Danio rerio

0 known processes

clic2

chloride intracellular channel 2

(Aliases: zgc:92762)

clic2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell activation GO:0050865 1 0.201
response to external stimulus GO:0009605 264 0.168
Fly
ion transport GO:0006811 114 0.114
Fly
small molecule metabolic process GO:0044281 77 0.107
regulation of cytokine production GO:0001817 3 0.103
response to stress GO:0006950 263 0.102
Fly
response to chemical GO:0042221 320 0.096
Fly
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.095
response to inorganic substance GO:0010035 38 0.091
positive regulation of cell activation GO:0050867 1 0.087
heart development GO:0007507 313 0.082
larval development GO:0002164 2 0.080
single organism localization GO:1902578 225 0.078
Fly
embryonic organ development GO:0048568 381 0.077
single fertilization GO:0007338 3 0.077
positive regulation of transport GO:0051050 2 0.077
positive regulation of cytokine production GO:0001819 2 0.075
muscle tissue development GO:0060537 110 0.075
regulation of primary metabolic process GO:0080090 311 0.073
organonitrogen compound metabolic process GO:1901564 74 0.070
regulation of cellular extravasation GO:0002691 1 0.066
collagen metabolic process GO:0032963 2 0.066
response to alkaloid GO:0043279 2 0.065
regulation of intracellular protein transport GO:0033157 3 0.062
nucleotide metabolic process GO:0009117 28 0.062
regulation of cell shape GO:0008360 1 0.062
astrocyte differentiation GO:0048708 1 0.061
single organism metabolic process GO:0044710 217 0.061
regulation of transporter activity GO:0032409 2 0.060
positive regulation of cellular component biogenesis GO:0044089 3 0.059
nuclear transport GO:0051169 4 0.058
nuclear import GO:0051170 3 0.057
cellular component morphogenesis GO:0032989 336 0.057
regulation of biological quality GO:0065008 263 0.056
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.052
protein import into nucleus GO:0006606 3 0.051
negative regulation of cytokine production GO:0001818 1 0.050
positive regulation of cellular catabolic process GO:0031331 3 0.050
nucleocytoplasmic transport GO:0006913 4 0.049
cellular localization GO:0051641 97 0.049
regulation of establishment of protein localization GO:0070201 4 0.048
establishment of localization GO:0051234 244 0.048
Fly
positive regulation of cellular process GO:0048522 201 0.048
superoxide metabolic process GO:0006801 2 0.048
positive regulation of biological process GO:0048518 253 0.047
cellular response to chemical stimulus GO:0070887 157 0.046
cell death GO:0008219 121 0.046
phagocytosis GO:0006909 3 0.046
muscle structure development GO:0061061 196 0.046
cellular response to external stimulus GO:0071496 2 0.046
biological adhesion GO:0022610 40 0.045
sensory system development GO:0048880 76 0.044
startle response GO:0001964 4 0.043
cellular component movement GO:0006928 335 0.043
multicellular organismal macromolecule metabolic process GO:0044259 2 0.042
regulation of circadian rhythm GO:0042752 4 0.041
sensory organ development GO:0007423 393 0.041
maintenance of location GO:0051235 4 0.041
negative regulation of cellular process GO:0048523 283 0.040
regulation of transmembrane transporter activity GO:0022898 2 0.040
transport GO:0006810 220 0.040
Fly
regulation of immune system process GO:0002682 34 0.040
purine containing compound metabolic process GO:0072521 29 0.039
defense response GO:0006952 47 0.039
lipid storage GO:0019915 1 0.037
reactive oxygen species biosynthetic process GO:1903409 1 0.036
nucleic acid metabolic process GO:0090304 244 0.036
regulation of protein transport GO:0051223 3 0.036
positive regulation of nucleoside metabolic process GO:0045979 1 0.036
antimicrobial humoral response GO:0019730 2 0.036
response to organic substance GO:0010033 153 0.036
Fly
morphogenesis of an epithelium GO:0002009 333 0.036
aging GO:0007568 2 0.035
Fly
response to drug GO:0042493 3 0.035
regulation of multicellular organism growth GO:0040014 4 0.035
cellular extravasation GO:0045123 1 0.035
regulation of ion transmembrane transporter activity GO:0032412 2 0.035
cellular nitrogen compound metabolic process GO:0034641 290 0.035
carboxylic acid metabolic process GO:0019752 22 0.034
