Danio rerio

0 known processes

clk4a

CDC-like kinase 4a

(Aliases: wu:fb37c01,clk4,wu:fa26d04)

clk4a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
organic cyclic compound metabolic process GO:1901360 301 0.161
larval development GO:0002164 2 0.155
cellular aromatic compound metabolic process GO:0006725 295 0.147
gene expression GO:0010467 252 0.120
microtubule organizing center organization GO:0031023 1 0.117
nucleobase containing compound metabolic process GO:0006139 274 0.114
cellular nitrogen compound metabolic process GO:0034641 290 0.113
nitrogen compound metabolic process GO:0006807 319 0.098
nucleic acid metabolic process GO:0090304 244 0.095
centrosome organization GO:0051297 1 0.094
cellular macromolecule metabolic process GO:0044260 391 0.090
regulation of metabolic process GO:0019222 359 0.087
regulation of biosynthetic process GO:0009889 250 0.087
ribonucleoside monophosphate catabolic process GO:0009158 4 0.086
centrosome cycle GO:0007098 1 0.086
regulation of establishment of protein localization GO:0070201 4 0.084
regulation of erk1 and erk2 cascade GO:0070372 4 0.084
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.084
regulation of nitrogen compound metabolic process GO:0051171 251 0.083
aging GO:0007568 2 0.083
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.081
purine nucleoside monophosphate catabolic process GO:0009128 4 0.081
carbohydrate biosynthetic process GO:0016051 1 0.080
heterocycle biosynthetic process GO:0018130 215 0.075
regulation of mrna splicing via spliceosome GO:0048024 3 0.072
signal transduction GO:0007165 455 0.072
centrosome duplication GO:0051298 1 0.071
biosynthetic process GO:0009058 294 0.071
alternative mrna splicing via spliceosome GO:0000380 1 0.068
nuclear transport GO:0051169 4 0.068
erk1 and erk2 cascade GO:0070371 4 0.065
cellular nitrogen compound biosynthetic process GO:0044271 218 0.064
regulation of cellular metabolic process GO:0031323 320 0.064
response to chemical GO:0042221 320 0.064
locomotion GO:0040011 313 0.063
response to organic substance GO:0010033 153 0.061
protein localization to nucleus GO:0034504 3 0.059
rna metabolic process GO:0016070 219 0.057
regulation of protein localization to nucleus GO:1900180 2 0.055
rna biosynthetic process GO:0032774 181 0.055
regulation of cytoplasmic transport GO:1903649 4 0.055
ubiquitin dependent protein catabolic process GO:0006511 3 0.055
regulation of transcription dna templated GO:0006355 213 0.055
regulation of primary metabolic process GO:0080090 311 0.054
regulation of mrna processing GO:0050684 3 0.054
negative regulation of biological process GO:0048519 304 0.052
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.052
nucleocytoplasmic transport GO:0006913 4 0.051
heterocycle metabolic process GO:0046483 290 0.051
regulation of gene expression GO:0010468 265 0.050
negative regulation of cellular process GO:0048523 283 0.049
regulation of cellular ketone metabolic process GO:0010565 7 0.047
cellular biosynthetic process GO:0044249 286 0.046
single organism transport GO:0044765 206 0.046
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.045
regulation of macromolecule metabolic process GO:0060255 317 0.045
cellular ketone metabolic process GO:0042180 11 0.045
maintenance of location GO:0051235 4 0.044
cellular carbohydrate metabolic process GO:0044262 4 0.044
single organism metabolic process GO:0044710 217 0.044
embryo development ending in birth or egg hatching GO:0009792 271 0.044
organic substance biosynthetic process GO:1901576 289 0.042
regulation of signaling GO:0023051 235 0.042
single organism localization GO:1902578 225 0.042
locomotor rhythm GO:0045475 3 0.041
positive regulation of neuron apoptotic process GO:0043525 1 0.040
negative regulation of protein import into nucleus GO:0042308 2 0.040
establishment of localization GO:0051234 244 0.039
organic cyclic compound biosynthetic process GO:1901362 223 0.039
regulation of protein transport GO:0051223 3 0.039
protein import GO:0017038 3 0.039
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.038
regulation of rna metabolic process GO:0051252 224 0.038
regulation of carbohydrate metabolic process GO:0006109 4 0.038
regulation of intracellular protein transport GO:0033157 3 0.038
