Danio rerio

33 known processes

cldnb

claudin b

(Aliases: wu:fa66b05,MGC92382)

cldnb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
establishment of endothelial barrier GO:0061028 3 0.965
Zebrafish
epiboly GO:0090504 41 0.945
Zebrafish
lateral line system development GO:0048925 76 0.938
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.879
Zebrafish
sensory system development GO:0048880 76 0.850
neuromast development GO:0048884 46 0.834
metal ion transport GO:0030001 58 0.660
sodium ion transport GO:0006814 24 0.658
sensory organ development GO:0007423 393 0.599
monovalent inorganic cation transport GO:0015672 42 0.593
single organism localization GO:1902578 225 0.566
morphogenesis of an epithelial sheet GO:0002011 49 0.514
Zebrafish
gastrulation with mouth forming second GO:0001702 44 0.445
Zebrafish
lateral line development GO:0048882 66 0.437
regulation of sodium ion transport GO:0002028 2 0.401
epithelial cell differentiation GO:0030855 116 0.397
Zebrafish
regulation of ion transport GO:0043269 22 0.396
epithelial cell development GO:0002064 42 0.375
Zebrafish
establishment of localization GO:0051234 244 0.350
neurological system process GO:0050877 62 0.345
regulation of localization GO:0032879 104 0.331
transport GO:0006810 220 0.322
regulation of muscle contraction GO:0006937 3 0.315
endothelial cell differentiation GO:0045446 20 0.309
Zebrafish
digestive system development GO:0055123 289 0.291
Zebrafish
endothelium development GO:0003158 25 0.282
Zebrafish
regulation of striated muscle contraction GO:0006942 2 0.272
ion transport GO:0006811 114 0.265
regulation of cardiac muscle cell contraction GO:0086004 1 0.256
endothelial cell development GO:0001885 12 0.251
Zebrafish
single organism transport GO:0044765 206 0.246
regulation of transport GO:0051049 45 0.246
gene expression GO:0010467 252 0.245
regulation of epithelial cell proliferation GO:0050678 3 0.242
gastrulation GO:0007369 208 0.239
Zebrafish
digestive tract morphogenesis GO:0048546 231 0.237
Zebrafish
multicellular organismal water homeostasis GO:0050891 1 0.234
morphogenesis of an epithelium GO:0002009 333 0.232
Zebrafish
regulation of biological quality GO:0065008 263 0.230
regulation of metal ion transport GO:0010959 4 0.214
localization of cell GO:0051674 244 0.205
cation transport GO:0006812 81 0.203
response to stress GO:0006950 263 0.192
locomotion GO:0040011 313 0.181
tube morphogenesis GO:0035239 349 0.180
Zebrafish
single organism metabolic process GO:0044710 217 0.171
tube formation GO:0035148 25 0.169
Zebrafish
biosynthetic process GO:0009058 294 0.160
cellular component movement GO:0006928 335 0.149
regulation of establishment of protein localization GO:0070201 4 0.144
cell motility GO:0048870 244 0.136
regulation of nitrogen compound metabolic process GO:0051171 251 0.132
organelle organization GO:0006996 227 0.122
system process GO:0003008 185 0.118
response to abiotic stimulus GO:0009628 122 0.117
cellular component biogenesis GO:0044085 178 0.113
single organism membrane fusion GO:0044801 2 0.113
desmosome assembly GO:0002159 2 0.112
immune system development GO:0002520 191 0.108
circulatory system process GO:0003013 87 0.108
regulation of primary metabolic process GO:0080090 311 0.106
digestive tract development GO:0048565 265 0.106
Zebrafish
organic cyclic compound metabolic process GO:1901360 301 0.104
negative regulation of cellular process GO:0048523 283 0.101
cellular response to endogenous stimulus GO:0071495 68 0.101
regulation of system process GO:0044057 40 0.100
regulation of dna templated transcription in response to stress GO:0043620 0 0.100
signal transduction GO:0007165 455 0.099
cardiocyte differentiation GO:0035051 44 0.099
regeneration GO:0031099 91 0.098
blood vessel development GO:0001568 246 0.098
muscle contraction GO:0006936 18 0.095
cognition GO:0050890 1 0.095
biological adhesion GO:0022610 40 0.094
Mouse
action potential GO:0001508 19 0.093
developmental growth GO:0048589 166 0.093
epidermal cell differentiation GO:0009913 36 0.091
fatty acid biosynthetic process GO:0006633 4 0.088
regulation of metabolic process GO:0019222 359 0.087