carbohydrate derivative metabolic process GO:1901135 61 0.034
regulation of cytoplasmic transport GO:1903649 4 0.034
establishment of protein localization to organelle GO:0072594 4 0.033
positive regulation of cellular extravasation GO:0002693 1 0.033
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.033
lateral line system development GO:0048925 76 0.032
response to carbohydrate GO:0009743 3 0.032
regulation of blood vessel size GO:0050880 2 0.032
regulation of nucleotide catabolic process GO:0030811 2 0.031
homeostatic process GO:0042592 142 0.031
response to nitrogen compound GO:1901698 19 0.031
central nervous system development GO:0007417 387 0.031
phosphate containing compound metabolic process GO:0006796 108 0.031
regulation of protein catabolic process GO:0042176 1 0.031
wound healing GO:0042060 90 0.030
muscle organ development GO:0007517 101 0.030
regulation of localization GO:0032879 104 0.030
organophosphate metabolic process GO:0019637 37 0.030
response to lipopolysaccharide GO:0032496 13 0.030
regulation of nucleocytoplasmic transport GO:0046822 2 0.029
nitrogen compound metabolic process GO:0006807 319 0.029
cell morphogenesis GO:0000902 289 0.029
multicellular organismal metabolic process GO:0044236 2 0.029
macromolecule biosynthetic process GO:0009059 227 0.028
positive regulation of catabolic process GO:0009896 4 0.028
cytoskeleton organization GO:0007010 96 0.028
positive regulation of leukocyte differentiation GO:1902107 1 0.028
cytokinesis GO:0000910 3 0.028
regulation of gene expression GO:0010468 265 0.027
apoptotic process GO:0006915 116 0.027
protein metabolic process GO:0019538 183 0.027
cell motility GO:0048870 244 0.027
response to amino acid GO:0043200 2 0.027
regulation of metal ion transport GO:0010959 4 0.027
cellular macromolecule metabolic process GO:0044260 391 0.027
regulation of macromolecule metabolic process GO:0060255 317 0.026
nucleobase containing compound metabolic process GO:0006139 274 0.026
regulation of multicellular organismal process GO:0051239 277 0.026
locomotion GO:0040011 313 0.026
Fly
response to metal ion GO:0010038 34 0.026
rna localization GO:0006403 4 0.026
response to amine GO:0014075 1 0.026
immune system development GO:0002520 191 0.026
regulation of response to stimulus GO:0048583 269 0.026
system process GO:0003008 185 0.026
ribonucleotide metabolic process GO:0009259 27 0.025
regulation of tube size GO:0035150 2 0.025
nuclear export GO:0051168 1 0.025
transmembrane transport GO:0055085 120 0.025
Fly
regulation of membrane potential GO:0042391 23 0.025
immune response GO:0006955 28 0.025
cellular component disassembly GO:0022411 1 0.025
regulation of protein targeting GO:1903533 2 0.025
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.024
spermatid differentiation GO:0048515 2 0.024
protein import GO:0017038 3 0.024
cell activation GO:0001775 16 0.024
cellular carbohydrate metabolic process GO:0044262 4 0.024
regulation of calcium ion transport GO:0051924 2 0.024
embryo development ending in birth or egg hatching GO:0009792 271 0.024
regulation of circadian sleep wake cycle GO:0042749 1 0.024
regulation of cellular component organization GO:0051128 86 0.024
single organism organelle organization GO:1902589 199 0.024
purine nucleotide metabolic process GO:0006163 27 0.023
protein localization to plasma membrane GO:0072659 1 0.023
regulation of catalytic activity GO:0050790 55 0.023
organic acid metabolic process GO:0006082 31 0.023
protein targeting to nucleus GO:0044744 3 0.023
cellular protein catabolic process GO:0044257 4 0.023
response to endogenous stimulus GO:0009719 83 0.023
organic substance transport GO:0071702 58 0.023
g1 s transition of mitotic cell cycle GO:0000082 1 0.023
lipid metabolic process GO:0006629 52 0.023
regulation of inflammatory response GO:0050727 2 0.022
response to oxygen containing compound GO:1901700 55 0.022
Fly
positive regulation of metabolic process GO:0009893 108 0.022
regulation of alcohol biosynthetic process GO:1902930 1 0.022
single organism nuclear import GO:1902593 3 0.022
positive regulation of immune effector process GO:0002699 3 0.022
positive regulation of gtp catabolic process GO:0033126 1 0.022
