001819 2 0.029
biosynthetic process GO:0009058 294 0.028
t cell activation GO:0042110 6 0.028
chordate embryonic development GO:0043009 271 0.028
nucleobase containing compound biosynthetic process GO:0034654 205 0.028
hematopoietic or lymphoid organ development GO:0048534 191 0.028
carboxylic acid metabolic process GO:0019752 22 0.028
regulation of ion transmembrane transporter activity GO:0032412 2 0.028
cellular response to radiation GO:0071478 4 0.028
cellular component assembly GO:0022607 170 0.028
lipid homeostasis GO:0055088 3 0.027
regulation of immune system process GO:0002682 34 0.027
small molecule metabolic process GO:0044281 77 0.027
morphogenesis of an epithelial sheet GO:0002011 49 0.027
Zebrafish
oxoacid metabolic process GO:0043436 31 0.027
negative regulation of protein kinase activity GO:0006469 4 0.026
lateral line development GO:0048882 66 0.026
Zebrafish
camera type eye development GO:0043010 222 0.026
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.026
larval development GO:0002164 2 0.026
mononuclear cell proliferation GO:0032943 1 0.026
renal absorption GO:0070293 1 0.026
endothelium development GO:0003158 25 0.026
Zebrafish
organic acid metabolic process GO:0006082 31 0.026
ventricular cardiac muscle tissue development GO:0003229 3 0.025
gtp catabolic process GO:0006184 2 0.025
epithelial cell development GO:0002064 42 0.025
Zebrafish
endoderm development GO:0007492 49 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
skeletal muscle organ development GO:0060538 78 0.025
gastrulation GO:0007369 208 0.025
Zebrafish
maintenance of location GO:0051235 4 0.025
regulation of cell substrate adhesion GO:0010810 1 0.025
regulation of cellular biosynthetic process GO:0031326 245 0.025
skeletal system development GO:0001501 181 0.025
regulation of developmental process GO:0050793 247 0.024
cortical cytoskeleton organization GO:0030865 1 0.024
cellular amine metabolic process GO:0044106 2 0.024
homeostatic process GO:0042592 142 0.024
neuromast development GO:0048884 46 0.024
Zebrafish
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.024
lipid storage GO:0019915 1 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.024
regulation of cellular ketone metabolic process GO:0010565 7 0.024
cilium assembly GO:0042384 58 0.024
skeletal system morphogenesis GO:0048705 102 0.023
peptidyl serine phosphorylation GO:0018105 1 0.023
negative regulation of kinase activity GO:0033673 4 0.023
adherens junction organization GO:0034332 4 0.023
cellular response to nutrient levels GO:0031669 2 0.023
ion transmembrane transport GO:0034220 91 0.023
negative regulation of developmental process GO:0051093 65 0.023
localization of cell GO:0051674 244 0.022
regulation of rna metabolic process GO:0051252 224 0.022
negative regulation of dna metabolic process GO:0051053 4 0.022
system process GO:0003008 185 0.022
mesenchyme development GO:0060485 127 0.022
cartilage development GO:0051216 96 0.022
atp catabolic process GO:0006200 4 0.022
kidney development GO:0001822 92 0.022
negative regulation of cell differentiation GO:0045596 46 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.021
striated muscle cell differentiation GO:0051146 129 0.021
digestive tract morphogenesis GO:0048546 231 0.021
Zebrafish
post golgi vesicle mediated transport GO:0006892 1 0.021
regulation of protein transport GO:0051223 3 0.021
cellular component movement GO:0006928 335 0.021
phagocytosis GO:0006909 3 0.021
transcription dna templated GO:0006351 181 0.021
chemotaxis GO:0006935 104 0.021
central nervous system development GO:0007417 387 0.020
cellular ketone metabolic process GO:0042180 11 0.020
calcium mediated signaling GO:0019722 2 0.020
positive regulation of cell substrate adhesion GO:0010811 1 0.020
gtp metabolic process GO:0046039 4 0.020
response to external stimulus GO:0009605 264 0.020
hepaticobiliary system development GO:0061008 98 0.020
guanosine containing compound catabolic process GO:1901069 2 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