keratinocyte differentiation GO:0030216 0 0.085
aromatic compound biosynthetic process GO:0019438 217 0.081
positive regulation of rna metabolic process GO:0051254 59 0.077
immune system process GO:0002376 241 0.075
regulation of biosynthetic process GO:0009889 250 0.073
cellular response to external stimulus GO:0071496 2 0.071
regulation of cellular metabolic process GO:0031323 320 0.071
embryo development ending in birth or egg hatching GO:0009792 271 0.070
female sex differentiation GO:0046660 4 0.070
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.068
nucleic acid metabolic process GO:0090304 244 0.066
homeostatic process GO:0042592 142 0.066
cardiac muscle cell contraction GO:0086003 1 0.065
small molecule metabolic process GO:0044281 77 0.064
striated muscle cell differentiation GO:0051146 129 0.062
inner ear development GO:0048839 126 0.062
cellular nitrogen compound metabolic process GO:0034641 290 0.060
nucleobase containing compound biosynthetic process GO:0034654 205 0.060
cellular component assembly involved in morphogenesis GO:0010927 107 0.060
neuronal action potential GO:0019228 18 0.060
cellular component assembly GO:0022607 170 0.059
intracellular signal transduction GO:0035556 85 0.059
regulation of protein transport GO:0051223 3 0.059
cellular macromolecule metabolic process GO:0044260 391 0.058
regulation of cellular component movement GO:0051270 55 0.058
regulation of macromolecule metabolic process GO:0060255 317 0.058
epidermis development GO:0008544 48 0.055
growth GO:0040007 174 0.054
muscle cell differentiation GO:0042692 139 0.054
long chain fatty acid metabolic process GO:0001676 1 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.053
single organism membrane organization GO:0044802 20 0.053
regulation of membrane potential GO:0042391 23 0.052
multicellular organismal signaling GO:0035637 22 0.052
cell proliferation GO:0008283 80 0.051
regulation of blood circulation GO:1903522 32 0.049
carboxylic acid metabolic process GO:0019752 22 0.049
reproductive process GO:0022414 40 0.049
cellular component morphogenesis GO:0032989 336 0.048
desmosome organization GO:0002934 3 0.048
response to chemical GO:0042221 320 0.048
positive regulation of cellular metabolic process GO:0031325 94 0.048
pigment granule transport GO:0051904 19 0.047
phagocytosis GO:0006909 3 0.047
cellular biosynthetic process GO:0044249 286 0.046
regulation of multicellular organismal process GO:0051239 277 0.046
establishment of protein localization to plasma membrane GO:0090002 1 0.046
mechanosensory lateral line system development GO:0048881 49 0.046
multicellular organismal homeostasis GO:0048871 29 0.045
positive regulation of macromolecule metabolic process GO:0010604 93 0.045
cell cell adhesion GO:0098609 6 0.045
Mouse
protein import GO:0017038 3 0.045
pigmentation GO:0043473 85 0.044
actin filament based movement GO:0030048 1 0.044
proximal distal pattern formation GO:0009954 1 0.043
chordate embryonic development GO:0043009 271 0.043
neuroblast differentiation GO:0014016 1 0.042
sensory perception GO:0007600 39 0.042
positive regulation of biosynthetic process GO:0009891 68 0.042
tissue regeneration GO:0042246 74 0.042
cell death GO:0008219 121 0.042
organonitrogen compound metabolic process GO:1901564 74 0.041
regulation of heart contraction GO:0008016 32 0.040
muscle cell development GO:0055001 115 0.040
negative regulation of biological process GO:0048519 304 0.040
vasculature development GO:0001944 278 0.040
multi organism reproductive process GO:0044703 36 0.039
positive regulation of cell cycle GO:0045787 3 0.039
regulation of cardiac muscle contraction GO:0055117 2 0.039
multi organism process GO:0051704 134 0.038
muscle structure development GO:0061061 196 0.038
regulation of water loss via skin GO:0033561 1 0.038
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.038
carbohydrate derivative metabolic process GO:1901135 61 0.038
positive regulation of cellular process GO:0048522 201 0.038
lipid biosynthetic process GO:0008610 22 0.038
oxoacid metabolic process GO:0043436 31 0.037
angiogenesis GO:0001525 158 0.036
organelle assembly GO:0070925 110 0.036