regulation of protein complex assembly GO:0043254 3 0.021
negative regulation of biological process GO:0048519 304 0.021
spermatid development GO:0007286 2 0.021
response to abiotic stimulus GO:0009628 122 0.021
Fly
cellular response to extracellular stimulus GO:0031668 2 0.021
single organism transport GO:0044765 206 0.021
Fly
membrane hyperpolarization GO:0060081 1 0.020
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.020
negative regulation of metabolic process GO:0009892 86 0.020
cellular macromolecule biosynthetic process GO:0034645 224 0.020
cardiac atrium morphogenesis GO:0003209 2 0.020
negative regulation of macromolecule metabolic process GO:0010605 76 0.020
nucleoside phosphate metabolic process GO:0006753 28 0.020
striated muscle cell differentiation GO:0051146 129 0.020
negative regulation of cellular metabolic process GO:0031324 77 0.020
regulation of biosynthetic process GO:0009889 250 0.020
brain development GO:0007420 293 0.020
tube morphogenesis GO:0035239 349 0.019
gtp metabolic process GO:0046039 4 0.019
regulation of cellular ketone metabolic process GO:0010565 7 0.019
oxoacid metabolic process GO:0043436 31 0.019
protein localization to nucleus GO:0034504 3 0.019
oxidation reduction process GO:0055114 41 0.019
g2 m transition of mitotic cell cycle GO:0000086 4 0.019
intracellular transport GO:0046907 32 0.019
eye development GO:0001654 277 0.019
heart valve formation GO:0003188 4 0.019
cellular protein metabolic process GO:0044267 129 0.019
innate immune response GO:0045087 13 0.019
detection of chemical stimulus GO:0009593 4 0.019
fertilization GO:0009566 3 0.019
cellular amino acid metabolic process GO:0006520 7 0.019
response to acid chemical GO:0001101 17 0.019
circadian sleep wake cycle sleep GO:0050802 1 0.019
protein targeting to membrane GO:0006612 1 0.019
angiogenesis GO:0001525 158 0.019
regulation of cellular metabolic process GO:0031323 320 0.019
regulation of signaling GO:0023051 235 0.019
cellular component assembly involved in morphogenesis GO:0010927 107 0.019
regulation of cell death GO:0010941 103 0.018
cellular response to molecule of bacterial origin GO:0071219 3 0.018
hemopoiesis GO:0030097 183 0.018
regulation of myeloid leukocyte differentiation GO:0002761 5 0.018
carbohydrate biosynthetic process GO:0016051 1 0.018
phosphorylation GO:0016310 69 0.018
cell adhesion GO:0007155 40 0.018
cell matrix adhesion GO:0007160 4 0.018
regulation of system process GO:0044057 40 0.018
signal transduction GO:0007165 455 0.018
protein complex disassembly GO:0043241 1 0.018
positive regulation of macromolecule metabolic process GO:0010604 93 0.018
protein secretion GO:0009306 1 0.018
endosomal transport GO:0016197 2 0.018
blood circulation GO:0008015 87 0.018
regulation of reproductive process GO:2000241 4 0.018
regulation of wound healing GO:0061041 2 0.017
positive regulation of defense response GO:0031349 9 0.017
heterocycle metabolic process GO:0046483 290 0.017
multicellular organism growth GO:0035264 4 0.017
regulation of molecular function GO:0065009 70 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
muscle cell differentiation GO:0042692 139 0.017
stem cell maintenance GO:0019827 4 0.017
negative regulation of cell death GO:0060548 60 0.017
regulation of cytokine biosynthetic process GO:0042035 1 0.017
gtp catabolic process GO:0006184 2 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
single organism membrane fusion GO:0044801 2 0.017
cellular biosynthetic process GO:0044249 286 0.017
positive regulation of cellular metabolic process GO:0031325 94 0.017
multicellular organismal homeostasis GO:0048871 29 0.017
tissue regeneration GO:0042246 74 0.016
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.016
activation of mapk activity GO:0000187 3 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
response to external biotic stimulus GO:0043207 97 0.016
actin polymerization or depolymerization GO:0008154 2 0.016
guanosine containing compound catabolic process GO:1901069 2 0.016
interspecies interaction between organisms GO:0044419 4 0.016
regulation of protein localization to nucleus GO:1900180 2 0.016
striated muscle tissue development GO:0014706 110 0.016