sensory system development GO:0048880 76 0.020
Zebrafish
cellular amino acid metabolic process GO:0006520 7 0.020
estrogen metabolic process GO:0008210 2 0.020
stem cell proliferation GO:0072089 4 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.020
single organism localization GO:1902578 225 0.019
Zebrafish
regulation of transmembrane transporter activity GO:0022898 2 0.019
regulation of cell differentiation GO:0045595 142 0.019
macromolecule biosynthetic process GO:0009059 227 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
positive regulation of endothelial cell migration GO:0010595 2 0.019
cytoskeleton organization GO:0007010 96 0.019
embryo development ending in birth or egg hatching GO:0009792 271 0.019
positive regulation of epithelial cell migration GO:0010634 2 0.019
regulation of circadian rhythm GO:0042752 4 0.019
response to alkaloid GO:0043279 2 0.019
regulation of blood vessel size GO:0050880 2 0.019
response to vitamin b3 GO:0033552 2 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.019
negative regulation of bmp signaling pathway GO:0030514 13 0.019
single organism organelle organization GO:1902589 199 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
regulation of protein localization to plasma membrane GO:1903076 1 0.019
regulation of tissue remodeling GO:0034103 2 0.019
regulation of chemotaxis GO:0050920 18 0.018
wound healing GO:0042060 90 0.018
multicellular organismal homeostasis GO:0048871 29 0.018
pigmentation GO:0043473 85 0.018
cell morphogenesis involved in differentiation GO:0000904 195 0.018
regulation of macromolecule metabolic process GO:0060255 317 0.018
vascular endothelial growth factor signaling pathway GO:0038084 3 0.018
cellular macromolecule biosynthetic process GO:0034645 224 0.018
inner ear morphogenesis GO:0042472 63 0.018
digestive system development GO:0055123 289 0.018
Zebrafish
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
receptor recycling GO:0001881 4 0.017
response to topologically incorrect protein GO:0035966 2 0.017
specification of symmetry GO:0009799 204 0.017
determination of left right symmetry GO:0007368 179 0.017
cell projection organization GO:0030030 284 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
regulation of notch signaling pathway GO:0008593 16 0.017
tissue remodeling GO:0048771 4 0.017
hatching gland development GO:0048785 3 0.017
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.017
protein localization to plasma membrane GO:0072659 1 0.017
cell activation GO:0001775 16 0.017
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.017
regulation of neural precursor cell proliferation GO:2000177 3 0.017
smooth muscle contraction GO:0006939 2 0.017
determination of bilateral symmetry GO:0009855 204 0.017
regulation of intracellular signal transduction GO:1902531 57 0.017
sprouting angiogenesis GO:0002040 53 0.016
regulation of positive chemotaxis GO:0050926 4 0.016
nucleocytoplasmic transport GO:0006913 4 0.016
single organism metabolic process GO:0044710 217 0.016
regulation of synapse organization GO:0050807 3 0.016
establishment of localization in cell GO:0051649 77 0.016
b cell activation GO:0042113 2 0.016
regulation of cell migration GO:0030334 40 0.016
lymphocyte proliferation GO:0046651 1 0.016
cardiac cell fate commitment GO:0060911 1 0.016
positive regulation of catabolic process GO:0009896 4 0.016
nucleoside monophosphate catabolic process GO:0009125 4 0.016
stem cell division GO:0017145 1 0.016
mesenchymal cell proliferation GO:0010463 1 0.016
carbohydrate homeostasis GO:0033500 1 0.016
monoamine transport GO:0015844 1 0.016
germ line stem cell division GO:0042078 1 0.016
purine nucleoside monophosphate catabolic process GO:0009128 4 0.016
gene expression GO:0010467 252 0.016
patterning of blood vessels GO:0001569 15 0.016
endocrine hormone secretion GO:0060986 2 0.016
tissue homeostasis GO:0001894 25 0.016
positive regulation of immune system process GO:0002684 17 0.016