establishment of protein localization to organelle GO:0072594 4 0.037
cellular protein metabolic process GO:0044267 129 0.037
stem cell division GO:0017145 1 0.036
nuclear import GO:0051170 3 0.036
regulation of cellular biosynthetic process GO:0031326 245 0.036
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.036
regulation of multicellular organism growth GO:0040014 4 0.035
mitotic dna damage checkpoint GO:0044773 4 0.035
mitochondrion organization GO:0007005 4 0.035
regulation of macromolecule biosynthetic process GO:0010556 225 0.035
cellular protein modification process GO:0006464 100 0.035
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.035
single organism nuclear import GO:1902593 3 0.034
regulation of cell communication GO:0010646 232 0.034
modification dependent macromolecule catabolic process GO:0043632 3 0.034
positive regulation of biological process GO:0048518 253 0.034
protein targeting to nucleus GO:0044744 3 0.034
negative regulation of cytoplasmic transport GO:1903650 2 0.033
generation of neurons GO:0048699 385 0.033
atp catabolic process GO:0006200 4 0.033
regulation of protein targeting GO:1903533 2 0.033
regulation of circadian rhythm GO:0042752 4 0.032
amino acid transport GO:0006865 2 0.031
cell cycle g1 s phase transition GO:0044843 1 0.031
regulation of developmental process GO:0050793 247 0.031
organelle organization GO:0006996 227 0.031
negative regulation of protein transport GO:0051224 3 0.031
protein import into nucleus GO:0006606 3 0.031
cellular component biogenesis GO:0044085 178 0.030
regulation of rna biosynthetic process GO:2001141 213 0.029
proteasomal protein catabolic process GO:0010498 2 0.029
regulation of nucleocytoplasmic transport GO:0046822 2 0.029
negative regulation of intracellular protein transport GO:0090317 3 0.029
multicellular organism growth GO:0035264 4 0.028
endocrine hormone secretion GO:0060986 2 0.028
negative regulation of intracellular transport GO:0032387 3 0.028
oxoacid metabolic process GO:0043436 31 0.027
rna localization GO:0006403 4 0.027
cellular amino acid metabolic process GO:0006520 7 0.027
regulation of nucleic acid templated transcription GO:1903506 213 0.027
positive regulation of cellular process GO:0048522 201 0.027
hormone transport GO:0009914 2 0.027
organic acid metabolic process GO:0006082 31 0.026
regulation of stem cell proliferation GO:0072091 2 0.026
positive regulation of catabolic process GO:0009896 4 0.026
lipid storage GO:0019915 1 0.026
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
negative regulation of cellular biosynthetic process GO:0031327 55 0.026
g protein coupled receptor signaling pathway GO:0007186 74 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
positive regulation of ras protein signal transduction GO:0046579 1 0.025
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.025
nucleoside monophosphate catabolic process GO:0009125 4 0.025
transport GO:0006810 220 0.025
glucose homeostasis GO:0042593 1 0.025
regulation of hormone secretion GO:0046883 2 0.025
regulation of protein import into nucleus GO:0042306 2 0.024
regulation of phosphate metabolic process GO:0019220 43 0.024
hormone secretion GO:0046879 2 0.024
small molecule metabolic process GO:0044281 77 0.024
cellular amine metabolic process GO:0044106 2 0.024
spindle assembly GO:0051225 2 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.023
protein metabolic process GO:0019538 183 0.023
cellular response to starvation GO:0009267 1 0.023
cytokinesis GO:0000910 3 0.023
alcohol biosynthetic process GO:0046165 2 0.023
cellular macromolecule biosynthetic process GO:0034645 224 0.023
multicellular organismal metabolic process GO:0044236 2 0.022
regulation of protein ubiquitination GO:0031396 3 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
organelle assembly GO:0070925 110 0.022
positive regulation of cellular catabolic process GO:0031331 3 0.022
amine metabolic process GO:0009308 2 0.022
mitotic dna integrity checkpoint GO:0044774 4 0.021
regulation of nucleoside metabolic process GO:0009118 2 0.021
regulation of epithelial cell proliferation GO:0050678 3 0.021
secondary metabolic process GO:0019748 3 0.021
positive regulation of cellular component biogenesis GO:0044089 3 0.021
cellular component morphogenesis GO:0032989 336 0.021