membrane fusion GO:0061025 2 0.016
organelle organization GO:0006996 227 0.016
head development GO:0060322 303 0.016
homeostasis of number of cells GO:0048872 62 0.016
regulation of reactive oxygen species metabolic process GO:2000377 2 0.016
cation transport GO:0006812 81 0.016
response to organic cyclic compound GO:0014070 51 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
modification dependent protein catabolic process GO:0019941 3 0.015
erythrocyte homeostasis GO:0034101 55 0.015
response to glucose GO:0009749 3 0.015
cellular response to nutrient levels GO:0031669 2 0.015
regulation of leukocyte migration GO:0002685 8 0.015
positive regulation of myeloid leukocyte differentiation GO:0002763 1 0.015
protein polymerization GO:0051258 4 0.015
response to hexose GO:0009746 3 0.015
chemical homeostasis GO:0048878 49 0.015
programmed cell death GO:0012501 119 0.015
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.015
cell cycle g2 m phase transition GO:0044839 4 0.014
ribonucleoside monophosphate catabolic process GO:0009158 4 0.014
reactive oxygen species metabolic process GO:0072593 6 0.014
compound eye development GO:0048749 2 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
regulation of carbohydrate metabolic process GO:0006109 4 0.014
regulation of response to external stimulus GO:0032101 31 0.014
transcription dna templated GO:0006351 181 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
purine ribonucleotide metabolic process GO:0009150 27 0.014
regulation of cell matrix adhesion GO:0001952 1 0.014
localization of cell GO:0051674 244 0.014
cellular component biogenesis GO:0044085 178 0.014
regulation of metabolic process GO:0019222 359 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
myeloid leukocyte differentiation GO:0002573 15 0.014
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.014
hindbrain development GO:0030902 91 0.014
hepaticobiliary system development GO:0061008 98 0.014
regulation of nucleotide metabolic process GO:0006140 17 0.014
rna transport GO:0050658 2 0.014
regulation of nitrogen compound metabolic process GO:0051171 251 0.014
macromolecular complex disassembly GO:0032984 1 0.014
regulation of apoptotic process GO:0042981 98 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
regulation of purine nucleotide metabolic process GO:1900542 17 0.014
circulatory system process GO:0003013 87 0.014
blood coagulation GO:0007596 12 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
cellular ketone metabolic process GO:0042180 11 0.014
neuron differentiation GO:0030182 353 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
positive regulation of map kinase activity GO:0043406 3 0.013
stem cell division GO:0017145 1 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
cortical actin cytoskeleton organization GO:0030866 1 0.013
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.013
regulation of protein localization to plasma membrane GO:1903076 1 0.013
mitotic dna integrity checkpoint GO:0044774 4 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
vasculature development GO:0001944 278 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
regulation of gtpase activity GO:0043087 2 0.013
determination of heart left right asymmetry GO:0061371 117 0.013
vasculogenesis GO:0001570 41 0.013
establishment of localization in cell GO:0051649 77 0.013
regulation of dna replication GO:0006275 3 0.013
regulation of protein metabolic process GO:0051246 56 0.013
cognition GO:0050890 1 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
cellular component maintenance GO:0043954 3 0.013
establishment of protein localization to membrane GO:0090150 3 0.013
atp catabolic process GO:0006200 4 0.013
amine metabolic process GO:0009308 2 0.013
cellular response to reactive oxygen species GO:0034614 2 0.013
regulation of phosphate metabolic process GO:0019220 43 0.013
camera type eye morphogenesis GO:0048593 108 0.013
response to biotic stimulus GO:0009607 97 0.013
response to hormone GO:0009725 48 0.013
establishment of protein localization to plasma membrane GO:0090002 1 0.012
exocytosis GO:0006887 1 0.012
regulation of heart contraction GO:0008016 32 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