alcohol biosynthetic process GO:0046165 2 0.016
cytoskeleton dependent cytokinesis GO:0061640 3 0.015
regulation of protein catabolic process GO:0042176 1 0.015
cytokinesis GO:0000910 3 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
forebrain development GO:0030900 96 0.015
muscle cell differentiation GO:0042692 139 0.015
cortical actin cytoskeleton organization GO:0030866 1 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
lymph vessel morphogenesis GO:0036303 25 0.015
neuron projection morphogenesis GO:0048812 161 0.015
regulation of response to external stimulus GO:0032101 31 0.015
organelle fusion GO:0048284 3 0.015
regulation of calcium ion transport GO:0051924 2 0.015
response to nutrient GO:0007584 3 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
pericardium morphogenesis GO:0003344 1 0.015
endocrine system development GO:0035270 65 0.015
mitochondrion organization GO:0007005 4 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
organelle assembly GO:0070925 110 0.015
regulation of metabolic process GO:0019222 359 0.015
regulation of establishment of protein localization GO:0070201 4 0.015
regulation of biosynthetic process GO:0009889 250 0.015
regionalization GO:0003002 274 0.015
cellular response to external stimulus GO:0071496 2 0.014
regulation of binding GO:0051098 3 0.014
regulation of tube size GO:0035150 2 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
regulation of reproductive process GO:2000241 4 0.014
pathway restricted smad protein phosphorylation GO:0060389 1 0.014
cellular nitrogen compound biosynthetic process GO:0044271 218 0.014
primitive hemopoiesis GO:0060215 27 0.014
blood circulation GO:0008015 87 0.014
proteasomal protein catabolic process GO:0010498 2 0.014
notochord cell differentiation GO:0060034 18 0.014
renal system development GO:0072001 94 0.014
response to food GO:0032094 1 0.014
locomotion GO:0040011 313 0.014
brain development GO:0007420 293 0.014
fin development GO:0033333 77 0.014
somatic stem cell maintenance GO:0035019 1 0.014
single organism nuclear import GO:1902593 3 0.014
ras protein signal transduction GO:0007265 7 0.014
cell projection morphogenesis GO:0048858 244 0.014
negative regulation of multicellular organismal process GO:0051241 69 0.014
regulation of fatty acid metabolic process GO:0019217 1 0.014
embryonic organ morphogenesis GO:0048562 274 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
cell migration GO:0016477 237 0.013
embryonic cranial skeleton morphogenesis GO:0048701 90 0.013
carbon dioxide transport GO:0015670 3 0.013
digestive tract development GO:0048565 265 0.013
Zebrafish
protein targeting to nucleus GO:0044744 3 0.013
head development GO:0060322 303 0.013
positive regulation of gtp catabolic process GO:0033126 1 0.013
ammonium transmembrane transport GO:0072488 2 0.013
regulation of transporter activity GO:0032409 2 0.013
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.013
cardiocyte differentiation GO:0035051 44 0.013
eye morphogenesis GO:0048592 144 0.013
fin morphogenesis GO:0033334 53 0.013
regulation of cardiac muscle tissue development GO:0055024 1 0.013
multicellular organismal signaling GO:0035637 22 0.013
sensory perception of chemical stimulus GO:0007606 3 0.013
negative regulation of dna replication GO:0008156 2 0.013
negative regulation of epithelial cell migration GO:0010633 1 0.013
muscle cell development GO:0055001 115 0.013
compound eye development GO:0048749 2 0.013
neuron differentiation GO:0030182 353 0.013
leukocyte activation GO:0045321 12 0.012
stem cell differentiation GO:0048863 117 0.012
cilium morphogenesis GO:0060271 85 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
negative regulation of defense response GO:0031348 2 0.012
establishment of protein localization to plasma membrane GO:0090002 1 0.012
protein homooligomerization GO:0051260 3 0.012
cellular response to starvation GO:0009267 1 0.012
protein import GO:0017038 3 0.012
protein acylation GO:0043543 3 0.012
regulation of cell motility GO:2000145 46 0.012