cellular response to chemical stimulus GO:0070887 157 0.036
regulation of cytoplasmic transport GO:1903649 4 0.035
establishment of protein localization to organelle GO:0072594 4 0.035
negative regulation of protein transport GO:0051224 3 0.035
heterocycle metabolic process GO:0046483 290 0.035
regulation of epidermis development GO:0045682 2 0.035
regulation of eye photoreceptor cell development GO:0042478 2 0.034
protein localization to plasma membrane GO:0072659 1 0.034
hemopoiesis GO:0030097 183 0.034
cell surface receptor signaling pathway GO:0007166 325 0.033
cytoskeleton organization GO:0007010 96 0.033
regulation of rna biosynthetic process GO:2001141 213 0.033
nucleic acid templated transcription GO:0097659 181 0.032
water homeostasis GO:0030104 4 0.032
regulation of cell motility GO:2000145 46 0.032
blood circulation GO:0008015 87 0.032
auditory receptor cell morphogenesis GO:0002093 4 0.031
positive regulation of metabolic process GO:0009893 108 0.031
aging GO:0007568 2 0.031
axis elongation involved in somitogenesis GO:0090245 2 0.031
membrane fusion GO:0061025 2 0.031
nuclear transport GO:0051169 4 0.030
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.030
response to glucocorticoid GO:0051384 1 0.030
regulation of multicellular organismal development GO:2000026 223 0.030
liver development GO:0001889 96 0.030
phosphate containing compound metabolic process GO:0006796 108 0.030
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.030
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.029
s adenosylmethionine metabolic process GO:0046500 1 0.029
nitrogen compound metabolic process GO:0006807 319 0.029
cell migration GO:0016477 237 0.029
blood vessel morphogenesis GO:0048514 216 0.029
positive regulation of gene expression GO:0010628 71 0.029
positive regulation of biological process GO:0048518 253 0.028
brain development GO:0007420 293 0.028
macromolecule biosynthetic process GO:0009059 227 0.028
regulation of rna metabolic process GO:0051252 224 0.028
single organism organelle organization GO:1902589 199 0.028
posterior lateral line system development GO:0048915 46 0.028
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.028
regulation of developmental process GO:0050793 247 0.027
response to drug GO:0042493 3 0.027
regulation of nucleic acid templated transcription GO:1903506 213 0.027
head development GO:0060322 303 0.027
positive regulation of transcription dna templated GO:0045893 57 0.027
cell morphogenesis GO:0000902 289 0.027
sexual reproduction GO:0019953 36 0.027
multicellular organism reproduction GO:0032504 35 0.026
positive regulation of nucleic acid templated transcription GO:1903508 57 0.026
positive regulation of cellular biosynthetic process GO:0031328 68 0.026
skin development GO:0043588 54 0.026
cardiac conduction system development GO:0003161 1 0.026
apoptotic process GO:0006915 116 0.025
caudal fin development GO:0033336 9 0.025
protein metabolic process GO:0019538 183 0.025
osteoclast development GO:0036035 1 0.025
negative regulation of epithelial cell proliferation GO:0050680 1 0.025
regulation of actin filament based movement GO:1903115 1 0.025
multicellular organismal reproductive process GO:0048609 35 0.025
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.025
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.024
larval development GO:0002164 2 0.024
response to wounding GO:0009611 116 0.024
response to organic cyclic compound GO:0014070 51 0.024
protein localization GO:0008104 40 0.024
heart field specification GO:0003128 1 0.024
negative regulation of multicellular organismal process GO:0051241 69 0.023
medial fin development GO:0033338 16 0.023
negative regulation of cytokine production GO:0001818 1 0.023
regulation of cytokine production GO:0001817 3 0.023
photoreceptor cell differentiation GO:0046530 55 0.023
extrinsic apoptotic signaling pathway GO:0097191 3 0.023
heart process GO:0003015 71 0.022
lipid metabolic process GO:0006629 52 0.022
very long chain fatty acid biosynthetic process GO:0042761 4 0.022
androgen metabolic process GO:0008209 2 0.021
striated muscle cell development GO:0055002 108 0.021