digestive tract morphogenesis GO:0048546 231 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
ion transmembrane transport GO:0034220 91 0.012
Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
myeloid cell homeostasis GO:0002262 56 0.012
protein localization GO:0008104 40 0.012
single organism membrane organization GO:0044802 20 0.012
positive regulation of cell death GO:0010942 29 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
regulation of rho protein signal transduction GO:0035023 2 0.012
regulation of developmental process GO:0050793 247 0.012
heart process GO:0003015 71 0.012
actomyosin structure organization GO:0031032 53 0.012
cellular response to biotic stimulus GO:0071216 3 0.012
circadian sleep wake cycle GO:0042745 2 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
immune system process GO:0002376 241 0.012
negative regulation of gene expression GO:0010629 65 0.012
positive regulation of catalytic activity GO:0043085 25 0.012
striated muscle cell development GO:0055002 108 0.012
regulation of nucleic acid templated transcription GO:1903506 213 0.012
regulation of glial cell differentiation GO:0045685 4 0.012
cell cycle arrest GO:0007050 1 0.012
negative regulation of cellular biosynthetic process GO:0031327 55 0.011
positive regulation of myeloid cell differentiation GO:0045639 2 0.011
metal ion homeostasis GO:0055065 26 0.011
small gtpase mediated signal transduction GO:0007264 8 0.011
regulation of muscle contraction GO:0006937 3 0.011
embryonic heart tube development GO:0035050 133 0.011
appendage development GO:0048736 80 0.011
neuromuscular process GO:0050905 7 0.011
regulation of synaptic plasticity GO:0048167 1 0.011
carbohydrate derivative biosynthetic process GO:1901137 43 0.011
nucleic acid templated transcription GO:0097659 181 0.011
fin development GO:0033333 77 0.011
phosphorus metabolic process GO:0006793 109 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
digestive tract development GO:0048565 265 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
neurological system process GO:0050877 62 0.011
response to lipid GO:0033993 60 0.011
regulation of programmed cell death GO:0043067 101 0.011
organelle assembly GO:0070925 110 0.011
heart looping GO:0001947 94 0.011
regulation of hydrolase activity GO:0051336 28 0.011
generation of neurons GO:0048699 385 0.011
negative regulation of developmental process GO:0051093 65 0.011
positive regulation of apoptotic process GO:0043065 29 0.011
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.011
protein modification by small protein removal GO:0070646 1 0.011
leukocyte activation GO:0045321 12 0.011
blood vessel development GO:0001568 246 0.011
organic substance biosynthetic process GO:1901576 289 0.011
smooth muscle contraction GO:0006939 2 0.011
epithelial cell differentiation GO:0030855 116 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
regulation of organ growth GO:0046620 3 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.010
camera type eye development GO:0043010 222 0.010
regulation of cellular protein metabolic process GO:0032268 52 0.010
mesenchymal cell development GO:0014031 78 0.010
mitotic cell cycle GO:0000278 64 0.010
negative regulation of defense response GO:0031348 2 0.010
circadian sleep wake cycle process GO:0022410 2 0.010
heart contraction GO:0060047 71 0.010
actin cytoskeleton organization GO:0030036 63 0.010
positive regulation of wound healing GO:0090303 1 0.010
glial cell differentiation GO:0010001 42 0.010
homeostasis of number of cells within a tissue GO:0048873 4 0.010
cellular aromatic compound metabolic process GO:0006725 295 0.010
multi organism process GO:0051704 134 0.010
regulation of defense response GO:0031347 14 0.010
heterocycle biosynthetic process GO:0018130 215 0.010
macromolecule localization GO:0033036 54 0.010
nucleobase containing small molecule metabolic process GO:0055086 32 0.010

clic2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.053
immune system disease DOID:2914 0 0.046
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
disease of metabolism DOID:0014667 0 0.018
organ system cancer DOID:0050686 0 0.011