regulation of sodium ion transport GO:0002028 2 0.012
Zebrafish
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
sensory perception of smell GO:0007608 2 0.012
cellular localization GO:0051641 97 0.012
pole plasm assembly GO:0007315 4 0.012
neural crest cell differentiation GO:0014033 72 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
diencephalon development GO:0021536 58 0.012
glucose homeostasis GO:0042593 1 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.012
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.012
negative regulation of muscle tissue development GO:1901862 2 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
negative regulation of cellular biosynthetic process GO:0031327 55 0.012
regulation of multicellular organismal development GO:2000026 223 0.012
cell fate commitment GO:0045165 99 0.012
heart trabecula morphogenesis GO:0061384 2 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
stem cell development GO:0048864 82 0.012
inner ear development GO:0048839 126 0.011
cardiac muscle tissue development GO:0048738 48 0.011
striated muscle tissue development GO:0014706 110 0.011
chronic inflammatory response GO:0002544 1 0.011
notch signaling pathway GO:0007219 35 0.011
single organism membrane fusion GO:0044801 2 0.011
leukocyte proliferation GO:0070661 1 0.011
cellular biosynthetic process GO:0044249 286 0.011
response to organic substance GO:0010033 153 0.011
embryonic skeletal joint development GO:0072498 3 0.011
glycerophospholipid biosynthetic process GO:0046474 1 0.011
meiotic cell cycle process GO:1903046 3 0.011
intracellular receptor signaling pathway GO:0030522 30 0.011
nuclear import GO:0051170 3 0.011
positive regulation of leukocyte migration GO:0002687 2 0.011
positive regulation of leukocyte differentiation GO:1902107 1 0.011
cell part morphogenesis GO:0032990 246 0.011
transmembrane transport GO:0055085 120 0.011
reflex GO:0060004 2 0.011
cell proliferation GO:0008283 80 0.011
response to chemical GO:0042221 320 0.011
dna templated transcription elongation GO:0006354 3 0.011
protein acetylation GO:0006473 2 0.011
bmp signaling pathway GO:0030509 52 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
multicellular organism growth GO:0035264 4 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
interspecies interaction between organisms GO:0044419 4 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
regulation of locomotion GO:0040012 55 0.011
neuron projection extension GO:1990138 45 0.011
cardiac muscle cell differentiation GO:0055007 30 0.011
regulation of cell matrix adhesion GO:0001952 1 0.011
membrane fusion GO:0061025 2 0.011
appendage morphogenesis GO:0035107 56 0.010
negative regulation of chemotaxis GO:0050922 4 0.010
peptidyl threonine modification GO:0018210 1 0.010
endothelial cell development GO:0001885 12 0.010
Zebrafish
pronephros development GO:0048793 69 0.010
monovalent inorganic cation transport GO:0015672 42 0.010
Zebrafish
post embryonic organ development GO:0048569 4 0.010
mitotic cytokinesis GO:0000281 3 0.010
lens development in camera type eye GO:0002088 22 0.010
regulation of muscle contraction GO:0006937 3 0.010
modification dependent protein catabolic process GO:0019941 3 0.010
negative regulation of striated muscle tissue development GO:0045843 2 0.010
cellular response to organic substance GO:0071310 105 0.010
cell growth GO:0016049 57 0.010
cellular component disassembly GO:0022411 1 0.010
response to hypoxia GO:0001666 25 0.010
protein import into nucleus GO:0006606 3 0.010
glial cell migration GO:0008347 3 0.010

cldn5b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.061
musculoskeletal system disease DOID:17 0 0.056
myopathy DOID:423 0 0.033
muscular disease DOID:0080000 0 0.033
muscle tissue disease DOID:66 0 0.033
cardiovascular system disease DOID:1287 0 0.023
disease of metabolism DOID:0014667 0 0.022
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
nervous system disease DOID:863 0 0.015
heart disease DOID:114 0 0.013