regulation of calcium ion transport GO:0051924 2 0.021
urogenital system development GO:0001655 97 0.021
regulation of intracellular protein transport GO:0033157 3 0.021
nucleobase containing compound metabolic process GO:0006139 274 0.021
programmed cell death GO:0012501 119 0.021
cellular response to extracellular stimulus GO:0031668 2 0.021
rna biosynthetic process GO:0032774 181 0.021
response to organic substance GO:0010033 153 0.021
cellular response to organic substance GO:0071310 105 0.021
gland development GO:0048732 143 0.021
single organism reproductive process GO:0044702 40 0.021
cardiac cell development GO:0055006 21 0.021
embryonic skeletal joint development GO:0072498 3 0.021
hematopoietic or lymphoid organ development GO:0048534 191 0.020
stem cell maintenance GO:0019827 4 0.020
positive regulation of neuron apoptotic process GO:0043525 1 0.020
regulation of protein localization to nucleus GO:1900180 2 0.020
metal ion homeostasis GO:0055065 26 0.020
regulation of blood pressure GO:0008217 1 0.020
erk1 and erk2 cascade GO:0070371 4 0.020
female gonad development GO:0008585 4 0.020
regulation of cellular biosynthetic process GO:0031326 245 0.019
polarized epithelial cell differentiation GO:0030859 4 0.019
rna metabolic process GO:0016070 219 0.019
renal tubule morphogenesis GO:0061333 1 0.019
muscle tissue development GO:0060537 110 0.019
neuron differentiation GO:0030182 353 0.019
cardiac cell fate commitment GO:0060911 1 0.019
endoplasmic reticulum unfolded protein response GO:0030968 2 0.018
regulation of cell proliferation GO:0042127 37 0.018
organic substance transport GO:0071702 58 0.018
heterocycle biosynthetic process GO:0018130 215 0.018
muscle system process GO:0003012 20 0.018
photoreceptor cell development GO:0042461 40 0.018
neuroblast proliferation GO:0007405 2 0.018
response to external stimulus GO:0009605 264 0.018
cell cell adhesion involved in mesendodermal cell migration GO:0003370 1 0.018
heart development GO:0007507 313 0.018
fin morphogenesis GO:0033334 53 0.018
wound healing GO:0042060 90 0.018
cellular localization GO:0051641 97 0.017
dna templated transcription elongation GO:0006354 3 0.017
regulation of nucleocytoplasmic transport GO:0046822 2 0.017
regulation of programmed cell death GO:0043067 101 0.017
calcium independent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016338 1 0.017
Mouse
organic acid metabolic process GO:0006082 31 0.017
organic substance biosynthetic process GO:1901576 289 0.017
cell adhesion GO:0007155 40 0.017
Mouse
nucleocytoplasmic transport GO:0006913 4 0.017
plasma membrane repair GO:0001778 2 0.017
regionalization GO:0003002 274 0.017
regulation of gene expression GO:0010468 265 0.017
transmission of nerve impulse GO:0019226 19 0.017
mitotic cell cycle process GO:1903047 48 0.017
response to topologically incorrect protein GO:0035966 2 0.016
regulation of locomotion GO:0040012 55 0.016
protein localization to nucleus GO:0034504 3 0.016
positive regulation of epithelial cell migration GO:0010634 2 0.016
cellular response to starvation GO:0009267 1 0.016
response to dexamethasone GO:0071548 1 0.016
positive regulation of transport GO:0051050 2 0.016
myofibril assembly GO:0030239 48 0.016
transcription from rna polymerase ii promoter GO:0006366 80 0.016
regulation of macromolecule biosynthetic process GO:0010556 225 0.016
actin filament based process GO:0030029 64 0.016
establishment of localization in cell GO:0051649 77 0.015
hepaticobiliary system development GO:0061008 98 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
chemical homeostasis GO:0048878 49 0.015
positive regulation of cell proliferation GO:0008284 15 0.015
actin mediated cell contraction GO:0070252 1 0.015
cell junction organization GO:0034330 11 0.015
cellular aromatic compound metabolic process GO:0006725 295 0.015
cellular response to organic cyclic compound GO:0071407 38 0.015
establishment of cell polarity involved in ameboidal cell migration GO:0003365 2 0.015
single organism biosynthetic process GO:0044711 71 0.015
regulation of cell cycle GO:0051726 52 0.015
androgen biosynthetic process GO:0006702 1 0.015