g1 s transition of mitotic cell cycle GO:0000082 1 0.021
negative regulation of protein localization to nucleus GO:1900181 2 0.021
cellular response to extracellular stimulus GO:0031668 2 0.021
macromolecule biosynthetic process GO:0009059 227 0.020
immune system development GO:0002520 191 0.020
peptidyl threonine phosphorylation GO:0018107 1 0.020
regulation of cellular amine metabolic process GO:0033238 0 0.020
cell morphogenesis GO:0000902 289 0.020
protein polymerization GO:0051258 4 0.020
cellular modified amino acid metabolic process GO:0006575 3 0.020
peptidyl serine phosphorylation GO:0018105 1 0.020
response to stress GO:0006950 263 0.020
macromolecule modification GO:0043412 111 0.020
regulation of response to stimulus GO:0048583 269 0.020
modification dependent protein catabolic process GO:0019941 3 0.020
er to golgi vesicle mediated transport GO:0006888 1 0.019
nucleobase containing compound biosynthetic process GO:0034654 205 0.019
mononuclear cell proliferation GO:0032943 1 0.019
ras protein signal transduction GO:0007265 7 0.019
regulation of biological quality GO:0065008 263 0.019
positive regulation of epithelial cell proliferation GO:0050679 1 0.019
regulation of reproductive process GO:2000241 4 0.019
protein modification process GO:0036211 100 0.019
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.019
phosphorylation GO:0016310 69 0.019
mrna metabolic process GO:0016071 20 0.019
regulation of phosphorus metabolic process GO:0051174 43 0.019
microtubule polymerization GO:0046785 2 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.019
cellular component assembly GO:0022607 170 0.018
regulation of reactive oxygen species metabolic process GO:2000377 2 0.018
positive regulation of stem cell proliferation GO:2000648 1 0.018
meiosis i GO:0007127 1 0.018
response to alkaloid GO:0043279 2 0.018
cellular protein catabolic process GO:0044257 4 0.018
negative regulation of cellular metabolic process GO:0031324 77 0.018
positive regulation of cell communication GO:0010647 56 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
cellular response to nutrient levels GO:0031669 2 0.018
response to glucose GO:0009749 3 0.018
regulation of protein catabolic process GO:0042176 1 0.018
positive regulation of neuron death GO:1901216 1 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
negative regulation of protein complex assembly GO:0031333 1 0.018
small gtpase mediated signal transduction GO:0007264 8 0.018
regulation of carbohydrate biosynthetic process GO:0043255 1 0.017
regulation of endocrine process GO:0044060 2 0.017
stem cell proliferation GO:0072089 4 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
phosphorus metabolic process GO:0006793 109 0.017
cellular amide metabolic process GO:0043603 4 0.017
carbohydrate homeostasis GO:0033500 1 0.017
peptide metabolic process GO:0006518 1 0.017
rna modification GO:0009451 2 0.017
extrinsic apoptotic signaling pathway GO:0097191 3 0.017
transcription dna templated GO:0006351 181 0.017
peptidyl lysine acetylation GO:0018394 2 0.017
rna processing GO:0006396 25 0.016
regulation of cytokine production GO:0001817 3 0.016
regulation of signal transduction GO:0009966 225 0.016
b cell activation GO:0042113 2 0.016
oocyte maturation GO:0001556 4 0.016
negative regulation of gene expression GO:0010629 65 0.016
neuroblast proliferation GO:0007405 2 0.016
circadian regulation of gene expression GO:0032922 8 0.016
peptide transport GO:0015833 1 0.016
stem cell maintenance GO:0019827 4 0.016
cognition GO:0050890 1 0.016
regulation of jak stat cascade GO:0046425 3 0.016
digestive tract development GO:0048565 265 0.016
cellular response to external stimulus GO:0071496 2 0.016
nucleic acid templated transcription GO:0097659 181 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
cellular response to radiation GO:0071478 4 0.016
intracellular signal transduction GO:0035556 85 0.016
single organism organelle organization GO:1902589 199 0.016
steroid hormone secretion GO:0035929 1 0.016
dicarboxylic acid transport GO:0006835 1 0.016
phagocytosis GO:0006909 3 0.016
response to carbohydrate GO:0009743 3 0.015
cell morphogenesis involved in differentiation GO:0000904 195 0.015
regulation of autophagy GO:0010506 3 0.015