macromolecule modification GO:0043412 111 0.015
protein secretion GO:0009306 1 0.015
response to corticosteroid GO:0031960 1 0.014
positive regulation of programmed cell death GO:0043068 29 0.014
skeletal system development GO:0001501 181 0.014
regulation of cell death GO:0010941 103 0.014
death GO:0016265 121 0.014
long chain fatty acid biosynthetic process GO:0042759 1 0.014
response to light stimulus GO:0009416 46 0.014
protein import into nucleus GO:0006606 3 0.014
cerebellum formation GO:0021588 2 0.014
response to radiation GO:0009314 51 0.014
apical junction assembly GO:0043297 1 0.014
regulation of response to external stimulus GO:0032101 31 0.014
kidney vasculature development GO:0061440 2 0.014
ear development GO:0043583 127 0.013
reproduction GO:0000003 40 0.013
behavior GO:0007610 74 0.013
negative regulation of cellular metabolic process GO:0031324 77 0.013
regulation of protein targeting GO:1903533 2 0.013
cell cell junction assembly GO:0007043 5 0.013
cell cycle process GO:0022402 53 0.013
nuclear import GO:0051170 3 0.013
specification of axis polarity GO:0065001 4 0.013
generation of neurons GO:0048699 385 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.012
ectodermal cell fate specification GO:0001715 2 0.012
regulation of cell migration involved in sprouting angiogenesis GO:0090049 3 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
cellular protein metabolic process GO:0044267 129 0.012
cell cycle g1 s phase transition GO:0044843 1 0.012
cellular response to oxygen levels GO:0071453 1 0.012
cellular macromolecule biosynthetic process GO:0034645 224 0.012
positive regulation of dna templated transcription elongation GO:0032786 1 0.012
bone mineralization GO:0030282 9 0.012
methylation GO:0032259 22 0.012
germ cell development GO:0007281 22 0.012
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.012
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.012
adherens junction organization GO:0034332 4 0.012
posterior lateral line development GO:0048916 38 0.012
axis specification GO:0009798 43 0.012
single organismal cell cell adhesion GO:0016337 29 0.012
axon ensheathment GO:0008366 18 0.012
eye morphogenesis GO:0048592 144 0.011
organic hydroxy compound transport GO:0015850 14 0.011
hair cell differentiation GO:0035315 32 0.011
cellular response to nutrient levels GO:0031669 2 0.011
mitotic cell cycle GO:0000278 64 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
negative regulation of stem cell differentiation GO:2000737 2 0.011
cellular protein modification process GO:0006464 100 0.011
cytokinesis GO:0000910 3 0.011
regulation of cellular ketone metabolic process GO:0010565 7 0.011
actin cytoskeleton organization GO:0030036 63 0.011
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 6 0.011
Mouse
regulation of vesicle mediated transport GO:0060627 9 0.011
divalent inorganic cation transport GO:0072511 21 0.011
response to light intensity GO:0009642 1 0.011
single organism cell adhesion GO:0098602 29 0.011
epidermis morphogenesis GO:0048730 4 0.010
lipid homeostasis GO:0055088 3 0.010
stem cell development GO:0048864 82 0.010
energy reserve metabolic process GO:0006112 2 0.010
organic cyclic compound biosynthetic process GO:1901362 223 0.010
positive regulation of cell death GO:0010942 29 0.010
pigment cell development GO:0070285 3 0.010
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.010
neuroblast fate commitment GO:0014017 1 0.010
gamete generation GO:0007276 33 0.010

cldnb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.596
muscular disease DOID:0080000 0 0.596
heart disease DOID:114 0 0.596
cardiomyopathy DOID:0050700 0 0.596
disease of anatomical entity DOID:7 0 0.596
cardiovascular system disease DOID:1287 0 0.596
musculoskeletal system disease DOID:17 0 0.596
muscle tissue disease DOID:66 0 0.596
disease of metabolism DOID:0014667 0 0.025
amyloidosis DOID:9120 0 0.025
acquired metabolic disease DOID:0060158 0 0.025
intrinsic cardiomyopathy DOID:0060036 0 0.016
breast cancer DOID:1612 0 0.012
thoracic cancer DOID:5093 0 0.012
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012