cellular macromolecule catabolic process GO:0044265 12 0.015
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.015
response to nutrient GO:0007584 3 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.015
regulation of phosphorylation GO:0042325 26 0.015
regulation of photoreceptor cell differentiation GO:0046532 2 0.015
positive regulation of cell cycle GO:0045787 3 0.015
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.015
regulation of receptor activity GO:0010469 2 0.015
growth GO:0040007 174 0.015
rna polyadenylation GO:0043631 2 0.015
muscle organ development GO:0007517 101 0.015
response to abiotic stimulus GO:0009628 122 0.015
female sex differentiation GO:0046660 4 0.015
response to monosaccharide GO:0034284 3 0.015
cellular response to oxygen levels GO:0071453 1 0.015
spindle assembly involved in mitosis GO:0090307 1 0.015
protein acetylation GO:0006473 2 0.015
nuclear export GO:0051168 1 0.015
cell part morphogenesis GO:0032990 246 0.015
positive regulation of protein complex assembly GO:0031334 2 0.015
nucleic acid transport GO:0050657 2 0.014
regulation of calcium ion transport GO:0051924 2 0.014
positive regulation of response to stimulus GO:0048584 80 0.014
toll like receptor signaling pathway GO:0002224 4 0.014
lymphocyte proliferation GO:0046651 1 0.014
peptidyl serine modification GO:0018209 2 0.014
nuclear migration GO:0007097 3 0.014
regulation of dna templated transcription elongation GO:0032784 3 0.014
negative regulation of ras protein signal transduction GO:0046580 1 0.014
regulation of endothelial cell proliferation GO:0001936 1 0.014
regulation of response to oxidative stress GO:1902882 2 0.014
regulation of cell shape GO:0008360 1 0.014
pole plasm assembly GO:0007315 4 0.014
protein acylation GO:0043543 3 0.014
positive regulation of metabolic process GO:0009893 108 0.014
regulation of cell activation GO:0050865 1 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
immune system process GO:0002376 241 0.014
endocrine process GO:0050886 2 0.014
regulation of transcription from rna polymerase ii promoter in response to stress GO:0043618 0 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
positive regulation of transport GO:0051050 2 0.013
female gonad development GO:0008585 4 0.013
aromatic compound biosynthetic process GO:0019438 217 0.013
mrna export from nucleus GO:0006406 1 0.013
organic substance transport GO:0071702 58 0.013
adult behavior GO:0030534 2 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
ribosomal small subunit biogenesis GO:0042274 2 0.013
double strand break repair via homologous recombination GO:0000724 1 0.013
blood vessel development GO:0001568 246 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
macromolecular complex assembly GO:0065003 35 0.013
regulation of oocyte development GO:0060281 3 0.013
regulation of blood pressure GO:0008217 1 0.013
positive regulation of blood circulation GO:1903524 2 0.013
regulation of binding GO:0051098 3 0.013
hepaticobiliary system development GO:0061008 98 0.013
response to hexose GO:0009746 3 0.013
mesoderm development GO:0007498 88 0.013
regulation of synapse assembly GO:0051963 3 0.013
meiotic nuclear division GO:0007126 4 0.013
regulation of chromosome segregation GO:0051983 1 0.013
meiotic cell cycle process GO:1903046 3 0.013
negative regulation of catabolic process GO:0009895 3 0.013
response to uv GO:0009411 3 0.013
response to lipid GO:0033993 60 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
regulation of production of molecular mediator of immune response GO:0002700 1 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
regulation of mesenchymal cell proliferation GO:0010464 1 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
meiotic chromosome segregation GO:0045132 3 0.013
cellular response to hypoxia GO:0071456 1 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
intracellular mrna localization GO:0008298 1 0.012
peptidyl lysine methylation GO:0018022 3 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
regulation of protein complex assembly GO:0043254 3 0.012
positive regulation of muscle tissue development GO:1901863 1 0.012
single fertilization GO:0007338 3 0.012
recombinational repair GO:0000725 1 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.012
regulation of tube size GO:0035150 2 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
cellular component disassembly GO:0022411 1 0.012
system process GO:0003008 185 0.012
regulation of dna templated transcription in response to stress GO:0043620 0 0.012
muscle structure development GO:0061061 196 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
membrane invagination GO:0010324 1 0.012
phagocytosis engulfment GO:0006911 1 0.012
negative regulation of kinase activity GO:0033673 4 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
neuron development GO:0048666 262 0.012
cell aging GO:0007569 2 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
regulation of microtubule cytoskeleton organization GO:0070507 3 0.012
regulation of blood vessel size GO:0050880 2 0.012
negative regulation of cell differentiation GO:0045596 46 0.012
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
sensory perception of pain GO:0019233 1 0.012
leukocyte proliferation GO:0070661 1 0.012
heart development GO:0007507 313 0.012
regulation of oxidative stress induced cell death GO:1903201 2 0.012
regulation of response to cytokine stimulus GO:0060759 3 0.011
regulation of cellular component organization GO:0051128 86 0.011
primary neural tube formation GO:0014020 1 0.011
determination of bilateral symmetry GO:0009855 204 0.011
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.011
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.011
regulation of steroid hormone secretion GO:2000831 1 0.011
germ line stem cell maintenance GO:0030718 2 0.011
protein heterooligomerization GO:0051291 1 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
cytoplasm organization GO:0007028 4 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
digestive system development GO:0055123 289 0.011
cell proliferation GO:0008283 80 0.011
rna 3 end processing GO:0031123 2 0.011
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.011
regulation of cell differentiation GO:0045595 142 0.011
astrocyte differentiation GO:0048708 1 0.011
head development GO:0060322 303 0.011
cell projection morphogenesis GO:0048858 244 0.011
regulation of histone methylation GO:0031060 3 0.011
mesenchymal cell proliferation GO:0010463 1 0.011
negative regulation of nuclear division GO:0051784 3 0.011
sleep GO:0030431 1 0.011
peptidyl threonine modification GO:0018210 1 0.011
rna export from nucleus GO:0006405 1 0.011
response to oxygen containing compound GO:1901700 55 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
circadian sleep wake cycle process GO:0022410 2 0.011
regulation of synapse organization GO:0050807 3 0.011
apoptotic process GO:0006915 116 0.011
programmed cell death GO:0012501 119 0.011
cellular transition metal ion homeostasis GO:0046916 3 0.011
morphogenesis of an epithelium GO:0002009 333 0.011
histone phosphorylation GO:0016572 2 0.011
apoptotic process involved in development GO:1902742 2 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
nuclear transcribed mrna catabolic process GO:0000956 4 0.010
positive regulation of muscle cell differentiation GO:0051149 1 0.010
regulation of inflammatory response GO:0050727 2 0.010
single organism biosynthetic process GO:0044711 71 0.010
antimicrobial humoral response GO:0019730 2 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.010
negative regulation of biosynthetic process GO:0009890 55 0.010
cell substrate adhesion GO:0031589 4 0.010
positive regulation of translation GO:0045727 1 0.010
positive regulation of cell division GO:0051781 2 0.010
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.010
establishment of rna localization GO:0051236 3 0.010
negative regulation of cytokine production GO:0001818 1 0.010
response to unfolded protein GO:0006986 2 0.010
mrna processing GO:0006397 14 0.010
regulation of multicellular organismal process GO:0051239 277 0.010
nephron epithelium morphogenesis GO:0072088 1 0.010
regionalization GO:0003002 274 0.010
response to vitamin GO:0033273 3 0.010

clk4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.034
nervous system disease DOID:863 0 0.022
musculoskeletal system disease DOID:17 0 0.020
bone disease DOID:0080001 0 0.012
connective tissue disease DOID:65 0 0.012
disease of metabolism DOID:0014667 0 0.011